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Aliases for INMT Gene

Aliases for INMT Gene

  • Indolethylamine N-Methyltransferase 2 3 5
  • Aromatic Alkylamine N-Methyltransferase 3 4
  • Indolamine N-Methyltransferase 3 4
  • Arylamine N-Methyltransferase 3 4
  • Thioether S-Methyltransferase 3 4
  • Amine N-Methyltransferase 3 4
  • EC 2.1.1.49 4 56
  • TEMT 3 4
  • Nicotine N-Methyltransferase 3
  • EC 2.1.1.96 4
  • EC 2.1.1 56

External Ids for INMT Gene

Previous GeneCards Identifiers for INMT Gene

  • GC07P030434
  • GC07P030534
  • GC07P030564
  • GC07P030758

Summaries for INMT Gene

Entrez Gene Summary for INMT Gene

  • N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for INMT Gene

INMT (Indolethylamine N-Methyltransferase) is a Protein Coding gene. Among its related pathways are superpathway of tryptophan utilization and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and amine N-methyltransferase activity. An important paralog of this gene is NNMT.

UniProtKB/Swiss-Prot for INMT Gene

  • Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

Additional gene information for INMT Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INMT Gene

Genomics for INMT Gene

GeneHancer (GH) Regulatory Elements for INMT Gene

Promoters and enhancers for INMT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I030748 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 559.3 +53.2 53180 5.8 CTCF ZNF282 FOXA2 REST NR2F2 NFIC CBX5 ZSCAN5C ZNF341 IKZF1 INMT INMT-MINDY4 MINDY4 CRHR2 ENSG00000244480 ENSG00000223419 LOC105375220
GH07I030770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 8.2 +73.5 73514 2.2 HDGF SMAD1 ATF1 SIN3A YY1 ETS1 POLR2B GLIS2 ZNF143 ATF7 MINDY4 INMT INMT-MINDY4 ENSG00000229263
GH07I030764 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +66.9 66862 1.7 NFIC RXRA ZNF184 NR2F2 INMT MINDY4 INMT-MINDY4
GH07I030798 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.4 +102.4 102350 3.2 FOXA2 INSM2 KLF17 BMI1 BATF IRF4 RAD21 GLIS2 SCRT2 ZNF143 MINDY4 ENSG00000250424 AQP1 ENSG00000229263 INMT INMT-MINDY4
GH07I030755 Enhancer 0.9 Ensembl ENCODE dbSUPER 9.2 +58.6 58648 2.7 CTCF HLF TEAD2 RCOR1 ZBTB33 NR2F2 CHD2 MINDY4 CRHR2 INMT INMT-MINDY4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INMT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INMT gene promoter:

Genomic Locations for INMT Gene

Genomic Locations for INMT Gene
chr7:30,697,985-30,757,602
(GRCh38/hg38)
Size:
59,618 bases
Orientation:
Plus strand
chr7:30,737,601-30,797,218
(GRCh37/hg19)

Genomic View for INMT Gene

Genes around INMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INMT Gene

Proteins for INMT Gene

  • Protein details for INMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95050-INMT_HUMAN
    Recommended name:
    Indolethylamine N-methyltransferase
    Protein Accession:
    O95050
    Secondary Accessions:
    • B8ZZ69
    • Q3KP49
    • Q9P1Y2
    • Q9UBY4
    • Q9UHQ0

    Protein attributes for INMT Gene

    Size:
    263 amino acids
    Molecular mass:
    28891 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for INMT Gene

    Alternative splice isoforms for INMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INMT Gene

Selected DME Specific Peptides for INMT Gene

O95050:
  • LAMECAC
  • LIDIGSG

Post-translational modifications for INMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for INMT Gene

Gene Families for INMT Gene

Suggested Antigen Peptide Sequences for INMT Gene

Graphical View of Domain Structure for InterPro Entry

O95050

UniProtKB/Swiss-Prot:

INMT_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
genes like me logo Genes that share domains with INMT: view

Function for INMT Gene

Molecular function for INMT Gene

GENATLAS Biochemistry:
indolethylamine N-metyltransferase,expressed in most tissues but not in the brain,catalyzing the N methylation of the tryptamine,serotonine,structurally related indoleamines and beta carbolines
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.9 mM for tryptamine {ECO:0000269 PubMed:10552930};
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium.
UniProtKB/Swiss-Prot Function:
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

Enzyme Numbers (IUBMB) for INMT Gene

Phenotypes From GWAS Catalog for INMT Gene

Gene Ontology (GO) - Molecular Function for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004790 thioether S-methyltransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0030748 amine N-methyltransferase activity IEA,IDA 10552930
genes like me logo Genes that share ontologies with INMT: view
genes like me logo Genes that share phenotypes with INMT: view

miRNA for INMT Gene

miRTarBase miRNAs that target INMT

Clone Products

  • Addgene plasmids for INMT

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INMT Gene

Localization for INMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for INMT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INMT gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 10552930
genes like me logo Genes that share ontologies with INMT: view

Pathways & Interactions for INMT Gene

genes like me logo Genes that share pathways with INMT: view

Interacting Proteins for INMT Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000013222%0d%0a9606.ENSP00000356230%0d%0a
Selected Interacting proteins: O95050-INMT_HUMAN ENSP00000013222 for INMT Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for INMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009308 amine metabolic process IDA 10552930
GO:0009636 response to toxic substance IEA --
GO:0032259 methylation IEA,IDA 10552930
genes like me logo Genes that share ontologies with INMT: view

