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In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger prote... See more...
Aliases for INCENP Gene
Aliases for INCENP Gene
External Ids for INCENP Gene
- HGNC: 6058
- NCBI Entrez Gene: 3619
- Ensembl: ENSG00000149503
- OMIM®: 604411
- UniProtKB/Swiss-Prot: Q9NQS7
Previous GeneCards Identifiers for INCENP Gene
- GC11U990069
- GC11P063467
- GC11P061666
- GC11P061648
- GC11P061891
- GC11P058219
Summaries for INCENP Gene
-
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
GeneCards Summary for INCENP Gene
INCENP (Inner Centromere Protein) is a Protein Coding gene. Diseases associated with INCENP include Nephronophthisis and Graham-Little-Piccardi-Lassueur Syndrome. Among its related pathways are Cell Cycle, Mitotic and Aurora B signaling.
UniProtKB/Swiss-Prot Summary for INCENP Gene
-
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).
Additional gene information for INCENP Gene
- HGNC (6058)
- NCBI Entrez Gene (3619)
- Ensembl (ENSG00000149503)
- OMIM® (604411)
- UniProtKB/Swiss-Prot (Q9NQS7)
- Open Targets Platform(ENSG00000149503)
- Monarch Initiative
- Alliance of Genome Resources
- Search for INCENP at DataMed
- Search for INCENP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for INCENP Gene
Genomics for INCENP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for INCENP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around INCENP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for INCENP
- Top Transcription factor binding sites by QIAGEN in the INCENP gene promoter:
-
- C/EBPalpha
- E47
- FAC1
- Hand1
- Pbx1a
- RFX1
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for INCENP Gene
Latest Assembly
- chr11:62,123,998-62,155,474
- (GRCh38/hg38)
- Size:
- 31,477 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:61,891,483-61,920,641
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 29,159 bases
- Orientation:
- Plus strand
Genomic View for INCENP Gene
Genes around INCENP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
INCENP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for INCENP Gene
Proteins for INCENP Gene
-
Protein details for INCENP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQS7-INCE_HUMAN
- Recommended name:
- Inner centromere protein
- Protein Accession:
- Q9NQS7
- A8MQD2
- Q5Y192
Protein attributes for INCENP Gene
- Size:
- 918 amino acids
- Molecular mass:
- 105429 Da
- Quaternary structure:
-
- Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex binds directly to AURKB or AURKC via the IN box, and forms a triple-helix bundle-based subcomplex with BIRC5 and CDCA8 via its N-terminus (PubMed:17956729, PubMed:27332895). The reported homodimerization is questioned as the SAH domain is shown to be monomeric (By similarity). Interacts with H2AZ1 (By similarity). Interacts with CBX1 and CBX3. Interacts with tubulin beta chain. Interacts with EVI5. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5; regulates INCENP (and probably CPC) localization to centromeres in interphase and not required for proper mitotic progression or sister chromatid cohesion. Interacts with POGZ. Interacts with JTB.
Three dimensional structures from OCA and Proteopedia for INCENP Gene
Protein Expression for INCENP Gene
Post-translational modifications for INCENP Gene
- Phosphorylation by AURKB or AURKC at its C-terminal part is important for AURKB or AURKC activation by INCENP.
-
Ubiquitination at Lys51, Lys321, and Lys602
- NX_Q9NQS7 (NX_Q9NQS7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for INCENP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for INCENP
-
Abcam antibodies for INCENP
- Invitrogen Antibodies for INCENP (AFLGC-Incenp)
-
Biorbyt antibodies for INCENP
-
Boster Bio Antibodies for INCENP
-
Custom Antibody ServicesProSci Antibodies for INCENP
-
Santa Cruz Biotechnology (SCBT) Antibodies for INCENP
Protein products for research
-
OriGene Purified Proteins for INCENP
- Search Origene for MassSpec and Protein Over-expression Lysates for INCENP
- Origene Custom Protein Services for INCENP
- Novus Biologicals proteins for INCENP
-
Abcam proteins for INCENP
Assay products for research
No data available for DME Specific Peptides for INCENP Gene
Domains & Families for INCENP Gene
Gene Families for INCENP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for INCENP Gene
- InterPro:
- Blocks:
-
- Inner centromere protein, ARK binding region
Suggested Antigen Peptide Sequences for INCENP Gene
- GenScript: Design optimal peptide antigens:
-
- Inner centromere protein (INCE_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQS7UniProtKB/Swiss-Prot:
INCE_HUMAN :- The IN box mediates interaction with AURKB and AURKC.
- Belongs to the INCENP family.
- Domain:
-
- The IN box mediates interaction with AURKB and AURKC.
- The SAH (single alpha-helix) region is characterized by a high content of charged residues which are predicted to stabilize the alpha-helical structure by ionic bonds. It can refold after extension suggesting an in vivo force-dependent function. The isolated SAH domain is monomeric.
- Family:
-
- Belongs to the INCENP family.
Function for INCENP Gene
Molecular function for INCENP Gene
- UniProtKB/Swiss-Prot Function:
- Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).
Phenotypes From GWAS Catalog for INCENP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 9864353 |
| GO:0043539 | protein serine/threonine kinase activator activity | IBA | 21873635 |
Phenotypes for INCENP Gene
- MGI mutant phenotypes for INCENP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for INCENP:
-
- Decreased viability
- no effect
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Inconclusive
- Increased ionizing radiation sensitivity
- Decreased viability of wild-type and TP53 knockout cells
- Increased cilium length after serum starvation
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased gamma-H2AX phosphorylation
- Multipolar spindles
- Decreased cell number
- Increased HPV16-GFP infection
- Cell division defect
- Increased cell number in G2M, increased number of polyploid cells, increased number of cells with high perimeter-to-area ratio nuclei
- Decreased cell number, increased 8N DNA content
- Inhibition of centrosomal clustering
Animal Models for INCENP Gene
- MGI Knock Outs for INCENP:
-
- Incenp Incenp<tm1Khac>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for INCENP - Starting at $85 >
- * INCENP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for INCENP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INCENP
-
Santa Cruz Biotechnology (SCBT) CRISPR for INCENP
miRNA for INCENP Gene
- miRTarBase miRNAs that target INCENP
-
- mmu-miR-301b-3p (MIRT008017)
- hsa-miR-142-3p (MIRT021587)
- hsa-miR-181a-5p (MIRT025087)
- hsa-miR-423-3p (MIRT042486)
- hsa-miR-181b-5p (MIRT131157)
- hsa-miR-181c-5p (MIRT131158)
- hsa-miR-299-3p (MIRT131161)
- hsa-miR-181d-5p (MIRT131162)
- hsa-miR-548u (MIRT131172)
- hsa-miR-7161-5p (MIRT131193)
- hsa-miR-524-5p (MIRT495002)
- hsa-miR-520d-5p (MIRT495003)
- hsa-miR-4452 (MIRT515471)
- hsa-miR-183-3p (MIRT515472)
- hsa-miR-4668-5p (MIRT515473)
- hsa-miR-3148 (MIRT515474)
- hsa-miR-219a-2-3p (MIRT515475)
- hsa-miR-219b-3p (MIRT515476)
- hsa-miR-554 (MIRT515477)
- hsa-miR-4756-3p (MIRT515478)
- hsa-miR-92b-3p (MIRT515479)
- hsa-miR-92a-3p (MIRT515480)
- hsa-miR-367-3p (MIRT515481)
- hsa-miR-363-3p (MIRT515482)
- hsa-miR-32-5p (MIRT515483)
- hsa-miR-25-3p (MIRT515484)
- hsa-miR-135a-3p (MIRT515485)
- hsa-miR-3123 (MIRT515486)
- hsa-miR-9500 (MIRT515487)
- hsa-miR-182-5p (MIRT550346)
- hsa-let-7g-3p (MIRT550347)
- hsa-let-7a-2-3p (MIRT550348)
- hsa-miR-4536-5p (MIRT550349)
- hsa-miR-5681b (MIRT550350)
- hsa-miR-4470 (MIRT550351)
- hsa-miR-4644 (MIRT550352)
- hsa-miR-4306 (MIRT550353)
- hsa-miR-185-5p (MIRT550354)
- hsa-miR-548x-5p (MIRT550355)
- hsa-miR-548g-5p (MIRT550356)
- hsa-miR-548f-5p (MIRT550357)
- hsa-miR-548aj-5p (MIRT550358)
- hsa-miR-4657 (MIRT550359)
- hsa-miR-4491 (MIRT550360)
- hsa-miR-5683 (MIRT550361)
- hsa-miR-4428 (MIRT550362)
- hsa-miR-3919 (MIRT550363)
- hsa-miR-5003-5p (MIRT550364)
- hsa-miR-6822-5p (MIRT550365)
- hsa-miR-6750-5p (MIRT550366)
- hsa-miR-5584-5p (MIRT550367)
- hsa-miR-4282 (MIRT550368)
- hsa-miR-6770-3p (MIRT709381)
- hsa-miR-4467 (MIRT709382)
- hsa-miR-3622b-5p (MIRT709383)
- hsa-miR-6847-3p (MIRT709384)
- hsa-miR-24-2-5p (MIRT709385)
- hsa-miR-24-1-5p (MIRT709386)
- hsa-miR-216a-5p (MIRT716934)
- bta-miR-378 (MIRT735528)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INCENP
- Browse OriGene Inhibitory RNA Products For INCENP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INCENP
Clone products for research
- Applied Biological Materials (abm): Clones for INCENP - Starting at $45 >
- * INCENP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for INCENP
- Addgene plasmids for INCENP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INCENP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INCENP Gene
