This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor... See more...

Aliases for ILK Gene

Aliases for ILK Gene

  • Integrin Linked Kinase 2 3 5
  • 59 KDa Serine/Threonine-Protein Kinase 3 4
  • Integrin-Linked Protein Kinase 3 4
  • P59ILK 3 4
  • ILK-1 3 4
  • ILK-2 3 4
  • Epididymis Secretory Protein Li 28 3
  • Integrin-Linked Kinase-2 3
  • Integrin-Linked Kinase 2
  • EC 2.7.11.1 4
  • HEL-S-28 3
  • ILK1 4
  • ILK2 4
  • P59 3

External Ids for ILK Gene

Previous GeneCards Identifiers for ILK Gene

  • GC11P007367
  • GC11P007085
  • GC11P006584
  • GC11P006590
  • GC11P006560
  • GC11P006283

Summaries for ILK Gene

Entrez Gene Summary for ILK Gene

  • This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for ILK Gene

ILK (Integrin Linked Kinase) is a Protein Coding gene. Diseases associated with ILK include Focal Segmental Glomerulosclerosis and Hypermobile Ehlers-Danlos Syndrome. Among its related pathways are Endometrial cancer and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot Summary for ILK Gene

  • Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).

Gene Wiki entry for ILK Gene

Additional gene information for ILK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ILK Gene

Genomics for ILK Gene

GeneHancer (GH) Regulatory Elements for ILK Gene

Promoters and enhancers for ILK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ILK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ILK

Top Transcription factor binding sites by QIAGEN in the ILK gene promoter:
  • ATF-2
  • STAT3

Genomic Locations for ILK Gene

Genomic Locations for ILK Gene
chr11:6,603,708-6,610,874
(GRCh38/hg38)
Size:
7,167 bases
Orientation:
Plus strand
chr11:6,624,961-6,632,102
(GRCh37/hg19)
Size:
7,142 bases
Orientation:
Plus strand

Genomic View for ILK Gene

Genes around ILK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILK Gene

Proteins for ILK Gene

  • Protein details for ILK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13418-ILK_HUMAN
    Recommended name:
    Integrin-linked protein kinase
    Protein Accession:
    Q13418
    Secondary Accessions:
    • B7Z1I0
    • B7Z418
    • D3DQU0
    • P57043
    • Q68DZ3

    Protein attributes for ILK Gene

    Size:
    452 amino acids
    Molecular mass:
    51419 Da
    Quaternary structure:
    • Interacts with FERMT2 (By similarity). Interacts with the cytoplasmic domain of ITGB1. Could also interact with integrin ITGB2, ITGB3 and/or ITGB5. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with PARVA and PARVB; these compete for the same binding site. Interacts probably also with TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1. Interacts with LIMD2; leading to activate the protein kinase activity (PubMed:24590809).
    SequenceCaution:
    • Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originally thought to be distinct gene (ILK2) (PubMed:10871859).; Evidence={ECO:0000305 PubMed:10871859};

    Three dimensional structures from OCA and Proteopedia for ILK Gene

    Alternative splice isoforms for ILK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILK Gene

Post-translational modifications for ILK Gene

  • Autophosphorylated on serine residues.
  • Ubiquitination at Lys165, Lys191, and Lys85
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ILK Gene

Domains & Families for ILK Gene

Gene Families for ILK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ILK Gene

Suggested Antigen Peptide Sequences for ILK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53825, highly similar to Integrin-linked protein kinase 1 (EC 2.7.11.1) (B7Z1I0_HUMAN)
  • cDNA FLJ50979, moderately similar to Integrin-linked protein kinase (EC 2.7.11.1) (B7Z418_HUMAN)
  • p59ILK (ILK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13418

UniProtKB/Swiss-Prot:

ILK_HUMAN :
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • A PH-like domain is involved in phosphatidylinositol phosphate binding.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with ILK: view

Function for ILK Gene

Molecular function for ILK Gene

UniProtKB/Swiss-Prot Function:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK. The protein kinase activity is stimulated by LIMD2 (PubMed:24590809).
GENATLAS Biochemistry:
integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal transduction,overlapping TAF2H by its 3'end (divergently oriented)

Enzyme Numbers (IUBMB) for ILK Gene

Gene Ontology (GO) - Molecular Function for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 9366252
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 11331582
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ILK: view

Phenotypes for ILK Gene

MGI mutant phenotypes for ILK:
inferred from 13 alleles
GenomeRNAi human phenotypes for ILK:
genes like me logo Genes that share phenotypes with ILK: view

Animal Models for ILK Gene

MGI Knock Outs for ILK:
  • Ilk Ilk<tm1.1(KOMP)Vlcg>
  • Ilk Ilk<tm2Ref>
  • Ilk Ilk<tm1Ref>
  • Ilk Ilk<tm2Star>

Animal Model Products

  • Taconic Biosciences Mouse Models for ILK

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILK

Clone Products

  • Addgene plasmids for ILK

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILK Gene

Localization for ILK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILK Gene

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILK gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
cytoskeleton 4
extracellular 3
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Focal adhesion sites (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 colocalizes_with stress fiber IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ILK: view

Pathways & Interactions for ILK Gene

PathCards logo

SuperPathways for ILK Gene

SuperPathway Contained pathways
1 Cell junction organization
2 Focal Adhesion
3 Sertoli-Sertoli Cell Junction Dynamics
.38
.38
.36
4 Endometrial cancer
.44
5 Adhesion
genes like me logo Genes that share pathways with ILK: view

