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This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays... See more...
Aliases for INHBA Gene
Aliases for INHBA Gene
External Ids for INHBA Gene
- HGNC: 6066
- Entrez Gene: 3624
- Ensembl: ENSG00000122641
- OMIM: 147290
- UniProtKB: P08476
Previous GeneCards Identifiers for INHBA Gene
- GC07M041375
- GC07M041469
- GC07M041502
- GC07M041695
- GC07M041724
- GC07M041686
Summaries for INHBA Gene
-
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
GeneCards Summary for INHBA Gene
INHBA (Inhibin Subunit Beta A) is a Protein Coding gene. Diseases associated with INHBA include Ovary Adenocarcinoma and Sex Cord-Gonadal Stromal Tumor. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling receptor binding. An important paralog of this gene is INHBB.
UniProtKB/Swiss-Prot Summary for INHBA Gene
-
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Additional gene information for INHBA Gene
- Monarch Initiative
- Search for INHBA at DataMed
- Search for INHBA at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INHBA Gene
Genomics for INHBA Gene
GeneHancer (GH) Regulatory Elements for INHBA Gene
Promoters and enhancers for INHBA Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J041694 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 502.6 | +5.3 | 5324 | 13.4 | HNRNPK ZNF217 EP300 CTCF USF1 JUND TEAD4 FOS ZFX REST | INHBA lnc-INHBA-1 INHBA-AS1 lnc-SUGCT-7 | |
| GH07J041708 | Promoter/Enhancer | 1.5 | EPDnew FANTOM5 ENCODE dbSUPER | 502.2 | -3.7 | -3749 | 1.7 | JUND FOS ZNF639 ATF2 FOXA2 OSR2 NR2F2 WT1 CREB1 ZNF263 | INHBA INHBA-AS1 piR-38351-427 lnc-SUGCT-7 | |
| GH07J040823 | Enhancer | 1 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 21.1 | +879.7 | 879734 | 5 | TEAD3 HNF4A RBBP5 POLR2A CEBPB MYC | INHBA piR-41405-068 HSALNG0057434 SUGCT | |
| GH07J040806 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 20.2 | +896.6 | 896633 | 5.6 | JUND REST EZH2 NFE2L2 POLR2A CEBPB | INHBA piR-41405-068 HSALNG0057434 SUGCT | |
| GH07J040814 | Enhancer | 0.7 | Ensembl ENCODE dbSUPER | 20.2 | +889.9 | 889930 | 1.8 | JUND CTCF | INHBA piR-41405-068 HSALNG0057434 SUGCT |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around INHBA on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INHBA
- Top Transcription factor binding sites by QIAGEN in the INHBA gene promoter:
-
- AREB6
- Arnt
- FOXC1
- Ik-3
- IRF-1
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Pax-5
- Sox5
Genomic Locations for INHBA Gene
Genomic Locations for INHBA Gene
- chr7:41,667,168-41,705,834
- (GRCh38/hg38)
- Size:
- 38,667 bases
- Orientation:
- Minus strand
- chr7:41,724,712-41,742,706
- (GRCh37/hg19)
- Size:
- 17,995 bases
- Orientation:
- Minus strand
Genomic View for INHBA Gene
Genes around INHBA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.1 by HGNC
- 7p14.1 by Entrez Gene
- 7p14.1 by Ensembl
INHBA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INHBA Gene
Proteins for INHBA Gene
-
Protein details for INHBA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08476-INHBA_HUMAN
- Recommended name:
- Inhibin beta A chain
- Protein Accession:
- P08476
- Q14599
Protein attributes for INHBA Gene
- Size:
- 426 amino acids
- Molecular mass:
- 47442 Da
- Quaternary structure:
-
- Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.
