Aliases for INO80C Gene

Aliases for INO80C Gene

  • INO80 Complex Subunit C 2 3 4 5
  • HIes6 2 3 4
  • IES6 Homolog 3 4
  • C18orf37 3 4
  • IES6 2 3
  • Chromosome 18 Open Reading Frame 37 2
  • IES6 Homolog (S. Cerevisiae) 2
  • FLJ38183 2
  • INO80C 5

External Ids for INO80C Gene

Previous HGNC Symbols for INO80C Gene

  • C18orf37

Previous GeneCards Identifiers for INO80C Gene

  • GC18M031289
  • GC18M033034
  • GC18M029908

Summaries for INO80C Gene

GeneCards Summary for INO80C Gene

INO80C (INO80 Complex Subunit C) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair.

UniProtKB/Swiss-Prot Summary for INO80C Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INO80C Gene

Genomics for INO80C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INO80C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INO80C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INO80C

Top Transcription factor binding sites by QIAGEN in the INO80C gene promoter:
  • FOXD1
  • N-Myc
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for INO80C Gene

Latest Assembly
45,750 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
29,628 bases
Minus strand

(GRCh37/hg19 by Ensembl)
45,762 bases
Minus strand

Genomic View for INO80C Gene

Genes around INO80C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80C Gene

Proteins for INO80C Gene

  • Protein details for INO80C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    INO80 complex subunit C
    Protein Accession:
    Secondary Accessions:
    • B4DUI4
    • E9PCS7
    • Q86WR1
    • Q8N994

    Protein attributes for INO80C Gene

    192 amino acids
    Molecular mass:
    20643 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

    Alternative splice isoforms for INO80C Gene


neXtProt entry for INO80C Gene

Post-translational modifications for INO80C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for INO80C Gene

Domains & Families for INO80C Gene

Gene Families for INO80C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INO80C Gene

Suggested Antigen Peptide Sequences for INO80C Gene

GenScript: Design optimal peptide antigens:
  • IES6 homolog (IN80C_HUMAN)
genes like me logo Genes that share domains with INO80C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for INO80C Gene

Function for INO80C Gene

Molecular function for INO80C Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for INO80C Gene

Gene Ontology (GO) - Molecular Function for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with INO80C: view
genes like me logo Genes that share phenotypes with INO80C: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80C Gene

Localization for INO80C Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80C gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031011 Ino80 complex IEA,IDA 21303910
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with INO80C: view

Pathways & Interactions for INO80C Gene

genes like me logo Genes that share pathways with INO80C: view

Gene Ontology (GO) - Biological Process for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA,IBA 21873635
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with INO80C: view

No data available for SIGNOR curated interactions for INO80C Gene

Drugs & Compounds for INO80C Gene

No Compound Related Data Available

Transcripts for INO80C Gene

mRNA/cDNA for INO80C Gene

10 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80C

Alternative Splicing Database (ASD) splice patterns (SP) for INO80C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - - - - -

Relevant External Links for INO80C Gene

GeneLoc Exon Structure for

Expression for INO80C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INO80C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INO80C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.1), Blymphocyte (7.3), CD8 Tcells (7.0), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INO80C Gene

Protein tissue co-expression partners for INO80C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INO80C

SOURCE GeneReport for Unigene cluster for INO80C Gene:


Evidence on tissue expression from TISSUES for INO80C Gene

  • Muscle(4.2)
  • Nervous system(4.2)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with INO80C: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80C Gene

Orthologs for INO80C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for INO80C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INO80C 29 30
  • 100 (n)
(Canis familiaris)
Mammalia -- 30
  • 95 (a)
INO80C 29
  • 92.19 (n)
(Bos Taurus)
Mammalia INO80C 29 30
  • 90.62 (n)
(Mus musculus)
Mammalia Ino80c 29 16 30
  • 83.94 (n)
(Rattus norvegicus)
Mammalia Ino80c 29
  • 83.6 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 77 (a)
(Gallus gallus)
Aves -- 30
  • 76 (a)
INO80C 29
  • 70.29 (n)
(Anolis carolinensis)
Reptilia -- 30
  • 65 (a)
(Danio rerio)
Actinopterygii ino80c 29 30
  • 72.27 (n)
wufj61b08 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9185 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008390 29
  • 58.97 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12659 30
  • 45 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IES6 32
Species where no ortholog for INO80C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INO80C Gene

Gene Tree for INO80C (if available)
Gene Tree for INO80C (if available)
Evolutionary constrained regions (ECRs) for INO80C: view image
Alliance of Genome Resources:
Additional Orthologs for INO80C

Paralogs for INO80C Gene

No data available for Paralogs for INO80C Gene

Variants for INO80C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INO80C Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs11081906 Benign: not provided 35,478,355(-) A/G
rs34130630 Benign: not provided 35,468,653(-) G/A
NM_194281.4(INO80C):c.537C>T (p.Thr179=)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for INO80C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for INO80C Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958
nsv2252 CNV deletion 18451855

Variation tolerance for INO80C Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INO80C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80C Gene

Disorders for INO80C Gene

Additional Disease Information for INO80C

No disorders were found for INO80C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80C Gene

Publications for INO80C Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4
  2. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4
  3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4
  4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y … Roeder RG (Cell 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for INO80C Gene

Sources for INO80C Gene