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The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008] See more...
Aliases for INSL5 Gene
Aliases for INSL5 Gene
External Ids for INSL5 Gene
- HGNC: 6088
- Entrez Gene: 10022
- Ensembl: ENSG00000172410
- OMIM: 606413
- UniProtKB: Q9Y5Q6
Previous GeneCards Identifiers for INSL5 Gene
- GC01M067223
- GC01M066194
- GC01M066621
- GC01M066633
- GC01M066975
- GC01M065371
Summaries for INSL5 Gene
-
The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]
GeneCards Summary for INSL5 Gene
INSL5 (Insulin Like 5) is a Protein Coding gene. Diseases associated with INSL5 include Fatal Infantile Hypertonic Myofibrillar Myopathy and Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is RLN3.
UniProtKB/Swiss-Prot Summary for INSL5 Gene
-
May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
Additional gene information for INSL5 Gene
- HGNC(6088)
- Entrez Gene(10022)
- Ensembl(ENSG00000172410)
- OMIM(606413)
- UniProtKB(Q9Y5Q6)
- Open Targets Platform(ENSG00000172410)
- Search for INSL5 at DataMed
- Search for INSL5 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INSL5 Gene
Genomics for INSL5 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for INSL5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around INSL5 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INSL5
- Top Transcription factor binding sites by QIAGEN in the INSL5 gene promoter:
-
- Cdc5
- CUTL1
- HNF-1
- HNF-1A
- HOXA9
- HOXA9B
- Meis-1
- Meis-1b
- Nkx6-1
Genomic Locations for INSL5 Gene
Genomic Locations for INSL5 Gene
- chr1:66,797,740-66,801,276
- (GRCh38/hg38)
- Size:
- 3,537 bases
- Orientation:
- Minus strand
- chr1:67,263,424-67,266,942
- (GRCh37/hg19)
- Size:
- 3,519 bases
- Orientation:
- Minus strand
Genomic View for INSL5 Gene
Genes around INSL5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
INSL5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INSL5 Gene
Proteins for INSL5 Gene
-
Protein details for INSL5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5Q6-INSL5_HUMAN
- Recommended name:
- Insulin-like peptide INSL5
- Protein Accession:
- Q9Y5Q6
- Q3MIY4
- Q5VYD8
Protein attributes for INSL5 Gene
- Size:
- 135 amino acids
- Molecular mass:
- 15333 Da
- Quaternary structure:
-
- Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Protein Expression for INSL5 Gene
Post-translational modifications for INSL5 Gene
No Post-translational modifications
Other Protein References for INSL5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ INSL5 Antibody
-
Custom Antibody ServicesOriGene Antibodies for INSL5
- Novus Biologicals Antibodies for INSL5
-
Abcam antibodies for INSL5
- Invitrogen Antibodies for INSL5 (AFLGC-INSL5)
-
Boster Bio Antibodies for INSL5
-
Santa Cruz Biotechnology (SCBT) Antibodies for INSL5
- Sino Biological Antibodies for INSL5
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for INSL5
- Origene Custom Protein Services for INSL5
-
Signalway Proteins for INSL5
-
Abcam proteins for INSL5
Assay Products
- G Biosciences Immunotag™ Human INSL5 (Insulin Like Protein 5) ELISA
- Novus Biologicals ELISA Kits for INSL5
No data available for DME Specific Peptides for INSL5 Gene
Domains & Families for INSL5 Gene
Gene Families for INSL5 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for INSL5 Gene
- InterPro:
- Blocks:
-
- Insulin/IGF/relaxin
- ProtoNet:
Suggested Antigen Peptide Sequences for INSL5 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like peptide INSL5 (INSL5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9Y5Q6- Family:
-
- Belongs to the insulin family.
Function for INSL5 Gene
Molecular function for INSL5 Gene
- UniProtKB/Swiss-Prot Function:
- May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor.
- GENATLAS Biochemistry:
- insulin-like 5,expressed in rectal,colon and uterine tissue
Phenotypes From GWAS Catalog for INSL5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | IBA | 21873635 |
| GO:0005179 | hormone activity | IEA | -- |
Phenotypes for INSL5 Gene
- MGI mutant phenotypes for INSL5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for INSL5:
Animal Model Products
-
Taconic Biosciences Mouse Models for INSL5
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for INSL5 - Select products 50% OFF >
- * INSL5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for INSL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INSL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for INSL5
miRNA for INSL5 Gene
- miRTarBase miRNAs that target INSL5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INSL5
- Browse OriGene Inhibitory RNA Products For INSL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INSL5
Clone Products
- Applied Biological Materials (abm): Clones for INSL5 - Select products 50% OFF >
- * INSL5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for INSL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INSL5
Cell Line Products
-
Horizon Cell Lines for INSL5
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INSL5 Gene
Localization for INSL5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for INSL5 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for INSL5 Gene
Pathways & Interactions for INSL5 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Relaxin signaling pathway | ||
Pathways by source for INSL5 Gene
8 Reactome pathways for INSL5 Gene
2 KEGG pathways for INSL5 Gene
Interacting Proteins for INSL5 Gene
Selected Interacting proteins:
Q9Y5Q6-INSL5_HUMAN
ENSP00000302724
for INSL5 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for INSL5
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
| GO:0008150 | biological_process | ND | -- |
| GO:2000253 | positive regulation of feeding behavior | IBA | 21873635 |
No data available for SIGNOR curated interactions for INSL5 Gene
Transcripts for INSL5 Gene
mRNA/cDNA for INSL5 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304526 715 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for INSL5 - Select products 50% OFF >
- * INSL5 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for INSL5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INSL5
-
Santa Cruz Biotechnology (SCBT) CRISPR for INSL5
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INSL5
- Browse OriGene Inhibitory RNA Products For INSL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INSL5
Clone Products
- Applied Biological Materials (abm): Clones for INSL5 - Select products 50% OFF >
- * INSL5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for INSL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INSL5
Relevant External Links for INSL5 Gene
- GeneLoc Exon Structure for
- INSL5
Expression for INSL5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for INSL5 Gene
This gene is overexpressed in Colon - Sigmoid (x14.6) and Colon - Transverse (x10.7).
