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This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-ino... See more...
Aliases for IMPA1 Gene
Aliases for IMPA1 Gene
External Ids for IMPA1 Gene
- HGNC: 6050
- Entrez Gene: 3612
- Ensembl: ENSG00000133731
- OMIM: 602064
- UniProtKB: P29218
Previous HGNC Symbols for IMPA1 Gene
- IMPA
Previous GeneCards Identifiers for IMPA1 Gene
- GC08M081447
- GC08M082618
- GC08M082293
- GC08M082620
- GC08M082732
- GC08M082569
- GC08M078058
Summaries for IMPA1 Gene
-
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
GeneCards Summary for IMPA1 Gene
IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. Diseases associated with IMPA1 include Mental Retardation, Autosomal Recessive 59 and Bipolar Disorder. Among its related pathways are Inositol phosphate metabolism (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and magnesium ion binding. An important paralog of this gene is IMPA2.
UniProtKB/Swiss-Prot Summary for IMPA1 Gene
-
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Additional gene information for IMPA1 Gene
- HGNC(6050)
- Entrez Gene(3612)
- Ensembl(ENSG00000133731)
- OMIM(602064)
- UniProtKB(P29218)
- Open Targets Platform(ENSG00000133731)
- Monarch Initiative
- Search for IMPA1 at DataMed
- Search for IMPA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IMPA1 Gene
Genomics for IMPA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IMPA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IMPA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IMPA1
- Top Transcription factor binding sites by QIAGEN in the IMPA1 gene promoter:
-
- c-Rel
- Egr-4
- Evi-1
- Hlf
- NRF-2
- POU2F1
- POU2F1a
- RORalpha1
- TBP
- TFIID
Genomic Locations for IMPA1 Gene
Genomic Locations for IMPA1 Gene
- chr8:81,656,914-81,686,354
- (GRCh38/hg38)
- Size:
- 29,441 bases
- Orientation:
- Minus strand
- chr8:82,569,151-82,598,928
- (GRCh37/hg19)
- Size:
- 29,778 bases
- Orientation:
- Minus strand
Genomic View for IMPA1 Gene
Genes around IMPA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q21.13 by HGNC
- 8q21.13 by Entrez Gene
- 8q21.13 by Ensembl
IMPA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IMPA1 Gene
Proteins for IMPA1 Gene
-
Protein details for IMPA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P29218-IMPA1_HUMAN
- Recommended name:
- Inositol monophosphatase 1
- Protein Accession:
- P29218
- B2R733
- B4DLN3
- B7Z6Q4
- J3KQT7
- Q9UK71
Protein attributes for IMPA1 Gene
- Size:
- 277 amino acids
- Molecular mass:
- 30189 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Homodimer.
Three dimensional structures from OCA and Proteopedia for IMPA1 Gene
Protein Expression for IMPA1 Gene
Selected DME Specific Peptides for IMPA1 Gene
- P29218:
-
- IIVTEAGGV
- DGTTNFVH
- NFVHRFP
- VGTAAVNMCLVATGGADAYYEMG
- GAFCNGQ
- FIGEESVA
- EFGVVYSC
Post-translational modifications for IMPA1 Gene
Other Protein References for IMPA1 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for IMPA1
- Novus Biologicals Antibodies for IMPA1
-
Abcam antibodies for IMPA1
- Invitrogen Antibodies for IMPA1 (AFLGC-Impa1)
-
Boster Bio Antibodies for IMPA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IMPA1
- Sino Biological Antibodies for IMPA1
Protein Products
- G Biosciences Human IMP1/IMPA1, Liquid
- Search Origene for MassSpec and Protein Over-expression Lysates for IMPA1
- Origene Custom Protein Services for IMPA1
- Sino Biological Recombinant Proteins for IMPA1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IMPA1
-
ProSci Proteins for IMPA1
-
Abcam proteins for IMPA1
Assay Products
- antibodies-online: Show 9 available IMPA1 Elisa Kits ranked by validation data
- Compare Top IMPA1 Elisa Kits
-
Quality Products:
Domains & Families for IMPA1 Gene
Gene Families for IMPA1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for IMPA1 Gene
- InterPro:
- Blocks:
-
- Inositol phosphatase/fructose-1,6-bisphosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for IMPA1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58981, highly similar to Inositol monophosphatase (EC 3.1.3.25) (B4DLN3_HUMAN)
- Lithium-sensitive myo-inositol monophosphatase A1 (IMPA1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P29218- Family:
-
- Belongs to the inositol monophosphatase superfamily.
