Aliases for ILRUN Gene

Aliases for ILRUN Gene

  • Inflammation And Lipid Regulator With UBA-Like And NBR1-Like Domains 2 3 5
  • Inflammation And Lipid Regulator With UBA-Like And NBR1-Like Domains Protein 3 4
  • Protein ILRUN 3 4
  • C6orf106 3 4
  • Chromosome 6 Open Reading Frame 106 2
  • Uncharacterized Protein C6orf106 3
  • DJ391O22.4 3
  • FP852 3

External Ids for ILRUN Gene

Previous HGNC Symbols for ILRUN Gene

  • C6orf106

Previous GeneCards Identifiers for ILRUN Gene

  • GC06M038987
  • GC06M039809
  • GC06M040092

Summaries for ILRUN Gene

GeneCards Summary for ILRUN Gene

ILRUN (Inflammation And Lipid Regulator With UBA-Like And NBR1-Like Domains) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ILRUN Gene

  • Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).

Additional gene information for ILRUN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ILRUN Gene

Genomics for ILRUN Gene

GeneHancer (GH) Regulatory Elements for ILRUN Gene

Promoters and enhancers for ILRUN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ILRUN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ILRUN

Genomic Locations for ILRUN Gene

Genomic Locations for ILRUN Gene
chr6:34,587,280-34,696,859
(GRCh38/hg38)
Size:
109,580 bases
Orientation:
Minus strand
chr6:34,555,065-34,664,636
(GRCh37/hg19)
Size:
109,572 bases
Orientation:
Minus strand

Genomic View for ILRUN Gene

Genes around ILRUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILRUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILRUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILRUN Gene

Proteins for ILRUN Gene

  • Protein details for ILRUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6K1-ILRUN_HUMAN
    Recommended name:
    Protein ILRUN
    Protein Accession:
    Q9H6K1
    Secondary Accessions:
    • B2R8K7
    • Q5VV77
    • Q96MG5
    • Q9BUR9

    Protein attributes for ILRUN Gene

    Size:
    298 amino acids
    Molecular mass:
    32872 Da
    Quaternary structure:
    • Interacts with IRF3; the interaction inhibits IRF3 binding to its DNA consensus sequence.

    Alternative splice isoforms for ILRUN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILRUN Gene

Post-translational modifications for ILRUN Gene

  • Ubiquitination at Lys15, Lys205, Lys218, Lys228, Lys240, and Lys287
  • Modification sites at PhosphoSitePlus

Other Protein References for ILRUN Gene

No data available for DME Specific Peptides for ILRUN Gene

Domains & Families for ILRUN Gene

Gene Families for ILRUN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ILRUN Gene

genes like me logo Genes that share domains with ILRUN: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ILRUN Gene

Function for ILRUN Gene

Molecular function for ILRUN Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199).
UniProtKB/Swiss-Prot Induction:
Expression is icreased in presence of dsRNA such as poly(I:C).

Phenotypes From GWAS Catalog for ILRUN Gene

Gene Ontology (GO) - Molecular Function for ILRUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 29802199
GO:0043130 ubiquitin binding IBA 21873635
genes like me logo Genes that share ontologies with ILRUN: view
genes like me logo Genes that share phenotypes with ILRUN: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ILRUN Gene

Localization for ILRUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILRUN Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILRUN gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytosol 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ILRUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 phagophore assembly site IBA 21873635
GO:0005634 nucleus IEA,IDA 29802199
GO:0005737 cytoplasm IEA,IDA 29802199
GO:0005776 autophagosome IBA 21873635
genes like me logo Genes that share ontologies with ILRUN: view

Pathways & Interactions for ILRUN Gene

PathCards logo

SuperPathways for ILRUN Gene

No Data Available

Interacting Proteins for ILRUN Gene

;

Gene Ontology (GO) - Biological Process for ILRUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0016236 macroautophagy IBA 21873635
GO:0032480 negative regulation of type I interferon production IMP 29802199
GO:0032720 negative regulation of tumor necrosis factor production IMP 29802199
GO:0043392 negative regulation of DNA binding IDA 29802199
genes like me logo Genes that share ontologies with ILRUN: view