No data available for SIGNOR curated interactions for INMT Gene

Drugs & Compounds for INMT Gene

(3) Drugs for INMT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0
Serotonin Pharma 3755
tryptamine Pharma Full agonist, Agonist 0

(9) Additional Compounds for INMT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxyindoleacetaldehyde
  • (5-hydroxy-1H-indol-3-yl)acetaldehyde
  • (5-hydroxyindol-3-yl)acetaldehyde
  • 5-Hial
  • 5-Hydroxy-1H-Indole-3-acetaldehyde
  • 5-Hydroxyindole-3-acetaldehyde
1892-21-3
Dimethyl selenide
  • (CH3)2Se
  • (methylselanyl)methane
  • Dimethyl-Selenide
  • Dimethylselenide
  • Dimethylselenium
593-79-3
Dimethylsulfide
  • Dimethyl sulfoxide(Reduced)
  • Methyl sulfide
  • Methylthiomethane
  • (methylsulfanyl)methane
  • 2-Thiapropane
75-18-3
L-Methionine
  • (2S)-2-amino-4-(methylsulfanyl)butanoate
  • (2S)-2-amino-4-(methylsulfanyl)butanoic acid
  • (L)-methionine
  • (S)-(+)-methionine
  • (S)-2-amino-4-(methylthio)-Butanoate
63-68-3
N-Methylserotonin
  • 3-(2-(Methylamino)ethyl)-1H-indol-5-ol
  • 3-[2-(Methylamino)ethyl]-1H-indol-5-ol
  • Lopac-M-1514
1134-01-6
genes like me logo Genes that share compounds with INMT: view

Transcripts for INMT Gene

Unigene Clusters for INMT Gene

Indolethylamine N-methyltransferase:
Representative Sequences:

Clone Products

  • Addgene plasmids for INMT

Alternative Splicing Database (ASD) splice patterns (SP) for INMT Gene

No ASD Table

Relevant External Links for INMT Gene

GeneLoc Exon Structure for
INMT
ECgene alternative splicing isoforms for
INMT

Expression for INMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INMT Gene

mRNA differential expression in normal tissues according to GTEx for INMT Gene

This gene is overexpressed in Lung (x10.2) and Artery - Coronary (x4.7).

Protein differential expression in normal tissues from HIPED for INMT Gene

This gene is overexpressed in Cardia (15.2), Adrenal (15.0), Testis (7.7), Lung (7.7), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INMT Gene



Protein tissue co-expression partners for INMT Gene

NURSA nuclear receptor signaling pathways regulating expression of INMT Gene:

INMT

SOURCE GeneReport for Unigene cluster for INMT Gene:

Hs.632629

mRNA Expression by UniProt/SwissProt for INMT Gene:

O95050-INMT_HUMAN
Tissue specificity: Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.

Evidence on tissue expression from TISSUES for INMT Gene

  • Lung(4.5)
  • Muscle(4.2)
  • Spleen(4.2)
genes like me logo Genes that share expression patterns with INMT: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INMT Gene

Orthologs for INMT Gene

This gene was present in the common ancestor of animals.

Orthologs for INMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INMT 33
  • 99.37 (n)
-- 34
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Inmt 33 16 34
  • 65.5 (n)
rat
(Rattus norvegicus)
Mammalia Inmt 33
  • 64.07 (n)
cow
(Bos Taurus)
Mammalia INMT 33 34
  • 63.87 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC107884 33
  • 57.18 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:64002 33 34 34
  • 47.71 (n)
worm
(Caenorhabditis elegans)
Secernentea anmt-2 34
  • 26 (a)
ManyToMany
anmt-3 34
  • 22 (a)
ManyToMany
anmt-1 34
  • 21 (a)
ManyToMany
Species where no ortholog for INMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for INMT Gene

ENSEMBL:
Gene Tree for INMT (if available)
TreeFam:
Gene Tree for INMT (if available)

Paralogs for INMT Gene

Paralogs for INMT Gene

(3) SIMAP similar genes for INMT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INMT: view

Variants for INMT Gene

Sequence variations from dbSNP and Humsavar for INMT Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs193920790 uncertain-significance, Malignant tumor of prostate 30,755,684(+) C/T coding_sequence_variant, missense_variant
rs61741736 benign, not specified 30,755,850(+) G/C stop_lost, terminator_codon_variant
rs1000196075 -- 30,754,432(+) C/T intron_variant
rs1000432477 -- 30,757,828(+) G/C downstream_transcript_variant
rs1000890203 -- 30,751,847(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for INMT Gene

Variant ID Type Subtype PubMed ID
dgv6316n100 CNV gain 25217958
esv2761316 CNV gain 21179565
nsv1068321 OTHER inversion 25765185
nsv1148830 OTHER inversion 26484159
nsv436557 CNV deletion 17901297
nsv527038 CNV gain 19592680
nsv606506 CNV loss 21841781
nsv606507 CNV loss 21841781
nsv830938 CNV gain 17160897
nsv830939 CNV loss 17160897

Variation tolerance for INMT Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.80; 95.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INMT Gene

Human Gene Mutation Database (HGMD)
INMT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INMT Gene

Disorders for INMT Gene

Additional Disease Information for INMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for INMT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INMT Gene

Publications for INMT Gene

  1. Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization. (PMID: 10552930) Thompson MA … Weinshilboum RM (Genomics 1999) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Potentially hallucinogenic 5-hydroxytryptamine receptor ligands bufotenine and dimethyltryptamine in blood and tissues. (PMID: 16095048) Kärkkäinen J … Hesso A (Scandinavian journal of clinical and laboratory investigation 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58

Products for INMT Gene

  • Addgene plasmids for INMT

Sources for INMT Gene

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