Pathways by source for ILK Gene

5 GeneGo (Thomson Reuters) pathways for ILK Gene
  • Cell adhesion PLAU signaling
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Cytoskeleton remodeling Reverse signaling by ephrin B
  • Development EGFR signaling pathway
  • Signal transduction PTEN pathway
5 Qiagen pathways for ILK Gene
  • Akt Signaling
  • Epithelial Tight Junctions
  • Germ Cell-Sertoli Cell Junction Dynamics
  • ILK Signaling
  • Sertoli-Sertoli Cell Junction Dynamics
1 Cell Signaling Technology pathway for ILK Gene

SIGNOR curated interactions for ILK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ILK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IMP 10637513
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0003151 outflow tract morphogenesis IEA --
genes like me logo Genes that share ontologies with ILK: view

Drugs & Compounds for ILK Gene

(13) Drugs for ILK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(15) Additional Compounds for ILK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ILK: view

Transcripts for ILK Gene

mRNA/cDNA for ILK Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILK

Clone Products

  • Addgene plasmids for ILK

Alternative Splicing Database (ASD) splice patterns (SP) for ILK Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: - - - -
SP12: -
SP13:
SP14: - - - - - -
SP15: -
SP16:

ExUns: 14a · 14b ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ILK Gene

GeneLoc Exon Structure for
ILK

Expression for ILK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ILK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ILK Gene

This gene is overexpressed in Platelet (15.1), Peripheral blood mononuclear cells (7.2), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ILK Gene



Protein tissue co-expression partners for ILK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ILK

SOURCE GeneReport for Unigene cluster for ILK Gene:

Hs.706355

mRNA Expression by UniProt/SwissProt for ILK Gene:

Q13418-ILK_HUMAN
Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Evidence on tissue expression from TISSUES for ILK Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Muscle(3.3)
  • Heart(3.1)
  • Lung(3.1)
  • Kidney(3)
  • Blood(2.6)
  • Skin(2.5)
  • Lymph node(2.4)
  • Eye(2.2)
  • Liver(2.2)
  • Pancreas(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with ILK: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILK Gene

Orthologs for ILK Gene

This gene was present in the common ancestor of animals.

Orthologs for ILK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ILK 31 30
  • 99.56 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ILK 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ILK 31 30
  • 94.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ILK 31 30
  • 93.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ilk 17 31 30
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Ilk 30
  • 91.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 3 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ILK 31 30
  • 80.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ILK 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ilk 30
  • 76.77 (n)
Str.1347 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5978 30
zebrafish
(Danio rerio)
Actinopterygii ilk 31 30
  • 77.29 (n)
OneToOne
zgc65842 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.222 30
fruit fly
(Drosophila melanogaster)
Insecta Ilk 31 32 30
  • 60.48 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006573 30
  • 60.33 (n)
worm
(Caenorhabditis elegans)
Secernentea pat-4 31 32 30
  • 57.85 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 62 (a)
OneToOne
Cin.11308 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11308 30
Species where no ortholog for ILK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILK Gene

ENSEMBL:
Gene Tree for ILK (if available)
TreeFam:
Gene Tree for ILK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ILK: view image

Paralogs for ILK Gene

(10) SIMAP similar genes for ILK Gene using alignment to 7 proteins:

  • ILK_HUMAN
  • B7Z1I0_HUMAN
  • B7Z418_HUMAN
  • E9PM54_HUMAN
  • E9PNR4_HUMAN
  • E9PQ27_HUMAN
  • E9PQ52_HUMAN
genes like me logo Genes that share paralogs with ILK: view

Variants for ILK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ILK Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
654152 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,610,558(+) C/T NONSENSE,THREE_PRIME_UTR_VARIANT
656354 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,608,192(+) A/T MISSENSE_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
662408 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,608,114(+) TGATCATGCGGGGGGC INFRAME_DELETION,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
666077 Uncertain Significance: Primary familial hypertrophic cardiomyopathy 6,608,901(+) G/A MISSENSE_VARIANT,NONSENSE,THREE_PRIME_UTR_VARIANT
668148 Likely Benign: not provided 6,608,190(+) A/G SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ILK Gene

Structural Variations from Database of Genomic Variants (DGV) for ILK Gene

Variant ID Type Subtype PubMed ID
esv996362 CNV deletion 20482838
nsv1035138 CNV gain 25217958
nsv553373 CNV loss 21841781
nsv825755 CNV gain 20364138

Variation tolerance for ILK Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ILK Gene

Human Gene Mutation Database (HGMD)
ILK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ILK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILK Gene

Disorders for ILK Gene

MalaCards: The human disease database

(14) MalaCards diseases for ILK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
focal segmental glomerulosclerosis
  • fgs
hypermobile ehlers-danlos syndrome
  • ehlers-danlos syndrome, hypermobility type
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
renal fibrosis
hyperphosphatemia
- elite association - COSMIC cancer census association via MalaCards
Search ILK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ILK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ILK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILK Gene

Publications for ILK Gene

  1. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PMID: 10871859) Janji B … Kieffer N (Oncogene 2000) 3 4 23 54
  2. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PMID: 9736715) Delcommenne M … Dedhar S (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 23 54
  3. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PMID: 8538749) Hannigan GE … Dedhar S (Nature 1996) 2 3 4 54
  4. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. (PMID: 20232298) Tseng WP … Tang CH (Journal of cellular physiology 2010) 3 23 54
  5. Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. (PMID: 20091050) Schaeffer DF … Owen DA (Virchows Archiv : an international journal of pathology 2010) 3 23 54

Products for ILK Gene

  • Addgene plasmids for ILK

Sources for ILK Gene