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Aliases for INHA Gene

Aliases for INHA Gene

  • Inhibin Alpha Subunit 2 3 5
  • Inhibin, Alpha 2

External Ids for INHA Gene

Previous GeneCards Identifiers for INHA Gene

  • GC02P218459
  • GC02P219158
  • GC02P220400
  • GC02P220639
  • GC02P220262
  • GC02P220145
  • GC02P220433
  • GC02P212289

Summaries for INHA Gene

Entrez Gene Summary for INHA Gene

  • This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]

GeneCards Summary for INHA Gene

INHA (Inhibin Alpha Subunit) is a Protein Coding gene. Diseases associated with INHA include Multidrug-Resistant Tuberculosis and Placental Site Trophoblastic Tumor. Among its related pathways are Peptide hormone metabolism and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity.

UniProtKB/Swiss-Prot for INHA Gene

  • Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Wiki entry for INHA Gene

Additional gene information for INHA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INHA Gene

Genomics for INHA Gene

GeneHancer (GH) Regulatory Elements for INHA Gene

Promoters and enhancers for INHA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I219569 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.6 +2.4 2369 4 PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 INHA OBSL1 ZNF142 RNF25 NHEJ1 SLC23A3 STK36 STK11IP GLB1L DNPEP
GH02I219574 Enhancer 1.2 ENCODE dbSUPER 23 +7.2 7170 3.6 PKNOX1 FOXA2 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1 INHA TMEM198 CHPF ENSG00000228973 SLC4A3 OBSL1 ASIC4 GMPPA RN7SKP213
GH02I219541 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.1 -25.0 -24973 5.1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TMEM198 CHPF ASIC4 OBSL1 INHA ENSG00000268896
GH02I219644 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.5 +76.2 76202 2 BACH1 MAFG ZBTB40 ZNF7 FOSL1 MAFF ZNF316 POLR2A IKZF1 KLF9 ENSG00000267919 OBSL1 TMEM198 CHPF INHA ENSG00000227432 ASIC4 CYP27A1 GC02M219685
GH02I219560 Enhancer 0.9 ENCODE dbSUPER 10.8 -7.6 -7624 2.9 ELF3 CTCF TFAP4 RAD21 ZNF48 ETS1 TEAD3 POLR2A VEZF1 ZNF143 INHA OBSL1 ENSG00000269068
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INHA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the INHA gene promoter:

Genomic Locations for INHA Gene

Genomic Locations for INHA Gene
chr2:219,569,162-219,575,713
(GRCh38/hg38)
Size:
6,552 bases
Orientation:
Plus strand
chr2:220,433,884-220,440,435
(GRCh37/hg19)

Genomic View for INHA Gene

Genes around INHA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INHA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INHA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INHA Gene

Proteins for INHA Gene

  • Protein details for INHA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05111-INHA_HUMAN
    Recommended name:
    Inhibin alpha chain
    Protein Accession:
    P05111
    Secondary Accessions:
    • A8K8H5

    Protein attributes for INHA Gene

    Size:
    366 amino acids
    Molecular mass:
    39670 Da
    Quaternary structure:
    • Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.

neXtProt entry for INHA Gene

Post-translational modifications for INHA Gene

  • Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference.
  • Glycosylation at isoforms=146, isoforms=268, and isoforms=302
  • Modification sites at PhosphoSitePlus

Other Protein References for INHA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INHA Gene

Domains & Families for INHA Gene

Gene Families for INHA Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for INHA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05111

UniProtKB/Swiss-Prot:

INHA_HUMAN :
  • Belongs to the TGF-beta family.
Family:
  • Belongs to the TGF-beta family.
genes like me logo Genes that share domains with INHA: view

Function for INHA Gene

Molecular function for INHA Gene

GENATLAS Biochemistry:
inhibin,alpha subunit,18kDa,dimerizing with INHBA or INHBB,TGFB superfamily member,to form inhibitin A or B respectively,inhibitors of FSH secretion,homodimerizing to form activing A stimulator of FSH secretion and involved in embryonic axis development or heterodimerizing with INHBB or INHA to form activin AB or inhibitin B,respectively
UniProtKB/Swiss-Prot Function:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Gene Ontology (GO) - Molecular Function for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 9032295
GO:0005125 cytokine activity TAS 12456957
GO:0005160 transforming growth factor beta receptor binding IBA --
GO:0005179 hormone activity TAS 12456957
GO:0005515 contributes_to protein binding IPI 10746731
genes like me logo Genes that share ontologies with INHA: view
genes like me logo Genes that share phenotypes with INHA: view

Animal Models for INHA Gene

MGI Knock Outs for INHA:

miRNA for INHA Gene

miRTarBase miRNAs that target INHA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INHA Gene

Localization for INHA Gene

Subcellular locations from UniProtKB/Swiss-Prot for INHA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INHA gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0001917 photoreceptor inner segment IEA --
GO:0005576 extracellular region TAS 12456957
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with INHA: view

