Aliases for INSC Gene
External Ids for INSC Gene
Previous GeneCards Identifiers for INSC Gene
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
GeneCards Summary for INSC Gene
INSC (INSC Spindle Orientation Adaptor Protein) is a Protein Coding gene. Diseases associated with INSC include Purulent Labyrinthitis and Neuronopathy, Distal Hereditary Motor, Type Iia. Gene Ontology (GO) annotations related to this gene include binding.
UniProtKB/Swiss-Prot Summary for INSC Gene
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity).