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This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redist... See more...
Aliases for ILF3 Gene
Aliases for ILF3 Gene
- Interleukin Enhancer Binding Factor 3 2 3 5
- Nuclear Factor Of Activated T-Cells 90 KDa 2 3 4
- Translational Control Protein 80 2 3 4
- M-Phase Phosphoprotein 4 2 3 4
- M Phase Phosphoprotein 4, Nuclear Factor Associated With DS RNA 2 3
- Interleukin Enhancer Binding Factor 3, 90kDa 2 3
- Interleukin Enhancer Binding Factor 3, 90kD 2 3
- Nuclear Factor Of Activated T-Cells 110 KDa 2 3
- Double-Stranded RNA-Binding Protein, 76 KD 2 3
- Interleukin Enhancer-Binding Factor 3 3 4
- Nuclear Factor Associated With DsRNA 3 4
- DsRNA Binding Protein NFAR-2/MPP4 2 3
- MPHOSPH4 3 4
- NF-AT-90 3 4
- DRBP76 3 4
- TCP80 3 4
- DRBF 3 4
- MPP4 3 4
External Ids for ILF3 Gene
- HGNC: 6038
- Entrez Gene: 3609
- Ensembl: ENSG00000129351
- OMIM: 603182
- UniProtKB: Q12906
Previous GeneCards Identifiers for ILF3 Gene
- GC19P010895
- GC19P010987
- GC19P010610
- GC19P010764
- GC19P010342
Summaries for ILF3 Gene
-
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
GeneCards Summary for ILF3 Gene
ILF3 (Interleukin Enhancer Binding Factor 3) is a Protein Coding gene. Diseases associated with ILF3 include Childhood Endodermal Sinus Tumor. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is STRBP.
UniProtKB/Swiss-Prot Summary for ILF3 Gene
-
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ILF3 Gene
Genomics for ILF3 Gene
GeneHancer (GH) Regulatory Elements for ILF3 Gene
Promoters and enhancers for ILF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ILF3 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ILF3
- Top Transcription factor binding sites by QIAGEN in the ILF3 gene promoter:
-
- HEN1
- TBP
- USF-1
- USF1
- USF2
Genomic Locations for ILF3 Gene
Genomic Locations for ILF3 Gene
- chr19:10,654,261-10,692,419
- (GRCh38/hg38)
- Size:
- 38,159 bases
- Orientation:
- Plus strand
- chr19:10,764,937-10,803,095
- (GRCh37/hg19)
- Size:
- 38,159 bases
- Orientation:
- Plus strand
Genomic View for ILF3 Gene
Genes around ILF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.2 by HGNC
- 19p13.2 by Entrez Gene
- 19p13.2 by Ensembl
ILF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ILF3 Gene
Proteins for ILF3 Gene
-
Protein details for ILF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q12906-ILF3_HUMAN
- Recommended name:
- Interleukin enhancer-binding factor 3
- Protein Accession:
- Q12906
- A8K6F2
- G5E9M5
- O43409
- Q6P1X1
- Q86XY7
- Q99544
- Q99545
- Q9BZH4
- Q9BZH5
- Q9NQ95
- Q9NQ96
- Q9NQ97
- Q9NQ98
- Q9NQ99
- Q9NQA0
- Q9NQA1
- Q9NQA2
- Q9NRN2
- Q9NRN3
- Q9NRN4
- Q9UMZ9
- Q9UN00
- Q9UN84
- Q9UNA2
Protein attributes for ILF3 Gene
- Size:
- 894 amino acids
- Molecular mass:
- 95338 Da
- Quaternary structure:
-
- Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with FUS and SMN. Interacts (via C-terminus) with PRMT1. Forms a complex with ILF2. Can also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of XRCC6/KU70 and XRCC5/KU80. Forms a heteromeric complex with ZNF346 and ILF3. Found in a nuclear export complex with XPO5, ILF3, Ran and double-stranded RNA or double-stranded minihelix VA1 RNA. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5 and ZNF346. Forms a complex with ILF2, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Interacts with AGO1 and AGO2. Interacts with DHX36; this interaction occurs in a RNA-dependent manner (PubMed:14731398). Interacts with ELAVL1; this interaction occurs in a RNA-dependent manner (PubMed:14731398).
- Miscellaneous:
-
- [Isoform 3]: Dubious isoform produced through aberrant splice sites.
- SequenceCaution:
-
- Sequence=AAA20994.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAH48314.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for ILF3 Gene
Post-translational modifications for ILF3 Gene
- Phosphorylated at Thr-188 and Thr-315 by PKR in response to certain RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication.