Protein Expression for INHBA Gene
Post-translational modifications for INHBA Gene
Other Protein References for INHBA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences INHBA / Inhibin Beta A Antibody (LS-B11625) and INHBA / Inhibin Beta A Antibody (LS-B13396)
- G Biosciences Immunotag™ Inhibin beta A Antibody
- RayBiotech Rabbit Anti-Human Inhibin A beta and Rabbit Anti-Human Inhibin
- Creative Diagnostics Anti-INHBA (aa 126-391) polyclonal antibody
- Creative Biolabs Recombinant Anti-human INHBA Antibody
- BioLegend Activin A Antibody (693604) and Activin A Antibody (693603)
- GeneTex Anti-Inhibin beta A antibody
- Novus Biologicals Antibodies for INHBA
-
Abcam antibodies for INHBA
- Invitrogen Antibodies for INHBA (AFLGC-INHBA)
-
Santa Cruz Biotechnology (SCBT) Antibodies for INHBA
- Sino Biological Antibodies for INHBA
Protein Products
- G Biosciences Human/Mouse/Rat Activin A/INHBA, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for INHBA
- Origene Custom Protein Services for INHBA
- Sino Biological Recombinant Proteins for INHBA
- Sino Biological Cell Lysates for INHBA
- ProSpec Recombinant Proteins for INHBA
-
ProSci Proteins for INHBA
-
Abcam proteins for INHBA
Assay Products
- RayBiotech Human Activin A ELISA and Human Activin AB ELISA
- Novus Biologicals ELISA Kits for INHBA
- antibodies-online: Show 62 available INHBA Elisa Kits ranked by validation data
- Compare Top INHBA Elisa Kits
-
Quality Products:
- ABIN6574094
- ABIN411254
- ABIN841598
- ABIN1570773
- ABIN4947691
- ABIN455428
- ABIN2708297
- ABIN2684744
- ABIN5592813
- ABIN510991
- ABIN1115499
- ABIN411255
- ABIN5521818
- ABIN2708562
- ABIN2684745
- ABIN5669915
- ABIN773314
- ABIN6254473
- ABIN2948476
- ABIN5073877
- ABIN411256
- ABIN431589
- ABIN1570774
- ABIN5521819
- ABIN2708665
- ABIN2684746
- ABIN841599
- ABIN578861
- ABIN5592814
- ABIN771970
- ABIN5510515
- ABIN841604
- ABIN455430
- ABIN779148
No data available for DME Specific Peptides for INHBA Gene
Domains & Families for INHBA Gene
Gene Families for INHBA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for INHBA Gene
- Blocks:
-
- Transforming growth factor beta (TGFb)
- Growth factor cystine knot superfamily signature
- Transforming growth factor beta (TGFb), N-terminal
- Inhibin beta A chain signature
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for INHBA Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ75379, highly similar to Homo sapiens inhibin, beta A (activin A, activin AB alpha polypeptide), mRNA (A4D1W7_HUMAN)
- Erythroid differentiation protein (INHBA_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08476- Family:
-
- Belongs to the TGF-beta family.
Function for INHBA Gene
Molecular function for INHBA Gene
- UniProtKB/Swiss-Prot Function:
- Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
- GENATLAS Biochemistry:
- inhibin,beta A subunit,14kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin A,respectively
LifeMap Function Summary for INHBA Gene
INHBA as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Eye
-
Endoderm
- Activin A-induced embryoid bodies
- Definitive endoderm
- Definitive endoderm
- Definitive endoderm
- Definitive Endoderm
- Definitive endoderm
- Definitive endoderm cells
- Definitive endoderm like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Endoderm-like cell
- Endoderm-like cells
- Endoderm-like cells
- Endoderm-like cells
- Primitive Streak
- Heart
- Epithelial Cells
- Kidney
- Epiblast
- Intermediate Mesoderm
- Mesoderm
- Ectoderm
- Pancreas
-
and also in
- Activin A-induced cells
- Activin A-induced cells
- Activin A-induced cells
- Activin A-induced embryoid bodies
- Activin A-induced embryoid bodies
- Activin-induced cells
- Anterior definitive endoderm
- Articular chondrocyte-like cells
- BMP4-induced embryoid bodies
- BMP4-induced embryoid bodies
- BMP4-induced embryoid bodies
- Cap mesenchyme-like cells
- Cardiomyocyte precursor cells
- Cardiomyocyte-like cells
- Definitive endoderm
- Definitive endoderm
