Aliases for INPP4B Gene
- Inositol Polyphosphate-4-Phosphatase Type II B 2 3 5
- Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa 2 3
- Type II Inositol 3,4-Bisphosphate 4-Phosphatase 3 4
- Inositol Polyphosphate 4-Phosphatase Type II 3 4
- EC 126.96.36.199 4 50
- Inositol Polyphosphate 4-Phosphatase II; 4-Phosphatase II 3
- Inositol Polyphosphate-4-Phosphatase, Type II, 105kD 2
- INPP4B 5
External Ids for INPP4B Gene
Previous GeneCards Identifiers for INPP4B Gene
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
GeneCards Summary for INPP4B Gene
INPP4B (Inositol Polyphosphate-4-Phosphatase Type II B) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include lipid binding and phosphatidylinositol trisphosphate phosphatase activity. An important paralog of this gene is INPP4A.
UniProtKB/Swiss-Prot Summary for INPP4B Gene
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612).