- Methylated by protein arginine N-methyltransferase 1.
-
Ubiquitination at Lys17, Lys100, Lys202, Lys257, Lys332, Lys413, and Lys577
- NX_Q12906 (NX_Q12906-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ILF3 Gene
- ENSEMBL proteins:
-
- ENSP00000466235
- ENSP00000466396
- ENSP00000466991
- ENSP00000468156
- ENSP00000404121
- ENSP00000467372
- ENSP00000466724
- ENSP00000465831
- ENSP00000465654
- ENSP00000468092
- ENSP00000468134
- ENSP00000468181
- ENSP00000465515
- ENSP00000465219
- ENSP00000464974
- ENSP00000467950
- ENSP00000468323
- ENSP00000467704
- ENSP00000250241
- ENSP00000384660
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ ILF3 Antibody
- Creative Diagnostics Anti-ILF3 monoclonal antibody, clone FQS4738
- Creative Biolabs Hi-Affi™ Recombinant Rabbit Anti-ILF3 Monoclonal Antibody (DS1820AB)
- Novus Biologicals Antibodies for ILF3
-
Abcam antibodies for ILF3
- Invitrogen Antibodies for ILF3 (AFLGC-ILF3)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ILF3
Protein Products
-
OriGene Purified Proteins for ILF3
- Search Origene for MassSpec and Protein Over-expression Lysates for ILF3
- Origene Custom Protein Services for ILF3
-
Abcam proteins for ILF3
No data available for DME Specific Peptides for ILF3 Gene
Domains & Families for ILF3 Gene
Gene Families for ILF3 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ILF3 Gene
Suggested Antigen Peptide Sequences for ILF3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58801, highly similar to Interleukin enhancer-binding factor 3 (B4DFG4_HUMAN)
- Translational control protein 80 (ILF3_HUMAN)
- ILF3 protein (Q9NXX0_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ILF3 Gene
Function for ILF3 Gene
Molecular function for ILF3 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).
Phenotypes From GWAS Catalog for ILF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IDA | 7519613 |
| GO:0003723 | RNA binding | NAS | 10400669 |
| GO:0003725 | double-stranded RNA binding | IDA,IBA | 10574923 |
| GO:0003727 | single-stranded RNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 9442054 |
Phenotypes for ILF3 Gene
- MGI mutant phenotypes for ILF3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ILF3:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased G2M DNA content, increased 8N DNA content
- Decreased shRNA abundance
- Increased Nanog expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased shRNA abundance (Z-score > 2)
- shRNA abundance <= 50%
- Increased viability
Animal Models for ILF3 Gene
- MGI Knock Outs for ILF3:
-
- Ilf3 Ilf3<tm1Pnk>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ILF3 - Select products 50% OFF >
- * ILF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ILF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ILF3
- genomics-online: gRNA clones - Search results for available ILF3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ILF3
miRNA for ILF3 Gene
- miRTarBase miRNAs that target ILF3
-
- hsa-mir-7-5p (MIRT025730)
- hsa-mir-1296-5p (MIRT036091)
- hsa-mir-532-3p (MIRT037927)
- hsa-mir-769-5p (MIRT039142)
- hsa-mir-615-3p (MIRT040110)
- hsa-mir-92b-3p (MIRT040678)
- hsa-mir-484 (MIRT041999)
- hsa-mir-200c-3p (MIRT044381)
- hsa-mir-320a (MIRT044800)
- hsa-mir-186-5p (MIRT045018)
- hsa-mir-149-5p (MIRT045490)
- hsa-mir-17-5p (MIRT050983)
- hsa-mir-590-5p (MIRT734377)
- hsa-mir-136-5p (MIRT737522)
- hsa-mir-204-3p (MIRT738824)
- hsa-mir-3192-5p (MIRT741018)
- hsa-mir-4314 (MIRT743978)
- hsa-mir-4646-5p (MIRT746433)
- hsa-mir-4729 (MIRT747916)
- hsa-mir-4778-5p (MIRT748718)
- hsa-mir-5187-5p (MIRT749856)
- hsa-mir-619-5p (MIRT752541)
- hsa-mir-6506-5p (MIRT752950)
- hsa-mir-6728-5p (MIRT753952)
- hsa-mir-6819-3p (MIRT756840)
- hsa-mir-6877-3p (MIRT758174)
- hsa-mir-7109-3p (MIRT758932)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ILF3
- Browse OriGene Inhibitory RNA Products For ILF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILF3
- genomics-online: shRNA clones - Search results for available ILF3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ILF3 - Select products 50% OFF >
- * ILF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210237
- MG224221
- MG224229
- MG224636
- MR210237
- MR210237L3
- MR210237L4
- MR224221
- MR224221L3
- MR224221L4
- MR224229
- MR224229L3
- MR224229L4
- MR224636
- MR224636L3
- MR224636L4
- MR231365
- MR231373
- RC214999
- RC214999L1
- RC214999L2
- RC214999L3
- RC214999L4
- RC219563
- RC219563L3
- RC219563L4
- RC219617
- RC219617L3
- RC219617L4
- RC226907
- RC226907L3
- RC226907L4
- RC226985
- RC226985L3
- RC226985L4
- RG214999
- RG219563
- RG219617
- RG226907
- RG226985
- RR214566
- RR214566L3
- RR214566L4
- MR210237L3V
