This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have... See more...

Aliases for INHA Gene

Aliases for INHA Gene

  • Inhibin Subunit Alpha 2 3 5
  • Inhibin Alpha Chain 3 4
  • Inhibin Alpha Subunit 3
  • A-Inhibin Subunit 3
  • Inhibin, Alpha 2
  • INHA 5

External Ids for INHA Gene

Previous GeneCards Identifiers for INHA Gene

  • GC02P218459
  • GC02P219158
  • GC02P220400
  • GC02P220639
  • GC02P220262
  • GC02P220145
  • GC02P220433
  • GC02P212289

Summaries for INHA Gene

Entrez Gene Summary for INHA Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHA Gene

INHA (Inhibin Subunit Alpha) is a Protein Coding gene. Diseases associated with INHA include Multidrug-Resistant Tuberculosis and Placental Site Trophoblastic Tumor. Among its related pathways are Peptide hormone metabolism and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is INHBE.

UniProtKB/Swiss-Prot Summary for INHA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INHA Gene

Genomics for INHA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for INHA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INHA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INHA

Top Transcription factor binding sites by QIAGEN in the INHA gene promoter:
  • E47
  • GATA-1
  • GATA-2
  • GATA-6
  • GR
  • GR-alpha
  • p53
  • Pax-5

Genomic Locations for INHA Gene

Latest Assembly
chr2:219,569,162-219,575,711
(GRCh38/hg38)
Size:
6,550 bases
Orientation:
Plus strand

Previous Assembly
chr2:220,437,032-220,440,433
(GRCh37/hg19 by Entrez Gene)
Size:
3,402 bases
Orientation:
Plus strand

chr2:220,433,884-220,440,435
(GRCh37/hg19 by Ensembl)
Size:
6,552 bases
Orientation:
Plus strand

Genomic View for INHA Gene

Genes around INHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHA Gene

Proteins for INHA Gene

  • Protein details for INHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05111-INHA_HUMAN
    Recommended name:
    Inhibin alpha chain
    Protein Accession:
    P05111
    Secondary Accessions:
    • A8K8H5

    Protein attributes for INHA Gene

    Size:
    366 amino acids
    Molecular mass:
    39670 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

neXtProt entry for INHA Gene

Post-translational modifications for INHA Gene

  • Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.
  • Glycosylation at Asn146, Asn268, and Asn302
  • Modification sites at PhosphoSitePlus

Other Protein References for INHA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for INHA Gene

Domains & Families for INHA Gene

Gene Families for INHA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for INHA Gene

InterPro:
Blocks:
  • Transforming growth factor beta (TGFb)
  • Inhibin alpha chain signature

Suggested Antigen Peptide Sequences for INHA Gene

GenScript: Design optimal peptide antigens:
  • Inhibin alpha (B6E5W7_HUMAN)
  • Inhibin alpha chain (INHA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05111

UniProtKB/Swiss-Prot:

INHA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHA: view

Function for INHA Gene

Molecular function for INHA Gene

UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GENATLAS Biochemistry:
inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin B,respectively

Phenotypes From GWAS Catalog for INHA Gene

Gene Ontology (GO) - Molecular Function for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IPI 9032295
GO:0005125 cytokine activity IBA,TAS 12456957
GO:0005179 hormone activity TAS 12456957
GO:0005515 contributes_to protein binding IPI 10746731
GO:0008083 growth factor activity TAS 12324653
genes like me logo Genes that share ontologies with INHA: view
genes like me logo Genes that share phenotypes with INHA: view

Animal Models for INHA Gene

MGI Knock Outs for INHA:

miRNA for INHA Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHA Gene

Localization for INHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHA gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005576 extracellular region TAS 12456957
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with INHA: view

Pathways & Interactions for INHA Gene

genes like me logo Genes that share pathways with INHA: view

Pathways by source for INHA Gene

1 KEGG pathway for INHA Gene
1 GeneGo (Thomson Reuters) pathway for INHA Gene
  • Signal transduction Activin A signaling regulation

SIGNOR curated interactions for INHA Gene

Inactivates:

Gene Ontology (GO) - Biological Process for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10865214
GO:0001541 ovarian follicle development IEA,NAS 9166111
GO:0007050 cell cycle arrest TAS 12456957
GO:0007165 signal transduction TAS 3267209
GO:0007166 cell surface receptor signaling pathway TAS 12456957
genes like me logo Genes that share ontologies with INHA: view

Drugs & Compounds for INHA Gene

(34) Drugs for INHA Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethionamide Approved Pharma Target, adduct 9
Isoniazid Approved, Investigational Pharma Target, adduct 238
Pretomanid Approved Pharma Target, other/unknown 0
Triclosan Approved, Investigational Pharma Target 77
(3S)-1-CYCLOHEXYL-5-OXO-N-PHENYLPYRROLIDINE-3-CARBOXAMIDE Experimental Pharma Target 0

(12) Additional Compounds for INHA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHA: view

Transcripts for INHA Gene

mRNA/cDNA for INHA Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INHA

Alternative Splicing Database (ASD) splice patterns (SP) for INHA Gene

No ASD Table

Relevant External Links for INHA Gene

GeneLoc Exon Structure for
INHA

Expression for INHA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for INHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHA Gene

This gene is overexpressed in Ovary (x14.3), Testis (x11.4), and Adrenal Gland (x9.3).

Protein differential expression in normal tissues from HIPED for INHA Gene

This gene is overexpressed in Testis (46.9), Fetal ovary (11.6), and Fetal testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INHA Gene



Protein tissue co-expression partners for INHA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INHA

SOURCE GeneReport for Unigene cluster for INHA Gene:

Hs.407506

mRNA Expression by UniProt/SwissProt for INHA Gene:

P05111-INHA_HUMAN
Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Evidence on tissue expression from TISSUES for INHA Gene

  • Nervous system(4.4)
  • Adrenal gland(2.6)
genes like me logo Genes that share expression patterns with INHA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INHA Gene

Orthologs for INHA Gene

This gene was present in the common ancestor of chordates.

Orthologs for INHA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia INHA 29 30
  • 99.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia INHA 29 30
  • 85.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia INHA 29 30
  • 83.47 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Inha 29 16 30
  • 82.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Inha 29
  • 82.44 (n)
Oppossum
(Monodelphis domestica)
Mammalia INHA 30
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia INHA 30
  • 41 (a)
OneToOne
Chicken
(Gallus gallus)
Aves INHA 29 30
  • 63.77 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia INHA 30
  • 48 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia inha 29
  • 57.25 (n)
Zebrafish
(Danio rerio)
Actinopterygii inha 29 30
  • 49.9 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9068 29
Species where no ortholog for INHA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for INHA Gene

ENSEMBL:
Gene Tree for INHA (if available)
TreeFam:
Gene Tree for INHA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INHA: view image
Alliance of Genome Resources:
Additional Orthologs for INHA

Paralogs for INHA Gene

(5) SIMAP similar genes for INHA Gene using alignment to 2 proteins:

  • INHA_HUMAN
  • B6E5W7_HUMAN
genes like me logo Genes that share paralogs with INHA: view

Variants for INHA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INHA Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
545464 Uncertain Significance: not provided 219,572,359(+) C/T
NM_002191.4(INHA):c.-16C>T
FIVE_PRIME_UTR
rs12720062 Benign/Likely Benign: Premature ovarian failure; not specified 219,575,194(+) G/Ap.Ala257Thr
NM_002191.4(INHA):c.769G>A (p.Ala257Thr)
MISSENSE
rs141940534 Benign: not provided 219,572,503(+) C/T
NM_002191.4(INHA):c.129C>T (p.Pro43=)
SYNONYMOUS
rs145398632 Likely Benign: not provided 219,574,923(+) C/T
NM_002191.4(INHA):c.498C>T (p.Pro166=)
SYNONYMOUS
rs34400751 Benign: not provided 219,572,569(+) G/T
NM_002191.4(INHA):c.195G>T (p.Gly65=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for INHA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for INHA Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489
nsv834545 CNV loss 17160897

Variation tolerance for INHA Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHA Gene

Human Gene Mutation Database (HGMD)
INHA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHA
Leiden Open Variation Database (LOVD)
INHA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHA Gene

Disorders for INHA Gene

MalaCards: The human disease database

(41) MalaCards diseases for INHA Gene - From: COP and GCD

Disorder Aliases PubMed IDs
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
placental site trophoblastic tumor
  • placental site trophoblastic tumour
sertoli cell tumor
  • tubular androblastoma
cystadenoma
  • cystoma
hemangioblastoma
  • capillary hemangioblastoma
- elite association - COSMIC cancer census association via MalaCards
Search INHA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INHA

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with INHA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHA Gene

Publications for INHA Gene

  1. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PMID: 18249384) Woad KJ … Shelling AN (Fertility and sterility 2009) 3 22 40
  2. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. (PMID: 18413775) Purdue MP … McGlynn KA (Cancer research 2008) 3 22 40
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 40
  4. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F … Feigelson HS (Human molecular genetics 2010) 3 40
  5. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. (PMID: 20716560) Hanna CW … Robinson WP (Human reproduction (Oxford, England) 2010) 3 40

Products for INHA Gene

Sources for INHA Gene