This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene a... See more...

Aliases for INHBB Gene

Aliases for INHBB Gene

  • Inhibin Subunit Beta B 2 3 5
  • Inhibin Beta B Chain 3 4
  • Activin Beta-B Chain 3 4
  • Inhibin, Beta B (Activin AB Beta Polypeptide) 2
  • Activin AB Beta Polypeptide 3
  • Inhibin Beta B Subunit 3
  • Inhibin, Beta B 2
  • Inhibin, Beta-2 3
  • INHBB 5

External Ids for INHBB Gene

Previous GeneCards Identifiers for INHBB Gene

  • GC02P118308
  • GC02P119023
  • GC02P121009
  • GC02P121198
  • GC02P120819
  • GC02P113427
  • GC02P120347
  • GC02P120349
  • GC02P120373

Summaries for INHBB Gene

Entrez Gene Summary for INHBB Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHBB Gene

INHBB (Inhibin Subunit Beta B) is a Protein Coding gene. Diseases associated with INHBB include Eclampsia and Pre-Eclampsia. Among its related pathways are Signaling by NODAL and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is INHBA.

UniProtKB/Swiss-Prot Summary for INHBB Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INHBB Gene

Genomics for INHBB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INHBB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J120343 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 250.7 +0.0 17 5.3 EZH2 ZNF654 ZNF600 KLF9 CEBPA ZSCAN16 CTCF REST ZNF341 ZBTB7B HSALNG0018378 INHBB LOC105373989 GLI2
GH02J120564 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.2 +219.4 219365 4.2 CEBPA FOXA1 ZFP64 FOXA2 KDM6A SMAD4 ETV4 RARA ZSCAN9 THRB INHBB GLI2 ENSG00000232140 lnc-GLI2-3 HSALNG0018393
GH02J120316 Enhancer 0.7 Ensembl 13 -25.2 -25235 8.2 MYC CEBPA HES1 BHLHE40 CTBP1 RUNX1 ZBTB40 HNF4A NR2F6 TEAD4 LOC105373584 INHBB ENSG00000224789 lnc-TMEM185B-6 ENSG00000235840 LOC105373989 RALB
GH02J120395 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.1 +52.4 52408 6.7 SSRP1 CEBPA JUND BRCA1 NFIC ZIC2 MXD4 FOXA1 KLF11 ZNF341 GLI2 INHBB RF00017-2981 HSALNG0018384
GH02J120372 Enhancer 0.8 ENCODE 0.3 +27.6 27585 1.7 PLRG1 FOXA1 RAD51 NONO HES1 CTBP1 NBN SP1 MLLT1 ESRRA HSALNG0018381 MTCO3P43 GLI2 HSALNG0018383 INHBB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INHBB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INHBB

Top Transcription factor binding sites by QIAGEN in the INHBB gene promoter:
  • AREB6
  • Arnt
  • Egr-3
  • Nkx2-5
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for INHBB Gene

Latest Assembly
chr2:120,346,136-120,351,803
(GRCh38/hg38)
Size:
5,668 bases
Orientation:
Plus strand

Previous Assembly
chr2:121,103,712-121,109,379
(GRCh37/hg19 by Entrez Gene)
Size:
5,668 bases
Orientation:
Plus strand

chr2:121,103,719-121,109,384
(GRCh37/hg19 by Ensembl)
Size:
5,666 bases
Orientation:
Plus strand

Genomic View for INHBB Gene

Genes around INHBB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBB Gene

Proteins for INHBB Gene

  • Protein details for INHBB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09529-INHBB_HUMAN
    Recommended name:
    Inhibin beta B chain
    Protein Accession:
    P09529
    Secondary Accessions:
    • Q53T31
    • Q8N1D3

    Protein attributes for INHBB Gene

    Size:
    407 amino acids
    Molecular mass:
    45122 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

neXtProt entry for INHBB Gene

Post-translational modifications for INHBB Gene

  • Glycosylation at Asn93
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INHBB Gene

Domains & Families for INHBB Gene

Gene Families for INHBB Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for INHBB Gene

InterPro:
Blocks:
  • Transforming growth factor beta (TGFb), N-terminal
  • Transforming growth factor beta (TGFb)
  • Growth factor cystine knot superfamily signature
  • Inhibin beta B chain signature

Suggested Antigen Peptide Sequences for INHBB Gene

GenScript: Design optimal peptide antigens:
  • INHBB protein (A0PK08_HUMAN)
  • Activin beta-B chain (INHBB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09529

UniProtKB/Swiss-Prot:

INHBB_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBB: view

Function for INHBB Gene

Molecular function for INHBB Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GENATLAS Biochemistry:
inhibin,beta B subunit,dimerizing with INHBA,homodimerizing to form activin B,heterodimerizing with INHBA or INHA to form activin AB or inhibitin B,respectively

