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Aliases for IMPA2 Gene

Aliases for IMPA2 Gene

  • Inositol Monophosphatase 2 2 3 3 5
  • Inositol(Myo)-1(Or 4)-Monophosphatase 2 2 3
  • Myo-Inositol Monophosphatase A2 3 4
  • Myo-Inositol Monophosphatase 2 2 3
  • IMPase 2 3 4
  • IMP 2 3 4
  • Inositol Monophosphatase 2 Variant 1 3
  • Inositol Monophosphatase 2 Variant 2 3
  • Inositol-1(Or 4)-Monophosphatase 2 4
  • Inosine Monophosphatase 2 3
  • EC 4
  • IMP.18P 4

External Ids for IMPA2 Gene

Previous GeneCards Identifiers for IMPA2 Gene

  • GC18P012247
  • GC18P012038
  • GC18P011971

Summaries for IMPA2 Gene

Entrez Gene Summary for IMPA2 Gene

  • This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

GeneCards Summary for IMPA2 Gene

IMPA2 (Inositol Monophosphatase 2) is a Protein Coding gene. Diseases associated with IMPA2 include Bipolar Disorder and Febrile Seizures. Among its related pathways are Inositol phosphate metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and inositol monophosphate 3-phosphatase activity. An important paralog of this gene is IMPA1.

UniProtKB/Swiss-Prot for IMPA2 Gene

  • Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.

Gene Wiki entry for IMPA2 Gene

Additional gene information for IMPA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IMPA2 Gene

Genomics for IMPA2 Gene

GeneHancer (GH) Regulatory Elements for IMPA2 Gene

Promoters and enhancers for IMPA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J011976 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 664 -0.7 -707 7.9 SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 IMPA2 MPPE1 PTPN2 PSMG2 ENSG00000267249 GC18P012646
GH18J012038 Enhancer 1.4 Ensembl ENCODE dbSUPER 23.4 +57.9 57873 1.6 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF213 ARID2 ZNF143 ATF7 ENSG00000266995 IMPA2 ENSG00000267733 MPPE1 CHMP1B ENSG00000267480 ENSG00000267247
GH18J012007 Enhancer 1.2 ENCODE dbSUPER 21.3 +30.1 30087 6.5 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 ZNF121 NFKBIZ IMPA2 MPPE1 CHMP1B ENSG00000267733 LOC101927511 ENSG00000266955 ENSG00000267480
GH18J011907 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.6 -72.3 -72259 2.9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 MPPE1 ENSG00000273141 IMPA2 CHMP1B PSMG2
GH18J011953 Enhancer 1.1 Ensembl ENCODE 19.4 -24.8 -24776 4.7 FOXA2 ARNT ARID4B ZNF48 ZNF280A CBX5 ZNF143 FOS ATF7 SP5 IMPA2 MPPE1 CHMP1B LOC101927511 GC18P012646
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IMPA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IMPA2 gene promoter:
  • N-Myc
  • Arnt
  • Zic1
  • ZIC2
  • HOXA3
  • LyF-1
  • TBP
  • C/EBPalpha

Genomic Locations for IMPA2 Gene

Genomic Locations for IMPA2 Gene
49,862 bases
Plus strand
49,862 bases
Plus strand

Genomic View for IMPA2 Gene

Genes around IMPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IMPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IMPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IMPA2 Gene

Proteins for IMPA2 Gene

  • Protein details for IMPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inositol monophosphatase 2
    Protein Accession:
    Secondary Accessions:
    • B0YJ29
    • Q9UJT3

    Protein attributes for IMPA2 Gene

    288 amino acids
    Molecular mass:
    31321 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IMPA2 Gene

    Alternative splice isoforms for IMPA2 Gene


neXtProt entry for IMPA2 Gene

Post-translational modifications for IMPA2 Gene

  • Ubiquitination at Lys184
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IMPA2 Gene

Domains & Families for IMPA2 Gene

Gene Families for IMPA2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol monophosphatase superfamily.
  • Belongs to the inositol monophosphatase superfamily.
genes like me logo Genes that share domains with IMPA2: view

