Aliases for IMMP1L Gene
External Ids for IMMP1L Gene
Previous HGNC Symbols for IMMP1L Gene
Previous GeneCards Identifiers for IMMP1L Gene
The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 and IMP2 (IMMP2L; MIM 605977) are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM, Sep 2008]
GeneCards Summary for IMMP1L Gene
IMMP1L (Inner Mitochondrial Membrane Peptidase Subunit 1) is a Protein Coding gene. Diseases associated with IMMP1L include Gillespie Syndrome and Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome. Among its related pathways are Protein export. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity. An important paralog of this gene is IMMP2L.
UniProtKB/Swiss-Prot Summary for IMMP1L Gene
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.