No data available for Pathways by source and SIGNOR curated interactions for ILRUN Gene

Drugs & Compounds for ILRUN Gene

No Compound Related Data Available

Transcripts for ILRUN Gene

mRNA/cDNA for ILRUN Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILRUN Gene

No ASD Table

Relevant External Links for ILRUN Gene

GeneLoc Exon Structure for
ILRUN

Expression for ILRUN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ILRUN

SOURCE GeneReport for Unigene cluster for ILRUN Gene:

Hs.643498

mRNA Expression by UniProt/SwissProt for ILRUN Gene:

Q9H6K1-ILRUN_HUMAN
Tissue specificity: Expressed in lung (at protein level).

Evidence on tissue expression from TISSUES for ILRUN Gene

  • Muscle(4.3)
  • Nervous system(4)
  • Eye(2.7)
  • Skin(2.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILRUN Gene

Orthologs for ILRUN Gene

This gene was present in the common ancestor of animals.

Orthologs for ILRUN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6ORF106 31
  • 100 (a)
OneToOne
LOC463186 30
  • 100 (n)
dog
(Canis familiaris)
Mammalia C6orf106 31
  • 99 (a)
OneToOne
C12H6orf106 30
  • 97.02 (n)
cow
(Bos Taurus)
Mammalia C6ORF106 31
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia D17Wsu92e 31 30
  • 94.39 (n)
OneToOne
Ilrun 17
oppossum
(Monodelphis domestica)
Mammalia C6orf106 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C6orf106 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves C26H6ORF106 31 30
  • 86.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C6orf106 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c6orf106 30
  • 72.9 (n)
zebrafish
(Danio rerio)
Actinopterygii C6H6orf106 31
  • 81 (a)
OneToOne
zgc:101577 30
  • 76.6 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000469 30
  • 50.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5445 31
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36E6.2 31
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5611 31
  • 35 (a)
OneToOne
Species where no ortholog for ILRUN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILRUN Gene

ENSEMBL:
Gene Tree for ILRUN (if available)
TreeFam:
Gene Tree for ILRUN (if available)

Paralogs for ILRUN Gene

Pseudogenes.org Pseudogenes for ILRUN Gene

genes like me logo Genes that share paralogs with ILRUN: view

No data available for Paralogs for ILRUN Gene

Variants for ILRUN Gene

Additional dbSNP identifiers (rs#s) for ILRUN Gene

Structural Variations from Database of Genomic Variants (DGV) for ILRUN Gene

Variant ID Type Subtype PubMed ID
dgv5954n100 CNV gain 25217958
esv1078185 CNV insertion 17803354
esv2665867 CNV deletion 23128226
esv2759418 CNV gain 17122850
esv2763967 CNV gain 21179565
esv3608664 CNV gain 21293372
esv3608665 CNV gain 21293372
esv3608666 CNV loss 21293372
esv988873 CNV deletion 20482838
nsv1033534 CNV gain 25217958
nsv516578 CNV loss 19592680
nsv5255 CNV deletion 18451855
nsv7888 CNV loss 18304495
nsv818410 CNV gain 17921354
nsv823667 CNV gain 20364138
nsv830640 CNV loss 17160897
nsv981134 CNV duplication 23825009

Variation tolerance for ILRUN Gene

Residual Variation Intolerance Score: 34.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ILRUN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ILRUN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ILRUN Gene

Disorders for ILRUN Gene

Additional Disease Information for ILRUN

No disorders were found for ILRUN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ILRUN Gene

Publications for ILRUN Gene

  1. C6orf106 is a novel inhibitor of the interferon-regulatory factor 3-dependent innate antiviral response. (PMID: 29802199) Ambrose RL … Stewart CR (The Journal of biological chemistry 2018) 2 3 4 54
  2. C6orf106 enhances NSCLC cell invasion by upregulating vimentin, and downregulating E-cadherin and P120ctn. (PMID: 25736925) Zhang X … Wang E (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 2 3 4 54
  3. A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers. (PMID: 30252044) Zhang M … International FTD-Genomics Consortium (IFGC) (Brain : a journal of neurology 2018) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

No data available for Mastermind for ILRUN Gene

Products for ILRUN Gene

Sources for ILRUN Gene