Free for academic non-profit institutions. Other users need a Commercial license

Aliases for INPP1 Gene

Aliases for INPP1 Gene

  • Inositol Polyphosphate-1-Phosphatase 2 3 5
  • IPPase 3 4
  • IPP 3 4
  • Inositol Polyphosphate 1-Phosphatase 3
  • EC 4

External Ids for INPP1 Gene

Previous GeneCards Identifiers for INPP1 Gene

  • GC02P189402
  • GC02P189911
  • GC02P191172
  • GC02P191410
  • GC02P191033
  • GC02P190916
  • GC02P183068

Summaries for INPP1 Gene

Entrez Gene Summary for INPP1 Gene

  • This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

GeneCards Summary for INPP1 Gene

INPP1 (Inositol Polyphosphate-1-Phosphatase) is a Protein Coding gene. Diseases associated with INPP1 include Bipolar Disorder. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include inositol-1,4-bisphosphate 1-phosphatase activity and inositol-1,3,4-trisphosphate 1-phosphatase activity. An important paralog of this gene is BPNT1.

Gene Wiki entry for INPP1 Gene

Additional gene information for INPP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INPP1 Gene

Genomics for INPP1 Gene

GeneHancer (GH) Regulatory Elements for INPP1 Gene

Promoters and enhancers for INPP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I190355 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 566.9 +14.9 14871 5 HDGF ELF3 ARID4B KLF5 THRB ZNF48 ETS1 ATF7 IKZF2 ZNF362 INPP1 HIBCH GC02P190361
GH02I190342 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 359 2.7 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF143 ZNF207 HIBCH INPP1
GH02I190352 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.8 +10.0 9954 2.8 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 SP5 NFYC HIBCH INPP1 MFSD6 GC02P190361
GH02I190406 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 4.2 +64.9 64879 3.1 RB1 ZFP64 ZNF76 SIN3A THRB ZNF335 GLIS2 BCLAF1 IKZF2 EGR2 MFSD6 NEMP2 ENSG00000233654 INPP1 GC02M190388
GH02I190577 Enhancer 1.4 FANTOM5 Ensembl ENCODE 5.3 +235.7 235738 3.4 HDGF ATF1 PKNOX1 SIN3A TCF12 ELK1 KLF7 NCOA1 ZNF592 NFIL3 MFSD6 NEMP2 ENSG00000233654 ENSG00000228509 NAB1 INPP1 GC02M190569
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INPP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INPP1 gene promoter:

Genomic Locations for INPP1 Gene

Genomic Locations for INPP1 Gene
28,196 bases
Plus strand

Genomic View for INPP1 Gene

Genes around INPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INPP1 Gene

Proteins for INPP1 Gene

  • Protein details for INPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol polyphosphate 1-phosphatase
    Protein Accession:

    Protein attributes for INPP1 Gene

    399 amino acids
    Molecular mass:
    43998 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

neXtProt entry for INPP1 Gene

Post-translational modifications for INPP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for INPP1 Gene

Domains & Families for INPP1 Gene

Gene Families for INPP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for INPP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol monophosphatase superfamily.
  • Belongs to the inositol monophosphatase superfamily.
genes like me logo Genes that share domains with INPP1: view

Function for INPP1 Gene

Molecular function for INPP1 Gene

GENATLAS Biochemistry:
inositol 1,4,5-triphosphate 1-phosphatase,ubiquitously expressed,with highest levels in kidney and pancreas,inositol signaling pathway,controled by calcineurin
UniProtKB/Swiss-Prot CatalyticActivity:
1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D-myo-inositol 4-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Li(+).

Enzyme Numbers (IUBMB) for INPP1 Gene

Phenotypes From GWAS Catalog for INPP1 Gene

Gene Ontology (GO) - Molecular Function for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity TAS --
GO:0005515 protein binding IPI 26871637
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0052829 inositol-1,3,4-trisphosphate 1-phosphatase activity TAS --
genes like me logo Genes that share ontologies with INPP1: view

Phenotypes for INPP1 Gene

genes like me logo Genes that share phenotypes with INPP1: view

Animal Models for INPP1 Gene

MGI Knock Outs for INPP1:

Animal Model Products

CRISPR Products

miRNA for INPP1 Gene

miRTarBase miRNAs that target INPP1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INPP1 Gene

Localization for INPP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INPP1 gene
Compartment Confidence
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with INPP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INPP1 Gene

Pathways & Interactions for INPP1 Gene

genes like me logo Genes that share pathways with INPP1: view

UniProtKB/Swiss-Prot P49441-INPP_HUMAN

  • Pathway: Signal transduction; phosphatidylinositol signaling pathway.

