Aliases for INS Gene
External Ids for INS Gene
Previous HGNC Symbols for INS Gene
Previous GeneCards Identifiers for INS Gene
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
GeneCards Summary for INS Gene
INS (Insulin) is a Protein Coding gene. Diseases associated with INS include Maturity-Onset Diabetes Of The Young, Type 10 and Hyperproinsulinemia. Among its related pathways are RET signaling and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protease binding. An important paralog of this gene is INS-IGF2.
UniProtKB/Swiss-Prot Summary for INS Gene
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.