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Aliases for INAFM1 Gene

Aliases for INAFM1 Gene

  • InaF Motif Containing 1 2 3 5
  • Putative Transmembrane Protein INAFM1 3 4
  • InaF-Motif-Containing Protein 1 3 4
  • Proline-Rich Protein 24 3 4
  • Proline Rich 24 2 3
  • PRR24 3 4

External Ids for INAFM1 Gene

Previous HGNC Symbols for INAFM1 Gene

  • PRR24

Summaries for INAFM1 Gene

GeneCards Summary for INAFM1 Gene

INAFM1 (InaF Motif Containing 1) is a Protein Coding gene. Diseases associated with INAFM1 include Severe Cutaneous Adverse Reaction.

Additional gene information for INAFM1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INAFM1 Gene

Genomics for INAFM1 Gene

GeneHancer (GH) Regulatory Elements for INAFM1 Gene

Promoters and enhancers for INAFM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around INAFM1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for INAFM1 Gene

Genomic Locations for INAFM1 Gene
chr19:47,274,402-47,275,723
(GRCh38/hg38)
Size:
1,322 bases
Orientation:
Plus strand
chr19:47,777,659-47,778,980
(GRCh37/hg19)
Size:
1,322 bases
Orientation:
Plus strand

Genomic View for INAFM1 Gene

Genes around INAFM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INAFM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INAFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INAFM1 Gene

Proteins for INAFM1 Gene

  • Protein details for INAFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JVW0-INAM1_HUMAN
    Recommended name:
    Putative transmembrane protein INAFM1
    Protein Accession:
    C9JVW0

    Protein attributes for INAFM1 Gene

    Size:
    142 amino acids
    Molecular mass:
    14668 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INAFM1 Gene

Post-translational modifications for INAFM1 Gene

No Post-translational modifications

Other Protein References for INAFM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INAFM1 Gene

Domains & Families for INAFM1 Gene

Gene Families for INAFM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INAFM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for INAFM1 Gene

GenScript: Design optimal peptide antigens:
  • Proline-rich protein 24 (PRR24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INAFM1: view

No data available for UniProtKB/Swiss-Prot for INAFM1 Gene

Function for INAFM1 Gene

Phenotypes From GWAS Catalog for INAFM1 Gene

Gene Ontology (GO) - Molecular Function for INAFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005246 calcium channel regulator activity IBA 21873635
genes like me logo Genes that share ontologies with INAFM1: view

Phenotypes for INAFM1 Gene

genes like me logo Genes that share phenotypes with INAFM1: view

Animal Model Products

CRISPR Products

miRNA for INAFM1 Gene

miRTarBase miRNAs that target INAFM1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INAFM1

Clone Products

  • Applied Biological Materials (abm): Clones for INAFM1 - Now 50% OFF >
  • * INAFM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * INAFM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for INAFM1 Gene

Localization for INAFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for INAFM1 Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for INAFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with INAFM1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for INAFM1 Gene

Pathways & Interactions for INAFM1 Gene

PathCards logo

SuperPathways for INAFM1 Gene

No Data Available

Interacting Proteins for INAFM1 Gene

Gene Ontology (GO) - Biological Process for INAFM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for INAFM1 Gene

Drugs & Compounds for INAFM1 Gene

No Compound Related Data Available

Transcripts for INAFM1 Gene

mRNA/cDNA for INAFM1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for INAFM1

Clone Products

  • Applied Biological Materials (abm): Clones for INAFM1 - Now 50% OFF >
  • * INAFM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * INAFM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for INAFM1 Gene

No ASD Table

Relevant External Links for INAFM1 Gene

GeneLoc Exon Structure for
INAFM1
ECgene alternative splicing isoforms for
INAFM1

Expression for INAFM1 Gene

Protein differential expression in normal tissues from HIPED for INAFM1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for INAFM1 Gene



Protein tissue co-expression partners for INAFM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of INAFM1 Gene:

INAFM1

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for INAFM1 Gene

Orthologs for INAFM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for INAFM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRR24 35 34
  • 98.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PRR24 34
  • 84.98 (n)
rat
(Rattus norvegicus)
Mammalia Prr24 34
  • 72.66 (n)
mouse
(Mus musculus)
Mammalia Prr24 35 34
  • 69.74 (n)
OneToOne
Inafm1 17
Species where no ortholog for INAFM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for INAFM1 Gene

ENSEMBL:
Gene Tree for INAFM1 (if available)
TreeFam:
Gene Tree for INAFM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INAFM1: view image

Paralogs for INAFM1 Gene

No data available for Paralogs for INAFM1 Gene

Variants for INAFM1 Gene

Sequence variations from dbSNP and Humsavar for INAFM1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000820712 -- 47,275,085(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000936321 -- 47,275,179(+) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1001696872 -- 47,273,166(+) T/C upstream_transcript_variant
rs1001992971 -- 47,274,064(+) C/T upstream_transcript_variant
rs1002369923 -- 47,274,470(+) T/G genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for INAFM1 Gene

Variant ID Type Subtype PubMed ID
esv3893225 CNV loss 25118596
nsv1059583 CNV loss 25217958
nsv1067417 CNV gain 25217958
nsv1071542 CNV deletion 25765185
nsv1143920 CNV deletion 24896259
nsv833852 CNV loss 17160897

Variation tolerance for INAFM1 Gene

Gene Damage Index Score: 7.06; 80.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INAFM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INAFM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for INAFM1 Gene

Disorders for INAFM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for INAFM1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
severe cutaneous adverse reaction
  • sjs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for INAFM1

genes like me logo Genes that share disorders with INAFM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for INAFM1 Gene

Publications for INAFM1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for INAFM1 Gene

Sources for INAFM1 Gene

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