Aliases for INPP5K Gene
External Ids for INPP5K Gene
Previous GeneCards Identifiers for INPP5K Gene
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
GeneCards Summary for INPP5K Gene
INPP5K (Inositol Polyphosphate-5-Phosphatase K) is a Protein Coding gene. Diseases associated with INPP5K include Muscular Dystrophy, Congenital, With Cataracts And Intellectual Disability and Marinesco-Sjogren Syndrome. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include vasopressin receptor activity and lipid phosphatase activity. An important paralog of this gene is INPP5J.
UniProtKB/Swiss-Prot for INPP5K Gene
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity).