This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011] See more...

Aliases for INO80B Gene

Aliases for INO80B Gene

  • INO80 Complex Subunit B 2 3 4 5
  • High Mobility Group AT-Hook 1-Like 4 2 3 4
  • PAPA-1 2 3 4
  • HIes2 2 3 4
  • Zinc Finger HIT Domain-Containing Protein 4 3 4
  • PAP-1-Associated Protein 1 3 4
  • Zinc Finger, HIT Type 4 2 3
  • PAP-1 Binding Protein 2 3
  • IES2 Homolog 3 4
  • HMGA1L4 3 4
  • HMGIYL4 2 3
  • PAP-1BP 2 3
  • ZNHIT4 3 4
  • PAPA1 3 4
  • IES2 2 3
  • PAP (Pim-1 Associated Protein) Associated Protein 1 3
  • IES2 Homolog (S. Cerevisiae) 2
  • INO80B 5

External Ids for INO80B Gene

Previous HGNC Symbols for INO80B Gene

  • HMGA1L4
  • ZNHIT4

Previous GeneCards Identifiers for INO80B Gene

  • GC02P074536
  • GC02P074682
  • GC02P074419

Summaries for INO80B Gene

Entrez Gene Summary for INO80B Gene

  • This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]

GeneCards Summary for INO80B Gene

INO80B (INO80 Complex Subunit B) is a Protein Coding gene. Diseases associated with INO80B include Dissociative Disorder and Waardenburg Syndrome, Type 1. Among its related pathways are Metabolism of proteins and Regulation of activated PAK-2p34 by proteasome mediated degradation. An important paralog of this gene is INO80B-WBP1.

UniProtKB/Swiss-Prot Summary for INO80B Gene

  • Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Additional gene information for INO80B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INO80B Gene

Genomics for INO80B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INO80B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INO80B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INO80B

Top Transcription factor binding sites by QIAGEN in the INO80B gene promoter:
  • E47
  • ER-alpha
  • GCNF
  • GCNF-1
  • GCNF-2
  • GR
  • GR-alpha
  • Hand1
  • HOXA9
  • p53

Genomic Locations for INO80B Gene

Genomic Locations for INO80B Gene
chr2:74,455,087-74,457,944
(GRCh38/hg38)
Size:
2,858 bases
Orientation:
Plus strand
chr2:74,682,150-74,688,011
(GRCh37/hg19)
Size:
5,862 bases
Orientation:
Plus strand

Genomic View for INO80B Gene

Genes around INO80B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80B Gene

Proteins for INO80B Gene

  • Protein details for INO80B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C086-IN80B_HUMAN
    Recommended name:
    INO80 complex subunit B
    Protein Accession:
    Q9C086

    Protein attributes for INO80B Gene

    Size:
    356 amino acids
    Molecular mass:
    38637 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with RP9.
    SequenceCaution:
    • Sequence=BAB21111.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INO80B Gene

neXtProt entry for INO80B Gene

Post-translational modifications for INO80B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INO80B Gene

No data available for DME Specific Peptides for INO80B Gene

Domains & Families for INO80B Gene

Gene Families for INO80B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INO80B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INO80B Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger HIT domain-containing protein 4 (IN80B_HUMAN)
genes like me logo Genes that share domains with INO80B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for INO80B Gene

Function for INO80B Gene

Molecular function for INO80B Gene

UniProtKB/Swiss-Prot Function:
Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Phenotypes From GWAS Catalog for INO80B Gene

Gene Ontology (GO) - Molecular Function for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19095771
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with INO80B: view
genes like me logo Genes that share phenotypes with INO80B: view

Animal Models for INO80B Gene

MGI Knock Outs for INO80B:
  • Ino80b Ino80b<tm1.1(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INO80B Gene

Localization for INO80B Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80B Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80B gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA --
GO:0031011 Ino80 complex IEA,IDA 21303910
genes like me logo Genes that share ontologies with INO80B: view

Pathways & Interactions for INO80B Gene

genes like me logo Genes that share pathways with INO80B: view

Gene Ontology (GO) - Biological Process for INO80B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with INO80B: view

No data available for SIGNOR curated interactions for INO80B Gene

Drugs & Compounds for INO80B Gene

No Compound Related Data Available

Transcripts for INO80B Gene

mRNA/cDNA for INO80B Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80B

Alternative Splicing Database (ASD) splice patterns (SP) for INO80B Gene

No ASD Table

Relevant External Links for INO80B Gene

GeneLoc Exon Structure for
INO80B

Expression for INO80B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INO80B Gene

Protein differential expression in normal tissues from HIPED for INO80B Gene

This gene is overexpressed in Liver (25.3), Lung (25.2), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INO80B Gene



Protein tissue co-expression partners for INO80B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INO80B

SOURCE GeneReport for Unigene cluster for INO80B Gene:

Hs.410786

Evidence on tissue expression from TISSUES for INO80B Gene

  • Intestine(4.2)
  • Nervous system(3.4)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with INO80B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80B Gene

Orthologs for INO80B Gene

This gene was present in the common ancestor of animals.

Orthologs for INO80B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INO80B 30 31
  • 99.34 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia INO80B 30 31
  • 89.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia INO80B 30 31
  • 89.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ino80b 30
  • 82.87 (n)
Mouse
(Mus musculus)
Mammalia Ino80b 30 17 31
  • 82.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia INO80B 31
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia INO80B 31
  • 69 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INO80B 31
  • 66 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100216277 30
  • 60.76 (n)
Str.7311 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5988 30
Zebrafish
(Danio rerio)
Actinopterygii ino80b 30 31
  • 63.78 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10395 31
  • 26 (a)
OneToOne
Species where no ortholog for INO80B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INO80B Gene

ENSEMBL:
Gene Tree for INO80B (if available)
TreeFam:
Gene Tree for INO80B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INO80B: view image

Paralogs for INO80B Gene

Paralogs for INO80B Gene

genes like me logo Genes that share paralogs with INO80B: view

Variants for INO80B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INO80B Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs1054209 - p.Trp152Gly

Additional dbSNP identifiers (rs#s) for INO80B Gene

Structural Variations from Database of Genomic Variants (DGV) for INO80B Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for INO80B Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INO80B Gene

Human Gene Mutation Database (HGMD)
INO80B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80B Gene

Disorders for INO80B Gene

MalaCards: The human disease database

(2) MalaCards diseases for INO80B Gene - From: DISEASES

Disorder Aliases PubMed IDs
dissociative disorder
  • dissociative disease
waardenburg syndrome, type 1
  • ws1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with INO80B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INO80B Gene

Publications for INO80B Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4
  2. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. (PMID: 15556297) Kuroda TS … Iguchi-Ariga SM (Gene 2004) 3 4 23
  3. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4
  4. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for INO80B Gene

Sources for INO80B Gene