- Definitive endoderm
- Definitive Endoderm
- Definitive endoderm
- Definitive endoderm cells
- Definitive endoderm like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Definitive endoderm-like cells
- Doxycycline-induced fibroblasts
- Embryoid bodies
- Embryoid Bodies
- Endoderm-like cell
- Endoderm-like cells
- Endoderm-like cells
- Endoderm-like cells
- Endoderm-like cells
- Epiblast-like cells
- Floating aggregates
- Floating retinal precursors
- Foregut endoderm
- Insulin-producing cells
- Intermediate mesoderm-like cells
- Mesendoderm-like cells
- Mesoderm embryoid bodies
- Mesodermal embryoid bodies
- Mesoderm-like cells
- Mesoderm-like cells
- Pigmented epithelium cell clusters
- Posterior intermediate mesoderm
- Posterior primitive streak cells
- Primitive Streak Mesendoderm cells
- Primitive streak-like cells
- Primitive streak-like cells
- Primitive streak-like cells
- Primitive streak-like cells
- PVA-expanded stem cells
- RA-induced cells
- Ureteric bud-like cells
Phenotypes From GWAS Catalog for INHBA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA | -- |
| GO:0005125 | cytokine activity | IDA | 9884026 |
| GO:0005160 | transforming growth factor beta receptor binding | IBA | 21873635 |
| GO:0005179 | hormone activity | TAS | 12456957 |
| GO:0005515 | protein binding | IPI | 2575216 |
Phenotypes for INHBA Gene
- MGI mutant phenotypes for INHBA:
-
inferred from 3 alleles
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for INHBA:
-
- Decreased viability ratio
- Decreased HPV16-GFP infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Synthetic lethal with MLN4924 (a NAE inhibitor)
Animal Models for INHBA Gene
- MGI Knock Outs for INHBA:
-
- Inhba Inhba<tm1Zuk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for INHBA - Select products 50% OFF >
- * INHBA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for INHBA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INHBA
- genomics-online: gRNA clones - Search for available INHBA gRNA products
- Overview of 144 available INHBA gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for INHBA
miRNA for INHBA Gene
- miRTarBase miRNAs that target INHBA
-
- hsa-mir-148b-3p (MIRT019457)
- hsa-mir-31-3p (MIRT038928)
- hsa-mir-10b-5p (MIRT047412)
- hsa-mir-218-5p (MIRT440456)
- hsa-mir-3065-5p (MIRT484714)
- hsa-mir-5688 (MIRT484715)
- hsa-mir-495-3p (MIRT484716)
- hsa-mir-3121-3p (MIRT484717)
- hsa-mir-548t-3p (MIRT484718)
- hsa-mir-548ap-3p (MIRT484719)
- hsa-mir-548aa (MIRT484720)
- hsa-mir-548z (MIRT484721)
- hsa-mir-548h-3p (MIRT484722)
- hsa-mir-548d-3p (MIRT484723)
- hsa-mir-548bb-3p (MIRT484724)
- hsa-mir-548ac (MIRT484725)
- hsa-mir-3973 (MIRT500217)
- hsa-mir-559 (MIRT500218)
- hsa-mir-548y (MIRT500219)
- hsa-mir-548w (MIRT500220)
- hsa-mir-548o-5p (MIRT500221)
- hsa-mir-548j-5p (MIRT500222)
- hsa-mir-548i (MIRT500223)
- hsa-mir-548h-5p (MIRT500224)
- hsa-mir-548d-5p (MIRT500225)
- hsa-mir-548c-5p (MIRT500226)
- hsa-mir-548bb-5p (MIRT500227)
- hsa-mir-548b-5p (MIRT500228)
- hsa-mir-548ay-5p (MIRT500229)
- hsa-mir-548au-5p (MIRT500230)
- hsa-mir-548as-5p (MIRT500231)
- hsa-mir-548ar-5p (MIRT500232)
- hsa-mir-548aq-5p (MIRT500233)
- hsa-mir-548ap-5p (MIRT500234)
- hsa-mir-548am-5p (MIRT500235)
- hsa-mir-548ak (MIRT500236)
- hsa-mir-548ae-5p (MIRT500237)
- hsa-mir-548ad-5p (MIRT500238)
- hsa-mir-548ab (MIRT500239)
- hsa-mir-548a-5p (MIRT500240)
- hsa-mir-214-5p (MIRT784230)
- hsa-mir-223-5p (MIRT784266)
- hsa-mir-4728-3p (MIRT786536)
- hsa-mir-4789-5p (MIRT786774)
- hsa-mir-574-5p (MIRT787859)
- hsa-mir-6514-3p (MIRT788331)
- hsa-mir-675-3p (MIRT788570)
- hsa-mir-6768-5p (MIRT788630)
- hsa-mir-6811-3p (MIRT788887)
- hsa-mir-6867-5p (MIRT789199)
- hsa-mir-8075 (MIRT789807)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INHBA
- Browse OriGene Inhibitory RNA Products For INHBA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBA
- genomics-online: shRNA clones - Search for available INHBA shRNA products
