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Aliases for ILF2 Gene

Aliases for ILF2 Gene

  • Interleukin Enhancer Binding Factor 2 2 3 5
  • Interleukin Enhancer Binding Factor 2, 45kDa 2 3
  • Interleukin Enhancer Binding Factor 2, 45kD 2 3
  • NF45 3 4
  • Nuclear Factor Of Activated T-Cells, 45-KDa 3
  • Nuclear Factor Of Activated T-Cells 45 KDa 4
  • Interleukin Enhancer-Binding Factor 2 3
  • PRO3063 3

External Ids for ILF2 Gene

Previous GeneCards Identifiers for ILF2 Gene

  • GC01M151483
  • GC01M149365
  • GC01M150409
  • GC01M150851
  • GC01M150447
  • GC01M151900
  • GC01M124997

Summaries for ILF2 Gene

Entrez Gene Summary for ILF2 Gene

  • The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

GeneCards Summary for ILF2 Gene

ILF2 (Interleukin Enhancer Binding Factor 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is ZFR.

UniProtKB/Swiss-Prot for ILF2 Gene

  • Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Gene Wiki entry for ILF2 Gene

Additional gene information for ILF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ILF2 Gene

Genomics for ILF2 Gene

GeneHancer (GH) Regulatory Elements for ILF2 Gene

Promoters and enhancers for ILF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J153669 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 677.3 0.0 -21 3.1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RCOR2 ILF2 TRX-CAT1-1 PIR54436 PIR58220 UBAP2L S100A1 CHTOP CREB3L4 CRTC2 INTS3
GH01J153727 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 42.5 -58.4 -58432 4.2 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 INTS3 UBAP2L ILF2 CRTC2 SLC27A3 CHTOP S100A1 ADAR ATP8B2 SLC39A1
GH01J154606 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.2 -937.4 -937417 4.1 HDGF ARNT ARID4B NEUROD1 SIN3A FEZF1 YBX1 ZNF2 IRF4 YY1 ADAR CLK2 CHTOP ILF2 ENSG00000271267 RUSC1-AS1 UBAP2L ASH1L-AS1 FLAD1 CRTC2
GH01J153919 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 33.5 -250.7 -250744 5.4 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GATAD2B LOC101928059 UBAP2L CRTC2 ILF2 INTS3 CHTOP CREB3L4 SLC27A3 ENSG00000272654
GH01J153965 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.7 -296.3 -296283 3.5 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 CREB3L4 ENSG00000273026 SLC39A1 UBAP2L ILF2 CRTC2 SLC27A3 INTS3 CHTOP ENSG00000238279
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ILF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ILF2 gene promoter:
  • GATA-1
  • E2F-1
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-1/L
  • ZID

Genomic Locations for ILF2 Gene

Genomic Locations for ILF2 Gene
9,261 bases
Minus strand
9,013 bases
Minus strand

Genomic View for ILF2 Gene

Genes around ILF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ILF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ILF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ILF2 Gene

Proteins for ILF2 Gene

  • Protein details for ILF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin enhancer-binding factor 2
    Protein Accession:
    Secondary Accessions:
    • A6NDB0
    • B2R8G7
    • Q5SR10
    • Q5SR11
    • Q7L7R3
    • Q9BWD4
    • Q9P1N0

    Protein attributes for ILF2 Gene

    390 amino acids
    Molecular mass:
    43062 Da
    Quaternary structure:
    • Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1.
    • Sequence=AAA20993.1; Type=Frameshift; Positions=376; Evidence={ECO:0000305}; Sequence=AAF29591.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=CAI13611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ILF2 Gene

Post-translational modifications for ILF2 Gene

  • Ubiquitination at isoforms=141, isoforms=59, and Lys45
  • Modification sites at PhosphoSitePlus

Other Protein References for ILF2 Gene

No data available for DME Specific Peptides for ILF2 Gene

Domains & Families for ILF2 Gene

Gene Families for ILF2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ILF2 Gene

Suggested Antigen Peptide Sequences for ILF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ILF2: view

No data available for UniProtKB/Swiss-Prot for ILF2 Gene

Function for ILF2 Gene

Molecular function for ILF2 Gene

UniProtKB/Swiss-Prot Function:
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus.