Function for IMPA1 Gene
Molecular function for IMPA1 Gene
- UniProtKB/Swiss-Prot Function:
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence={ECO:0000269|PubMed:1377913, ECO:0000269|PubMed:8068620, ECO:0000269|PubMed:8718889, ECO:0000269|PubMed:9462881};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=alpha-D-galactose 1-phosphate + H2O = D-galactose + phosphate; Xref=Rhea:RHEA:29315, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58336; EC=3.1.3.94; Evidence={ECO:0000269|PubMed:9462881};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=42 uM for D-myo-inositol 1-phosphate {ECO:0000269|PubMed:8068620}; KM=62 uM for L-myo-inositol 1-phosphate {ECO:0000269|PubMed:8068620}; pH dependence: Optimum pH is 7.0-7.5. {ECO:0000269|PubMed:17068342};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
- GENATLAS Biochemistry:
- myo-inositol monophosphatase 1,putatively involved in response to lithium treatment
Enzyme Numbers (IUBMB) for IMPA1 Gene
Phenotypes From GWAS Catalog for IMPA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000287 | magnesium ion binding | IDA | 9462881 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008934 | inositol monophosphate 1-phosphatase activity | IEA,IMP | 1377913 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0030145 | manganese ion binding | IDA | 9462881 |
Phenotypes for IMPA1 Gene
- MGI mutant phenotypes for IMPA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IMPA1:
Animal Models for IMPA1 Gene
- MGI Knock Outs for IMPA1:
-
- Impa1 Impa1<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for IMPA1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IMPA1 - Select products 50% OFF >
- * IMPA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IMPA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IMPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IMPA1
miRNA for IMPA1 Gene
- miRTarBase miRNAs that target IMPA1
-
- hsa-miR-34a-5p (MIRT006254)
- mmu-miR-340-5p (MIRT010537)
- mmu-miR-9-5p (MIRT015498)
- hsa-miR-132-3p (MIRT021823)
- hsa-miR-215-5p (MIRT024884)
- hsa-miR-192-5p (MIRT026629)
- hsa-miR-365a-3p (MIRT044020)
- hsa-miR-27a-3p (MIRT050020)
- hsa-miR-6504-3p (MIRT124241)
- hsa-miR-548aw (MIRT517923)
- hsa-miR-6807-5p (MIRT517924)
- hsa-miR-7151-3p (MIRT517925)
- hsa-miR-5095 (MIRT517926)
- hsa-miR-4252 (MIRT517927)
- hsa-miR-1468-3p (MIRT517928)
- hsa-miR-548x-5p (MIRT517929)
- hsa-miR-548g-5p (MIRT517930)
- hsa-miR-548f-5p (MIRT517931)
- hsa-miR-548aj-5p (MIRT517932)
- hsa-miR-6889-3p (MIRT517933)
- hsa-miR-4438 (MIRT517934)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IMPA1
- Browse OriGene Inhibitory RNA Products For IMPA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IMPA1
Clone Products
- Applied Biological Materials (abm): Clones for IMPA1 - Select products 50% OFF >
- * IMPA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203703
- MG203735
- MR203703
- MR203703L3
- MR203703L4
- MR203735
- MR203735L3
- MR203735L4
- RC202784
- RC202784L3
- RC202784L4
- RC227545
- RC227545L3
- RC227545L4
- RC227552
- RC227552L3
- RC227552L4
- RG202784
- RG227545
- RG227552
- RR208568
- RR208568L3
- RR208568L4
- MR203703L3V
- MR203703L4V
- MR203735L3V
- MR203735L4V
- RC202784L3V
- RC202784L4V
- RC227545L3V
- RC227545L4V
- RC227552L3V
- RC227552L4V
- RR208568L3V
- RR208568L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IMPA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IMPA1
Cell Line Products
-
Horizon Cell Lines for IMPA1
No data available for Transcription Factor Targets and HOMER Transcription for IMPA1 Gene
Localization for IMPA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IMPA1 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| mitochondrion | 4 |
| nucleus | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 1377913 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for IMPA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inositol phosphate metabolism (KEGG) | ||
| 2 | Inositol phosphate metabolism (REACTOME) | ||
| 3 | Metabolism |
.40
|
|
| 4 | MAPK Erk Pathway |
.32
|
|
| 5 | Integrated Breast Cancer Pathway | ||
Pathways by source for IMPA1 Gene
2 Sino Biological pathways for IMPA1 Gene
3 Reactome pathways for IMPA1 Gene
3 KEGG pathways for IMPA1 Gene
UniProtKB/Swiss-Prot P29218-IMPA1_HUMAN
- Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Interacting Proteins for IMPA1 Gene
