Aliases for INHA Gene
External Ids for INHA Gene
Previous GeneCards Identifiers for INHA Gene
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
GeneCards Summary for INHA Gene
INHA (Inhibin Subunit Alpha) is a Protein Coding gene. Diseases associated with INHA include Multidrug-Resistant Tuberculosis and Placental Site Trophoblastic Tumor. Among its related pathways are Peptide hormone metabolism and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and cytokine activity. An important paralog of this gene is INHBE.
UniProtKB/Swiss-Prot Summary for INHA Gene
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.