The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene... See more...

Aliases for ING3 Gene

Aliases for ING3 Gene

  • Inhibitor Of Growth Family Member 3 2 3 5
  • P47ING3 2 3 4
  • Inhibitor Of Growth Protein 3 3 4
  • MEAF4 2 3
  • Eaf4 2 3
  • FLJ20089 2
  • ING2 3
  • ING3 5

External Ids for ING3 Gene

Previous GeneCards Identifiers for ING3 Gene

  • GC07P119068
  • GC07P120131
  • GC07P120145
  • GC07P120184
  • GC07P120378
  • GC07P120590
  • GC07P114954

Summaries for ING3 Gene

Entrez Gene Summary for ING3 Gene

  • The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for ING3 Gene

ING3 (Inhibitor Of Growth Family Member 3) is a Protein Coding gene. Diseases associated with ING3 include Squamous Cell Carcinoma, Head And Neck and Lateral Meningocele Syndrome. Among its related pathways are Chromatin organization. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and methylated histone binding. An important paralog of this gene is ING4.

UniProtKB/Swiss-Prot Summary for ING3 Gene

  • Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Gene Wiki entry for ING3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ING3 Gene

Genomics for ING3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ING3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J120949 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 638.5 +0.3 282 3.4 SP1 CREB1 ATF7 PRDM10 REST ZNF629 ZNF512 SIX5 LEF1 IKZF1 ING3 TSPAN12 NONHSAG048645.2 CPED1
GH07J120987 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 45.8 +40.1 40112 7.1 CTCF HNRNPL PRDM10 ZNF629 REST LEF1 IKZF1 ZNF692 JUND DDX20 CPED1 ING3 TSPAN12 NONHSAG048646.2-001 NONHSAG048646.2-002 lnc-ING3-3 WNT16
GH07J121393 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 31.4 +445.4 445440 5.8 SP1 CTCF HNRNPL TEAD4 PRDM10 ZNF629 TFE3 ZNF692 POLR2A ZNF174 FAM3C ING3 CYCSP19 lnc-WNT16-1 lnc-TSPAN12-6 WNT16
GH07J121075 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 23.1 +126.8 126760 3.4 HNRNPL ZNF512 LEF1 IKZF1 JUND PRDM1 DDX20 MTA2 PKNOX1 ZNF24 CPED1 ING3 RNA5SP241 lnc-ING3-6 WNT16
GH07J121081 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 23.1 +134.4 134375 7.4 CTCF PRDM10 ZNF629 JUND PRDM1 PHF21A HNRNPUL1 PKNOX1 ZNF24 REST RF00001-311 RNA5SP241 CPED1 ING3 piR-57387-049 WNT16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ING3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ING3

Top Transcription factor binding sites by QIAGEN in the ING3 gene promoter:
  • ATF6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Meis-1a
  • Pbx1a
  • S8

Genomic Locations for ING3 Gene

Genomic Locations for ING3 Gene
chr7:120,950,749-120,977,216
(GRCh38/hg38)
Size:
26,468 bases
Orientation:
Plus strand
chr7:120,590,803-120,617,270
(GRCh37/hg19)
Size:
26,468 bases
Orientation:
Plus strand

Genomic View for ING3 Gene

Genes around ING3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING3 Gene

Proteins for ING3 Gene

  • Protein details for ING3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR8-ING3_HUMAN
    Recommended name:
    Inhibitor of growth protein 3
    Protein Accession:
    Q9NXR8
    Secondary Accessions:
    • A8K790
    • O60394
    • Q567P3
    • Q6GMT3
    • Q7Z762
    • Q969G0
    • Q96DT4
    • Q9HC99
    • Q9P081

    Protein attributes for ING3 Gene

    Size:
    418 amino acids
    Molecular mass:
    46743 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. HTATTIP/TIP60, EPC1, and ING3 together constitute a minimal HAT complex termed Piccolo NuA4. Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAF28979.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH73865.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Three dimensional structures from OCA and Proteopedia for ING3 Gene

    Alternative splice isoforms for ING3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING3 Gene

Post-translational modifications for ING3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING3 Gene

No data available for DME Specific Peptides for ING3 Gene

Domains & Families for ING3 Gene

Gene Families for ING3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ING3 Gene

Suggested Antigen Peptide Sequences for ING3 Gene

GenScript: Design optimal peptide antigens:
  • ING3 protein (B7ZKQ7_HUMAN)
  • p47ING3 (ING3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXR8

UniProtKB/Swiss-Prot:

ING3_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING3: view

Function for ING3 Gene

Molecular function for ING3 Gene

UniProtKB/Swiss-Prot Function:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.

