Aliases for IMPDH2 Gene
External Ids for IMPDH2 Gene
Previous GeneCards Identifiers for IMPDH2 Gene
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
GeneCards Summary for IMPDH2 Gene
IMPDH2 (Inosine Monophosphate Dehydrogenase 2) is a Protein Coding gene. Diseases associated with IMPDH2 include Impdh2 Enzyme Activity, Variation In and Retinitis Pigmentosa. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include RNA binding and oxidoreductase activity. An important paralog of this gene is IMPDH1.
UniProtKB/Swiss-Prot Summary for IMPDH2 Gene
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.