This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under... See more...

Aliases for INHBE Gene

Aliases for INHBE Gene

  • Inhibin Subunit Beta E 2 3 5
  • Inhibin Beta E Chain 3 4
  • Activin Beta-E Chain 3 4
  • Inhibin Beta E Subunit 3
  • Inhibin, Beta E 2
  • Activin 2
  • MGC4638 2
  • INHBE 5

External Ids for INHBE Gene

Previous GeneCards Identifiers for INHBE Gene

  • GC12P057992
  • GC12P057565
  • GC12P056135
  • GC12P057849
  • GC12P054886

Summaries for INHBE Gene

Entrez Gene Summary for INHBE Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016]

GeneCards Summary for INHBE Gene

INHBE (Inhibin Subunit Beta E) is a Protein Coding gene. Diseases associated with INHBE include Brachydactyly, Type A2 and Liver Benign Neoplasm. Among its related pathways are PEDF Induced Signaling and TGF-beta signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity and hormone activity. An important paralog of this gene is INHBC.

UniProtKB/Swiss-Prot Summary for INHBE Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INHBE Gene

Genomics for INHBE Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INHBE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057454 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.4 +6.4 6409 9.4 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 REST ZNF629 GLI1 NONHSAG011428.2 INHBE NEMP1 BAZ2A ZBTB39 MBD6 PRIM1 RN7SL809P ARHGAP9
GH12J057450 Promoter/Enhancer 1.3 EPDnew ENCODE 600.7 -0.3 -262 3.2 HNRNPL GATAD2A CTCF PRDM10 REST ZNF629 TFE3 SOX13 IKZF1 NFKBIZ INHBE ENSG00000224713 piR-55377 INHBC
GH12J057242 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -209.1 -209128 2 BRCA1 CREB1 CTCF TEAD4 PRDM10 RFX1 KDM1A ZNF692 JUND ZNF143 NEMP1 ARHGAP9 BAZ2A CTDSP2 NXPH4 RN7SL809P CDK4 RNU6-343P STAT2 INHBE
GH12J057238 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 10.5 -212.6 -212583 4.5 ARHGAP35 CEBPG SP1 HNRNPL CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 AB372660-001 NDUFA4L2 lnc-NDUFA4L2-1 DTX3 NXPH4 ANKRD52 ENSG00000257740 NAB2 INHBE TSPAN31
GH12J057279 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11 -171.9 -171922 3.6 SP1 CREB1 GATAD2A ZNF629 TFE3 LEF1 ZHX2 JUND MTA2 ZNF143 piR-61945-104 R3HDM2 EEF1AKMT3 NEMP1 PAN2 CDK4 ENSG00000224713 TSPAN31 CTDSP2 LOC283387
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INHBE on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INHBE

Top Transcription factor binding sites by QIAGEN in the INHBE gene promoter:
  • c-Myb
  • NF-1
  • Nkx2-5
  • p53
  • Sp1
  • STAT5A

Genomic Locations for INHBE Gene

Genomic Locations for INHBE Gene
chr12:57,452,323-57,459,280
(GRCh38/hg38)
Size:
6,958 bases
Orientation:
Plus strand
chr12:57,846,106-57,853,063
(GRCh37/hg19)
Size:
6,958 bases
Orientation:
Plus strand

Genomic View for INHBE Gene

Genes around INHBE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBE Gene

Proteins for INHBE Gene

  • Protein details for INHBE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58166-INHBE_HUMAN
    Recommended name:
    Inhibin beta E chain
    Protein Accession:
    P58166

    Protein attributes for INHBE Gene

    Size:
    350 amino acids
    Molecular mass:
    38561 Da
    Quaternary structure:
    • Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).

neXtProt entry for INHBE Gene

Post-translational modifications for INHBE Gene

  • Glycosylation at Asn198
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • INHBE_HUMAN (2094)

Other Protein References for INHBE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBE Gene

Domains & Families for INHBE Gene

Gene Families for INHBE Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for INHBE Gene

InterPro:
Blocks:
  • Transforming growth factor beta (TGFb)
  • Growth factor cystine knot superfamily signature
ProtoNet:

Suggested Antigen Peptide Sequences for INHBE Gene

GenScript: Design optimal peptide antigens:
  • Activin beta-E chain (INHBE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58166

UniProtKB/Swiss-Prot:

