This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays... See more...

Aliases for INHBA Gene

Aliases for INHBA Gene

  • Inhibin Subunit Beta A 2 3 5
  • Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) 2 3
  • Erythroid Differentiation Protein 3 4
  • Activin Beta-A Chain 3 4
  • Inhibin Beta A Chain 3 4
  • EDF 3 4
  • Follicle-Stimulating Hormone-Releasing Protein 3
  • Erythroid Differentiation Factor 3
  • Inhibin Beta A Subunit 3
  • FSH-Releasing Protein 3
  • Inhibin, Beta-1 3
  • Inhibin, Beta A 2
  • FRP 3

External Ids for INHBA Gene

Previous GeneCards Identifiers for INHBA Gene

  • GC07M041375
  • GC07M041469
  • GC07M041502
  • GC07M041695
  • GC07M041724
  • GC07M041686

Summaries for INHBA Gene

Entrez Gene Summary for INHBA Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHBA Gene

INHBA (Inhibin Subunit Beta A) is a Protein Coding gene. Diseases associated with INHBA include Ovary Adenocarcinoma and Sex Cord-Gonadal Stromal Tumor. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling receptor binding. An important paralog of this gene is INHBB.

UniProtKB/Swiss-Prot Summary for INHBA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHBA Gene

Additional gene information for INHBA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INHBA Gene

Genomics for INHBA Gene

GeneHancer (GH) Regulatory Elements for INHBA Gene

Promoters and enhancers for INHBA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J041694 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 502.6 +5.3 5324 13.4 HNRNPK ZNF217 EP300 CTCF USF1 JUND TEAD4 FOS ZFX REST INHBA lnc-INHBA-1 INHBA-AS1 lnc-SUGCT-7
GH07J041708 Promoter/Enhancer 1.5 EPDnew FANTOM5 ENCODE dbSUPER 502.2 -3.7 -3749 1.7 JUND FOS ZNF639 ATF2 FOXA2 OSR2 NR2F2 WT1 CREB1 ZNF263 INHBA INHBA-AS1 piR-38351-427 lnc-SUGCT-7
GH07J040823 Enhancer 1 Ensembl ENCODE CraniofacialAtlas dbSUPER 21.1 +879.7 879734 5 TEAD3 HNF4A RBBP5 POLR2A CEBPB MYC INHBA piR-41405-068 HSALNG0057434 SUGCT
GH07J040806 Enhancer 0.8 Ensembl ENCODE dbSUPER 20.2 +896.6 896633 5.6 JUND REST EZH2 NFE2L2 POLR2A CEBPB INHBA piR-41405-068 HSALNG0057434 SUGCT
GH07J040814 Enhancer 0.7 Ensembl ENCODE dbSUPER 20.2 +889.9 889930 1.8 JUND CTCF INHBA piR-41405-068 HSALNG0057434 SUGCT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INHBA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INHBA

Top Transcription factor binding sites by QIAGEN in the INHBA gene promoter:
  • AREB6
  • Arnt
  • FOXC1
  • Ik-3
  • IRF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Pax-5
  • Sox5

Genomic Locations for INHBA Gene

Genomic Locations for INHBA Gene
chr7:41,667,168-41,705,834
(GRCh38/hg38)
Size:
38,667 bases
Orientation:
Minus strand
chr7:41,724,712-41,742,706
(GRCh37/hg19)
Size:
17,995 bases
Orientation:
Minus strand

Genomic View for INHBA Gene

Genes around INHBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHBA Gene

Proteins for INHBA Gene

  • Protein details for INHBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08476-INHBA_HUMAN
    Recommended name:
    Inhibin beta A chain
    Protein Accession:
    P08476
    Secondary Accessions:
    • Q14599

    Protein attributes for INHBA Gene

    Size:
    426 amino acids
    Molecular mass:
    47442 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.

    Three dimensional structures from OCA and Proteopedia for INHBA Gene

neXtProt entry for INHBA Gene

Post-translational modifications for INHBA Gene

  • Glycosylation at Asn165
  • Modification sites at PhosphoSitePlus

Other Protein References for INHBA Gene

No data available for DME Specific Peptides for INHBA Gene

Domains & Families for INHBA Gene

Gene Families for INHBA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for INHBA Gene

Blocks:
  • Transforming growth factor beta (TGFb)
  • Growth factor cystine knot superfamily signature
  • Transforming growth factor beta (TGFb), N-terminal
  • Inhibin beta A chain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INHBA Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA (A4D1W7_HUMAN)
  • Erythroid differentiation protein (INHBA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08476

UniProtKB/Swiss-Prot:

INHBA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHBA: view

Function for INHBA Gene

Molecular function for INHBA Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GENATLAS Biochemistry:
inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin A,respectively

LifeMap Function Summary for INHBA Gene

INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for INHBA Gene

Gene Ontology (GO) - Molecular Function for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005125 cytokine activity IDA 9884026
GO:0005160 transforming growth factor beta receptor binding IBA 21873635
GO:0005179 hormone activity TAS 12456957
GO:0005515 protein binding IPI 2575216
genes like me logo Genes that share ontologies with INHBA: view
genes like me logo Genes that share phenotypes with INHBA: view