- Overview of 144 available INHBA gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for INHBA - Select products 50% OFF >
- * INHBA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for INHBA
- Addgene plasmids for INHBA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INHBA
- genomics-online: cdna clones - Search for available INHBA CDNA products
- Overview of 144 available INHBA gene related products
-
Recommended
- orf clones - Search for available INHBA ORF products
- Overview of 144 available INHBA gene related products
-
Recommended
Cell Line Products
-
Horizon Cell Lines for INHBA
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for INHBA Gene
Localization for INHBA Gene
Subcellular locations from UniProtKB/Swiss-Prot for INHBA Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0043509 | activin A complex | IDA | 7890768 |
| GO:0043512 | inhibin A complex | IDA | 7890768 |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for INHBA Gene
Pathways & Interactions for INHBA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide hormone metabolism | ||
| 2 | Signaling by NODAL | ||
| 3 | PEDF Induced Signaling | ||
| 4 | Signaling pathways regulating pluripotency of stem cells | ||
| 5 | TGF-beta signaling pathway (KEGG) | ||
Pathways by source for INHBA Gene
6 BioSystems pathways for INHBA Gene
7 Reactome pathways for INHBA Gene
3 KEGG pathways for INHBA Gene
2 GeneGo (Thomson Reuters) pathways for INHBA Gene
- Development Role of Activin A in cell differentiation and proliferation
- Signal transduction Activin A signaling regulation
1 R&D Systems pathway for INHBA Gene
Interacting Proteins for INHBA Gene
Selected Interacting proteins:
P08476-INHBA_HUMAN
ENSP00000242208
for INHBA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for INHBA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IDA | 9884026 |
| GO:0001541 | ovarian follicle development | NAS | 9166111 |
| GO:0001707 | mesoderm formation | IEA | -- |
| GO:0001942 | hair follicle development | IGI | 10932194 |
| GO:0002244 | hematopoietic progenitor cell differentiation | IDA | 15451575 |
Drugs & Compounds for INHBA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for INHBA Gene
mRNA/cDNA for INHBA Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000242208 6046 bps (ENST00000242208.5)
- ENST00000416150 386 bps (ENST00000416150.1)
- ENST00000442711 1632 bps (ENST00000442711.1)
- ENST00000464515 2403 bps (ENST00000464515.1)
- ENST00000638023 2002 bps (ENST00000638023.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for INHBA - Select products 50% OFF >
- * INHBA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for INHBA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INHBA
- genomics-online: gRNA clones - Search for available INHBA gRNA products
- Overview of 144 available INHBA gene related products
-
Recommended
-
Santa Cruz Biotechnology (SCBT) CRISPR for INHBA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INHBA
- Browse OriGene Inhibitory RNA Products For INHBA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBA
- genomics-online: shRNA clones - Search for available INHBA shRNA products
- Overview of 144 available INHBA gene related products
-
Recommended
Clone Products
- Applied Biological Materials (abm): Clones for INHBA - Select products 50% OFF >
- * INHBA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for INHBA
- Addgene plasmids for INHBA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INHBA
- genomics-online: cdna clones - Search for available INHBA CDNA products
- Overview of 144 available INHBA gene related products
-
Recommended
- orf clones - Search for available INHBA ORF products
- Overview of 144 available INHBA gene related products
-
Recommended
Relevant External Links for INHBA Gene
- GeneLoc Exon Structure for
- INHBA
Expression for INHBA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for INHBA Gene
This gene is overexpressed in Artery - Tibial (x6.8), Artery - Coronary (x6.4), and Artery - Aorta (x4.9).
