This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in... See more...

Aliases for ING5 Gene

Aliases for ING5 Gene

  • Inhibitor Of Growth Family Member 5 2 3 5
  • P28ING5 2 3 4
  • Inhibitor Of Growth Protein 5 3 4
  • FLJ23842 2
  • ING5 5

External Ids for ING5 Gene

Previous GeneCards Identifiers for ING5 Gene

  • GC02M238853
  • GC02M239540
  • GC02P242661
  • GC02P242962
  • GC02P242361
  • GC02P242291
  • GC02P234396
  • GC02P242641

Summaries for ING5 Gene

Entrez Gene Summary for ING5 Gene

  • This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GeneCards Summary for ING5 Gene

ING5 (Inhibitor Of Growth Family Member 5) is a Protein Coding gene. Diseases associated with ING5 include Ohdo Syndrome, Sbbys Variant and Atrophy Of Testis. Among its related pathways are Regulation of TP53 Activity through Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot Summary for ING5 Gene

  • Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).

Gene Wiki entry for ING5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ING5 Gene

Genomics for ING5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ING5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ING5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ING5

Top Transcription factor binding sites by QIAGEN in the ING5 gene promoter:
  • AREB6
  • GATA-3
  • Lmo2
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Nkx5-1
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ING5 Gene

Latest Assembly
chr2:241,687,017-241,729,481
(GRCh38/hg38)
Size:
42,465 bases
Orientation:
Plus strand

Previous Assembly
chr2:242,626,435-242,668,893
(GRCh37/hg19 by Entrez Gene)
Size:
42,459 bases
Orientation:
Plus strand

chr2:242,641,450-242,668,893
(GRCh37/hg19 by Ensembl)
Size:
27,444 bases
Orientation:
Plus strand

Genomic View for ING5 Gene

Genes around ING5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING5 Gene

Proteins for ING5 Gene

  • Protein details for ING5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYH8-ING5_HUMAN
    Recommended name:
    Inhibitor of growth protein 5
    Protein Accession:
    Q8WYH8
    Secondary Accessions:
    • A8K1P3
    • Q53NU6
    • Q57Z54
    • Q9BS30

    Protein attributes for ING5 Gene

    Size:
    240 amino acids
    Molecular mass:
    27751 Da
    Quaternary structure:
    • Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358). Interacts with H3K4me3 and to a lesser extent with H3K4me2 (PubMed:16728974, PubMed:18623064). Interacts with EP300 and p53/TP53 (PubMed:12750254). Interacts with INCA1 (PubMed:21750715).

    Three dimensional structures from OCA and Proteopedia for ING5 Gene

    Alternative splice isoforms for ING5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING5 Gene

Post-translational modifications for ING5 Gene

  • Ubiquitination at Lys67
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for ING5

No data available for DME Specific Peptides for ING5 Gene

Domains & Families for ING5 Gene

Gene Families for ING5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ING5 Gene

Suggested Antigen Peptide Sequences for ING5 Gene

GenScript: Design optimal peptide antigens:
  • p28ING5 (ING5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WYH8

UniProtKB/Swiss-Prot:

ING5_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING5: view

Function for ING5 Gene

Molecular function for ING5 Gene

UniProtKB/Swiss-Prot Function:
Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).

Phenotypes From GWAS Catalog for ING5 Gene

Gene Ontology (GO) - Molecular Function for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA 21873635
GO:0005515 protein binding IPI 12750254
GO:0035064 methylated histone binding IBA,IDA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING5: view
genes like me logo Genes that share phenotypes with ING5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ING5 Gene

Localization for ING5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING5 Gene

Nucleus. Chromosome. Note=Localizes to transcription start sites. {ECO:0000269 PubMed:24065767}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING5 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 24065767
GO:0005634 nucleus IEA,IDA 18794358
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0070776 MOZ/MORF histone acetyltransferase complex IEA,IDA 16387653
genes like me logo Genes that share ontologies with ING5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ING5 Gene

