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This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
INHBA (Inhibin Subunit Beta A) is a Protein Coding gene. Diseases associated with INHBA include Ovary Adenocarcinoma and Sex Cord-Gonadal Stromal Tumor. Among its related pathways are Signaling by GPCR and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and signaling receptor binding. An important paralog of this gene is INHBB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA | -- |
GO:0005125 | cytokine activity | IDA | 9884026 |
GO:0005179 | hormone activity | TAS | 12456957 |
GO:0005515 | protein binding | IPI | 2575216 |
GO:0008083 | growth factor activity | TAS | 12324653 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0043509 | activin A complex | IDA | 7890768 |
GO:0043512 | inhibin A complex | IDA | 7890768 |
GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide hormone metabolism | ||
2 | Signaling by NODAL | ||
3 | PEDF Induced Signaling | ||
4 | Signaling pathways regulating pluripotency of stem cells | ||
5 | TGF-beta signaling pathway (KEGG) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000082 | G1/S transition of mitotic cell cycle | IDA | 9884026 |
GO:0001541 | ovarian follicle development | NAS | 9166111 |
GO:0001707 | mesoderm formation | IEA | -- |
GO:0001942 | hair follicle development | IGI | 10932194 |
GO:0002244 | hematopoietic progenitor cell differentiation | IDA | 15451575 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
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Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
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This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | INHBA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | INHBA 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | INHBA 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Inhba 30 |
|
||
Dog (Canis familiaris) |
Mammalia | INHBA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Inhba 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | INHBA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | INHBA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | INHBA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | inhba 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | inhbab 30 31 |
|
OneToMany | |
inhbaa 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Actbeta 30 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1562565534 | Not Provided: not provided | 41,689,881(-) | G/C | MISSENSE_VARIANT | |
rs1361491625 | - | p.Asn386Ser | |||
rs41294833 | - | p.Gln299Pro | |||
VAR_072640 | - | p.Gly280Glu |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovary adenocarcinoma |
|
|
sex cord-gonadal stromal tumor |
|
|
preterm premature rupture of the membranes |
|
|
taqi polymorphism |
|
|
esophageal cancer |
|