Aliases for IMPDH2 Gene
External Ids for IMPDH2 Gene
Previous GeneCards Identifiers for IMPDH2 Gene
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
GeneCards Summary for IMPDH2 Gene
IMPDH2 (Inosine Monophosphate Dehydrogenase 2) is a Protein Coding gene. Diseases associated with IMPDH2 include Bartter Syndrome, Type 3 and Argentine Hemorrhagic Fever. Among its related pathways are Innate Immune System and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include RNA binding and oxidoreductase activity. An important paralog of this gene is IMPDH1.
UniProtKB/Swiss-Prot for IMPDH2 Gene
Catalyzes the conversion of inosine 5-phosphate (IMP) to xanthosine 5-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.