The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene... See more...

Aliases for IL9 Gene

Aliases for IL9 Gene

  • Interleukin 9 2 3 5
  • T-Cell Growth Factor P40 2 3 4
  • Homolog Of Mouse T Cell And Mast Cell Growth Factor 40 2 3
  • P40 T-Cell And Mast Cell Growth Factor 2 3
  • Interleukin-9 3 4
  • Cytokine P40 3 4
  • P40 Cytokine 2 3
  • IL-9 3 4
  • HP40 3
  • P40 3

External Ids for IL9 Gene

Previous GeneCards Identifiers for IL9 Gene

  • GC05M135103
  • GC05M135258
  • GC05M135304
  • GC05M135255
  • GC05M130416
  • GC05M135227

Summaries for IL9 Gene

Entrez Gene Summary for IL9 Gene

  • The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL9 Gene

IL9 (Interleukin 9) is a Protein Coding gene. Diseases associated with IL9 include Severe Combined Immunodeficiency, X-Linked and Asthma. Among its related pathways are ERK Signaling and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot Summary for IL9 Gene

  • Supports IL-2 independent and IL-4 independent growth of helper T-cells.

Gene Wiki entry for IL9 Gene

Additional gene information for IL9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL9 Gene

Genomics for IL9 Gene

GeneHancer (GH) Regulatory Elements for IL9 Gene

Promoters and enhancers for IL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135894 Enhancer 0.7 Ensembl 500.7 +0.5 541 0.6 REST WT1 ZNF263 SAP130 CEBPB PBX2 FOSL1 CTCF VEZF1 ZNF398 HSALNG0045060 IL9 lnc-TGFBI-4
GH05J135895 Promoter 0.5 EPDnew 500.7 0.0 -20 0.1 REST CTCF ENSG00000254239 HSALNG0045060 IL9
GH05J136051 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -160.1 -160120 9 EP300 FOXK2 ZNF217 CTCF ZSCAN5C TCF12 POLR2G NCOR1 RBAK JUND LECT2 ENSG00000254239 IL9 SMAD5 SMIM32 HSALNG0045075 TGFBI
GH05J135992 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 -102.0 -101977 10.4 EP300 TCF12 JUND FOS ZIC2 REST TRIM28 ATF2 MXI1 GATA3 TGFBI LECT2 SMAD5 ENSG00000254239 IL9 SMAD5-AS1 SLC25A48 HSALNG0045068 lnc-LECT2-2
GH05J135929 Promoter/Enhancer 1.2 Ensembl ENCODE 11.5 -34.8 -34759 1.2 ZSCAN5C POLR2G PHF8 ZIC2 ZBTB10 ZBTB26 ZBTB7A SKI ZNF341 POLR2A FBXL21P lnc-SLC25A48-4 LECT2 ENSG00000254239 IL9 C5orf66 lnc-IL9-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL9

Top Transcription factor binding sites by QIAGEN in the IL9 gene promoter:
  • IRF-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A

Genomic Locations for IL9 Gene

Genomic Locations for IL9 Gene
chr5:135,892,246-135,895,841
(GRCh38/hg38)
Size:
3,596 bases
Orientation:
Minus strand
chr5:135,227,935-135,231,516
(GRCh37/hg19)
Size:
3,582 bases
Orientation:
Minus strand

Genomic View for IL9 Gene

Genes around IL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL9 Gene

Proteins for IL9 Gene

  • Protein details for IL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15248-IL9_HUMAN
    Recommended name:
    Interleukin-9
    Protein Accession:
    P15248

    Protein attributes for IL9 Gene

    Size:
    144 amino acids
    Molecular mass:
    15909 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL9 Gene

Post-translational modifications for IL9 Gene

  • Glycosylation at Asn50, Asn63, Asn78, and Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for IL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL9
  • Boster Bio Antibodies for IL9
  • Santa Cruz Biotechnology (SCBT) Antibodies for IL9

No data available for DME Specific Peptides for IL9 Gene

Domains & Families for IL9 Gene

Gene Families for IL9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for IL9 Gene

Blocks:
  • Interleukin-7/interleukin-9
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL9 Gene

GenScript: Design optimal peptide antigens:
  • T-cell growth factor P40 (IL9_HUMAN)
  • Interleukin 9 (Q6NZ74_HUMAN)
  • Interleukin 9 (Q6NZ75_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15248

UniProtKB/Swiss-Prot:

IL9_HUMAN :
  • Belongs to the IL-7/IL-9 family.
Family:
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL9: view

Function for IL9 Gene

Molecular function for IL9 Gene

UniProtKB/Swiss-Prot Function:
Supports IL-2 independent and IL-4 independent growth of helper T-cells.
GENATLAS Biochemistry:
interleukin 9,mouse T cell growth factor P40 homolog,determining factor in controlling bronchial hyperresponsiveness

