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In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
INSC (INSC Spindle Orientation Adaptor Protein) is a Protein Coding gene. Diseases associated with INSC include Cone-Rod Dystrophy 6. Gene Ontology (GO) annotations related to this gene include binding.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J015114 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE CraniofacialAtlas | 259.7 | +3.6 | 3582 | 1.2 | RAD21 EZH2 | INSC HSALNG0082850 | |
GH11J015112 | Enhancer | 0.3 | ENCODE | 259.3 | +1.0 | 1026 | 0.6 | ZSCAN4 | INSC HSALNG0082850 | |
GH11J015075 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 10.3 | -37.0 | -37015 | 2.4 | ZBTB10 CEBPA CTCF ZIC2 HOMEZ ZNF610 SIN3A REST ZNF639 ZNF341 | CALCB COPB1 CYP2R1 CALCA INSC HSALNG0082848 lnc-INSC-4 | |
GH11J015194 | Enhancer | 0.8 | Ensembl ENCODE | 20.4 | +84.8 | 84826 | 2.7 | RXRA JUND HNF4A RAD21 REST MAX SP1 HNF1A ZNF644 NFIA | INSC NONHSAG007732.2 HSALNG0082850 HSALNG0082851 | |
GH11J015577 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 10.7 | +467.5 | 467485 | 7 | HES1 REST TAL1 RXRA FOXA2 ZFP91 ZNF316 FOSL1 SPI1 NFE2 | lnc-SOX6-6 INSC ENSG00000253072 ENSG00000254789 piR-55985-023 LINC02751 LOC105376568 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 16458856 |
GO:0008093 | cytoskeletal adaptor activity | IBA | 21873635 |
GO:0019904 | protein domain specific binding | IPI | 22074847 |
GO:0030674 | protein binding, bridging | IPI | 16458856 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | IMP | 22074847 |
GO:0005938 | colocalizes_with cell cortex | IMP | 22074847 |
GO:0032991 | protein-containing complex | IMP | 22074847 |
GO:0045179 | apical cortex | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000132 | establishment of mitotic spindle orientation | IBA | 21873635 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0007399 | nervous system development | IEA | -- |
GO:0008356 | asymmetric cell division | IEA | -- |
GO:0009786 | regulation of asymmetric cell division | IBA | 21873635 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | INSC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | INSC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | INSC 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Insc 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Insc 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | INSC 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | INSC 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | insc 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101885356 30 |
|
||
INSC 31 |
|
OneToOne | |||
Worm (Caenorhabditis elegans) |
Secernentea | insc-1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs61745926 | Benign: not provided | 15,200,836(+) |
G/A NM_001042536.3(INSC):c.706G>A (p.Val236Ile) |
MISSENSE_VARIANT,INTRON | |
rs17507577 | - |
p.Asp333Asn |
|||
rs7123855 | - |
p.Gln450Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1060n100 | CNV | gain | 25217958 |
dgv325e212 | CNV | loss | 25503493 |
esv3578261 | CNV | gain | 25503493 |
esv3579380 | CNV | loss | 25503493 |
esv3891932 | CNV | gain | 25118596 |
nsv1036474 | CNV | gain | 25217958 |
nsv477521 | CNV | novel sequence insertion | 20440878 |
nsv516403 | CNV | loss | 19592680 |
nsv832072 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cone-rod dystrophy 6 |
|
|