The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016] See more...

Aliases for INIP Gene

Aliases for INIP Gene

  • INTS3 And NABP Interacting Protein 2 3 5
  • Sensor Of Single-Strand DNA Complex Subunit C 2 3 4
  • Single-Stranded DNA-Binding Protein-Interacting Protein 1 3 4
  • Minute INTS3/HSSB-Associated Element 2 3
  • HSSB-Interacting Protein 1 2 3
  • Sensor Of SsDNA Subunit C 3 4
  • SSB-Interacting Protein 1 3 4
  • SOSS Complex Subunit C 3 4
  • C9orf80 3 4
  • HSSBIP1 3 4
  • SSBIP1 3 4
  • INTS3- And NABP-Interacting Protein 4
  • Chromosome 9 Open Reading Frame 80 2
  • HSPC043 3
  • SOSS-C 4
  • SOSSC 3
  • MISE 3

External Ids for INIP Gene

Previous HGNC Symbols for INIP Gene

  • C9orf80

Previous GeneCards Identifiers for INIP Gene

  • GC09M115449

Summaries for INIP Gene

Entrez Gene Summary for INIP Gene

  • The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016]

GeneCards Summary for INIP Gene

INIP (INTS3 And NABP Interacting Protein) is a Protein Coding gene. Diseases associated with INIP include Cervical Incompetence and Superficial Mycosis.

UniProtKB/Swiss-Prot Summary for INIP Gene

  • Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Additional gene information for INIP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INIP Gene

Genomics for INIP Gene

GeneHancer (GH) Regulatory Elements for INIP Gene

Promoters and enhancers for INIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J112717 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.4 448 2.6 ZBTB40 ZNF217 EP300 CTCF NRF1 POLR2G SP1 GTF2E2 ZIC2 POLR2A INIP lnc-SLC46A2-4 PRPF4 ENSG00000213529 lnc-KIAA1958-1
GH09J112719 Enhancer 0.6 ENCODE 500.7 -1.4 -1409 1 RBM25 ZNF316 MAFF MAFK BCOR BATF IRF4 MAFG JUNB ZMYM3 INIP lnc-SLC46A2-4 RF00017-7831 lnc-KIAA1958-1
GH09J112485 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas 10.4 +228.6 228645 8.2 FOXK2 HNRNPK ZBTB40 ZNF217 SIN3A NRF1 TCF12 MYC POLR2G SP1 C9orf147 KIAA1958 HSDL2 INIP ENSG00000226609 SNX30
GH09J112749 Promoter/Enhancer 2 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -35.4 -35364 8 HNRNPK ZNF217 TCF12 NRF1 POLR2G USF1 PHF8 JUND FOS ZFX INIP SLC46A2 SNX30 ENSG00000226609 ENSG00000271631 piR-57134-114
GH09J112763 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 -46.7 -46652 2 POLR2G USF1 FOS CLOCK HES1 TOE1 SKI RAD51 KMT2B WT1 RF00017-7833 INIP SLC46A2 ENSG00000226609 SNX30 piR-52680-369
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INIP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INIP

Genomic Locations for INIP Gene

Genomic Locations for INIP Gene
chr9:112,683,926-112,718,149
(GRCh38/hg38)
Size:
34,224 bases
Orientation:
Minus strand
chr9:115,446,206-115,480,516
(GRCh37/hg19)
Size:
34,311 bases
Orientation:
Minus strand

Genomic View for INIP Gene

Genes around INIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INIP Gene

Proteins for INIP Gene

  • Protein details for INIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRY2-SOSSC_HUMAN
    Recommended name:
    SOSS complex subunit C
    Protein Accession:
    Q9NRY2
    Secondary Accessions:
    • Q5VWJ7
    • Q96E04
    • Q9P090

    Protein attributes for INIP Gene

    Size:
    104 amino acids
    Molecular mass:
    11425 Da
    Quaternary structure:
    • Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.
    SequenceCaution:
    • Sequence=AAF28969.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for INIP Gene

    Alternative splice isoforms for INIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for INIP Gene

Post-translational modifications for INIP Gene

  • Ubiquitination at Lys28
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for INIP Gene

Domains & Families for INIP Gene

Gene Families for INIP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INIP Gene

GenScript: Design optimal peptide antigens:
  • Single-stranded DNA-binding protein-interacting protein 1 (SOSSC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NRY2

UniProtKB/Swiss-Prot:

SOSSC_HUMAN :
  • Belongs to the SOSS-C family.
Family:
  • Belongs to the SOSS-C family.
genes like me logo Genes that share domains with INIP: view

