This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transc... See more...

Aliases for INO80 Gene

Aliases for INO80 Gene

  • INO80 Complex ATPase Subunit 2 3 5
  • INO80 Complex Subunit A 2 3 4
  • INO80A 2 3 4
  • DNA Helicase-Related INO80 Complex Homolog 1 3 4
  • DNA Helicase-Related Protein INO80 3 4
  • Chromatin-Remodeling ATPase INO80 3 4
  • KIAA1259 2 4
  • HINO80 2 4
  • INOC1 3 4
  • Putative DNA Helicase INO80 Complex Homolog 1 3
  • INO80 Complex Homolog 1 (S. Cerevisiae) 2
  • INO80 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast INO80 3
  • DNA Helicase INO80 3
  • EC 3.6.1.23 51
  • EC 3.6.4.- 4
  • EC 3.6.1 51
  • INO80 5

External Ids for INO80 Gene

Previous HGNC Symbols for INO80 Gene

  • INOC1

Previous GeneCards Identifiers for INO80 Gene

  • GC15M039058
  • GC15M041271
  • GC15M018119

Summaries for INO80 Gene

Entrez Gene Summary for INO80 Gene

  • This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for INO80 Gene

INO80 (INO80 Complex ATPase Subunit) is a Protein Coding gene. Diseases associated with INO80 include Grange Syndrome and Hepatosplenic T-Cell Lymphoma. Among its related pathways are Metabolism of proteins and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include actin binding and DNA helicase activity. An important paralog of this gene is EP400.

UniProtKB/Swiss-Prot Summary for INO80 Gene

  • ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).

Additional gene information for INO80 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INO80 Gene

Genomics for INO80 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INO80 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INO80 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INO80

Top Transcription factor binding sites by QIAGEN in the INO80 gene promoter:
  • AREB6
  • CREB
  • E47
  • N-Myc
  • NF-kappaB1
  • Nkx6-1
  • RelA
  • TBP

Genomic Locations for INO80 Gene

Genomic Locations for INO80 Gene
chr15:40,978,880-41,117,778
(GRCh38/hg38)
Size:
138,899 bases
Orientation:
Minus strand
chr15:41,271,078-41,408,552
(GRCh37/hg19)
Size:
137,475 bases
Orientation:
Minus strand

Genomic View for INO80 Gene

Genes around INO80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INO80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INO80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INO80 Gene

Proteins for INO80 Gene

  • Protein details for INO80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG1-INO80_HUMAN
    Recommended name:
    Chromatin-remodeling ATPase INO80
    Protein Accession:
    Q9ULG1
    Secondary Accessions:
    • A6H8X4
    • Q9NTG6

    Protein attributes for INO80 Gene

    Size:
    1556 amino acids
    Molecular mass:
    176753 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; three different complex modules assemble on different domains of INO80 (PubMed:16230350, PubMed:18026119, PubMed:18922472, PubMed:21303910). Interacts with DDB1 (PubMed:20855601). Interacts with transcriptional repressor protein YY1; the interaction recruits the INO80 complex to YY1 target genes (PubMed:17721549, PubMed:18026119). Interacts with YY1AP1 (PubMed:27939641). Interacts with tubulin alpha (PubMed:20237820).
    SequenceCaution:
    • Sequence=BAA86573.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Although the ATP-dependent helicase activity displayed by the INO80 complex requires INO80 ATPase activity, it is likely that the helicase function is carried out by the other components of the complex, RUVBL1 and RUVBL2, and not by INO80 itself.

    Three dimensional structures from OCA and Proteopedia for INO80 Gene

neXtProt entry for INO80 Gene

Selected DME Specific Peptides for INO80 Gene

Q9ULG1:
  • IDIGGGV
  • LKPFMLRR
  • NLTAADTVIF
  • DEMGLGKT
  • ADTVIFY
  • NRLLLTGTP
  • ISGGNFKPD
  • KVLPYWG
  • RKVCNHP
  • KDIESHA
  • NWLANLY
  • ITSYQLV
  • GTIEERI
  • CRNRLLL
  • FYDSDWNP
  • FLLSTRA
  • QAMDRAHR
  • AGGLGINL
  • NGILADE
  • QVTVYRL
  • GLGKTVQ
  • LLHFIMP
  • LSTRAGGLG

Post-translational modifications for INO80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for INO80 Gene

Gene Families for INO80 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for INO80 Gene

InterPro:
Blocks:
  • SNF2 related domain
ProtoNet:

Suggested Antigen Peptide Sequences for INO80 Gene

GenScript: Design optimal peptide antigens:
  • Putative DNA helicase INO80 complex homolog 1 (INO80_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULG1

UniProtKB/Swiss-Prot:

INO80_HUMAN :
  • The DBINO region is involved in binding to DNA.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The DBINO region is involved in binding to DNA.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with INO80: view

Function for INO80 Gene

Molecular function for INO80 Gene

UniProtKB/Swiss-Prot Function:
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed:16230350, PubMed:16298340, PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA (PubMed:16298340, PubMed:21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed:16230350, PubMed:21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed:17721549). Involved in UV-damage excision DNA repair (PubMed:20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed:20687897). Involved in DNA replication (PubMed:20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed:20237820).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:21303910};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=167 uM for ATP {ECO:0000269|PubMed:16298340}; pH dependence: Optimum pH is 7. {ECO:0000269|PubMed:16298340}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269|PubMed:16298340};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated upon binding to double stranded DNA or nucleosomes.

