Aliases for INHBE Gene
External Ids for INHBE Gene
Previous GeneCards Identifiers for INHBE Gene
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]
GeneCards Summary for INHBE Gene
INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. Diseases associated with INHBE include Brachydactyly, Type A2 and Liver Benign Neoplasm. Among its related pathways are PEDF Induced Signaling and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is INHBC.
UniProtKB/Swiss-Prot Summary for INHBE Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.