Function for IMPA2 Gene

Molecular function for IMPA2 Gene

UniProtKB/Swiss-Prot Function:
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
UniProtKB/Swiss-Prot CatalyticActivity:
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by high Li(+) and restricted Mg(2+) concentrations.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 mM for myo-inositol 1-monophosphate {ECO:0000269 PubMed:17068342}; pH dependence: Optimum pH is 7.5-8.0. {ECO:0000269 PubMed:17068342};
UniProtKB/Swiss-Prot Induction:
Repressed by Li(+).
GENATLAS Biochemistry:
inositol(myo)-1(or 4)-monophosphatase 2,widely expressed in adult and fetal tissues but minimally in brain

Enzyme Numbers (IUBMB) for IMPA2 Gene

Phenotypes From GWAS Catalog for IMPA2 Gene

Gene Ontology (GO) - Molecular Function for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008934 inositol monophosphate 1-phosphatase activity TAS --
GO:0016787 hydrolase activity IEA --
GO:0042803 protein homodimerization activity IDA 17068342
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with IMPA2: view
genes like me logo Genes that share phenotypes with IMPA2: view

Animal Models for IMPA2 Gene

MGI Knock Outs for IMPA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for IMPA2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IMPA2 Gene

Localization for IMPA2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IMPA2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17068342
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IMPA2 Gene

Pathways & Interactions for IMPA2 Gene

genes like me logo Genes that share pathways with IMPA2: view

UniProtKB/Swiss-Prot O14732-IMPA2_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Gene Ontology (GO) - Biological Process for IMPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006020 inositol metabolic process IBA --
GO:0006021 inositol biosynthetic process IEA --
GO:0006796 phosphate-containing compound metabolic process TAS 9322233
GO:0007165 signal transduction TAS 9322233
GO:0043647 inositol phosphate metabolic process TAS --
genes like me logo Genes that share ontologies with IMPA2: view

No data available for SIGNOR curated interactions for IMPA2 Gene

Drugs & Compounds for IMPA2 Gene

(6) Drugs for IMPA2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma Target, inhibitor 0
Inositol Approved, Investigational, Withdrawn Nutra 91
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Magnesium Approved Nutra 0

(6) Additional Compounds for IMPA2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1D-myo-Inositol 3-phosphate
  • 1D-myo-Inositol 3-monophosphate
  • 1l-myo-Inositol 1-phosphate
  • D-myo-Inositol 3-monophosphate
  • D-myo-Inositol 3-phosphate
  • Inositol 3-monophosphate
D-Myo-inositol 4-phosphate
  • 1D-myo-Inositol 4-monophosphate
  • 1D-myo-Inositol 4-monophosphoric acid
  • D-myo-Inositol 4-phosphoric acid
  • 1D-myo-Inositol 4-phosphate
  • D-myo-Inositol-4-phosphate
Inositol phosphate
  • D-myo-Inositol (6)-monophosphate
  • D-myo-Inositol (6)-phosphate
  • I6P
  • Ins(6)P
  • Ins6p
Myo-inositol 1-phosphate
  • 1D-myo-Inositol 3-monophosphate
  • 1l-myo-Inositol 1-phosphate
  • D-myo-Inositol 3-monophosphate
  • D-myo-Inositol 3-phosphate
  • Inositol 3-phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with IMPA2: view

Transcripts for IMPA2 Gene

mRNA/cDNA for IMPA2 Gene

Unigene Clusters for IMPA2 Gene

Inositol(myo)-1(or 4)-monophosphatase 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IMPA2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -

Relevant External Links for IMPA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IMPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IMPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IMPA2 Gene

This gene is overexpressed in Pancreas (x7.0), Muscle - Skeletal (x5.8), and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for IMPA2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.7), Tonsil (11.3), Oral epithelium (6.9), and Pancreas (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IMPA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IMPA2 Gene:


SOURCE GeneReport for Unigene cluster for IMPA2 Gene:


Evidence on tissue expression from TISSUES for IMPA2 Gene

  • Skin(4.4)
  • Kidney(2.5)
  • Muscle(2.3)
  • Pancreas(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with IMPA2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IMPA2 Gene

Orthologs for IMPA2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IMPA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IMPA2 34 33
  • 99.42 (n)
(Canis familiaris)
Mammalia IMPA2 34 33
  • 88.98 (n)
(Rattus norvegicus)
Mammalia Impa2 33
  • 88.08 (n)
(Mus musculus)
Mammalia Impa2 16 34 33
  • 87.38 (n)
(Ornithorhynchus anatinus)
Mammalia IMPA2 34
  • 86 (a)
(Monodelphis domestica)
Mammalia IMPA2 34
  • 85 (a)
(Bos Taurus)
Mammalia IMPA2 34 33
  • 82.75 (n)
(Gallus gallus)
Aves IMPA2 34 33
  • 77.2 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia impa2 33
  • 71.48 (n)
Str.15017 33
(Danio rerio)
Actinopterygii impa2 34 33
  • 65.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9389 35 33
  • 51.44 (n)
CG9391 35
  • 46 (a)
CG17028 34
  • 34 (a)
CG17029 34 35
  • 33 (a)
CG17027 34 35
  • 32 (a)
CG17026 34 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea F13G3.5 35
  • 43 (a)
ttx-7 34
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INM1 34
  • 27 (a)
INM2 34
  • 27 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06022 33
  • 49.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for IMPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IMPA2 Gene

Gene Tree for IMPA2 (if available)
Gene Tree for IMPA2 (if available)
Evolutionary constrained regions (ECRs) for IMPA2: view image

Paralogs for IMPA2 Gene

Paralogs for IMPA2 Gene

(1) SIMAP similar genes for IMPA2 Gene using alignment to 13 proteins:

  • K7EL65_HUMAN
genes like me logo Genes that share paralogs with IMPA2: view

Variants for IMPA2 Gene

Sequence variations from dbSNP and Humsavar for IMPA2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000050585 -- 12,029,389(+) C/T intron_variant
rs1000221246 -- 12,028,241(+) A/C intron_variant
rs1000222223 -- 11,997,396(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000236548 -- 12,021,708(+) G/A intron_variant
rs1000268738 -- 11,982,844(+) T/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IMPA2 Gene

Variant ID Type Subtype PubMed ID
esv2663207 CNV deletion 23128226
esv2758713 CNV loss 17122850
esv3641826 CNV loss 21293372
esv3893075 CNV gain 25118596
esv9600 CNV gain 19470904
nsv1071430 CNV deletion 25765185
nsv1129331 OTHER inversion 24896259
nsv1153637 OTHER inversion 26484159
nsv528699 CNV loss 19592680
nsv576495 CNV loss 21841781

Variation tolerance for IMPA2 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IMPA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA2 Gene

Disorders for IMPA2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IMPA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bipolar disorder
  • major affective disorder 1
febrile seizures
  • seizures febrile
mood disorder
  • episodic mood disorder
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search IMPA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IMPA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IMPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IMPA2 Gene

Publications for IMPA2 Gene

  1. Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T … Yoshikawa T (The Journal of biological chemistry 2007) 3 4 22 25 58
  2. A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. (PMID: 9322233) Yoshikawa T … Detera-Wadleigh SD (Molecular psychiatry 1997) 2 3 4 22 58
  3. A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription. (PMID: 17251911) Ohnishi T … Yoshikawa T (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007) 3 22 25 58
  4. Genetic variants in the IMPA2 gene do not confer increased risk of febrile seizures in Caucasian patients. (PMID: 17388992) Blair MA … Hedera P (European journal of neurology 2007) 3 22 44 58
  5. Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures. (PMID: 17340635) Arai R … Yokoyama S (Proteins 2007) 3 4 22 58

Products for IMPA2 Gene

Sources for IMPA2 Gene

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