This gene is overexpressed in Rectum (34.7) and Colon (34.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INSL5 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INSL5
SOURCE GeneReport for Unigene cluster for INSL5 Gene:
Hs.251380mRNA Expression by UniProt/SwissProt for INSL5 Gene:
Q9Y5Q6-INSL5_HUMAN
Tissue specificity:
Highly expressed in rectum with lower levels in uterus and ascending and descending colon.
Evidence on tissue expression from TISSUES for INSL5 Gene
- Intestine(4.6)
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for INSL5
-
OriGene qPCR primer pairs and template standards for INSL5
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INSL5 Gene
Orthologs for INSL5 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | INSL5 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | INSL5 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Insl5 30 17 31 |
|
OneToOne |
- Species where no ortholog for INSL5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for INSL5 Gene
- ENSEMBL:
- Gene Tree for INSL5 (if available)
- TreeFam:
- Gene Tree for INSL5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for INSL5: view image
Paralogs for INSL5 Gene
Variants for INSL5 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INSL5 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs549148 | - | p.Gln50Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3893623 | CNV | gain | 25118596 |
| nsv830093 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.44;
9.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for INSL5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- INSL5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INSL5 Gene
Disorders for INSL5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fatal infantile hypertonic myofibrillar myopathy |
|
|
| cryptorchidism, unilateral or bilateral |
|
|
Search INSL5 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for INSL5
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for INSL5 Gene
Publications for INSL5 Gene
- Identification of INSL5, a new member of the insulin superfamily. (PMID: 10458910) Conklin D … Jaspers S (Genomics 1999) 2 3 4 23
- Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. (PMID: 19178384) Haugaard-Jönsson LM … Rosengren KJ (The Biochemical journal 2009) 3 4 23
- INSL5 is a high affinity specific agonist for GPCR142 (GPR100). (PMID: 15525639) Liu C … Lovenberg TW (The Journal of biological chemistry 2005) 3 4 23
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
- Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5). (PMID: 18576448) Akhter Hossain M … Wade JD (Chembiochem : a European journal of chemical biology 2008) 4 23
ExternalLinks
Products for INSL5 Gene
- Custom Antibody ServicesOriGene Antibodies for INSL5
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for INSL5
- Origene Custom Protein Services for INSL5
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INSL5
- Browse OriGene Inhibitory RNA Products For INSL5
- OriGene qPCR primer pairs for INSL5
- OriGene qPCR primer pairs and template standards for INSL5
- OriGene CRISPR knockouts for INSL5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For INSL5
- Sino Biological Human cDNA Clone for INSL5
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for INSL5
- Browse Sino Biological Assays
- Browse Antibodies
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for INSL5
- Novus Biologicals proteins and lysates for INSL5
- Novus Biologicals ELISA Kits for INSL5
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for INSL5
- Abcam proteins for INSL5
- Find your target
- Browse Primary Antibodies
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- Taconic Biosciences Mouse Models for INSL5
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for INSL5 (AFLGC-INSL5)
- VectorBuilder Custom and pre-made DNA vectors for INSL5 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for INSL5 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for INSL5 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for INSL5 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for INSL5
- antibodies-online: Show 6 available INSL5 Antibodies ranked by validation data
- Compare Top INSL5 Antibodies
- antibodies-online: Show 55 available INSL5 Elisa Kits ranked by validation data
- Compare Top INSL5 Elisa Kits
- antibodies-online: Show 6 available INSL5 Proteins ranked by validation data
- Compare Top INSL5 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for INSL5
- Search Santa Cruz Biotechnology (SCBT) for INSL5 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for INSL5
- Horizon Cell Lines for INSL5
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INSL5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INSL5
- Search GeneCopoeia for miRNA 3'UTR Target clone products for INSL5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INSL5
- Boster Bio Antibodies for INSL5
- Browse Boster Bio ELISA Kits
Sources for INSL5 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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