- MR210237L4V
- MR224221L3V
- MR224221L4V
- MR224229L3V
- MR224229L4V
- MR224636L3V
- MR224636L4V
- RC214999L1V
- RC214999L2V
- RC214999L3V
- RC214999L4V
- RC219563L3V
- RC219563L4V
- RC219617L3V
- RC219617L4V
- RC226907L3V
- RC226907L4V
- RC226985L3V
- RC226985L4V
- RR214566L3V
- RR214566L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ILF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ILF3
- genomics-online: cdna clones - Search results for available ILF3 gene related products
- orf clones - Search results for available ILF3 gene related products
Cell Line Products
-
Horizon Cell Lines for ILF3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF3 Gene
Localization for ILF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ILF3 Gene
- Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269 PubMed:21123651}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli (3)
- Nucleoplasm (3)
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | HDA | 27068509 |
| GO:0005634 | nucleus | IBA,NAS | 10400669 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005730 | nucleolus | IEA,IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 21123651 |
Pathways & Interactions for ILF3 Gene
Interacting Proteins for ILF3 Gene
Selected Interacting proteins:
Q12906-ILF3_HUMAN
ENSP00000404121
for ILF3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ILF3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IDA,IEA | 21123651 |
| GO:0017148 | negative regulation of translation | ISS,IEA | -- |
| GO:0045071 | negative regulation of viral genome replication | ISS,IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA | 11739746 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA | 11739746 |
No data available for Pathways by source for ILF3 Gene
Transcripts for ILF3 Gene
mRNA/cDNA for ILF3 Gene
- 5 REFSEQ mRNAs :
- 34 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000250241 3035 bps (ENST00000250241.12)
- ENST00000407004 3671 bps (ENST00000407004.7)
- ENST00000449870 6119 bps (ENST00000449870.5)
- ENST00000585835 849 bps (ENST00000585835.1)
- ENST00000586544 3859 bps (ENST00000586544.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ILF3 - Select products 50% OFF >
- * ILF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ILF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ILF3
- genomics-online: gRNA clones - Search results for available ILF3 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ILF3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ILF3
- Browse OriGene Inhibitory RNA Products For ILF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILF3
- genomics-online: shRNA clones - Search results for available ILF3 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ILF3 - Select products 50% OFF >
- * ILF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210237
- MG224221
- MG224229
- MG224636
- MR210237
- MR210237L3
- MR210237L4
- MR224221
- MR224221L3
- MR224221L4
- MR224229
- MR224229L3
- MR224229L4
- MR224636
- MR224636L3
- MR224636L4
- MR231365
- MR231373
- RC214999
- RC214999L1
- RC214999L2
- RC214999L3
- RC214999L4
- RC219563
- RC219563L3
- RC219563L4
- RC219617
- RC219617L3
- RC219617L4
- RC226907
- RC226907L3
- RC226907L4
- RC226985
- RC226985L3
- RC226985L4
- RG214999
- RG219563
- RG219617
- RG226907
- RG226985
- RR214566
- RR214566L3
- RR214566L4
- MR210237L3V
- MR210237L4V
- MR224221L3V
- MR224221L4V
- MR224229L3V
- MR224229L4V
- MR224636L3V
- MR224636L4V
- RC214999L1V
- RC214999L2V
- RC214999L3V
- RC214999L4V
- RC219563L3V
- RC219563L4V
- RC219617L3V
- RC219617L4V
- RC226907L3V
- RC226907L4V
- RC226985L3V
- RC226985L4V
- RR214566L3V
- RR214566L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ILF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ILF3
- genomics-online: cdna clones - Search results for available ILF3 gene related products
- orf clones - Search results for available ILF3 gene related products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||
| SP6: | |||||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | - | - | - | - | |||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: |
Relevant External Links for ILF3 Gene
- GeneLoc Exon Structure for
- ILF3
Expression for ILF3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ILF3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ILF3
SOURCE GeneReport for Unigene cluster for ILF3 Gene:
Hs.465885mRNA Expression by UniProt/SwissProt for ILF3 Gene:
Q12906-ILF3_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for ILF3 Gene
- Nervous system(4.9)
- Intestine(4.7)
- Liver(4.5)
- Blood(4.4)
- Skin(3.8)
- Lung(3.6)
- Eye(3.4)
- Pancreas(2.7)
