Free for academic non-profit institutions. Other users need a Commercial license
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
INCENP (Inner Centromere Protein) is a Protein Coding gene. Diseases associated with INCENP include Roberts Syndrome and Graham-Little-Piccardi-Lassueur Syndrome. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by GPCR.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9864353 |
GO:0043539 | protein serine/threonine kinase activator activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | IEA,IDA | 11084331 |
GO:0000776 | kinetochore | IBA,IDA | 16760428 |
GO:0000777 | condensed chromosome kinetochore | IEA | -- |
GO:0000793 | condensed chromosome | IBA | 21873635 |
GO:0000795 | synaptonemal complex | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | Mitotic Prometaphase | ||
4 | Metabolism of proteins | ||
5 | Signaling by Rho GTPases |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000070 | mitotic sister chromatid segregation | IEA | -- |
GO:0000281 | mitotic cytokinesis | IBA,IMP | 16239925 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007059 | chromosome segregation | IMP | 16239925 |
GO:0010032 | meiotic chromosome condensation | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Reversine | Experimental | Pharma | Target | A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor | 0 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | INCENP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | INCENP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | INCENP 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Incenp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Incenp 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | INCENP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | INCENP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | INCENP 30 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | incenp 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | INCENP 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Incenp 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | icp-1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
768453 | Benign: not provided | 62,145,672(+) | C/T | MISSENSE_VARIANT | |
774693 | Benign: not provided | 62,129,932(+) | C/T | SYNONYMOUS_VARIANT | |
774694 | Benign: not provided | 62,151,919(+) | G/A | SYNONYMOUS_VARIANT | |
776619 | Benign: not provided | 62,129,996(+) | G/A | MISSENSE_VARIANT | |
779201 | Benign: not provided | 62,129,826(+) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv655e59 | CNV | tandem duplication | 20981092 |
esv2480486 | CNV | deletion | 19546169 |
esv2658380 | CNV | deletion | 23128226 |
esv2744601 | CNV | deletion | 23290073 |
esv2751033 | CNV | gain | 17911159 |
esv2759832 | CNV | gain | 17122850 |
esv3404378 | CNV | duplication | 20981092 |
esv997129 | CNV | gain | 20482838 |
nsv1036085 | CNV | gain | 25217958 |
nsv1129516 | CNV | tandem duplication | 24896259 |
nsv7219 | OTHER | inversion | 18451855 |
nsv952460 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
roberts syndrome |
|
|
graham-little-piccardi-lassueur syndrome |
|
|
cholestasis, intrahepatic, of pregnancy, 1 |
|
|
nephronophthisis |
|
|
sveinsson chorioretinal atrophy |
|
|