Localization for INCENP Gene
Subcellular locations from UniProtKB/Swiss-Prot for INCENP Gene
- Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome, centromere, kinetochore. Note=Colocalized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters. Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (By similarity). Colocalizes with AURKB at mitotic chromosomes (PubMed:11453556). Localizes to inner kinetochore (PubMed:16760428). Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:15316025). Cocalizes to the equatorial cell cortex at anaphase (PubMed:11453556). {ECO:0000250 UniProtKB:Q9WU62, ECO:0000269 PubMed:11453556, ECO:0000269 PubMed:15316025, ECO:0000269 PubMed:16760428}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Kinetochore (3)
- Midbody (3)
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | IEA,IDA | 11084331 |
| GO:0000776 | kinetochore | IBA,IDA | 16760428 |
| GO:0000777 | condensed chromosome kinetochore | IEA | -- |
| GO:0000793 | condensed chromosome | IBA | 21873635 |
| GO:0000795 | synaptonemal complex | IEA | -- |
Pathways & Interactions for INCENP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Mitotic Metaphase and Anaphase |
.94
|
|
| 3 | Mitotic Prometaphase | ||
| 4 | Metabolism of proteins | ||
| 5 | Signaling by Rho GTPases | ||
Pathways by source for INCENP Gene
4 BioSystems pathways for INCENP Gene
17 Reactome pathways for INCENP Gene
1 GeneGo (Thomson Reuters) pathway for INCENP Gene
- Cell cycle_Chromosome condensation in prometaphase
1 Cell Signaling Technology pathway for INCENP Gene
Interacting Proteins for INCENP Gene
Selected Interacting proteins:
Q9NQS7-INCE_HUMAN
ENSP00000378295
for INCENP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for INCENP
SIGNOR curated interactions for INCENP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000070 | mitotic sister chromatid segregation | IEA | -- |
| GO:0000281 | mitotic cytokinesis | IMP | 16239925 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007059 | chromosome segregation | IMP | 16239925 |
| GO:0010032 | meiotic chromosome condensation | IBA | 21873635 |
Drugs & Compounds for INCENP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Reversine | Experimental | Pharma | Target | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 0 |
Transcripts for INCENP Gene
mRNA/cDNA for INCENP Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000278849 3698 nts (view in UCSC)
- ENST00000394818 4114 nts (view in UCSC)
- ENST00000528037 1372 nts (view in UCSC)
- ENST00000528375 808 nts (view in UCSC)
- ENST00000531099 561 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for INCENP - Starting at $85 >
- * INCENP CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for INCENP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INCENP
-
Santa Cruz Biotechnology (SCBT) CRISPR for INCENP
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for INCENP
- Browse OriGene Inhibitory RNA Products For INCENP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INCENP
Clone products for research
- Applied Biological Materials (abm): Clones for INCENP - Starting at $45 >
- * INCENP as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for INCENP
- Addgene plasmids for INCENP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for INCENP
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for INCENP Gene
- GeneLoc Exon Structure for
- INCENP
Expression for INCENP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
This gene is overexpressed in Synovial fluid (47.5), Fetal gut (8.3), and Spleen (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for INCENP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for INCENP
SOURCE GeneReport for Unigene cluster for INCENP Gene:
Hs.142179Evidence on tissue expression from TISSUES for INCENP Gene
- Lung(4.3)
- Skin(2.3)
- Intestine(2.2)
- Nervous system(2.1)
Primer products for research
-
OriGene qPCR primer pairs for INCENP
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INCENP Gene