Human Phenotype Ontology for INHBA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for INHBA Gene

MGI Knock Outs for INHBA:

Animal Model Products

CRISPR Products

miRNA for INHBA Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBA

Clone Products

  • Addgene plasmids for INHBA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for INHBA Gene

Localization for INHBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHBA gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0043509 activin A complex IDA 7890768
GO:0043512 inhibin A complex IDA 7890768
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with INHBA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for INHBA Gene

Pathways & Interactions for INHBA Gene

genes like me logo Genes that share pathways with INHBA: view

Pathways by source for INHBA Gene

2 GeneGo (Thomson Reuters) pathways for INHBA Gene
  • Development Role of Activin A in cell differentiation and proliferation
  • Signal transduction Activin A signaling regulation

SIGNOR curated interactions for INHBA Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for INHBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IDA 9884026
GO:0001541 ovarian follicle development NAS 9166111
GO:0001707 mesoderm formation IEA --
GO:0001942 hair follicle development IGI 10932194
GO:0002244 hematopoietic progenitor cell differentiation IDA 15451575
genes like me logo Genes that share ontologies with INHBA: view

Drugs & Compounds for INHBA Gene

(4) Drugs for INHBA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for INHBA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHBA: view

Transcripts for INHBA Gene

mRNA/cDNA for INHBA Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBA

Clone Products

  • Addgene plasmids for INHBA

Alternative Splicing Database (ASD) splice patterns (SP) for INHBA Gene

No ASD Table

Relevant External Links for INHBA Gene

GeneLoc Exon Structure for
INHBA

Expression for INHBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INHBA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHBA Gene

This gene is overexpressed in Artery - Tibial (x6.8), Artery - Coronary (x6.4), and Artery - Aorta (x4.9).

Protein differential expression in normal tissues from HIPED for INHBA Gene

This gene is overexpressed in Amniocyte (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INHBA Gene



Protein tissue co-expression partners for INHBA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INHBA

SOURCE GeneReport for Unigene cluster for INHBA Gene:

Hs.583348

Evidence on tissue expression from TISSUES for INHBA Gene

  • Eye(4.1)
genes like me logo Genes that share expression patterns with INHBA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBA Gene

Orthologs for INHBA Gene

This gene was present in the common ancestor of animals.

Orthologs for INHBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHBA 31 30
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia INHBA 31 30
  • 91.69 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHBA 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Inhba 30
  • 90.09 (n)
dog
(Canis familiaris)
Mammalia INHBA 31 30
  • 89.86 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Inhba 17 31 30
  • 89.78 (n)
oppossum
(Monodelphis domestica)
Mammalia INHBA 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHBA 31 30
  • 80.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia INHBA 31
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inhba 30
  • 69.91 (n)
zebrafish
(Danio rerio)
Actinopterygii inhbab 31 30
  • 63.74 (n)
OneToMany
inhbaa 31
  • 57 (a)
OneToMany
-- 30
fruit fly
(Drosophila melanogaster)
Insecta Actbeta 31 30
  • 46.98 (n)
OneToMany
Species where no ortholog for INHBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHBA Gene

ENSEMBL:
Gene Tree for INHBA (if available)
TreeFam:
Gene Tree for INHBA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INHBA: view image

Paralogs for INHBA Gene

(2) SIMAP similar genes for INHBA Gene using alignment to 2 proteins:

  • INHBA_HUMAN
  • A4D1W7_HUMAN
genes like me logo Genes that share paralogs with INHBA: view

Variants for INHBA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INHBA Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1562565534 Not Provided: not provided 41,689,881(-) G/C MISSENSE_VARIANT
rs1361491625 - p.Asn386Ser
rs41294833 - p.Gln299Pro
VAR_072640 - p.Gly280Glu

Additional dbSNP identifiers (rs#s) for INHBA Gene

Variation tolerance for INHBA Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHBA Gene

Human Gene Mutation Database (HGMD)
INHBA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHBA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INHBA Gene

Disorders for INHBA Gene

MalaCards: The human disease database

(7) MalaCards diseases for INHBA Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovary adenocarcinoma
  • adenocarcinoma of the ovary
sex cord-gonadal stromal tumor
  • malignant testicular sex cord-stromal tumor
preterm premature rupture of the membranes
  • pprom
taqi polymorphism
  • taq1
specific language impairment
  • language impairment, specific
- elite association - COSMIC cancer census association via MalaCards
Search INHBA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INHBA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with INHBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHBA Gene

Publications for INHBA Gene

  1. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 23 41 54
  2. Germline mutations of inhibins in early-onset ovarian epithelial tumors. (PMID: 24302632) Tournier I … Frebourg T (Human mutation 2014) 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41 54

Products for INHBA Gene

  • Addgene plasmids for INHBA

Sources for INHBA Gene