ILF3 Gene (Protein Coding)

Interleukin Enhancer Binding Factor 3

GC19P010625
GIFtS:
38
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redist... See more...

Aliases for ILF3 Gene

Aliases for ILF3 Gene

  • Interleukin Enhancer Binding Factor 3 2 3 5
  • Nuclear Factor Of Activated T-Cells 90 KDa 2 3 4
  • Translational Control Protein 80 2 3 4
  • M-Phase Phosphoprotein 4 2 3 4
  • MPHOSPH4 2 3 4
  • DRBP76 2 3 4
  • MPP4 2 3 4
  • NF90 2 3 4
  • M Phase Phosphoprotein 4, Nuclear Factor Associated With DS RNA 2 3
  • Interleukin Enhancer Binding Factor 3, 90kDa 2 3
  • Nuclear Factor Of Activated T-Cells 110 KDa 2 3
  • Interleukin Enhancer Binding Factor 3, 90kD 2 3
  • Double-Stranded RNA-Binding Protein, 76 KD 2 3
  • Interleukin Enhancer-Binding Factor 3 3 4
  • Nuclear Factor Associated With DsRNA 3 4
  • DsRNA Binding Protein NFAR-2/MPP4 2 3
  • NF-AT-90 3 4
  • MPP4110 2 3
  • NF90ctv 2 3
  • NFAR110 2 3
  • NF110b 2 3
  • NFAR-1 2 3
  • NFAR-2 2 3
  • NFAR90 2 3
  • TCP110 2 3
  • NF110 2 3
  • NF90a 2 3
  • NF90c 2 3
  • TCP80 3 4
  • DRBF 3 4
  • NFAR 3 4
  • Nuclear Factor Of Activated T-Cells, 90 KD 3
  • Double-Stranded RNA-Binding Protein 76 4
  • NF90b 3
  • NFAR2 3
  • CBTF 3
  • MMP4 3
  • ILF3 5

External Ids for ILF3 Gene

Previous GeneCards Identifiers for ILF3 Gene

  • GC19P010895
  • GC19P010987
  • GC19P010610
  • GC19P010764
  • GC19P010342

Summaries for ILF3 Gene

Entrez Gene Summary for ILF3 Gene

  • This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

GeneCards Summary for ILF3 Gene

ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include Childhood Endodermal Sinus Tumor. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STRBP.

UniProtKB/Swiss-Prot Summary for ILF3 Gene

  • RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).

Gene Wiki entry for ILF3 Gene

Additional gene information for ILF3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ILF3 Gene

Genomics for ILF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ILF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J010651 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 676.6 +0.3 267 5.7 ZNF221 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 REST ILF3 ILF3-DT piR-46435 piR-61384 ZNF627 LOC100419831 FBXL12 ZNF562 KRI1 DNMT1
GH19J010670 Promoter 0.6 EPDnew 600.4 +16.2 16238 0.1 POLR2A OSR2 PRDM6 lnc-SLC44A2-1 ILF3 SLC44A2 ATG4D RF00017-2810 QTRT1 lnc-TIMM29-1
GH19J010100 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 100.1 -549.9 -549874 8.3 SP1 CREB1 GATAD2A HNRNPL ZNF629 TFE3 ZNF512 RFX1 SIX5 NFKBIZ PPAN ANGPTL6 PPAN-P2RY11 ILF3 ZNF699 LOC100419831 ZNF317 KRI1 FBXL12 ZNF559
GH19J010379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 115 -273.8 -273760 2.2 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 RFX1 LEF1 IKZF1 TYK2 lnc-PDE4A-3 lnc-CDC37-1 ILF3 KRI1 FBXL12 PPAN RAVER1 ZNF561 LOC100419831
GH19J010415 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 108.4 -233.3 -233345 10.6 ZNF221 BRCA1 RNF2 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A CTCF ATF7 PDE4A CDC37 ILF3 ZNF266 KRI1 LOC100419831 DNMT1 RAVER1 FBXL12 PPAN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ILF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ILF3

Top Transcription factor binding sites by QIAGEN in the ILF3 gene promoter:
  • HEN1
  • TBP
  • USF-1
  • USF1
  • USF2

Genomic Locations for ILF3 Gene

Genomic Locations for ILF3 Gene
chr19:10,654,261-10,692,419
(GRCh38/hg38)
Size:
38,159 bases
Orientation:
Plus strand
chr19:10,764,937-10,803,095
(GRCh37/hg19)
Size:
38,159 bases
Orientation:
Plus strand