Function for INIP Gene

Molecular function for INIP Gene

UniProtKB/Swiss-Prot Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Phenotypes From GWAS Catalog for INIP Gene

Gene Ontology (GO) - Molecular Function for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19683501
genes like me logo Genes that share ontologies with INIP: view
genes like me logo Genes that share phenotypes with INIP: view

Clone Products

  • Addgene plasmids for INIP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INIP Gene

Localization for INIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for INIP Gene

Nucleus. Note=Localizes to nuclear foci following DNA damage.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INIP gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19605351
GO:0005654 nucleoplasm IDA --
GO:0070876 SOSS complex IDA,IEA 18449195
genes like me logo Genes that share ontologies with INIP: view

Pathways & Interactions for INIP Gene

PathCards logo

SuperPathways for INIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for INIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IMP,IEA 19605351
GO:0006974 cellular response to DNA damage stimulus IMP,IEA 19683501
GO:0010212 response to ionizing radiation IMP 19605351
genes like me logo Genes that share ontologies with INIP: view

No data available for Pathways by source and SIGNOR curated interactions for INIP Gene

Drugs & Compounds for INIP Gene

No Compound Related Data Available

Transcripts for INIP Gene

mRNA/cDNA for INIP Gene

7 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for INIP

Alternative Splicing Database (ASD) splice patterns (SP) for INIP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - - -

Relevant External Links for INIP Gene

GeneLoc Exon Structure for
INIP

Expression for INIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INIP Gene

Protein differential expression in normal tissues from HIPED for INIP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.2), Monocytes (13.5), Spleen (7.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INIP Gene



Protein tissue co-expression partners for INIP Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INIP

SOURCE GeneReport for Unigene cluster for INIP Gene:

Hs.658575

Evidence on tissue expression from TISSUES for INIP Gene

  • Blood(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with INIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INIP Gene

Orthologs for INIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for INIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9ORF80 31
  • 100 (a)
OneToOne
C9H9orf80 30
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia INIP 31 30
  • 95.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia INIP 31 30
  • 93.59 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Inip 17 31 30
  • 90.38 (n)
rat
(Rattus norvegicus)
Mammalia Inip 30
  • 86.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia INIP 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF80 31 30
  • 84.79 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INIP 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inip 30
  • 75.69 (n)
Str.10998 30
African clawed frog
(Xenopus laevis)
Amphibia hspc043-A-prov 30
zebrafish
(Danio rerio)
Actinopterygii inip 31 30
  • 77.67 (n)
OneToOne
zgc56259 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10677 30
Species where no ortholog for INIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INIP Gene

ENSEMBL:
Gene Tree for INIP (if available)
TreeFam:
Gene Tree for INIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INIP: view image

Paralogs for INIP Gene

Pseudogenes.org Pseudogenes for INIP Gene

genes like me logo Genes that share paralogs with INIP: view

No data available for Paralogs for INIP Gene

Variants for INIP Gene

Additional dbSNP identifiers (rs#s) for INIP Gene

Structural Variations from Database of Genomic Variants (DGV) for INIP Gene

Variant ID Type Subtype PubMed ID
dgv262e55 CNV gain 17911159
dgv7701n100 CNV gain 25217958
esv2759710 CNV gain 17122850
esv2761275 CNV gain 21179565
esv3621517 CNV gain 21293372
esv3621518 CNV gain 21293372
nsv415734 CNV deletion 16902084
nsv442163 CNV gain 18776908
nsv471317 CNV gain 18288195
nsv515121 CNV gain 21397061
nsv515899 CNV gain+loss 19592680
nsv615198 CNV gain 21841781

Variation tolerance for INIP Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INIP Gene

Human Gene Mutation Database (HGMD)
INIP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INIP Gene

Disorders for INIP Gene

MalaCards: The human disease database

(3) MalaCards diseases for INIP Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervical incompetence
  • uterine cervical incompetence
superficial mycosis
  • piedra
kabuki syndrome 1
  • kms
- elite association - COSMIC cancer census association via MalaCards
Search INIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INIP

genes like me logo Genes that share disorders with INIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INIP Gene

Publications for INIP Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 54
  2. HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. (PMID: 19605351) Li Y … Wang W (The Journal of biological chemistry 2009) 3 4 54
  3. SOSS complexes participate in the maintenance of genomic stability. (PMID: 19683501) Huang J … Chen J (Molecular cell 2009) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54

Products for INIP Gene

Sources for INIP Gene