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Aliases for INO80E Gene

Aliases for INO80E Gene

  • INO80 Complex Subunit E 2 3 3 5
  • Coiled-Coil Domain-Containing Protein 95 3 4
  • Coiled-Coil Domain Containing 95 2 3
  • CCDC95 3 4

External Ids for INO80E Gene

Previous HGNC Symbols for INO80E Gene

  • CCDC95

Previous GeneCards Identifiers for INO80E Gene

  • GC16P029916
  • GC16P027668

Summaries for INO80E Gene

GeneCards Summary for INO80E Gene

INO80E (INO80 Complex Subunit E) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transcription-Coupled Nucleotide Excision Repair (TC-NER).

UniProtKB/Swiss-Prot for INO80E Gene

  • Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Additional gene information for INO80E Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80E Gene

Genomics for INO80E Gene

GeneHancer (GH) Regulatory Elements for INO80E Gene

Promoters and enhancers for INO80E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029898 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 701.6 -94.7 -94746 3.8 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 INO80E ASPHD1 GC16M029899 GC16M029900 SEZ6L2 SMG1P5 SMG1P2 SRCAP ZNF785 ENSG00000260853
GH16J029992 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 692.8 -0.4 -370 4.8 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 INO80E HIRIP3 GC16M029996 PIR37996 PIR46335 SRCAP SMG1P5 SETD1A SMG1P2 ENSG00000198106
GH16J030566 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 130 +574.6 574580 6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 ZNF688 SETD1A SRCAP ENSG00000260267 NPIPB13 INO80E ZNF764 ZNF747 SMG1P5 SMG1P2
GH16J030052 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 142.2 +58.9 58911 3.1 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ALDOA FAM57B ENSG00000285043 SETD1A SRCAP INO80E NPIPB12 ZNF764 SMG1P5 SMG1P2
GH16J029972 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 104.4 -19.7 -19737 6.1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TAOK2 INO80E SETD1A SRCAP NPIPB12 NPIPB13 ENSG00000260367 ZNF764 BCL7C SMG1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INO80E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INO80E gene promoter:
  • COUP-TF1
  • HNF-4alpha2
  • COUP
  • COUP-TF
  • HNF-4alpha1

Genomic Locations for INO80E Gene

Genomic Locations for INO80E Gene
chr16:29,995,294-30,005,793
(GRCh38/hg38)
Size:
10,500 bases
Orientation:
Plus strand
chr16:30,006,615-30,017,114
(GRCh37/hg19)
Size:
10,500 bases
Orientation:
Plus strand

Genomic View for INO80E Gene

Genes around INO80E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80E Gene

Proteins for INO80E Gene

  • Protein details for INO80E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBZ0-IN80E_HUMAN
    Recommended name:
    INO80 complex subunit E
    Protein Accession:
    Q8NBZ0
    Secondary Accessions:
    • Q6Y2K3

    Protein attributes for INO80E Gene

    Size:
    244 amino acids
    Molecular mass:
    26478 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

    Alternative splice isoforms for INO80E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INO80E Gene

Post-translational modifications for INO80E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INO80E Gene

Domains & Families for INO80E Gene

Gene Families for INO80E Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INO80E Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80E: view

No data available for UniProtKB/Swiss-Prot for INO80E Gene

Function for INO80E Gene

Molecular function for INO80E Gene

UniProtKB/Swiss-Prot Function:
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for INO80E Gene

Gene Ontology (GO) - Molecular Function for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16230350
genes like me logo Genes that share ontologies with INO80E: view
genes like me logo Genes that share phenotypes with INO80E: view

Animal Models for INO80E Gene

MGI Knock Outs for INO80E:
  • Ino80e Ino80e<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INO80E Gene

Localization for INO80E Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80E gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0031011 Ino80 complex IDA 21303910
genes like me logo Genes that share ontologies with INO80E: view

Pathways & Interactions for INO80E Gene

genes like me logo Genes that share pathways with INO80E: view

Gene Ontology (GO) - Biological Process for INO80E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80E: view

No data available for SIGNOR curated interactions for INO80E Gene

Drugs & Compounds for INO80E Gene

No Compound Related Data Available

Transcripts for INO80E Gene

Unigene Clusters for INO80E Gene

INO80 complex subunit E:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80E Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d
SP1:
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - - - - - -

Relevant External Links for INO80E Gene

GeneLoc Exon Structure for
INO80E
ECgene alternative splicing isoforms for
INO80E

Expression for INO80E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INO80E Gene

Protein differential expression in normal tissues from HIPED for INO80E Gene

This gene is overexpressed in Serum (44.6) and Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INO80E Gene



Protein tissue co-expression partners for INO80E Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INO80E Gene:

INO80E

SOURCE GeneReport for Unigene cluster for INO80E Gene:

Hs.434864

Evidence on tissue expression from TISSUES for INO80E Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with INO80E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80E Gene

Orthologs for INO80E Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INO80E 34 33
  • 99.45 (n)
OneToOne
dog
(Canis familiaris)
Mammalia INO80E 34 33
  • 92.9 (n)
OneToOne
cow
(Bos Taurus)
Mammalia INO80E 34 33
  • 92.08 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ino80e 33
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia INO80E 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ino80e 16 34 33
  • 87.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INO80E 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INO80E 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ino80e 33
  • 63.35 (n)
zebrafish
(Danio rerio)
Actinopterygii ino80e 34 33
  • 55.95 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG18004 34
  • 25 (a)
OneToOne
Species where no ortholog for INO80E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80E Gene

ENSEMBL:
Gene Tree for INO80E (if available)
TreeFam:
Gene Tree for INO80E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INO80E: view image

Paralogs for INO80E Gene

(2) SIMAP similar genes for INO80E Gene using alignment to 7 proteins:

  • IN80E_HUMAN
  • H3BNM4_HUMAN
  • I3L0W8_HUMAN
  • I3L270_HUMAN
  • I3NI13_HUMAN
  • J3KNE2_HUMAN
  • Q6Y2K3_HUMAN
genes like me logo Genes that share paralogs with INO80E: view

No data available for Paralogs for INO80E Gene

Variants for INO80E Gene

Sequence variations from dbSNP and Humsavar for INO80E Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000336416 -- 30,000,640(+) C/T intron_variant
rs1000638423 -- 29,994,476(+) A/G upstream_transcript_variant
rs1000680812 -- 29,998,616(+) A/G intron_variant
rs1000793929 -- 30,000,404(+) T/C intron_variant
rs1001178089 -- 29,998,747(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for INO80E Gene

Variant ID Type Subtype PubMed ID
esv997840 CNV deletion 20482838
esv3638378 CNV loss 21293372

Variation tolerance for INO80E Gene

Residual Variation Intolerance Score: 80.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INO80E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80E Gene

Disorders for INO80E Gene

Additional Disease Information for INO80E

No disorders were found for INO80E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80E Gene

Publications for INO80E Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 58
  2. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 58
  3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for INO80E Gene

Sources for INO80E Gene

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