Enzyme Numbers (IUBMB) for INO80 Gene

Phenotypes From GWAS Catalog for INO80 Gene

Gene Ontology (GO) - Molecular Function for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IDA 16298340
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18026119
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with INO80: view
genes like me logo Genes that share phenotypes with INO80: view

Animal Models for INO80 Gene

MGI Knock Outs for INO80:
  • Ino80 Ino80<tm1a(EUCOMM)Hmgu>
  • Ino80 Ino80<tm1.1Schg>
  • Ino80 Ino80<tm1.2Jland>
  • Ino80 Ino80<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INO80 Gene

Localization for INO80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INO80 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome. Note=Localizes to the cytoplasm in quiescent cell (PubMed:20237820). Associates with spindle microtubules during mitosis (PubMed:20237820). Colocalizes with PCNA at replication forks during S-phase (PubMed:20237820). Recruited to DNA damage sites in a ACTR8-dependent manner (PubMed:20971067). {ECO:0000269 PubMed:20237820, ECO:0000269 PubMed:20971067}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INO80 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16298340
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with INO80: view

Pathways & Interactions for INO80 Gene

genes like me logo Genes that share pathways with INO80: view

Gene Ontology (GO) - Biological Process for INO80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 20237820
GO:0000724 double-strand break repair via homologous recombination IMP 18026119
GO:0006281 DNA repair IEA,IBA 21873635
GO:0006302 double-strand break repair IMP 20687897
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with INO80: view

No data available for SIGNOR curated interactions for INO80 Gene

Drugs & Compounds for INO80 Gene

(3) Drugs for INO80 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for INO80 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with INO80: view

Transcripts for INO80 Gene

mRNA/cDNA for INO80 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INO80

Alternative Splicing Database (ASD) splice patterns (SP) for INO80 Gene

No ASD Table

Relevant External Links for INO80 Gene

GeneLoc Exon Structure for
INO80

Expression for INO80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INO80 Gene

Protein differential expression in normal tissues from HIPED for INO80 Gene

This gene is overexpressed in Esophagus (26.1), Monocytes (10.1), Peripheral blood mononuclear cells (8.4), and Adrenal (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INO80 Gene



Protein tissue co-expression partners for INO80 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INO80

SOURCE GeneReport for Unigene cluster for INO80 Gene:

Hs.292949

mRNA Expression by UniProt/SwissProt for INO80 Gene:

Q9ULG1-INO80_HUMAN
Tissue specificity: According to PubMed:10574462, widely expressed. According to PubMed:16298340, specifically expressed in brain, liver and pancreas.

Evidence on tissue expression from TISSUES for INO80 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with INO80: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for INO80 Gene

Orthologs for INO80 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for INO80 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INO80 30 31
  • 99.74 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia INO80 31
  • 96 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia INO80 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia INO80 30 31
  • 93.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia INO80 30 31
  • 93.19 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ino80 30
  • 91.02 (n)
Mouse
(Mus musculus)
Mammalia Ino80 30 17 31
  • 90.79 (n)
OneToOne
Chicken
(Gallus gallus)
Aves INO80 30 31
  • 80.71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INO80 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ino80 30
  • 73.58 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9075 30
Zebrafish
(Danio rerio)
Actinopterygii ino80 30 31
  • 69.94 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Ino80 30 31
  • 55.51 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005035 30
  • 54.81 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INO80 31
  • 33 (a)
OneToOne
Wheat
(Triticum aestivum)
Liliopsida Ta.4945 30
Species where no ortholog for INO80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Worm (Caenorhabditis elegans)

Evolution for INO80 Gene

ENSEMBL:
Gene Tree for INO80 (if available)
TreeFam:
Gene Tree for INO80 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INO80: view image

Paralogs for INO80 Gene

(3) SIMAP similar genes for INO80 Gene using alignment to 4 proteins:

  • INO80_HUMAN
  • H0YKH3_HUMAN
  • H0YMN5_HUMAN
  • H0YNL3_HUMAN
genes like me logo Genes that share paralogs with INO80: view

Variants for INO80 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INO80 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
691356 Uncertain Significance: Pyloric stenosis; Esophageal atresia 40,982,966(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
711614 Benign: not provided 41,092,112(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
714529 Benign: not provided 41,044,998(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
717029 Likely Benign: not provided 41,095,913(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
719735 Likely Benign: not provided 40,985,417(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for INO80 Gene

Structural Variations from Database of Genomic Variants (DGV) for INO80 Gene

Variant ID Type Subtype PubMed ID
dgv4499n54 CNV loss 21841781
esv2496899 CNV insertion 19546169
nsv1053462 CNV gain 25217958
nsv1116068 CNV deletion 24896259
nsv1122952 CNV deletion 24896259
nsv474933 CNV novel sequence insertion 20440878
nsv976923 CNV duplication 23825009

Variation tolerance for INO80 Gene

Residual Variation Intolerance Score: 2.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INO80 Gene

Human Gene Mutation Database (HGMD)
INO80
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INO80

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INO80 Gene

Disorders for INO80 Gene

MalaCards: The human disease database

(6) MalaCards diseases for INO80 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search INO80 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INO80

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with INO80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INO80 Gene

Publications for INO80 Gene

  1. Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. (PMID: 20237820) Hur SK … Kwon J (Cellular and molecular life sciences : CMLS 2010) 2 3 4
  2. Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. (PMID: 16298340) Bakshi R … Brahmachari V (Biochemical and biophysical research communications 2006) 2 3 4
  3. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4
  4. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4
  5. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. (PMID: 20855601) Jiang Y … Li L (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4

Products for INO80 Gene

Sources for INO80 Gene