Selected Interacting proteins:
P29218-IMPA1_HUMAN
ENSP00000408526
for IMPA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IMPA1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006020 | inositol metabolic process | IBA | 21873635 |
| GO:0006021 | inositol biosynthetic process | IEA | -- |
| GO:0006661 | phosphatidylinositol biosynthetic process | IMP | 1377913 |
| GO:0006796 | phosphate-containing compound metabolic process | IMP | 1377913 |
| GO:0007165 | signal transduction | IBA,IMP | 1377913 |
No data available for SIGNOR curated interactions for IMPA1 Gene
Drugs & Compounds for IMPA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Inositol | Approved, Investigational, Withdrawn | Pharma | 110 | |||
| Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
| Lithium carbonate | Approved | Pharma | Target | Mood stabilizer; inhibits Na+/K+ ATPase pump activity | 301 | |
| Lithium citrate | Approved | Pharma | Target | 0 | ||
| Phosphoric acid | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1D-myo-Inositol 3-phosphate |
|
2831-74-5 |
|
|||
| D-Myo-inositol 4-phosphate |
|
46495-39-0 |
|
|
||
| Inositol phosphate |
|
15421-51-9 |
|
|
||
| Myo-inositol 1-phosphate |
|
573-35-3 |
|
|
||
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
(2) ApexBio Compounds for IMPA1 Gene
Transcripts for IMPA1 Gene
mRNA/cDNA for IMPA1 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000256108 3369 nts (view in UCSC)
- ENST00000311489 1106 nts (view in UCSC)
- ENST00000449740 1180 nts (view in UCSC)
- ENST00000518188 773 nts (view in UCSC)
- ENST00000518202 627 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IMPA1 - Select products 50% OFF >
- * IMPA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IMPA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IMPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IMPA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IMPA1
- Browse OriGene Inhibitory RNA Products For IMPA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IMPA1
Clone Products
- Applied Biological Materials (abm): Clones for IMPA1 - Select products 50% OFF >
- * IMPA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203703
- MG203735
- MR203703
- MR203703L3
- MR203703L4
- MR203735
- MR203735L3
- MR203735L4
- RC202784
- RC202784L3
- RC202784L4
- RC227545
- RC227545L3
- RC227545L4
- RC227552
- RC227552L3
- RC227552L4
- RG202784
- RG227545
- RG227552
- RR208568
- RR208568L3
- RR208568L4
- MR203703L3V
- MR203703L4V
- MR203735L3V
- MR203735L4V
- RC202784L3V
- RC202784L4V
- RC227545L3V
- RC227545L4V
- RC227552L3V
- RC227552L4V
- RR208568L3V
- RR208568L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IMPA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IMPA1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: |
Relevant External Links for IMPA1 Gene
- GeneLoc Exon Structure for
- IMPA1
Expression for IMPA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IMPA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IMPA1
SOURCE GeneReport for Unigene cluster for IMPA1 Gene:
Hs.656694Evidence on tissue expression from TISSUES for IMPA1 Gene
- Nervous system(4.9)
- Blood(4.5)
- Kidney(2.3)
- Muscle(2.3)
- Heart(2.2)
Primer Products
-
OriGene qPCR primer pairs for IMPA1
-
OriGene qPCR primer pairs and template standards for IMPA1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IMPA1 Gene
Orthologs for IMPA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | LOC100613673 30 |
|
||
| IMPA1 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | IMPA1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IMPA1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Impa1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Impa1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IMPA1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IMPA1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IMPA1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IMPA1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | impa1 30 |
|
||
| Str.15926 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | impa1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | impa1 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9875 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9391 30 31 32 |
|
ManyToMany | |
| CG17026 31 32 |