Phenotypes From GWAS Catalog for ILF2 Gene

Gene Ontology (GO) - Molecular Function for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 7519613
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003725 double-stranded RNA binding IDA 10574923
GO:0005515 protein binding IPI 9442054
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ILF2: view
genes like me logo Genes that share phenotypes with ILF2: view

Animal Models for ILF2 Gene

MGI Knock Outs for ILF2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ILF2 Gene

Localization for ILF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ILF2 Gene

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ILF2 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (4)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,TAS --
GO:0005634 nucleus IDA 21123651
GO:0005730 nucleolus IDA 11790298
GO:0005737 cytoplasm IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with ILF2: view

Pathways & Interactions for ILF2 Gene

genes like me logo Genes that share pathways with ILF2: view

Pathways by source for ILF2 Gene

1 BioSystems pathway for ILF2 Gene
3 Reactome pathways for ILF2 Gene

Gene Ontology (GO) - Biological Process for ILF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA,IEA 11739746
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response IEA --
GO:0043312 neutrophil degranulation TAS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 11739746
genes like me logo Genes that share ontologies with ILF2: view

No data available for SIGNOR curated interactions for ILF2 Gene

Drugs & Compounds for ILF2 Gene

(2) Drugs for ILF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ILF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ILF2: view

Transcripts for ILF2 Gene

mRNA/cDNA for ILF2 Gene

Unigene Clusters for ILF2 Gene

Interleukin enhancer binding factor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ILF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: - - -
SP6: - -
SP7: -

Relevant External Links for ILF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ILF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ILF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ILF2 Gene

Protein tissue co-expression partners for ILF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ILF2 Gene:


SOURCE GeneReport for Unigene cluster for ILF2 Gene:


Evidence on tissue expression from TISSUES for ILF2 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Liver(4.6)
  • Intestine(3.5)
  • Blood(3.3)
  • Skin(3.3)
  • Eye(2.9)
  • Kidney(2.3)
  • Heart(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ILF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ILF2 Gene

Orthologs for ILF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ILF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ILF2 34 33
  • 99.91 (n)
(Monodelphis domestica)
Mammalia ILF2 34
  • 98 (a)
(Bos Taurus)
Mammalia ILF2 34 33
  • 94.02 (n)
(Canis familiaris)
Mammalia ILF2 34 33
  • 93.25 (n)
(Mus musculus)
Mammalia Ilf2 16 34 33
  • 91.54 (n)
(Ornithorhynchus anatinus)
Mammalia ILF2 34
  • 69 (a)
(Gallus gallus)
Aves ILF2 34 33
  • 80.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia ilf2-prov 33
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75701 33
(Danio rerio)
Actinopterygii ilf2 34 33
  • 77.71 (n)
wufb34h01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1694 33
fruit fly
(Drosophila melanogaster)
Insecta CG5641 34 35 33
  • 60.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001997 33
  • 58.81 (n)
(Caenorhabditis elegans)
Secernentea CELE_R11H6.5 33
  • 45.9 (n)
R11H6.5 34 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5584 34
  • 58 (a)
Cin.3994 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3994 33
Species where no ortholog for ILF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ILF2 Gene

Gene Tree for ILF2 (if available)
Gene Tree for ILF2 (if available)
Evolutionary constrained regions (ECRs) for ILF2: view image

Paralogs for ILF2 Gene

Paralogs for ILF2 Gene Pseudogenes for ILF2 Gene

genes like me logo Genes that share paralogs with ILF2: view

Variants for ILF2 Gene

Sequence variations from dbSNP and Humsavar for ILF2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000996435 -- 153,669,022(-) T/C intron_variant
rs1001074206 -- 153,661,400(-) CA/ downstream_transcript_variant
rs1001203403 -- 153,661,358(-) A/G downstream_transcript_variant
rs1001338250 -- 153,661,628(-) T/G downstream_transcript_variant
rs1001470536 -- 153,667,054(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ILF2 Gene

Variant ID Type Subtype PubMed ID
dgv582n54 CNV gain 21841781
nsv1122407 CNV deletion 24896259
nsv464028 CNV gain 19166990
nsv476355 CNV novel sequence insertion 20440878

Variation tolerance for ILF2 Gene

Residual Variation Intolerance Score: 21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 3.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ILF2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ILF2 Gene

Disorders for ILF2 Gene

Additional Disease Information for ILF2

No disorders were found for ILF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ILF2 Gene

Publications for ILF2 Gene

  1. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. (PMID: 7519613) Kao PN … Corthésy B (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. (PMID: 9442054) Ting NS … Lees-Miller SP (The Journal of biological chemistry 1998) 3 4 22 58
  3. Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense. (PMID: 21123651) Harashima A … Barber GN (Genes & development 2010) 3 4 58
  4. NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells. (PMID: 20051514) Kiesler P … Vercelli D (The Journal of biological chemistry 2010) 3 22 58
  5. NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response. (PMID: 19893574) Graber TE … Holcik M (Cell death and differentiation 2010) 3 22 58

Products for ILF2 Gene

Sources for ILF2 Gene

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