Aliases for INHBB Gene
External Ids for INHBB Gene
Previous GeneCards Identifiers for INHBB Gene
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]
GeneCards Summary for INHBB Gene
INHBB (Inhibin Subunit Beta B) is a Protein Coding gene. Diseases associated with INHBB include Eclampsia and Pre-Eclampsia. Among its related pathways are Signaling by NODAL and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity. An important paralog of this gene is INHBA.
UniProtKB/Swiss-Prot Summary for INHBB Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.