Phenotypes From GWAS Catalog for IL9 Gene

Gene Ontology (GO) - Molecular Function for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005140 interleukin-9 receptor binding IBA 21873635
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL9: view
genes like me logo Genes that share phenotypes with IL9: view

Animal Models for IL9 Gene

MGI Knock Outs for IL9:
  • Il9 Il9<tm1Anjm>
  • Il9 Il9<tm1Flv>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL9 Gene

Localization for IL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL9 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IL9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL9 Gene

Pathways & Interactions for IL9 Gene

PathCards logo

SuperPathways for IL9 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
3 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
4 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
5 ERK Signaling
.61
.61
.58
.51
.49
genes like me logo Genes that share pathways with IL9: view

Pathways by source for IL9 Gene

1 GeneGo (Thomson Reuters) pathway for IL9 Gene
  • Immune response IL-9 signaling pathway
70 Qiagen pathways for IL9 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for IL9 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 9371819
GO:0006955 immune response IEA --
GO:0008284 positive regulation of cell proliferation TAS 1680606
GO:0030307 positive regulation of cell growth IEA --
GO:0038113 interleukin-9-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL9: view

Drugs & Compounds for IL9 Gene

(15) Drugs for IL9 Gene - From: ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Immunologic Factors Pharma 30591
s 1 (combination) Pharma 517
Vaccines Pharma 7866
MEDI-528 Pharma inhibitor 0

(12) Additional Compounds for IL9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL9: view

Transcripts for IL9 Gene

mRNA/cDNA for IL9 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL9 Gene

No ASD Table

Relevant External Links for IL9 Gene

GeneLoc Exon Structure for
IL9

Expression for IL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL9 Gene

This gene is overexpressed in Nerve - Tibial (x17.9), Brain - Hippocampus (x5.2), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for IL9 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL9 Gene



Protein tissue co-expression partners for IL9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL9

SOURCE GeneReport for Unigene cluster for IL9 Gene:

Hs.960

Evidence on tissue expression from TISSUES for IL9 Gene

  • Blood(4.5)
genes like me logo Genes that share expression patterns with IL9: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL9 Gene

Orthologs for IL9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL9 31 30
  • 99.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL9 30
  • 76.3 (n)
cow
(Bos Taurus)
Mammalia IL9 31 30
  • 72.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il9 30
  • 70.16 (n)
mouse
(Mus musculus)
Mammalia Il9 17 31 30
  • 69 (n)
oppossum
(Monodelphis domestica)
Mammalia IL9 31
  • 29 (a)
OneToOne
Species where no ortholog for IL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL9 Gene

ENSEMBL:
Gene Tree for IL9 (if available)
TreeFam:
Gene Tree for IL9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL9: view image

Paralogs for IL9 Gene

Pseudogenes.org Pseudogenes for IL9 Gene

genes like me logo Genes that share paralogs with IL9: view

No data available for Paralogs for IL9 Gene

Variants for IL9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL9 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
733830 Likely Benign: not provided 135,895,433(-) T/C INTRON_VARIANT
747477 Likely Benign: not provided 135,892,466(-) G/A SYNONYMOUS_VARIANT
rs2069885 - p.Thr117Met

Additional dbSNP identifiers (rs#s) for IL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL9 Gene

Variant ID Type Subtype PubMed ID
esv2759380 CNV loss 17122850

Variation tolerance for IL9 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL9 Gene

Human Gene Mutation Database (HGMD)
IL9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL9 Gene

Disorders for IL9 Gene

MalaCards: The human disease database

(43) MalaCards diseases for IL9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
severe combined immunodeficiency, x-linked
  • scidx1
asthma
  • asthma, susceptibility to
allergic asthma
  • atopic asthma
trichuriasis
  • infection by trichuris trichura
peanut allergy
  • allergy to peanuts
- elite association - COSMIC cancer census association via MalaCards
Search IL9 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL9 Gene

Publications for IL9 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 23 41 54
  2. The synergistic effects of the IL-9 gene and environmental exposures on asthmatic Taiwanese families as determined by the transmission/disequilibrium test. (PMID: 16611254) Wang TN … Ko YC (International journal of immunogenetics 2006) 3 23 41 54
  3. Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells. (PMID: 1901233) Kelleher K … Yang YC (Blood 1991) 3 4 23 54
  4. Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene. (PMID: 1971295) Renauld JC … Van Snick J (Journal of immunology (Baltimore, Md. : 1950) 1990) 3 4 23 54
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54

Products for IL9 Gene

Sources for IL9 Gene