Pathways & Interactions for INHA Gene

genes like me logo Genes that share pathways with INHA: view

Pathways by source for INHA Gene

1 GeneGo (Thomson Reuters) pathway for INHA Gene

SIGNOR curated interactions for INHA Gene

Inactivates:

Gene Ontology (GO) - Biological Process for INHA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 10865214
GO:0001541 ovarian follicle development IEA,NAS 9166111
GO:0007050 cell cycle arrest TAS 12456957
GO:0007165 signal transduction TAS 3267209
GO:0007166 cell surface receptor signaling pathway TAS 12456957
genes like me logo Genes that share ontologies with INHA: view

Drugs & Compounds for INHA Gene

(21) Drugs for INHA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for INHA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with INHA: view

Transcripts for INHA Gene

mRNA/cDNA for INHA Gene

Unigene Clusters for INHA Gene

Inhibin, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INHA Gene

No ASD Table

Relevant External Links for INHA Gene

GeneLoc Exon Structure for
INHA
ECgene alternative splicing isoforms for
INHA

Expression for INHA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for INHA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for INHA Gene

This gene is overexpressed in Ovary (x14.3), Testis (x11.4), and Adrenal Gland (x9.3).

Protein differential expression in normal tissues from HIPED for INHA Gene

This gene is overexpressed in Testis (46.9), Fetal ovary (11.6), and Fetal testis (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for INHA Gene



Protein tissue co-expression partners for INHA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INHA Gene:

INHA

SOURCE GeneReport for Unigene cluster for INHA Gene:

Hs.407506

mRNA Expression by UniProt/SwissProt for INHA Gene:

P05111-INHA_HUMAN
Tissue specificity: Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Evidence on tissue expression from TISSUES for INHA Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with INHA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for INHA Gene

Orthologs for INHA Gene

This gene was present in the common ancestor of chordates.

Orthologs for INHA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia INHA 33 34
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia INHA 33 34
  • 85.1 (n)
dog
(Canis familiaris)
Mammalia INHA 33 34
  • 83.47 (n)
mouse
(Mus musculus)
Mammalia Inha 33 16 34
  • 82.61 (n)
rat
(Rattus norvegicus)
Mammalia Inha 33
  • 82.44 (n)
oppossum
(Monodelphis domestica)
Mammalia INHA 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia INHA 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves INHA 33 34
  • 63.77 (n)
lizard
(Anolis carolinensis)
Reptilia INHA 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia inha 33
  • 57.25 (n)
zebrafish
(Danio rerio)
Actinopterygii inha 33 34
  • 49.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9068 33
Species where no ortholog for INHA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INHA Gene

ENSEMBL:
Gene Tree for INHA (if available)
TreeFam:
Gene Tree for INHA (if available)

Paralogs for INHA Gene

(5) SIMAP similar genes for INHA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with INHA: view

No data available for Paralogs for INHA Gene

Variants for INHA Gene

Sequence variations from dbSNP and Humsavar for INHA Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs10180675 benign, not specified, Three M syndrome 219,570,312(+) A/G upstream_transcript_variant
rs1061399 benign, Three M syndrome, not specified 219,570,653(+) G/A upstream_transcript_variant
rs186348476 uncertain-significance, Three M syndrome 219,570,640(+) G/T upstream_transcript_variant
rs191256186 benign, not specified, not provided 219,571,114(+) G/C upstream_transcript_variant
rs199929590 uncertain-significance, Three M syndrome 219,570,471(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for INHA Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489
nsv834545 CNV loss 17160897

Variation tolerance for INHA Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.73; 57.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INHA Gene

Human Gene Mutation Database (HGMD)
INHA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
INHA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INHA Gene

Disorders for INHA Gene

MalaCards: The human disease database

(32) MalaCards diseases for INHA Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
multidrug-resistant tuberculosis
  • tuberculosis multidrug-resistant
placental site trophoblastic tumor
  • placental-site gestational trophoblastic neoplasm
trophoblastic neoplasm
  • trophoblastic neoplasm nos
cystadenoma
  • cystoma
sertoli cell tumor
  • tubular androblastoma nos
- elite association - COSMIC cancer census association via MalaCards
Search INHA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for INHA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with INHA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INHA Gene

Publications for INHA Gene

  1. Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. (PMID: 18249384) Woad KJ … Shelling AN (Fertility and sterility 2009) 3 22 44 58
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  3. Mutational analysis of inhibin alpha gene revealed three novel variations in Indian women with premature ovarian failure. (PMID: 19324345) Prakash GJ … Sujatha M (Fertility and sterility 2010) 3 44 58
  4. Inhibin and premature ovarian failure. (PMID: 19752047) Chand AL … Shelling AN (Human reproduction update 2010) 3 44 58
  5. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F … Feigelson HS (Human molecular genetics 2010) 3 44 58

Products for INHA Gene

Sources for INHA Gene

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