Phenotypes From GWAS Catalog for INHBB Gene

Gene Ontology (GO) - Molecular Function for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA,TAS 3122219
GO:0005179 hormone activity TAS 3122219
GO:0005515 protein binding IPI 2575216
GO:0008083 growth factor activity IEA --
GO:0042803 protein homodimerization activity IPI 2575216
genes like me logo Genes that share ontologies with INHBB: view
genes like me logo Genes that share phenotypes with INHBB: view

Animal Models for INHBB Gene

MGI Knock Outs for INHBB:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHBB Gene

Localization for INHBB Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBB gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 3122219
GO:0005615 extracellular space IBA 21873635
GO:0048471 perinuclear region of cytoplasm IEA,IDA 16650820
GO:0071944 cell periphery IEA --
genes like me logo Genes that share ontologies with INHBB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INHBB Gene

Pathways & Interactions for INHBB Gene

genes like me logo Genes that share pathways with INHBB: view

Pathways by source for INHBB Gene

1 GeneGo (Thomson Reuters) pathway for INHBB Gene
  • Signal transduction Activin A signaling regulation

Gene Ontology (GO) - Biological Process for INHBB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development NAS 12790766
GO:0006952 defense response TAS 3122219
GO:0009267 cellular response to starvation IEA,ISS --
GO:0009611 response to wounding IEP 10320815
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA 21873635
genes like me logo Genes that share ontologies with INHBB: view

No data available for SIGNOR curated interactions for INHBB Gene

Drugs & Compounds for INHBB Gene

(1) Additional Compounds for INHBB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHBB: view

Transcripts for INHBB Gene

mRNA/cDNA for INHBB Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBB

Alternative Splicing Database (ASD) splice patterns (SP) for INHBB Gene

No ASD Table

Relevant External Links for INHBB Gene

GeneLoc Exon Structure for
INHBB

Expression for INHBB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INHBB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBB Gene

This gene is overexpressed in Adipose - Subcutaneous (x6.8), Breast - Mammary Tissue (x4.7), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for INHBB Gene

This gene is overexpressed in Rectum (15.7), Prostate (14.9), Testis (14.8), Lung (10.8), and Urinary Bladder (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INHBB Gene



Protein tissue co-expression partners for INHBB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INHBB

SOURCE GeneReport for Unigene cluster for INHBB Gene:

Hs.1735

Evidence on tissue expression from TISSUES for INHBB Gene

  • Nervous system(4.7)
  • Stomach(3.2)
  • Heart(3.1)
  • Kidney(3)
  • Muscle(3)
  • Intestine(2.8)
  • Liver(2.7)
genes like me logo Genes that share expression patterns with INHBB: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBB Gene

Orthologs for INHBB Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INHBB 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia INHBB 30
  • 95 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Inhbb 29
  • 90.99 (n)
Cow
(Bos Taurus)
Mammalia INHBB 29 30
  • 90.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Inhbb 29 16 30
  • 90.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia INHBB 30
  • 88 (a)
OneToOne
Chicken
(Gallus gallus)
Aves INHBB 29 30
  • 79.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INHBB 30
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1090 29
Zebrafish
(Danio rerio)
Actinopterygii inhbb 29 30
  • 70.53 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta activin-&bgr; 31
  • 30 (a)
Actbeta 30
  • 12 (a)
OneToMany
Species where no ortholog for INHBB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INHBB Gene

ENSEMBL:
Gene Tree for INHBB (if available)
TreeFam:
Gene Tree for INHBB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INHBB: view image
Alliance of Genome Resources:
Additional Orthologs for INHBB

Paralogs for INHBB Gene

(4) SIMAP similar genes for INHBB Gene using alignment to 2 proteins:

  • INHBB_HUMAN
  • A0PK08_HUMAN
genes like me logo Genes that share paralogs with INHBB: view

Variants for INHBB Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for INHBB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for INHBB Gene

Variant ID Type Subtype PubMed ID
nsv1126562 CNV deletion 24896259
nsv1143957 CNV deletion 24896259
nsv582786 CNV loss 21841781
nsv582787 CNV loss 21841781
nsv829640 CNV loss 20364138
nsv829641 CNV gain 20364138
nsv954803 CNV deletion 24416366

Variation tolerance for INHBB Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHBB Gene

Human Gene Mutation Database (HGMD)
INHBB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBB
Leiden Open Variation Database (LOVD)
INHBB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INHBB Gene

Disorders for INHBB Gene

MalaCards: The human disease database

(3) MalaCards diseases for INHBB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
eclampsia
  • eclampsia in puerperium
pre-eclampsia
  • gestational hypertension
posterior fossa ependymoma
- elite association - COSMIC cancer census association via MalaCards
Search INHBB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INHBB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with INHBB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBB Gene

Publications for INHBB Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 22 40
  2. A genome-wide association study on obesity and obesity-related traits. (PMID: 21552555) Wang K … Price RA (PloS one 2011) 3 40
  3. Family-based analysis of candidate genes for polycystic ovary syndrome. (PMID: 20200332) Ewens KG … Spielman RS (The Journal of clinical endocrinology and metabolism 2010) 3 40
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 40
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40

Products for INHBB Gene

Sources for INHBB Gene