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This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
IMP3 (IMP U3 Small Nucleolar Ribonucleoprotein 3) is a Protein Coding gene. Diseases associated with IMP3 include Progressive Myoclonus Epilepsy 9 and Corneal Dystrophy, Subepithelial Mucinous. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 12655004 |
GO:0019843 | rRNA binding | IEA | -- |
GO:0030515 | snoRNA binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IEA,IDA | 12655004 |
GO:0030684 | preribosome | IDA | 12655004 |
GO:0032040 | small-subunit processome | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | rRNA processing in the nucleus and cytosol |
.89
|
|
2 | MAPK Erk Pathway |
.32
|
|
3 | Ribosome biogenesis in eukaryotes | ||
4 | Gene Expression |
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006364 | rRNA processing | IBA,TAS | -- |
GO:0042254 | ribosome biogenesis | IEA | -- |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IMP3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IMP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IMP3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Imp3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Imp3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IMP3 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IMP3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | imp3 30 |
|
||
Str.17594 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.10835 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | imp3 30 31 |
|
OneToOne | |
zgc56526 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP006372 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4866 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | C48B6.2 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADL131C 30 |
|
||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E15995g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IMP3 30 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G15750 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.5075 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.3731 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os04g0662100 30 |
|
||
Os.15267 30 |
|
||||
Wheat (Triticum aestivum) |
Liliopsida | Ta.13412 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.3908 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.54 31 |
|
OneToOne | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU01008 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | imp3 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2749894 | CNV | deletion | 23290073 |
esv2749895 | CNV | deletion | 23290073 |
nsv1116463 | OTHER | inversion | 24896259 |
nsv527186 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
progressive myoclonus epilepsy 9 |
|
|
corneal dystrophy, subepithelial mucinous |
|
|