Aliases for ING5 Gene
External Ids for ING5 Gene
Previous GeneCards Identifiers for ING5 Gene
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
GeneCards Summary for ING5 Gene
ING5 (Inhibitor Of Growth Family Member 5) is a Protein Coding gene. Diseases associated with ING5 include Ohdo Syndrome, Sbbys Variant and Atrophy Of Testis. Among its related pathways are Regulation of TP53 Activity through Acetylation and Chromatin organization. Gene Ontology (GO) annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is ING4.
UniProtKB/Swiss-Prot Summary for ING5 Gene
Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653). Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653). Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).