This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] See more...

Aliases for ING2 Gene

Aliases for ING2 Gene

  • Inhibitor Of Growth Family Member 2 2 3 5
  • Inhibitor Of Growth 1-Like Protein 3 4
  • Inhibitor Of Growth Protein 2 3 4
  • P33ING2 3 4
  • ING1Lp 3 4
  • ING1L 3 4
  • P32 3 4
  • Inhibitor Of Growth Family, Member 1-Like 2

External Ids for ING2 Gene

Previous HGNC Symbols for ING2 Gene

  • ING1L

Previous GeneCards Identifiers for ING2 Gene

  • GC00U990666
  • GC0XM068188
  • GC0XM068944
  • GC0XM069578
  • GC0XM070494
  • GC04P184802
  • GC04P184663
  • GC04P184426
  • GC04P180185

Summaries for ING2 Gene

Entrez Gene Summary for ING2 Gene

  • This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for ING2 Gene

ING2 (Inhibitor Of Growth Family Member 2) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of TP53 Activity through Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding and phosphatidylinositol binding. An important paralog of this gene is ING1.

UniProtKB/Swiss-Prot Summary for ING2 Gene

  • Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).

Gene Wiki entry for ING2 Gene

Additional gene information for ING2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ING2 Gene

Genomics for ING2 Gene

GeneHancer (GH) Regulatory Elements for ING2 Gene

Promoters and enhancers for ING2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J183502 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 506.8 +0.9 930 7.2 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 PHF8 ING2 ENSG00000232648 LOC389247 STOX2 lnc-ING2-1
GH04J183617 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 +115.4 115424 6.3 FOXK2 CTCF NCOR1 ZBTB5 KDM6A TCF7 FOXA1 RFX1 ZBTB25 TGIF2 RWDD4 TRAPPC11 ENSG00000232648 ING2 RNU6-1053P RF00026-840 RNU6-479P RF01210-300
GH04J183455 Enhancer 0.6 FANTOM5 Ensembl 16.3 -49.2 -49249 2.4 TAL1 TEAD4 GATA1 CBFA2T2 CBFA2T3 ING2 ENSG00000232648 CLDN24 piR-37788 lnc-CDKN2AIP-1
GH04J183571 Enhancer 0.8 ENCODE dbSUPER 11.8 +66.8 66797 1.3 RFX1 CTBP1 FOS SPI1 SMAD4 BMI1 BCL6 RFX5 POLR2A ELF4 HSALNG0038953 ENSG00000232648 ING2 HSALNG0038950
GH04J183587 Enhancer 0.8 ENCODE 11.3 +83.3 83336 1.5 EP300 TRIM28 OSR2 WT1 SP2 ZBTB17 ZNF263 CEBPG NR3C1 CEBPB ENSG00000232648 ING2 TRAPPC11 RNU6-1053P RF01210-300 RF00026-840 RNU6-479P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ING2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ING2

Top Transcription factor binding sites by QIAGEN in the ING2 gene promoter:
  • ARP-1
  • FAC1
  • HSF2
  • Nkx6-1
  • p300
  • Sp1
  • Spz1
  • STAT5B
  • TBP

Genomic Locations for ING2 Gene

Genomic Locations for ING2 Gene
chr4:183,505,050-183,512,429
(GRCh38/hg38)
Size:
7,380 bases
Orientation:
Plus strand
chr4:184,426,147-184,432,249
(GRCh37/hg19)
Size:
6,103 bases
Orientation:
Plus strand

Genomic View for ING2 Gene

Genes around ING2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ING2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ING2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ING2 Gene

Proteins for ING2 Gene

  • Protein details for ING2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H160-ING2_HUMAN
    Recommended name:
    Inhibitor of growth protein 2
    Protein Accession:
    Q9H160
    Secondary Accessions:
    • B6ZDS1
    • O95698

    Protein attributes for ING2 Gene

    Size:
    280 amino acids
    Molecular mass:
    32808 Da
    Quaternary structure:
    • Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.
    Miscellaneous:
    • [Isoform ING2b]: Low expression except in testis, where it reaches half of ING2a levels.

    Alternative splice isoforms for ING2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ING2 Gene

Post-translational modifications for ING2 Gene

  • Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ING2 Gene

No data available for DME Specific Peptides for ING2 Gene

Domains & Families for ING2 Gene

Gene Families for ING2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ING2 Gene

Suggested Antigen Peptide Sequences for ING2 Gene

GenScript: Design optimal peptide antigens:
  • p33ING2 (ING2_HUMAN)
  • Transcriptional regulator ING2 (Q5GRH6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H160

UniProtKB/Swiss-Prot:

ING2_HUMAN :
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • Belongs to the ING family.
Domain:
  • The PHD-type zinc finger mediates the binding to H3K4me3.
  • The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
Family:
  • Belongs to the ING family.
genes like me logo Genes that share domains with ING2: view

Function for ING2 Gene

Molecular function for ING2 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
UniProtKB/Swiss-Prot Induction:
Induced by the DNA-damaging agents etoposide and neocarzinostatin.