Gene Ontology (GO) - Biological Process for INPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 8390685
GO:0007165 signal transduction TAS 8390685
GO:0016311 dephosphorylation IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0046854 phosphatidylinositol phosphorylation IEA --
genes like me logo Genes that share ontologies with INPP1: view

No data available for SIGNOR curated interactions for INPP1 Gene

Drugs & Compounds for INPP1 Gene

(8) Drugs for INPP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 0
Magnesium Approved Nutra 0
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
D-Myo-Inositol-1,4-Bisphosphate Experimental Pharma 0

(11) Additional Compounds for INPP1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-Myo-inositol 3,4-bisphosphate
  • 1D-Myo-inositol 3,4-bis(dihydrogen phosphate)
  • D-Myo-Inositol 3,4-bisphosphate
  • Inositol 3,4-bisphosphate
D-Myo-inositol 4-phosphate
  • 1D-Myo-inositol 4-monophosphate
  • 1D-Myo-inositol 4-phosphate
  • D-Myo-inositol-4-phosphate
  • D-Myoinositol 4-phosphate
  • Inositol 4-phosphate
Inositol 1,3,4-trisphosphate
  • 1,3,4-Itp
  • 1D-Myo-Inositol 1,3,4-trisphosphate
  • D-Myo-Inositol 1,3,4-trisphosphate
  • I3S
  • Inositol 1,3,4-triphosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
genes like me logo Genes that share compounds with INPP1: view

Transcripts for INPP1 Gene

Unigene Clusters for INPP1 Gene

Inositol polyphosphate-1-phosphatase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for INPP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP4: - - - -
SP5: - - -
SP6: - - -
SP7: - -

Relevant External Links for INPP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INPP1 Gene

This gene is overexpressed in Oral epithelium (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INPP1 Gene

Protein tissue co-expression partners for INPP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INPP1 Gene:


SOURCE GeneReport for Unigene cluster for INPP1 Gene:


mRNA Expression by UniProt/SwissProt for INPP1 Gene:

Tissue specificity: Ubiquitously expressed, with highest levels in pancreas and kidney.

Evidence on tissue expression from TISSUES for INPP1 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with INPP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for INPP1 Gene

Orthologs for INPP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for INPP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INPP1 33 34
  • 99.58 (n)
(Bos Taurus)
Mammalia INPP1 33 34
  • 84.29 (n)
(Rattus norvegicus)
Mammalia Inpp1 33
  • 82.32 (n)
(Mus musculus)
Mammalia Inpp1 33 16 34
  • 81.01 (n)
(Canis familiaris)
Mammalia INPP1 33 34
  • 76.19 (n)
(Monodelphis domestica)
Mammalia INPP1 34
  • 76 (a)
(Anolis carolinensis)
Reptilia INPP1 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia inpp1 33
  • 61.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68618 33
(Danio rerio)
Actinopterygii LOC555899 33
  • 52.99 (n)
CR318593.1 34
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001047 33
  • 49.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ipp 35 33 34
  • 49.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for INPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INPP1 Gene

Gene Tree for INPP1 (if available)
Gene Tree for INPP1 (if available)

Paralogs for INPP1 Gene

Paralogs for INPP1 Gene Pseudogenes for INPP1 Gene

genes like me logo Genes that share paralogs with INPP1: view

Variants for INPP1 Gene

Sequence variations from dbSNP and Humsavar for INPP1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000022965 -- 190,348,033(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000104334 -- 190,370,023(+) A/G intron_variant
rs1000193353 -- 190,355,322(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000245630 -- 190,355,635(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000282108 -- 190,368,977(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INPP1 Gene

Variant ID Type Subtype PubMed ID
nsv215297 CNV insertion 16902084
esv2721267 CNV deletion 23290073
esv2721265 CNV deletion 23290073
esv2131026 CNV deletion 18987734
esv2005944 CNV deletion 18987734
dgv626e201 CNV deletion 23290073

Variation tolerance for INPP1 Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INPP1 Gene

Disorders for INPP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INPP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search INPP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INPP1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with INPP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INPP1 Gene

Publications for INPP1 Gene

  1. Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. (PMID: 8390685) York JD … Majerus PW (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 22 58
  2. The pharmacogenetics of lithium response depends upon clinical co-morbidity. (PMID: 17570738) Bremer T … Kelsoe JR (Molecular diagnosis & therapy 2007) 3 22 44 58
  3. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder. (PMID: 16787706) Michelon L … Vallada H (Neuroscience letters 2006) 3 22 44 58
  4. Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes. (PMID: 11901356) Piccardi MP … Del Zompo M (Psychiatric genetics 2002) 3 22 44 58
  5. Genomic structure and sequence analysis of a human inositol polyphosphate 1-phosphatase gene (INPP1). (PMID: 10780272) Løvlie R … Steen VM (Pharmacogenetics 1999) 3 4 22 58

Products for INPP1 Gene

Sources for INPP1 Gene

Loading form....