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Aliases for INPP4A Gene

Aliases for INPP4A Gene

  • Inositol Polyphosphate-4-Phosphatase Type I A 2 3 5
  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa 2 3
  • Inositol Polyphosphate-4-Phosphatase, Type I, 107kD 2 3
  • EC 4 56
  • Type I Inositol 3,4-Bisphosphate 4-Phosphatase 3
  • Inositol Polyphosphate 4-Phosphatase Type I 4
  • TVAS1 3
  • INPP4 3

External Ids for INPP4A Gene

Previous HGNC Symbols for INPP4A Gene

  • INPP4

Previous GeneCards Identifiers for INPP4A Gene

  • GC02P097017
  • GC02P097513
  • GC02P098665
  • GC02P098682
  • GC02P099061
  • GC02P092826

Summaries for INPP4A Gene

Entrez Gene Summary for INPP4A Gene

  • This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]

GeneCards Summary for INPP4A Gene

INPP4A (Inositol Polyphosphate-4-Phosphatase Type I A) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and Metabolism. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. An important paralog of this gene is INPP4B.

UniProtKB/Swiss-Prot for INPP4A Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.

Gene Wiki entry for INPP4A Gene

Additional gene information for INPP4A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP4A Gene

Genomics for INPP4A Gene

GeneHancer (GH) Regulatory Elements for INPP4A Gene

Promoters and enhancers for INPP4A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I098444 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 561.5 +1.1 1139 3.6 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 ZNF48 ZNF143 INPP4A LIPT1 PIR47012
GH02I098462 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.2 +24.2 24159 12.9 HDGF PKNOX1 SMAD1 IRF4 TCF12 ZNF121 ZNF766 GLIS2 GATA2 ZNF207 INPP4A LOC101927070 TMEM131 UNC50 MGAT4A PIR47012
GH02I098501 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.3 +60.9 60865 8.6 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ATF7 RUNX3 RXRA INPP4A MITD1 TMEM131 ENSG00000273306 REV1 UNC50 LOC550644 CNGA3 ENSG00000227987 MGAT4A
GH02I098606 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.3 +164.0 163969 4.2 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF207 UNC50 COA5 INPP4A RNU7-46P LIPT1 TSGA10 MRPL30 PIR57027
GH02I098451 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +12.2 12240 10.2 HDGF PKNOX1 FOXA2 IRF4 ZNF143 ZNF207 ATF7 FOS RUNX3 RXRA INPP4A MGAT4A LOC101927070 COX5B TMEM131 PIR47012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INPP4A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INPP4A gene promoter:

Genomic Locations for INPP4A Gene

Genomic Locations for INPP4A Gene
149,537 bases
Plus strand

Genomic View for INPP4A Gene

Genes around INPP4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP4A Gene

Proteins for INPP4A Gene

  • Protein details for INPP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Type I inositol 3,4-bisphosphate 4-phosphatase
    Protein Accession:
    Secondary Accessions:
    • O15326
    • Q13187
    • Q53TD8
    • Q8TC02

    Protein attributes for INPP4A Gene

    977 amino acids
    Molecular mass:
    109956 Da
    Quaternary structure:
    • Interacts with INPP5F.

    Alternative splice isoforms for INPP4A Gene


neXtProt entry for INPP4A Gene

Selected DME Specific Peptides for INPP4A Gene


Post-translational modifications for INPP4A Gene

  • Ubiquitination at posLast=959959
  • Modification sites at PhosphoSitePlus

Domains & Families for INPP4A Gene

Gene Families for INPP4A Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INPP4A Gene


Suggested Antigen Peptide Sequences for INPP4A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
  • Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.
genes like me logo Genes that share domains with INPP4A: view

Function for INPP4A Gene

Molecular function for INPP4A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.

Enzyme Numbers (IUBMB) for INPP4A Gene

Phenotypes From GWAS Catalog for INPP4A Gene

Gene Ontology (GO) - Molecular Function for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25869668
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0017161 inositol-1,3,4-trisphosphate 4-phosphatase activity TAS --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA --
genes like me logo Genes that share ontologies with INPP4A: view
genes like me logo Genes that share phenotypes with INPP4A: view

Animal Models for INPP4A Gene

MGI Knock Outs for INPP4A:

Animal Model Products

  • Taconic Biosciences Mouse Models for INPP4A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP4A Gene

Localization for INPP4A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INPP4A gene
Compartment Confidence
cytosol 5
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP4A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP4A Gene

Pathways & Interactions for INPP4A Gene

genes like me logo Genes that share pathways with INPP4A: view

UniProtKB/Swiss-Prot Q96PE3-INP4A_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway.