- Kidney(2.3)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for ILF3
- genomics-online: primer clones - Search results for available ILF3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILF3 Gene
Orthologs for ILF3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ILF3 31 30 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | ILF3 31 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ILF3 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ILF3 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ilf3 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Ilf3 17 31 30 |
|
||
| chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | ILF3 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ilf3 30 |
|
||
| Str.20533 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3647 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ilf3b 31 30 |
|
OneToOne | |
| Dr.20053 30 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.12225 30 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y95B8A.8 31 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5593 31 |
|
ManyToMany |
- Species where no ortholog for ILF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ILF3 Gene
- ENSEMBL:
- Gene Tree for ILF3 (if available)
- TreeFam:
- Gene Tree for ILF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ILF3: view image
Paralogs for ILF3 Gene
Paralogs for ILF3 Gene
(3) SIMAP similar genes for ILF3 Gene using alignment to 15 proteins:
- ILF3_HUMAN
- K7EJ09_HUMAN
- K7EKJ9_HUMAN
- K7EKY0_HUMAN
- K7ELV3_HUMAN
- K7EM82_HUMAN
- K7EMZ8_HUMAN
- K7ENK6_HUMAN
- K7EPG3_HUMAN
- K7EQ75_HUMAN
- K7EQR9_HUMAN
- K7ER69_HUMAN
- K7ERM6_HUMAN
- L8E9J1_HUMAN
- Q9NXX0_HUMAN
Variants for ILF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ILF3 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 781442 | Benign: not provided | 10,683,737(+) | A/G | SYNONYMOUS_VARIANT | |
| rs1064493 | - | p.Asp50His | |||
| rs34520379 | - | p.Ala501Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1002882 | CNV | deletion | 20482838 |
| esv3643657 | CNV | loss | 21293372 |
| nsv1160584 | CNV | deletion | 26073780 |
| nsv1160585 | CNV | deletion | 26073780 |
| nsv833745 | CNV | loss | 17160897 |
| nsv833746 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
1.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.11;
75.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ILF3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF3 Gene
Disorders for ILF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| childhood endodermal sinus tumor |
|
|
Search ILF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ILF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ILF3 Gene
Publications for ILF3 Gene
- Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao PN … Corthésy B (The Journal of biological chemistry 1994) 2 3 4 23 54
- Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. (PMID: 15254228) Chen T … Macara IG (Molecular and cellular biology 2004) 3 4 23 54
- Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. (PMID: 14570900) Gwizdek C … Dargemont C (The Journal of biological chemistry 2004) 3 4 23 54
- Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. (PMID: 11777942) Brownawell AM … Macara IG (The Journal of cell biology 2002) 3 4 23 54
- Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. (PMID: 11438536) Saunders LR … Barber GN (The Journal of biological chemistry 2001) 3 4 23 54
ExternalLinks
Products for ILF3 Gene
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- antibodies-online: Show 30 available ILF3 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ILF3
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- Horizon Cell Lines for ILF3
- genomics-online: cdna clones - Search results for available ILF3 gene related products
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- genomics-online: shRNA clones - Search results for available ILF3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ILF3
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for ILF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ILF3
Sources for ILF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) H-invDB
- (47) HORDE
- (48) HUGE
- (49) IMGT
- (50) Leiden
- (51) miRBase
- (52) DME
- (53) OriGene
- (54) PubMed
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- (64) OCA
- (65) Proteopedia
- (66) MOPED
- (67) neXtProt
- (68) Reactome
- (69) GeneGo (Thomson Reuters)
- (70) DISEASES
- (71) SIMAP
- (72) GenomeRNAi
- (73) LifeMap
- (74) miRTarBase
- (75) MalaCards
- (76) Invitrogen
- (77) BitterDB
- (78) ESI-BIO
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- (85) COMPARTMENTS
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