Aliases for INPP4A Gene
- Inositol Polyphosphate-4-Phosphatase Type I A 2 3 4 5
- Type I Inositol 3,4-Bisphosphate 4-Phosphatase 2 3 4
- Inositol Polyphosphate-4-Phosphatase, Type I, 107kDa 2 3
- Inositol Polyphosphate-4-Phosphatase, Type I, 107kD 2 3
- EC 184.108.40.206 4 50
- Inositol Polyphosphate 4-Phosphatase Type I 4
- INPP4A 5
- INPP4 3
- TVAS1 3
External Ids for INPP4A Gene
Previous HGNC Symbols for INPP4A Gene
Previous GeneCards Identifiers for INPP4A Gene
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
GeneCards Summary for INPP4A Gene
INPP4A (Inositol Polyphosphate-4-Phosphatase Type I A) is a Protein Coding gene. Diseases associated with INPP4A include Alacrima, Achalasia, And Mental Retardation Syndrome and Disease Of Mental Health. Among its related pathways are Glycerophospholipid biosynthesis and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. An important paralog of this gene is INPP4B.
UniProtKB/Swiss-Prot Summary for INPP4A Gene
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
[Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.