Genomic View for ILF3 Gene

Genes around ILF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILF3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ILF3 Gene

Proteins for ILF3 Gene

Products:

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  • Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12906-ILF3_HUMAN
    Recommended name:
    Interleukin enhancer-binding factor 3
    Protein Accession:
    Q12906
    Secondary Accessions:
    • A8K6F2
    • G5E9M5
    • O43409
    • Q6P1X1
    • Q86XY7
    • Q99544
    • Q99545
    • Q9BZH4
    • Q9BZH5
    • Q9NQ95
    • Q9NQ96
    • Q9NQ97
    • Q9NQ98
    • Q9NQ99
    • Q9NQA0
    • Q9NQA1
    • Q9NQA2
    • Q9NRN2
    • Q9NRN3
    • Q9NRN4
    • Q9UMZ9
    • Q9UN00
    • Q9UN84
    • Q9UNA2

    Protein attributes for ILF3 Gene

    Size:
    894 amino acids
    Molecular mass:
    95338 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN. Interacts (via C-terminus) with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2. Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner (PubMed:14731398).
    SequenceCaution:
    • Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 3]: Dubious isoform produced through aberrant splice sites.

    Three dimensional structures from OCA and Proteopedia for ILF3 Gene

    Alternative splice isoforms for ILF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ILF3 Gene

Protein Expression for ILF3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ILF3 Gene

  • Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
  • Methylated by protein arginine N-methyltransferase 1.
  • Ubiquitination at Lys17, Lys100, Lys202, Lys257, Lys332, Lys413, and Lys577
  • Modification sites at PhosphoSitePlus

Other Protein References for ILF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ILF3 Gene

Domains & Families for ILF3 Gene

Gene Families for ILF3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ILF3 Gene

InterPro:
Blocks:
  • Double-stranded RNA binding (DsRBD) domain
ProtoNet:

Suggested Antigen Peptide Sequences for ILF3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58801, highly similar to Interleukin enhancer-binding factor 3 (B4DFG4_HUMAN)
  • Translational control protein 80 (ILF3_HUMAN)
  • ILF3 protein (Q9NXX0_HUMAN)
genes like me logo Genes that share domains with ILF3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ILF3 Gene

Function for ILF3 Gene

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  2. CRISPR
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  6. Cell Line

Molecular function for ILF3 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).

Phenotypes From GWAS Catalog for ILF3 Gene

Gene Ontology (GO) - Molecular Function for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,IDA 7519613
GO:0003723 RNA binding NAS 10400669
GO:0003725 double-stranded RNA binding IBA,IDA 10574923
GO:0003727 single-stranded RNA binding IBA 21873635
GO:0005515 protein binding IPI 9442054
genes like me logo Genes that share ontologies with ILF3: view
genes like me logo Genes that share phenotypes with ILF3: view

Animal Models for ILF3 Gene

MGI Knock Outs for ILF3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF3 Gene

Localization for ILF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269 PubMed:21123651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILF3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
extracellular 4
cytoskeleton 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005634 nucleus IBA,NAS 10400669
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA,IDA --
GO:0005737 cytoplasm IEA,IDA 21123651
genes like me logo Genes that share ontologies with ILF3: view

Pathways & Interactions for ILF3 Gene

PathCards logo

SuperPathways for ILF3 Gene

No Data Available

SIGNOR curated interactions for ILF3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ILF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 21123651
GO:0017148 negative regulation of translation IEA,ISS --
GO:0045071 negative regulation of viral genome replication IEA,ISS --
GO:0045892 negative regulation of transcription, DNA-templated IDA 11739746
GO:0045893 positive regulation of transcription, DNA-templated IDA 11739746
genes like me logo Genes that share ontologies with ILF3: view

No data available for Pathways by source for ILF3 Gene

Drugs & Compounds for ILF3 Gene

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  1. Drug

(2) Drugs for ILF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ILF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ILF3: view

Transcripts for ILF3 Gene

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  1. CRISPR
  2. miRNA
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mRNA/cDNA for ILF3 Gene

5 REFSEQ mRNAs :
34 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILF3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7: -
SP8: -
SP9: - -
SP10:
SP11: -
SP12:

ExUns: 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:
SP10: - - - -
SP11:
SP12:

Relevant External Links for ILF3 Gene

GeneLoc Exon Structure for
ILF3

Expression for ILF3 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ILF3 Gene

mRNA expression in normal human tissues for ILF3 Gene
mRNA expression by GTEx for ILF3 GenemRNA expression by BioGPS for ILF3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ILF3 Gene



Protein tissue co-expression partners for ILF3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ILF3

SOURCE GeneReport for Unigene cluster for ILF3 Gene:

Hs.465885

mRNA Expression by UniProt/SwissProt for ILF3 Gene:

Q12906-ILF3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ILF3 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Liver(4.6)
  • Blood(4.5)
  • Skin(4.2)
  • Lung(3.9)
  • Eye(3.7)
  • Kidney(3.2)
  • Pancreas(3.1)
  • Muscle(2.7)
  • Lymph node(2.7)
  • Bone marrow(2.7)
  • Spleen(2.6)
  • Heart(2.6)
  • Thyroid gland(2.3)
  • Stomach(2.2)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with ILF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILF3 Gene

Orthologs for ILF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ILF3 30 31
  • 99.28 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 93 (a)
 ManyToMany
-- 31
  • 64 (a)
 ManyToMany
-- 31
  • 61 (a)
 ManyToMany
-- 31
  • 11 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia ILF3 31
  • 93 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ILF3 30 31
  • 91.05 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ILF3 30 31
  • 89.78 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ilf3 30
  • 87.76 (n)
Mouse
(Mus musculus)
 Mammalia Ilf3 30 17 31
  • 86.97 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves -- 31
  • 87 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia ILF3 31
  • 87 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ilf3 30
  • 71.72 (n)
Str.20533 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.3647 30
Zebrafish
(Danio rerio)
 Actinopterygii ilf3b 30 31
  • 64.69 (n)
 OneToOne
Dr.20053 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.12225 30
Worm
(Caenorhabditis elegans)
 Secernentea Y95B8A.8 31
  • 15 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.5593 31
  • 4 (a)
 ManyToMany
Species where no ortholog for ILF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ILF3 Gene

ENSEMBL:
Gene Tree for ILF3 (if available)
TreeFam:
Gene Tree for ILF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ILF3: view image

Paralogs for ILF3 Gene

Paralogs for ILF3 Gene

(3) SIMAP similar genes for ILF3 Gene using alignment to 15 proteins:

  • ILF3_HUMAN
  • K7EJ09_HUMAN
  • K7EKJ9_HUMAN
  • K7EKY0_HUMAN
  • K7ELV3_HUMAN
  • K7EM82_HUMAN
  • K7EMZ8_HUMAN
  • K7ENK6_HUMAN
  • K7EPG3_HUMAN
  • K7EQ75_HUMAN
  • K7EQR9_HUMAN
  • K7ER69_HUMAN
  • K7ERM6_HUMAN
  • L8E9J1_HUMAN
  • Q9NXX0_HUMAN
genes like me logo Genes that share paralogs with ILF3: view

Variants for ILF3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ILF3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
781442 Benign: not provided 10,683,737(+) A/G SYNONYMOUS_VARIANT
rs1064493 - p.Asp50His
rs34520379 - p.Ala501Ser

Additional dbSNP identifiers (rs#s) for ILF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ILF3 Gene

Variant ID Type Subtype PubMed ID
esv1002882 CNV deletion 20482838
esv3643657 CNV loss 21293372
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Variation tolerance for ILF3 Gene

Residual Variation Intolerance Score: 1.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ILF3 Gene

Human Gene Mutation Database (HGMD)
ILF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ILF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene

Disorders for ILF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ILF3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood endodermal sinus tumor
  • childhood endodermal sinus neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search ILF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ILF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ILF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ILF3 Gene

Publications for ILF3 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao PN … Corthésy B (The Journal of biological chemistry 1994) 2 3 4 23
  2. Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PMID: 14570900) Gwizdek C … Dargemont C (The Journal of biological chemistry 2004) 3 4 23
  3. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. (PMID: 15254228) Chen T … Macara IG (Molecular and cellular biology 2004) 3 4 23
  4. Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. (PMID: 11777942) Brownawell AM … Macara IG (The Journal of cell biology 2002) 3 4 23
  5. Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. (PMID: 11438536) Saunders LR … Barber GN (The Journal of biological chemistry 2001) 3 4 23

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