INHBE_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBE: view

Function for INHBE Gene

Molecular function for INHBE Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Phenotypes From GWAS Catalog for INHBE Gene

Gene Ontology (GO) - Molecular Function for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005179 hormone activity IEA --
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with INHBE: view
genes like me logo Genes that share phenotypes with INHBE: view

Animal Models for INHBE Gene

MGI Knock Outs for INHBE:

Animal Model Products

  • Taconic Biosciences Mouse Models for INHBE

CRISPR Products

miRNA for INHBE Gene

miRTarBase miRNAs that target INHBE

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBE

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBE Gene

Localization for INHBE Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBE gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0062023 collagen-containing extracellular matrix HDA 25037231
genes like me logo Genes that share ontologies with INHBE: view

Pathways & Interactions for INHBE Gene

genes like me logo Genes that share pathways with INHBE: view

Gene Ontology (GO) - Biological Process for INHBE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA 21873635
GO:0060395 SMAD protein signal transduction IBA 21873635
genes like me logo Genes that share ontologies with INHBE: view

No data available for SIGNOR curated interactions for INHBE Gene

Drugs & Compounds for INHBE Gene

No Compound Related Data Available

Transcripts for INHBE Gene

mRNA/cDNA for INHBE Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBE

Alternative Splicing Database (ASD) splice patterns (SP) for INHBE Gene

No ASD Table

Relevant External Links for INHBE Gene

GeneLoc Exon Structure for
INHBE

Expression for INHBE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INHBE Gene

mRNA differential expression in normal tissues according to GTEx for INHBE Gene

This gene is overexpressed in Liver (x48.0).

Protein differential expression in normal tissues from HIPED for INHBE Gene

This gene is overexpressed in Heart (28.2), Plasma (13.6), Liver (10.0), and Adrenal (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INHBE Gene



Protein tissue co-expression partners for INHBE Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INHBE

SOURCE GeneReport for Unigene cluster for INHBE Gene:

Hs.632713

Evidence on tissue expression from TISSUES for INHBE Gene

  • Liver(4.6)
  • Muscle(4.5)
genes like me logo Genes that share expression patterns with INHBE: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBE Gene

Orthologs for INHBE Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBE Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INHBE 30 31
  • 99.43 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia INHBE 30 31
  • 85.43 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Inhbe 30 17 31
  • 83.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Inhbe 30
  • 81.85 (n)
Dog
(Canis familiaris)
Mammalia INHBE 30 31
  • 81.24 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INHBE 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia inhbc 30
  • 50.11 (n)
Zebrafish
(Danio rerio)
Actinopterygii INHBE 31
  • 34 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Actbeta 31
  • 9 (a)
OneToMany
Species where no ortholog for INHBE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INHBE Gene

ENSEMBL:
Gene Tree for INHBE (if available)
TreeFam:
Gene Tree for INHBE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INHBE: view image

Paralogs for INHBE Gene

(3) SIMAP similar genes for INHBE Gene using alignment to 2 proteins:

  • INHBE_HUMAN
  • F8VNP4_HUMAN
genes like me logo Genes that share paralogs with INHBE: view

Variants for INHBE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INHBE Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_036198 A breast cancer sample p.Arg62Thr
VAR_036199 A breast cancer sample p.Gln215His

Additional dbSNP identifiers (rs#s) for INHBE Gene

Structural Variations from Database of Genomic Variants (DGV) for INHBE Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789

Variation tolerance for INHBE Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHBE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHBE Gene

Disorders for INHBE Gene

MalaCards: The human disease database

(2) MalaCards diseases for INHBE Gene - From: DISEASES

Disorder Aliases PubMed IDs
brachydactyly, type a2
  • bda2
liver benign neoplasm
  • epithelial hepatic and intrahepatic bile duct neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search INHBE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INHBE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with INHBE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBE Gene

Publications for INHBE Gene

  1. cDNA cloning and expression of human activin betaE subunit. (PMID: 12242034) Hashimoto O … Hasegawa Y (Molecular and cellular endocrinology 2002) 2 3 4 23
  2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 23 41
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41
  4. Inhibin/activin-betaE subunit in normal and malignant human cervical tissue and cervical cancer cell lines. (PMID: 20033758) Bergauer F … Mylonas I (Journal of molecular histology 2009) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for INHBE Gene

  • Signalway ELISA kits for INHBE

Sources for INHBE Gene