Gene Ontology (GO) - Biological Process for INPP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007165 signal transduction TAS 7608176
GO:0016311 dephosphorylation IEA --
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with INPP4A: view

No data available for SIGNOR curated interactions for INPP4A Gene

Drugs & Compounds for INPP4A Gene

(2) Drugs for INPP4A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(5) Additional Compounds for INPP4A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
  • D-Myo-Inositol 3,4-bisphosphate
  • Inositol 3,4-bisphosphate
1D-myo-Inositol 3-phosphate
  • 1D-Myo-Inositol 3-monophosphate
  • 1L-Myo-Inositol 1-phosphate
  • D-Myo-Inositol 3-monophosphate
  • D-Myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • 1-Phosphatidyl-1D-myo-inositol 3-phosphate
  • Phosphatidylinositol 3-phosphate
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with INPP4A: view

Transcripts for INPP4A Gene

Unigene Clusters for INPP4A Gene

Inositol polyphosphate-4-phosphatase, type I, 107kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP4A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28
SP1: - -

Relevant External Links for INPP4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INPP4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP4A Gene

This gene is overexpressed in CD8 Tcells (10.1), Brain (9.1), Lymph node (7.4), and Frontal cortex (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP4A Gene

Protein tissue co-expression partners for INPP4A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INPP4A Gene:


SOURCE GeneReport for Unigene cluster for INPP4A Gene:


mRNA Expression by UniProt/SwissProt for INPP4A Gene:

Tissue specificity: Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.

Evidence on tissue expression from TISSUES for INPP4A Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with INPP4A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for INPP4A Gene

Orthologs for INPP4A Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INPP4A 33 34
  • 99.69 (n)
(Canis familiaris)
Mammalia INPP4A 33 34
  • 92.73 (n)
(Monodelphis domestica)
Mammalia INPP4A 34
  • 91 (a)
(Bos Taurus)
Mammalia INPP4A 33 34
  • 90.56 (n)
(Mus musculus)
Mammalia Inpp4a 33 16 34
  • 89.98 (n)
(Rattus norvegicus)
Mammalia Inpp4a 33
  • 89.45 (n)
(Gallus gallus)
Aves INPP4A 33 34
  • 79.9 (n)
(Anolis carolinensis)
Reptilia INPP4A 34
  • 89 (a)
(Danio rerio)
Actinopterygii inpp4ab 34
  • 82 (a)
inpp4aa 33 34
  • 71.77 (n)
Dr.12539 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000124 33
  • 47.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42271 33 34
  • 47.07 (n)
CG1846 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea R01H10.7 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for INPP4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for INPP4A Gene

Gene Tree for INPP4A (if available)
Gene Tree for INPP4A (if available)

Paralogs for INPP4A Gene

Paralogs for INPP4A Gene

(1) SIMAP similar genes for INPP4A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with INPP4A: view

Variants for INPP4A Gene

Sequence variations from dbSNP and Humsavar for INPP4A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000024572 -- 98,443,769(+) T/C upstream_transcript_variant
rs1000057402 -- 98,518,050(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000058408 -- 98,519,866(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000121412 -- 98,512,148(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000146666 -- 98,471,118(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INPP4A Gene

Variant ID Type Subtype PubMed ID
nsv1007244 CNV gain 25217958
nsv1133477 CNV deletion 24896259
nsv2840 CNV deletion 18451855
nsv518056 CNV gain 19592680

Variation tolerance for INPP4A Gene

Residual Variation Intolerance Score: 5.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INPP4A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP4A Gene

Disorders for INPP4A Gene

Additional Disease Information for INPP4A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for INPP4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INPP4A Gene

Publications for INPP4A Gene

  1. The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family. (PMID: 9295334) Norris FA … Majerus PW (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. (PMID: 18187694) Sharma M … Ghosh B (American journal of respiratory and critical care medicine 2008) 3 22 44 58
  3. Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. (PMID: 11485317) Shearn CT … Norris FA (Biochemical and biophysical research communications 2001) 3 4 22 58
  4. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. (PMID: 7608176) Norris FA … Majerus PW (The Journal of biological chemistry 1995) 2 3 4 58
  5. Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway. (PMID: 25869668) Nakatsu F … De Camilli P (The Journal of cell biology 2015) 3 4 58

Products for INPP4A Gene

Sources for INPP4A Gene

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