This gene is overexpressed in Amniocyte (68.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INHBA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INHBA
SOURCE GeneReport for Unigene cluster for INHBA Gene:
Hs.583348Evidence on tissue expression from TISSUES for INHBA Gene
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs for INHBA
-
OriGene qPCR primer pairs and template standards for INHBA
- genomics-online: primer clones - Search for available INHBA Primer products
- Overview of 144 available INHBA gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INHBA Gene
Orthologs for INHBA Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | INHBA 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | INHBA 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | INHBA 31 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Inhba 30 |
|
||
| dog (Canis familiaris) |
Mammalia | INHBA 31 30 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Inhba 17 31 30 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | INHBA 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | INHBA 31 30 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | INHBA 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | inhba 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | inhbab 31 30 |
|
OneToMany | |
| inhbaa 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Actbeta 31 30 |
|
OneToMany |
- Species where no ortholog for INHBA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for INHBA Gene
- ENSEMBL:
- Gene Tree for INHBA (if available)
- TreeFam:
- Gene Tree for INHBA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for INHBA: view image
Paralogs for INHBA Gene
Paralogs for INHBA Gene
(2) SIMAP similar genes for INHBA Gene using alignment to 2 proteins:
- INHBA_HUMAN
- A4D1W7_HUMAN
Variants for INHBA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INHBA Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1562565534 | Not Provided: not provided | 41,689,881(-) | G/C | MISSENSE_VARIANT | |
| rs1361491625 | - | p.Asn386Ser | |||
| rs41294833 | - | p.Gln299Pro | |||
| VAR_072640 | - | p.Gly280Glu |
Residual Variation Intolerance Score:
21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.57% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for INHBA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INHBA Gene
Disorders for INHBA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovary adenocarcinoma |
|
|
| sex cord-gonadal stromal tumor |
|
|
| preterm premature rupture of the membranes |
|
|
| taqi polymorphism |
|
|
| specific language impairment |
|
|
Search INHBA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for INHBA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for INHBA Gene
Publications for INHBA Gene
- Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 23 41 54
- Germline mutations of inhibins in early-onset ovarian epithelial tumors. (PMID: 24302632) Tournier I … Frebourg T (Human mutation 2014) 3 4 54
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41 54
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41 54
ExternalLinks
Products for INHBA Gene
- View all 16 R&D Systems INHBA (Activin A) Products
- View all R&D Systems INHBA (INHBA) Products
- View all 6 R&D Systems INHBA (Activin A) Proteins and Enzymes
- View all 6 R&D Systems INHBA (Activin A) Primary Antibodies
- View all R&D Systems INHBA (INHBA) Primary Antibodies
- View all 3 R&D Systems INHBA (Activin A) ELISAs
- View all R&D Systems INHBA (Activin A) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom INHBA antibody, protein, and immunoassay development services
- Custom Antibody Services
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for INHBA
- Origene Custom Protein Services for INHBA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INHBA
- Browse OriGene Inhibitory RNA Products For INHBA
- OriGene qPCR primer pairs for INHBA
- OriGene qPCR primer pairs and template standards for INHBA
- OriGene CRISPR knockouts for INHBA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For INHBA
- Sino Biological Human cDNA Clone for INHBA
- Sino Biological Recombinant Proteins for INHBA
- Sino Biological Cell Lysates for INHBA
- Sino Biological Antibodies for INHBA
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for INHBA
- Novus Biologicals proteins and lysates for INHBA
- Novus Biologicals ELISA Kits for INHBA