Phenotypes From GWAS Catalog for ING3 Gene

Gene Ontology (GO) - Molecular Function for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004402 contributes_to histone acetyltransferase activity IBA,IDA 14966270
GO:0005515 protein binding IPI --
GO:0035064 methylated histone binding IDA 16728974
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ING3: view
genes like me logo Genes that share phenotypes with ING3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ING3 Gene

Localization for ING3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0032777 Piccolo NuA4 histone acetyltransferase complex IDA 14966270
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with ING3: view

Pathways & Interactions for ING3 Gene

PathCards logo

SuperPathways for ING3 Gene

genes like me logo Genes that share pathways with ING3: view

Pathways by source for ING3 Gene

Gene Ontology (GO) - Biological Process for ING3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0040008 regulation of growth IEA --
GO:0043065 positive regulation of apoptotic process IDA 16387653
GO:0043967 histone H4 acetylation IDA 14966270
GO:0043968 histone H2A acetylation IDA 14966270
genes like me logo Genes that share ontologies with ING3: view

No data available for SIGNOR curated interactions for ING3 Gene

Drugs & Compounds for ING3 Gene

No Compound Related Data Available

Transcripts for ING3 Gene

mRNA/cDNA for ING3 Gene

3 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ING3

Alternative Splicing Database (ASD) splice patterns (SP) for ING3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for ING3 Gene

GeneLoc Exon Structure for
ING3

Expression for ING3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ING3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ING3 Gene

This gene is overexpressed in Fetal Brain (19.1), CD8 Tcells (18.6), and Peripheral blood mononuclear cells (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ING3 Gene



Protein tissue co-expression partners for ING3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ING3

SOURCE GeneReport for Unigene cluster for ING3 Gene:

Hs.489811

mRNA Expression by UniProt/SwissProt for ING3 Gene:

Q9NXR8-ING3_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.

Evidence on tissue expression from TISSUES for ING3 Gene

  • Muscle(4.4)
  • Lung(4.4)
  • Liver(4.4)
  • Blood(4.4)
  • Pancreas(4.3)
  • Nervous system(2.8)
  • Bone marrow(2.2)
  • Intestine(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ING3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING3 Gene

Orthologs for ING3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ING3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ING3 30 31
  • 99.92 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ING3 30 31
  • 93.7 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ING3 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia ING3 30 31
  • 92.26 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ing3 30
  • 88.2 (n)
Mouse
(Mus musculus)
Mammalia Ing3 30 17 31
  • 87.4 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ING3 31
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ING3 30 31
  • 82.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ING3 31
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ing3 30
  • 78.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia ing3-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ing3 30 31
  • 73.62 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6632 32
  • 62 (a)
Ing3 31
  • 29 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ing-3 31
  • 20 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNG2 31
  • 25 (a)
OneToOne
YNG1 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ING1 30
  • 53.02 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0143600 30
  • 52.08 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1861 30
Species where no ortholog for ING3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ING3 Gene

ENSEMBL:
Gene Tree for ING3 (if available)
TreeFam:
Gene Tree for ING3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ING3: view image

Paralogs for ING3 Gene

Paralogs for ING3 Gene

(3) SIMAP similar genes for ING3 Gene using alignment to 3 proteins:

  • ING3_HUMAN
  • B7ZKQ7_HUMAN
  • E7ET07_HUMAN
genes like me logo Genes that share paralogs with ING3: view

Variants for ING3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ING3 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
776256 Benign: not provided 120,951,195(+) C/T SYNONYMOUS_VARIANT
778332 Benign: not provided 120,967,539(+) T/C SYNONYMOUS_VARIANT
VAR_021263 Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355] p.Asp20Gly

Additional dbSNP identifiers (rs#s) for ING3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ING3 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER inversion 18451855
nsv831114 CNV loss 17160897

Variation tolerance for ING3 Gene

Residual Variation Intolerance Score: 11.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ING3 Gene

Disorders for ING3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ING3 Gene - From: UniProtKB/Swiss-Prot and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search ING3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ING3_HUMAN
  • Squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355]: A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. {ECO:0000269 PubMed:12080476}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ING3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ING3: view

No data available for Genatlas for ING3 Gene

Publications for ING3 Gene

  1. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. (PMID: 12545155) Nagashima M … Harris CC (Oncogene 2003) 3 4 23
  2. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. (PMID: 12080476) Gunduz M … Shimizu K (Oncogene 2002) 2 3 4
  3. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A … Hamiche A (Nature 2014) 3 4
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E … IMGSAC (Molecular psychiatry 2010) 3 41
  5. Arabidopsis ING and Alfin1-like protein families localize to the nucleus and bind to H3K4me3/2 via plant homeodomain fingers. (PMID: 19154204) Lee WY … Kwon CS (The Plant journal : for cell and molecular biology 2009) 3 4

Products for ING3 Gene

Sources for ING3 Gene