Aliases for INS Gene
External Ids for INS Gene
Previous HGNC Symbols for INS Gene
Previous GeneCards Identifiers for INS Gene
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]
GeneCards Summary for INS Gene
INS (Insulin) is a Protein Coding gene. Diseases associated with INS include Hyperproinsulinemia and Diabetes Mellitus, Insulin-Dependent, 2. Among its related pathways are Vesicle-mediated transport and PI3K/AKT activation. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding. An important paralog of this gene is INS-IGF2.
UniProtKB/Swiss-Prot Summary for INS Gene
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.