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for INHBA
- Abcam proteins for INHBA
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for INHBA (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for INHBA (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for INHBA (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for INHBA CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for INHBA
- Addgene plasmids for INHBA
- antibodies-online: Show 53 available INHBA Antibodies ranked by validation data
- Compare Top INHBA Antibodies
- antibodies-online: Show 62 available INHBA Elisa Kits ranked by validation data
- Compare Top INHBA Elisa Kits
- Quality Products:
- ABIN6574094
- ABIN411254
- ABIN841598
- ABIN1570773
- ABIN4947691
- ABIN455428
- ABIN2708297
- ABIN2684744
- ABIN5592813
- ABIN510991
- ABIN1115499
- ABIN411255
- ABIN5521818
- ABIN2708562
- ABIN2684745
- ABIN5669915
- ABIN773314
- ABIN6254473
- ABIN2948476
- ABIN5073877
- ABIN411256
- ABIN431589
- ABIN1570774
- ABIN5521819
- ABIN2708665
- ABIN2684746
- ABIN841599
- ABIN578861
- ABIN5592814
- ABIN771970
- ABIN5510515
- ABIN841604
- ABIN455430
- ABIN779148
- antibodies-online: Show 45 available INHBA Proteins ranked by validation data
- Compare Top INHBA Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for INHBA
- Search Santa Cruz Biotechnology (SCBT) for INHBA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for INHBA
- Horizon Cell Lines for INHBA
- genomics-online: cdna clones - Search for available INHBA CDNA products
- Overview of 144 available INHBA gene related products
- Recommended
- orf clones - Search for available INHBA ORF products
- Overview of 144 available INHBA gene related products
- Recommended
- genomics-online: gRNA clones - Search for available INHBA gRNA products
- Overview of 144 available INHBA gene related products
- Recommended
- genomics-online: primer clones - Search for available INHBA Primer products
- Overview of 144 available INHBA gene related products
- Recommended
- genomics-online: shRNA clones - Search for available INHBA shRNA products
- Overview of 144 available INHBA gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INHBA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INHBA
- Search GeneCopoeia for miRNA 3'UTR Target clone products for INHBA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHBA
Sources for INHBA Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
- (55) R&D Systems
- (56) TGDB
- (57) Tocris
- (58) Abcam
- (59) Novus Biologicals
- (60) ProSpec
- (61) Sino Biological
- (62) GenScript
- (63) Qiagen
- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
- (79) RefSeq
- (80) BioSystems
- (81) MaxQB
- (82) IUPHAR
- (83) BioGPS
- (84) Illumina
- (85) COMPARTMENTS
- (86) HOMER
- (87) PaxDb
- (88) ApexBio
- (89) Addgene
- (90) antibodies-online
- (91) CYP
- (92) NONCODE
- (93) TreeFam
- (94) PathCards
- (95) GeneReviews
- (96) GeneTex
- (97) Taconic Biosciences
- (98) GTEx
- (99) ProteomicsDB
- (100) SCBT
- (101) DGIdb
- (102) ClinicalTrials
- (103) RVIS
- (104) SIGNOR
- (105) diseasecard
- (106) NIH Rare Diseases
- (107) Orphanet
- (108) UMLS
- (109) GTR
- (110) Disease Ontology
- (111) Genetics Home Reference
- (112) MeSH
- (113) MedlinePlus
- (114) CDC
- (115) NINDS
- (116) NCBI Bookshelf
- (117) ClinVar
- (118) Gene Damage Index
- (119) HPO
- (120) UDN
- (121) VISTA
- (122) FANTOM5
- (123) ENCODE
- (124) ProSci
- (125) Horizon
- (126) The Signaling Pathways Project (SPP)
- (127) IID
- (128) VectorBuilder
- (129) SNPedia
- (130) BRCA Exchange
- (131) CIViC
- (132) ProteoGenix
- (133) dbSUPER
- (134) TISSUES
- (135) Gene ORGANizer
- (136) abm
- (137) Human Protein Atlas
- (138) GWAS Catalog
- (139) Monarch Initiative
- (140) DataMed
- (141) HumanCyc
- (142) genomics-online
- (143) UCNEbase
- (144) EPDnew
- (145) Applied Biosystems
- (146) GlyConnect
- (147) Aminode
- (148) GeneCopoeia
- (149) GPS-Prot
- (150) RNACentral
- (151) LncRNADisease
- (152) LOVD
- (153) miR2Disease
- (154) DiseaseEnhancer
- (155) Boster Bio
- (156) Biorbyt
- (157) Biocompare
- (158) Mastermind
- (159) CTD^2 Dashboard
- (160) CraniofacialAtlas
- (161) GeneImprint
- (162) Synthego
- (163) Bio Basic
- (164) ENA
- (165) GtRNAdb
- (166) LncBase
- (167) LncBook
- (168) LNCipedia
- (169) LncRNAdb
- (170) Modomics
- (171) PDBe
- (172) Rfam
- (173) SILVA
- (174) snOPY
- (175) SRPDB
- (176) GENCODE
- (177) TarBase
- (178) MyBioSource
- (179) Signalway Antibody