Orthologs for INCENP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | INCENP 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | INCENP 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | INCENP 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Incenp 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Incenp 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | INCENP 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | INCENP 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | INCENP 29 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | incenp 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | INCENP 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Incenp 30 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | icp-1 30 |
|
OneToOne |
- Species where no ortholog for INCENP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for INCENP Gene
- ENSEMBL:
- Gene Tree for INCENP (if available)
- TreeFam:
- Gene Tree for INCENP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for INCENP: view image
- Alliance of Genome Resources:
- Additional Orthologs for INCENP
Paralogs for INCENP Gene
No data available for Paralogs for INCENP Gene
Variants for INCENP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for INCENP Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs112218336 | Benign: not provided | 62,129,932(+) |
C/T NM_001040694.2(INCENP):c.405C>T (p.Thr135=) |
SYNONYMOUS | |
| rs116462742 | Benign: not provided | 62,145,672(+) |
C/T NM_001040694.2(INCENP):c.1880C>T (p.Ala627Val) |
MISSENSE | |
| rs12281503 | Benign: not provided | 62,129,826(+) |
G/Ap.Arg100His NM_001040694.2(INCENP):c.299G>A (p.Arg100His) |
MISSENSE | |
| rs34210125 | Benign: not provided | 62,129,996(+) |
G/A NM_001040694.2(INCENP):c.469G>A (p.Glu157Lys) |
MISSENSE | |
| rs3781968 | Benign: not provided | 62,151,919(+) |
G/A NM_001040694.2(INCENP):c.2700G>A (p.Pro900=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv655e59 | CNV | tandem duplication | 20981092 |
| esv2480486 | CNV | deletion | 19546169 |
| esv2658380 | CNV | deletion | 23128226 |
| esv2744601 | CNV | deletion | 23290073 |
| esv2751033 | CNV | gain | 17911159 |
| esv2759832 | CNV | gain | 17122850 |
| esv3404378 | CNV | duplication | 20981092 |
| esv997129 | CNV | gain | 20482838 |
| nsv1036085 | CNV | gain | 25217958 |
| nsv1129516 | CNV | tandem duplication | 24896259 |
| nsv7219 | OTHER | inversion | 18451855 |
| nsv952460 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.71;
98.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for INCENP Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INCENP Gene
Disorders for INCENP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nephronophthisis |
|
|
| graham-little-piccardi-lassueur syndrome |
|
|
| juvenile nephronophthisis |
|
|
| cholestasis, intrahepatic, of pregnancy, 1 |
|
|
| sveinsson chorioretinal atrophy |
|
|
Search INCENP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for INCENP
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for INCENP Gene
Publications for INCENP Gene
- Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells. (PMID: 11453556) Adams RR … Earnshaw WC (Chromosoma 2001) 2 3 4 22
- Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. (PMID: 17956729) Jeyaprakash AA … Conti E (Cell 2007) 3 4 22
- EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis. (PMID: 16764853) Faitar SL … Cowell JK (Experimental cell research 2006) 3 4 22
- Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. (PMID: 16571674) Klein UR … Gruneberg U (Molecular biology of the cell 2006) 3 4 22
- Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. (PMID: 14610074) Wheatley SP … Earnshaw WC (The Journal of biological chemistry 2004) 3 4 22
ExternalLinks
Products for INCENP Gene
- Custom Antibody Services
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- Addgene plasmids for INCENP
- antibodies-online: Show 11 available INCENP Antibodies ranked by validation data
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- antibodies-online: Show 5 available INCENP Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for INCENP
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for INCENP
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- Boster Bio Antibodies for INCENP
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Sources for INCENP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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