Aliases for IMPA2 Gene
External Ids for IMPA2 Gene
Previous GeneCards Identifiers for IMPA2 Gene
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
GeneCards Summary for IMPA2 Gene
IMPA2 (Inositol Monophosphatase 2) is a Protein Coding gene. Diseases associated with IMPA2 include Bipolar Disorder and Febrile Seizures. Among its related pathways are Inositol phosphate metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and inositol monophosphate 3-phosphatase activity. An important paralog of this gene is IMPA1.
UniProtKB/Swiss-Prot Summary for IMPA2 Gene
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.