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Aliases for INO80C Gene

Aliases for INO80C Gene

  • INO80 Complex Subunit C 2 3 5
  • IES6 Homolog 3 4
  • C18orf37 3 4
  • HIes6 3 4
  • Chromosome 18 Open Reading Frame 37 2
  • IES6 Homolog (S. Cerevisiae) 2
  • IES6 3

External Ids for INO80C Gene

Previous HGNC Symbols for INO80C Gene

  • C18orf37

Previous GeneCards Identifiers for INO80C Gene

  • GC18M031289
  • GC18M033034
  • GC18M029908

Summaries for INO80C Gene

GeneCards Summary for INO80C Gene

INO80C (INO80 Complex Subunit C) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. An important paralog of this gene is ENSG00000267140.

UniProtKB/Swiss-Prot for INO80C Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Additional gene information for INO80C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INO80C Gene

Genomics for INO80C Gene

GeneHancer (GH) Regulatory Elements for INO80C Gene

Promoters and enhancers for INO80C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I035495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 558.3 +0.9 946 3.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 INO80C ENSG00000267140 ENSG00000268573 ZNF397 ZSCAN30 ELP2 RPRD1A C18orf21 ZNF271P ZNF396
GH18I035455 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +37.3 37294 9.7 HDGF FOXA2 ARNT ARID4B CBX5 FOS ZHX2 REST ZNF592 KAT8 INO80C LOC101927809 ENSG00000267583 MAPRE2 ENSG00000267140 LOC105372063
GH18I035475 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +18.5 18515 7 PKNOX1 FOXA2 MLX ARID4B YY1 ATF7 FOS RXRA NFYC MIER2 INO80C ZNF396 MAPRE2 ZNF24 ENSG00000279074 ENSG00000267583 ENSG00000267140
GH18I035501 Enhancer 1 Ensembl ENCODE dbSUPER 8.7 -4.0 -4025 1 MAFG MIER2 ZNF644 ZNF316 MAFF GABPB1 ZSCAN29 EMSY MAFK SPI1 GALNT1 ZNF396 INO80C
GH18I035512 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.1 -16.5 -16546 4.4 JUN MAX KLF17 ZIC2 RAD21 ZNF316 GLIS2 GATA3 POLR2A SMC3 GALNT1 ZNF396 INO80C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INO80C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INO80C gene promoter:

Genomic Locations for INO80C Gene

Genomic Locations for INO80C Gene
45,762 bases
Minus strand

Genomic View for INO80C Gene

Genes around INO80C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80C Gene

Proteins for INO80C Gene

  • Protein details for INO80C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    INO80 complex subunit C
    Protein Accession:
    Secondary Accessions:
    • B4DUI4
    • E9PCS7
    • Q86WR1
    • Q8N994

    Protein attributes for INO80C Gene

    192 amino acids
    Molecular mass:
    20643 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

    Alternative splice isoforms for INO80C Gene


neXtProt entry for INO80C Gene

Post-translational modifications for INO80C Gene

  • Ubiquitination at posLast=2121, posLast=2222, and posLast=4141

No data available for DME Specific Peptides for INO80C Gene

Domains & Families for INO80C Gene

Gene Families for INO80C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for INO80C Gene


Suggested Antigen Peptide Sequences for INO80C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INO80C: view

No data available for UniProtKB/Swiss-Prot for INO80C Gene

Function for INO80C Gene

Molecular function for INO80C Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for INO80C Gene

Gene Ontology (GO) - Molecular Function for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with INO80C: view
genes like me logo Genes that share phenotypes with INO80C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INO80C Gene

Localization for INO80C Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80C gene
Compartment Confidence
nucleus 5
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031011 Ino80 complex IDA,IEA 21303910
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with INO80C: view

Pathways & Interactions for INO80C Gene

genes like me logo Genes that share pathways with INO80C: view

Gene Ontology (GO) - Biological Process for INO80C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IBA,IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with INO80C: view

No data available for SIGNOR curated interactions for INO80C Gene

Drugs & Compounds for INO80C Gene

No Compound Related Data Available

Transcripts for INO80C Gene

Unigene Clusters for INO80C Gene

INO80 complex subunit C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for INO80C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - - - - - - -

Relevant External Links for INO80C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for INO80C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INO80C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for INO80C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.1), Blymphocyte (7.3), CD8 Tcells (7.0), and NK cells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for INO80C Gene

Protein tissue co-expression partners for INO80C Gene

NURSA nuclear receptor signaling pathways regulating expression of INO80C Gene:


SOURCE GeneReport for Unigene cluster for INO80C Gene:


Evidence on tissue expression from TISSUES for INO80C Gene

  • Muscle(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INO80C: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80C Gene

Orthologs for INO80C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for INO80C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia INO80C 33 34
  • 100 (n)
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
INO80C 33
  • 92.19 (n)
(Bos Taurus)
Mammalia INO80C 33 34
  • 90.62 (n)
(Mus musculus)
Mammalia Ino80c 33 16 34
  • 83.94 (n)
(Rattus norvegicus)
Mammalia Ino80c 33
  • 83.6 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
(Gallus gallus)
Aves -- 34
  • 76 (a)
INO80C 33
  • 70.29 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
(Danio rerio)
Actinopterygii ino80c 34 33
  • 72.27 (n)
wufj61b08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9185 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008390 33
  • 58.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12659 34
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IES6 36
Species where no ortholog for INO80C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INO80C Gene

Gene Tree for INO80C (if available)
Gene Tree for INO80C (if available)

Paralogs for INO80C Gene

Paralogs for INO80C Gene

genes like me logo Genes that share paralogs with INO80C: view

Variants for INO80C Gene

Sequence variations from dbSNP and Humsavar for INO80C Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000004294 -- 35,474,139(-) T/C intron_variant
rs1000016143 -- 35,473,654(-) T/A intron_variant
rs1000028025 -- 35,498,787(-) A/G upstream_transcript_variant
rs1000098530 -- 35,473,710(-) C/G intron_variant
rs1000257090 -- 35,498,513(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for INO80C Gene

Variant ID Type Subtype PubMed ID
nsv2252 CNV deletion 18451855
nsv1065113 CNV loss 25217958

Variation tolerance for INO80C Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INO80C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80C Gene

Disorders for INO80C Gene

Additional Disease Information for INO80C

No disorders were found for INO80C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INO80C Gene

Publications for INO80C Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 58
  2. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 58
  3. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4 58
  4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y … Roeder RG (Cell 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for INO80C Gene

Sources for INO80C Gene

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