|
ManyToMany | |||
| CG17027 31 32 |
|
ManyToMany | |||
| CG17029 31 32 |
|
ManyToMany | |||
| CG17028 31 |
|
ManyToMany | |||
| CG9389 31 32 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006570 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | ttx-7 30 31 |
|
OneToMany | |
| F13G3.5 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | INM2 30 31 33 |
|
ManyToMany | |
| INM1 31 |
|
ManyToMany | |||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | VTC4 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0587000 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06348 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11400 30 |
|
- Species where no ortholog for IMPA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for IMPA1 Gene
- ENSEMBL:
- Gene Tree for IMPA1 (if available)
- TreeFam:
- Gene Tree for IMPA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IMPA1: view image
Paralogs for IMPA1 Gene
(21) SIMAP similar genes for IMPA1 Gene using alignment to 9 proteins:
- IMPA1_HUMAN
- E5RG13_HUMAN
- E5RG94_HUMAN
- E5RGY4_HUMAN
- E5RHE9_HUMAN
- E5RI82_HUMAN
- E5RIF4_HUMAN
- E5RIP7_HUMAN
- H0YBL1_HUMAN
Pseudogenes.org Pseudogenes for IMPA1 Gene
Variants for IMPA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IMPA1 Gene
| SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 713363 | Likely Benign: not provided | 81,680,732(-) | G/A | MISSENSE_VARIANT | |
| 716533 | Benign: not provided | 81,676,288(-) | A/T | INTRON_VARIANT | |
| 764254 | Likely Benign: not provided | 81,679,182(-) | G/T | SYNONYMOUS_VARIANT | |
| 780760 | Benign: not provided | 81,685,828(-) | T/C | MISSENSE_VARIANT,INTRON_VARIANT | |
| rs1057519491 | Pathogenic: Mental retardation, autosomal recessive 59 | 81,671,011(-) | G/GAGCCC | FRAMESHIFT_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1774004 | CNV | insertion | 17803354 |
| esv2665097 | CNV | deletion | 23128226 |
| esv2737230 | CNV | deletion | 23290073 |
| esv3572858 | CNV | loss | 25503493 |
| nsv1117492 | CNV | tandem duplication | 24896259 |
| nsv1120564 | CNV | tandem duplication | 24896259 |
| nsv1132974 | CNV | insertion | 24896259 |
| nsv1140913 | CNV | deletion | 24896259 |
| nsv1141590 | CNV | duplication | 24896259 |
| nsv1142033 | OTHER | inversion | 24896259 |
| nsv1146710 | CNV | insertion | 26484159 |
| nsv465721 | CNV | gain | 19166990 |
| nsv611607 | CNV | gain | 21841781 |
| nsv831368 | CNV | gain | 17160897 |
| nsv831369 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
53.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.72;
32.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IMPA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IMPA1 Gene
Disorders for IMPA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation, autosomal recessive 59 |
|
|
| bipolar disorder |
|
|
| mood disorder |
|
|
| tooth resorption |
|
|
| gingival recession |
|
|
Search IMPA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IMPA1_HUMAN- Mental retardation, autosomal recessive 59 (MRT59) [MIM:617323]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT59 transmission pattern is consistent with autosomal recessive inheritance. {ECO:0000269 PubMed:26416544}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IMPA1
No data available for Genatlas for IMPA1 Gene
Publications for IMPA1 Gene
- Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. (PMID: 17068342) Ohnishi T … Yoshikawa T (The Journal of biological chemistry 2007) 3 4 23 26
- cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. (PMID: 1377913) McAllister G … Ragan CI (The Biochemical journal 1992) 2 3 4 23
- Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). (PMID: 9339367) Sjøholt G … Steen VM (Genomics 1997) 3 4 23
- Brain inositol monophosphatase identified as a galactose 1-phosphatase. (PMID: 9462881) Parthasarathy R … Vadnal R (Brain research 1997) 3 4 23
- Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis. (PMID: 8068621) Bone R … Atack JR (Biochemistry 1994) 3 4 23
ExternalLinks
Products for IMPA1 Gene
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Sources for IMPA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
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- (36) Pseudogene
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- (67) Reactome
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