Pathways & Interactions for ING5 Gene

genes like me logo Genes that share pathways with ING5: view

Gene Ontology (GO) - Biological Process for ING5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IDA 16387653
GO:0006325 chromatin organization IEA --
GO:0006473 protein acetylation IDA 12750254
GO:0008285 negative regulation of cell proliferation IEA,IGI 21750715
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with ING5: view

No data available for SIGNOR curated interactions for ING5 Gene

Drugs & Compounds for ING5 Gene

No Compound Related Data Available

Transcripts for ING5 Gene

mRNA/cDNA for ING5 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING5

Alternative Splicing Database (ASD) splice patterns (SP) for ING5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5:

Relevant External Links for ING5 Gene

GeneLoc Exon Structure for
ING5

Expression for ING5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ING5 Gene

Protein differential expression in normal tissues from HIPED for ING5 Gene

This gene is overexpressed in NK cells (27.7), Liver (11.5), Monocytes (10.3), and Breast (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ING5 Gene



Protein tissue co-expression partners for ING5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ING5

SOURCE GeneReport for Unigene cluster for ING5 Gene:

Hs.529172

mRNA Expression by UniProt/SwissProt for ING5 Gene:

Q8WYH8-ING5_HUMAN
Tissue specificity: Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.

Evidence on tissue expression from TISSUES for ING5 Gene

  • Nervous system(4.5)
  • Skin(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with ING5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING5 Gene

Orthologs for ING5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ING5 30 31
  • 99.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ING5 31
  • 96 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ING5 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ING5 30 31
  • 90.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ING5 30 31
  • 89.03 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ing5 30 17 31
  • 88.47 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ING5 30 31
  • 84.07 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ING5 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ing5 30
  • 73.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii ing5a 30 31
  • 71.69 (n)
OneToMany
ing5b 31
  • 67 (a)
OneToMany
-- 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG9293 31
  • 48 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 31
  • 20 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 55 (a)
OneToMany
Species where no ortholog for ING5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ING5 Gene

ENSEMBL:
Gene Tree for ING5 (if available)
TreeFam:
Gene Tree for ING5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ING5: view image

Paralogs for ING5 Gene

Paralogs for ING5 Gene

(3) SIMAP similar genes for ING5 Gene using alignment to 2 proteins:

  • ING5_HUMAN
  • E9PEN0_HUMAN
genes like me logo Genes that share paralogs with ING5: view

Variants for ING5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ING5 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs146454591 Benign: not provided 241,709,346(+) C/T
NM_032329.6(ING5):c.240C>T (p.Asp80=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ING5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ING5 Gene

Variant ID Type Subtype PubMed ID
dgv165e55 CNV loss 17911159
nsv1002941 CNV gain 25217958
nsv1006733 CNV gain 25217958
nsv1073033 CNV deletion 25765185
nsv1143973 CNV deletion 24896259
nsv508901 CNV insertion 20534489
nsv584974 CNV gain 21841781
nsv584975 CNV loss 21841781
nsv997984 CNV gain 25217958

Variation tolerance for ING5 Gene

Residual Variation Intolerance Score: 27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING5 Gene

Disorders for ING5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ING5 Gene - From: COP

Disorder Aliases PubMed IDs
ohdo syndrome, sbbys variant
  • sbbyss
atrophy of testis
ohdo syndrome
  • ohdo blepharophimosis syndrome
kleefstra syndrome 1
  • klefs1
- elite association - COSMIC cancer census association via MalaCards
Search ING5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ING5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ING5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ING5 Gene

Publications for ING5 Gene

  1. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. (PMID: 12750254) Shiseki M … Harris CC (Cancer research 2003) 2 3 4 23
  2. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. (PMID: 24065767) Lalonde ME … Côté J (Genes & development 2013) 3 4
  3. The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. (PMID: 21750715) Zhang F … Müller-Tidow C (PloS one 2011) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PMID: 18794358) Ullah M … Yang XJ (Molecular and cellular biology 2008) 3 4

Products for ING5 Gene

Sources for ING5 Gene