Aliases for INKA2 Gene

Aliases for INKA2 Gene

  • Inka Box Actin Regulator 2 2 3 4 5
  • Induced In Neural Crest By AP2-Alpha Protein-Related Homolog 3 4
  • Family With Sequence Similarity 212 Member B 2 3
  • PAK4-Inhibitor INKA2 3 4
  • C1orf183 3 4
  • FAM212B 3 4
  • HInca-R 3 4
  • Family With Sequence Similarity 212, Member B 2
  • Chromosome 1 Open Reading Frame 183 2
  • Protein FAM212B 3
  • FLJ31105 2
  • INKA2 5

External Ids for INKA2 Gene

Previous HGNC Symbols for INKA2 Gene

  • C1orf183
  • FAM212B

Summaries for INKA2 Gene

GeneCards Summary for INKA2 Gene

INKA2 (Inka Box Actin Regulator 2) is a Protein Coding gene. Diseases associated with INKA2 include Visual Cortex Disease and Visual Pathway Disease. An important paralog of this gene is INKA1.

UniProtKB/Swiss-Prot Summary for INKA2 Gene

  • Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.

Additional gene information for INKA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INKA2 Gene

Genomics for INKA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INKA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111731 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 603.3 +19.2 19196 9.5 RNF2 SP1 HNRNPL GATAD2A ATF7 PRDM10 ZNF629 TFE3 ZNF512 RFX1 INKA2-AS1 INKA2 DDX20 RAP1A C1orf162 lnc-FAM212B-2 lnc-KCND3-3 TMIGD3
GH01J111754 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.1 -93 3 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A CTCF HNRNPL PRDM10 ZNF629 RFX1 DDX20 ENSG00000284830 LOC101928718 INKA2 ST7L DENND2D CAPZA1 INKA2-AS1 lnc-FAM212B-3 KCND3
GH01J111755 Promoter 0.3 Ensembl 600.7 +1.7 1723 0.2 DDX20 ENSG00000284830 LOC101928718 INKA2 lnc-FAM212B-2 TMIGD3
GH01J111469 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.1 +281.6 281603 8.7 SP1 LEF1 BACH1 STAT3 RELA PKNOX1 ZNF24 IKZF2 POLR2A TRIM22 C1orf162 NONHSAG002411.2 INKA2 ENSG00000260948 RAP1A OVGP1 WDR77 ATP5PB RNU6-151P KRT18P57
GH01J111489 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 10.7 +265.5 265523 2.6 SP1 CEBPA CEBPB MGA ZNF766 NFE2 ZNF316 YY1 MAFG EHMT2 TMIGD3 RF00026-062 RNU6-792P lnc-ADORA3-5 DDX20 INKA2 ADORA3 C1orf162
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INKA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INKA2

Genomic Locations for INKA2 Gene

Genomic Locations for INKA2 Gene
chr1:111,680,630-111,755,824
(GRCh38/hg38)
Size:
75,195 bases
Orientation:
Minus strand
chr1:112,223,252-112,298,446
(GRCh37/hg19)
Size:
75,195 bases
Orientation:
Minus strand

Genomic View for INKA2 Gene

Genes around INKA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INKA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INKA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INKA2 Gene

Proteins for INKA2 Gene

  • Protein details for INKA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTI7-INKA2_HUMAN
    Recommended name:
    PAK4-inhibitor INKA2
    Protein Accession:
    Q9NTI7
    Secondary Accessions:
    • B3KP38
    • B4DF94
    • Q9NTI6

    Protein attributes for INKA2 Gene

    Size:
    297 amino acids
    Molecular mass:
    32759 Da
    Quaternary structure:
    • Interacts with PAK4 (PubMed:26607847).
    SequenceCaution:
    • Sequence=BAG57355.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAB69909.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for INKA2 Gene

Post-translational modifications for INKA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for INKA2 Gene

No data available for DME Specific Peptides for INKA2 Gene

Domains & Families for INKA2 Gene

Gene Families for INKA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INKA2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9NTI7

UniProtKB/Swiss-Prot:

INKA2_HUMAN :
  • The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.
  • Belongs to the INKA family.
Domain:
  • The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.
Family:
  • Belongs to the INKA family.
genes like me logo Genes that share domains with INKA2: view

No data available for Suggested Antigen Peptide Sequences for INKA2 Gene

Function for INKA2 Gene

Molecular function for INKA2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.

Phenotypes From GWAS Catalog for INKA2 Gene

Gene Ontology (GO) - Molecular Function for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IBA,IPI 26607847
GO:0030291 protein serine/threonine kinase inhibitor activity IEA,ISS --
genes like me logo Genes that share ontologies with INKA2: view
genes like me logo Genes that share phenotypes with INKA2: view

Animal Models for INKA2 Gene

MGI Knock Outs for INKA2:
  • Inka2 Inka2<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for INKA2 Gene

miRTarBase miRNAs that target INKA2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INKA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INKA2 Gene

Localization for INKA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INKA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INKA2 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 26607847
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with INKA2: view

Pathways & Interactions for INKA2 Gene

PathCards logo

SuperPathways for INKA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with INKA2: view

No data available for Pathways by source and SIGNOR curated interactions for INKA2 Gene

Drugs & Compounds for INKA2 Gene

No Compound Related Data Available

Transcripts for INKA2 Gene

mRNA/cDNA for INKA2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INKA2

Alternative Splicing Database (ASD) splice patterns (SP) for INKA2 Gene

No ASD Table

Relevant External Links for INKA2 Gene

GeneLoc Exon Structure for
INKA2

Expression for INKA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INKA2

Evidence on tissue expression from TISSUES for INKA2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with INKA2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INKA2 Gene

Orthologs for INKA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for INKA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM212B 30 31
  • 99.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM212B 30 31
  • 85.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam212b 30
  • 80.36 (n)
Mouse
(Mus musculus)
Mammalia Fam212b 30 31
  • 80.13 (n)
OneToOne
Inka2 17
Oppossum
(Monodelphis domestica)
Mammalia FAM212B 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM212B 31
  • 50 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C1ORF183 30
  • 62.85 (n)
FAM212B 31
  • 49 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM212B 31
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam212b 30
  • 54.41 (n)
Str.19495 30
Zebrafish
(Danio rerio)
Actinopterygii LOC101886856 30
  • 48.65 (n)
Species where no ortholog for INKA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INKA2 Gene

ENSEMBL:
Gene Tree for INKA2 (if available)
TreeFam:
Gene Tree for INKA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INKA2: view image

Paralogs for INKA2 Gene

Paralogs for INKA2 Gene

genes like me logo Genes that share paralogs with INKA2: view

Variants for INKA2 Gene

Additional dbSNP identifiers (rs#s) for INKA2 Gene

Variation tolerance for INKA2 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INKA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INKA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for INKA2 Gene

Disorders for INKA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for INKA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
visual cortex disease
  • visual cortex dysfunction
visual pathway disease
  • disorder of visual pathways
- elite association - COSMIC cancer census association via MalaCards
Search INKA2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with INKA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INKA2 Gene

Publications for INKA2 Gene

  1. An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. (PMID: 26607847) Baskaran Y … Robinson RC (Nature communications 2015) 3 4
  2. Expression profiles of inka2 in the murine nervous system. (PMID: 26292052) Iwasaki Y … Sakakibara S (Gene expression patterns : GEP 2015) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for INKA2 Gene

Sources for INKA2 Gene