Aliases for ILF3 Gene
Aliases for ILF3 Gene
- Interleukin Enhancer Binding Factor 3 2 3 5
- M-Phase Phosphoprotein 4 2 3 4
- Interleukin Enhancer Binding Factor 3, 90kDa 2 3
- Interleukin Enhancer Binding Factor 3, 90kD 2 3
- Nuclear Factor Of Activated T-Cells 90 KDa 3 4
- Nuclear Factor Associated With DsRNA 3 4
- Translational Control Protein 80 3 4
- MPHOSPH4 3 4
- NF-AT-90 3 4
- DRBP76 3 4
- TCP80 3 4
- DRBF 3 4
- MPP4 3 4
- NF90 3 4
- NFAR 3 4
External Ids for ILF3 Gene
- HGNC: 6038
- Entrez Gene: 3609
- Ensembl: ENSG00000129351
- OMIM: 603182
- UniProtKB: Q12906
Previous GeneCards Identifiers for ILF3 Gene
- GC19P010895
- GC19P010987
- GC19P010610
- GC19P010764
- GC19P010342
Summaries for ILF3 Gene
-
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
GeneCards Summary for ILF3 Gene
ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include Ovarian Mucinous Cystadenocarcinoma. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STRBP.
UniProtKB/Swiss-Prot for ILF3 Gene
-
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF3 Gene
Genomics for ILF3 Gene
GeneHancer (GH) Regulatory Elements for ILF3 Gene
Promoters and enhancers for ILF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ILF3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ILF3 Gene
Genomic Locations for ILF3 Gene
- chr19:10,654,261-10,692,419
- (GRCh38/hg38)
- Size:
- 38,159 bases
- Orientation:
- Plus strand
- chr19:10,764,937-10,803,095
- (GRCh37/hg19)
Genomic View for ILF3 Gene
Genes around ILF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
ILF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ILF3 Gene
Proteins for ILF3 Gene
-
Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12906-ILF3_HUMAN
- Recommended name:
- Interleukin enhancer-binding factor 3
- Protein Accession:
- Q12906
- A8K6F2
- G5E9M5
- O43409
- Q6P1X1
- Q86XY7
- Q99544
- Q99545
- Q9BZH4
- Q9BZH5
- Q9NQ95
- Q9NQ96
- Q9NQ97
- Q9NQ98
- Q9NQ99
- Q9NQA0
- Q9NQA1
- Q9NQA2
- Q9NRN2
- Q9NRN3
- Q9NRN4
- Q9UMZ9
- Q9UN00
- Q9UN84
- Q9UNA2
Protein attributes for ILF3 Gene
- Size:
- 894 amino acids
- Molecular mass:
- 95338 Da
- Quaternary structure:
-
- Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN. Interacts (via C-terminus) with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2.
- SequenceCaution:
-
- Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ILF3 Gene
Post-translational modifications for ILF3 Gene
- Methylated by protein arginine N-methyltransferase 1.
- Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
- Ubiquitination at posLast=1717, posLast=100100, posLast=202202, posLast=257257, isoforms=2, 3, 4, 5, 6, 7332, isoforms=2, 3, 4, 5, 6, 7413, and posLast=577577
- Modification sites at PhosphoSitePlus
Other Protein References for ILF3 Gene
- ENSEMBL proteins:
-
- ENSP00000250241
- ENSP00000384660
- ENSP00000464974
- ENSP00000465219
- ENSP00000465515
- ENSP00000465654
- ENSP00000465831
- ENSP00000466235
- ENSP00000466396
- ENSP00000466724
- ENSP00000466991
- ENSP00000467372
- ENSP00000467704
- ENSP00000467950
- ENSP00000468092
- ENSP00000468134
- ENSP00000468156
- ENSP00000468181
- ENSP00000468323
- ENSP00000404121
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ILF3
-
Abcam antibodies for ILF3
-
Cloud-Clone Corp. Antibodies for ILF3
- Invitrogen Antibodies for ILF3
- antibodies-online: Search results for 2 available MMP4 Antibodies ranked by validation data
- Compare Top MMP4 Antibodies
-
Recommended
- Search GeneTex for Antibodies for ILF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ILF3
Protein Products
-
OriGene Purified Proteins for ILF3
- Search Origene for MassSpec and Protein Over-expression Lysates for ILF3
- Origene Custom Protein Services for ILF3
-
Cloud-Clone Corp. Proteins for ILF3
- antibodies-online: Search results for available MMP4 related products ranked by validation data
- Search GeneTex for Proteins for ILF3
-
Abcam proteins for ILF3
Assay Products
No data available for DME Specific Peptides for ILF3 Gene
Domains & Families for ILF3 Gene
Gene Families for ILF3 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ILF3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ILF3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ILF3 Gene
Function for ILF3 Gene
Molecular function for ILF3 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
Phenotypes From GWAS Catalog for ILF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 7519613 |
| GO:0003723 | RNA binding | NAS | 10400669 |
| GO:0003725 | double-stranded RNA binding | IDA | 10574923 |
| GO:0005515 | protein binding | IPI | 9442054 |
Phenotypes for ILF3 Gene
- MGI mutant phenotypes for ILF3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ILF3:
Animal Models for ILF3 Gene
- MGI Knock Outs for ILF3:
-
- Ilf3 tm1Pnk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ILF3
-
- Search ViGene Biosciences for ILF3
CRISPR Products
-
OriGene CRISPR knockouts for ILF3
- genomics-online: gRNA clones - Search results for available MMP4 gene related products
- Applied Biological Materials CRISPR for ILF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ILF3
- GenScript: Design CRISPR guide RNA sequences for ILF3
miRNA for ILF3 Gene
- miRTarBase miRNAs that target ILF3
-
- hsa-mir-7-5p (MIRT025730)
- hsa-mir-1296-5p (MIRT036091)
- hsa-mir-532-3p (MIRT037927)
- hsa-mir-769-5p (MIRT039142)
- hsa-mir-615-3p (MIRT040110)
- hsa-mir-92b-3p (MIRT040678)
- hsa-mir-484 (MIRT041999)
- hsa-mir-200c-3p (MIRT044381)
- hsa-mir-320a (MIRT044800)
- hsa-mir-186-5p (MIRT045018)
- hsa-mir-149-5p (MIRT045490)
- hsa-mir-17-5p (MIRT050983)
- hsa-mir-590-5p (MIRT734377)
- hsa-mir-136-5p (MIRT737522)
- hsa-mir-204-3p (MIRT738824)
- hsa-mir-3192-5p (MIRT741018)
- hsa-mir-4314 (MIRT743978)
- hsa-mir-4646-5p (MIRT746433)
- hsa-mir-4729 (MIRT747916)
- hsa-mir-4778-5p (MIRT748718)
- hsa-mir-5187-5p (MIRT749856)
- hsa-mir-619-5p (MIRT752541)
- hsa-mir-6506-5p (MIRT752950)
- hsa-mir-6728-5p (MIRT753952)
- hsa-mir-6819-3p (MIRT756840)
- hsa-mir-6877-3p (MIRT758174)
- hsa-mir-7109-3p (MIRT758932)
miRNA Products
- Search ViGene Biosciences for ILF3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ILF3
- Browse OriGene Inhibitory RNA Products For ILF3
- genomics-online: shRNA clones - Search results for available MMP4 gene related products
Clone Products
-
OriGene ORF clones in human for ILF3
- RG219617
- RC219617L2
- RC219617L1
- RC219617
- RG226907
- RC226907L2
- RC226907L1
- RC226907
- RG214999
- RC214999L2
- RC214999L1
- RC214999
- RG219563
- RC219563L2
- RC219563L1
- RC219563
- RG226985
- RC226985L2
- RC226985L1
- RC226985
- RC219617L2V
- RC219617L1V
- RC226907L2V
- RC226907L1V
- RC214999L2V
- RC214999L1V
- RC219563L2V
- RC219563L1V
- RC226985L2V
- RC226985L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ILF3
- VectorBuilder custom plasmid, inducible vectors for ILF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ILF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MMP4 gene related products
- orf clones - Search results for available MMP4 gene related products
- Applied Biological Materials Clones for ILF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ILF3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF3 Gene
Localization for ILF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene
- Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269 PubMed:21123651}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IDA | 27068509 |
| GO:0005634 | nucleus | NAS | 10400669 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA,IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 21123651 |
Pathways & Interactions for ILF3 Gene
No Data Available
Interacting Proteins for ILF3 Gene
Selected Interacting proteins:
Q12906-ILF3_HUMAN
ENSP00000404121
for ILF3 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006468 | protein phosphorylation | IDA,IEA | 21123651 |
| GO:0017148 | negative regulation of translation | IEA,ISS | -- |
| GO:0045071 | negative regulation of viral genome replication | ISS,IEA | -- |
No data available for Pathways by source for ILF3 Gene
Transcripts for ILF3 Gene
mRNA/cDNA for ILF3 Gene
- (12) REFSEQ mRNAs :
- (29) Additional mRNA sequences :
- (1019) Selected AceView cDNA sequences:
- (24) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ILF3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ILF3
- genomics-online: gRNA clones - Search results for available MMP4 gene related products
- Applied Biological Materials CRISPR for ILF3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ILF3
- GenScript: Design CRISPR guide RNA sequences for ILF3
miRNA Products
- Search ViGene Biosciences for ILF3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ILF3
- Browse OriGene Inhibitory RNA Products For ILF3
- genomics-online: shRNA clones - Search results for available MMP4 gene related products
Clone Products
-
OriGene ORF clones in human for ILF3
- RG219617
- RC219617L2
- RC219617L1
- RC219617
- RG226907
- RC226907L2
- RC226907L1
- RC226907
- RG214999
- RC214999L2
- RC214999L1
- RC214999
- RG219563
- RC219563L2
- RC219563L1
- RC219563
- RG226985
- RC226985L2
- RC226985L1
- RC226985
- RC219617L2V
- RC219617L1V
- RC226907L2V
- RC226907L1V
- RC214999L2V
- RC214999L1V
- RC219563L2V
- RC219563L1V
- RC226985L2V
- RC226985L1V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ILF3
