Aliases for IL7R Gene
External Ids for IL7R Gene
Previous GeneCards Identifiers for IL7R Gene
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]
GeneCards Summary for IL7R Gene
IL7R (Interleukin 7 Receptor) is a Protein Coding gene. Diseases associated with IL7R include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Multiple Sclerosis 3. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Akt Signaling. Gene Ontology (GO) annotations related to this gene include antigen binding and interleukin-7 receptor activity. An important paralog of this gene is CSF2RB.
UniProtKB/Swiss-Prot Summary for IL7R Gene
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).