Gene Ontology (GO) - Molecular Function for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15243141
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18334480
GO:0035064 methylated histone binding IBA,IDA 16728974
GO:0035091 phosphatidylinositol binding IDA 16893883
genes like me logo Genes that share ontologies with ING2: view
genes like me logo Genes that share phenotypes with ING2: view

Animal Models for ING2 Gene

MGI Knock Outs for ING2:
  • Ing2 Ing2<tm1.1(KOMP)Vlcg>
  • Ing2 Ing2<tm1.1Ccha>

Animal Model Products

CRISPR Products

miRNA for ING2 Gene

miRTarBase miRNAs that target ING2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ING2 Gene

Localization for ING2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ING2 Gene

Nucleus. Note=Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ING2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
plasma membrane 3
extracellular 2
cytoskeleton 1
mitochondrion 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IMP 25578879
GO:0005654 nucleoplasm IDA,TAS --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IMP 25578879
genes like me logo Genes that share ontologies with ING2: view

Pathways & Interactions for ING2 Gene

genes like me logo Genes that share pathways with ING2: view

SIGNOR curated interactions for ING2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ING2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 15243141
GO:0007141 male meiosis I ISS 21124965
GO:0007165 signal transduction TAS 10072587
GO:0007283 spermatogenesis IEA,ISS 21124965
genes like me logo Genes that share ontologies with ING2: view

Drugs & Compounds for ING2 Gene

No Compound Related Data Available

Transcripts for ING2 Gene

mRNA/cDNA for ING2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ING2 Gene

No ASD Table

Relevant External Links for ING2 Gene

GeneLoc Exon Structure for
ING2

Expression for ING2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ING2 Gene

Protein differential expression in normal tissues from HIPED for ING2 Gene

This gene is overexpressed in Cervix (51.5) and Plasma (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ING2 Gene



Protein tissue co-expression partners for ING2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ING2

SOURCE GeneReport for Unigene cluster for ING2 Gene:

Hs.107153

mRNA Expression by UniProt/SwissProt for ING2 Gene:

Q9H160-ING2_HUMAN
Tissue specificity: Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.

Evidence on tissue expression from TISSUES for ING2 Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Thyroid gland(2.2)
genes like me logo Genes that share expression patterns with ING2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ING2 Gene

Orthologs for ING2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ING2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ING2 31 30
  • 99.88 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ING2 31 30
  • 94.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ING2 31 30
  • 91.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ing2 30
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Ing2 17 31 30
  • 90.6 (n)
oppossum
(Monodelphis domestica)
Mammalia ING2 31
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ING2 31 30
  • 75.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ING2 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ing2 30
  • 71.68 (n)
Str.6306 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398266 30
zebrafish
(Danio rerio)
Actinopterygii ing2 31 30
  • 67.7 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7379 31
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHO23 31
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10422 31
  • 30 (a)
OneToMany
Species where no ortholog for ING2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ING2 Gene

ENSEMBL:
Gene Tree for ING2 (if available)
TreeFam:
Gene Tree for ING2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ING2: view image

Paralogs for ING2 Gene

Paralogs for ING2 Gene

(4) SIMAP similar genes for ING2 Gene using alignment to 3 proteins:

  • ING2_HUMAN
  • C9J4X5_HUMAN
  • Q5GRH6_HUMAN
genes like me logo Genes that share paralogs with ING2: view

Variants for ING2 Gene

Additional dbSNP identifiers (rs#s) for ING2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ING2 Gene

Variant ID Type Subtype PubMed ID
nsv1030766 CNV gain 25217958
nsv822873 CNV gain 20364138
nsv830165 CNV loss 17160897

Variation tolerance for ING2 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ING2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ING2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ING2 Gene

Disorders for ING2 Gene

Additional Disease Information for ING2

No disorders were found for ING2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ING2 Gene

Publications for ING2 Gene

  1. Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. (PMID: 10072587) Shimada Y … Horie M (Cytogenetics and cell genetics 1998) 2 3 4 23 54
  2. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. (PMID: 12859901) Gozani O … Yuan J (Cell 2003) 3 4 23 54
  3. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. (PMID: 11481424) Nagashima M … Harris CC (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 23 54
  4. Sumoylation of ING2 regulates the transcription mediated by Sin3A. (PMID: 20676127) Ythier D … Pedeux R (Oncogene 2010) 3 4 54
  5. ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. (PMID: 19437536) Kumamoto K … Harris CC (International journal of cancer 2009) 3 23 54

Products for ING2 Gene

Sources for ING2 Gene