- VectorBuilder custom plasmid, inducible vectors for ILF3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ILF3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MMP4 gene related products
- orf clones - Search results for available MMP4 gene related products
- Applied Biological Materials Clones for ILF3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: |
Expression for ILF3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ILF3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ILF3 Gene:
ILF3SOURCE GeneReport for Unigene cluster for ILF3 Gene:
Hs.465885mRNA Expression by UniProt/SwissProt for ILF3 Gene:
Q12906-ILF3_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for ILF3 Gene
- Nervous system(4.9)
- Intestine(4.7)
- Liver(4.5)
- Blood(4.4)
- Skin(3.8)
- Lung(3.6)
- Eye(3.4)
- Pancreas(2.7)
- Kidney(2.3)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for ILF3
- genomics-online: primer clones - Search results for available MMP4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILF3 Gene
Orthologs for ILF3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ILF3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ILF3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| dog (Canis familiaris) |
Mammalia | ILF3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ILF3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ilf3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ilf3 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ILF3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ilf3 33 |
|
||
| Str.20533 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3647 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ilf3b 33 34 |
|
||
| Dr.20053 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12225 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y95B8A.8 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5593 34 |
|
ManyToMany |
- Species where no ortholog for ILF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ILF3 Gene
(3) SIMAP similar genes for ILF3 Gene using alignment to 15 proteins:
Variants for ILF3 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000108372 | -- | 10,652,476(+) | A/G | upstream_transcript_variant | |
| rs1000131095 | -- | 10,666,195(+) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000159157 | -- | 10,652,268(+) | A/G | upstream_transcript_variant | |
| rs1000247357 | -- | 10,688,890(+) | C/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000327142 | -- | 10,661,056(+) | A/G | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1002882 | CNV | deletion | 20482838 |
| esv3643657 | CNV | loss | 21293372 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv1160585 | CNV | deletion | 26073780 |
| nsv833745 | CNV | loss | 17160897 |
| nsv833746 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
1.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.11;
75.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ILF3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene
Disorders for ILF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian mucinous cystadenocarcinoma |
|
|
Search ILF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ILF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ILF3 Gene
Publications for ILF3 Gene
- Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao PN … Corthésy B (The Journal of biological chemistry 1994) 2 3 4 22 58
- Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PMID: 14570900) Gwizdek C … Dargemont C (The Journal of biological chemistry 2004) 3 4 22 58
- Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. (PMID: 15254228) Chen T … Macara IG (Molecular and cellular biology 2004) 3 4 22 58
- Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. (PMID: 11777942) Brownawell AM … Macara IG (The Journal of cell biology 2002) 3 4 22 58
- The 90- and 110-kDa human NFAR proteins are translated from two differentially spliced mRNAs encoded on chromosome 19p13. (PMID: 11161820) Saunders LR … Barber GN (Genomics 2001) 3 4 22 58
Products for ILF3 Gene
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- genomics-online: cdna clones - Search results for available MMP4 gene related products
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Sources for ILF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
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- (123) CDC
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (135) Horizon
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- (139) VectorBuilder
- (140) SNPedia
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- (142) St John's Lab
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems