The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally... See more...

Aliases for IL7 Gene

Aliases for IL7 Gene

  • Interleukin 7 2 3 5
  • IL-7 2 3 4
  • Interleukin-7 3 4
  • IL7 5

External Ids for IL7 Gene

Previous GeneCards Identifiers for IL7 Gene

  • GC08M079682
  • GC08M079311
  • GC08M079694
  • GC08M079807
  • GC08M075134
  • GC08M079587

Summaries for IL7 Gene

Entrez Gene Summary for IL7 Gene

  • The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]

GeneCards Summary for IL7 Gene

IL7 (Interleukin 7) is a Protein Coding gene. Diseases associated with IL7 include Epidermodysplasia Verruciformis 5 and Epidermodysplasia Verruciformis 1. Among its related pathways are PEDF Induced Signaling and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot Summary for IL7 Gene

  • Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Gene Wiki entry for IL7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL7 Gene

Genomics for IL7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL7

Top Transcription factor binding sites by QIAGEN in the IL7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • FOXO1
  • FOXO1a
  • GATA-3
  • IRF-7A
  • p53
  • STAT1

Genomic Locations for IL7 Gene

Latest Assembly
chr8:78,675,743-78,806,830
(GRCh38/hg38)
Size:
131,088 bases
Orientation:
Minus strand

Previous Assembly
chr8:79,645,007-79,717,698
(GRCh37/hg19 by Entrez Gene)
Size:
72,692 bases
Orientation:
Minus strand

chr8:79,587,978-79,717,758
(GRCh37/hg19 by Ensembl)
Size:
129,781 bases
Orientation:
Minus strand

Genomic View for IL7 Gene

Genes around IL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL7 Gene

Proteins for IL7 Gene

  • Protein details for IL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13232-IL7_HUMAN
    Recommended name:
    Interleukin-7
    Protein Accession:
    P13232
    Secondary Accessions:
    • A0N0L3
    • Q5FBY5
    • Q5FBY9

    Protein attributes for IL7 Gene

    Size:
    177 amino acids
    Molecular mass:
    20187 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL7 Gene

    Alternative splice isoforms for IL7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL7 Gene

Post-translational modifications for IL7 Gene

  • Glycosylation at Asn141, Asn95, and Asn116

Antibodies for research

  • Abcam antibodies for IL7

No data available for DME Specific Peptides for IL7 Gene

Domains & Families for IL7 Gene

Gene Families for IL7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL7 Gene

InterPro:
Blocks:
  • Interleukin-7/interleukin-9
  • Interleukin-7

Suggested Antigen Peptide Sequences for IL7 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 7 (D0EYG7_HUMAN)
  • Interleukin-7 (IL7_HUMAN)
  • IL7 nirs variant 1 (Q5FBX5_HUMAN)
  • IL7 nirs variant 5 (Q5FBY8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13232

UniProtKB/Swiss-Prot:

IL7_HUMAN :
  • Belongs to the IL-7/IL-9 family.
Family:
  • Belongs to the IL-7/IL-9 family.
genes like me logo Genes that share domains with IL7: view

Function for IL7 Gene

Molecular function for IL7 Gene

UniProtKB/Swiss-Prot Function:
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
GENATLAS Biochemistry:
interleukin 7,20.2kDa,stimulating the proliferation of lymphoid progenitor cells

LifeMap Function Summary for IL7 Gene

It affects the following cells:
IL7 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IL7 Gene

Gene Ontology (GO) - Molecular Function for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IDA 11418668
GO:0005126 cytokine receptor binding IEA --
GO:0005139 interleukin-7 receptor binding IEA --
GO:0005515 protein binding IPI 8266077
GO:0008083 growth factor activity IEA,ISS --
genes like me logo Genes that share ontologies with IL7: view
genes like me logo Genes that share phenotypes with IL7: view

Human Phenotype Ontology for IL7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL7 Gene

MGI Knock Outs for IL7:
  • Il7 Il7<tm1.1Mysl>
  • Il7 Il7<tm1Dnax>
  • Il7 Il7<tm1Hms>
  • Il7 Il7<tm1.1Iku>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL7 Gene

Localization for IL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL7 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
GO:0062023 collagen-containing extracellular matrix HDA 28675934
genes like me logo Genes that share ontologies with IL7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL7 Gene

Pathways & Interactions for IL7 Gene

PathCards logo

SuperPathways for IL7 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.40
3 JAK-STAT signaling pathway
.01
4 Akt Signaling
.60
.60
.55
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with IL7: view

SIGNOR curated interactions for IL7 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001961 positive regulation of cytokine-mediated signaling pathway IDA 11418668
GO:0002360 T cell lineage commitment IEA --
GO:0006955 immune response IEA --
GO:0006959 humoral immune response TAS 2643102
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with IL7: view

Drugs & Compounds for IL7 Gene

(36) Drugs for IL7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(27) Additional Compounds for IL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL7: view

Transcripts for IL7 Gene

mRNA/cDNA for IL7 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL7

Alternative Splicing Database (ASD) splice patterns (SP) for IL7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for IL7 Gene

GeneLoc Exon Structure for
IL7

Expression for IL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL7

SOURCE GeneReport for Unigene cluster for IL7 Gene:

Hs.591873

Evidence on tissue expression from TISSUES for IL7 Gene

  • Pancreas(4.4)
  • Blood(3.4)
  • Spleen(3.3)
  • Lymph node(3.3)
  • Bone marrow(2.9)
  • Skin(2.9)
  • Intestine(2.9)
  • Liver(2.7)
  • Lung(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Nervous system(2.5)
  • Muscle(2.3)
  • Stomach(2.3)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with IL7: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL7 Gene

Orthologs for IL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL7 29 30
  • 99.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL7 29 30
  • 84.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL7 29 30
  • 84.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il7 29 16 30
  • 80.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il7 29
  • 80 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL7 30
  • 34 (a)
OneToOne
Species where no ortholog for IL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL7 Gene

ENSEMBL:
Gene Tree for IL7 (if available)
TreeFam:
Gene Tree for IL7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL7: view image
Alliance of Genome Resources:
Additional Orthologs for IL7

Paralogs for IL7 Gene

No data available for Paralogs for IL7 Gene

Variants for IL7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL7 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs1486611027 Risk Factor: Epidermodysplasia verruciformis, susceptibility to, 5 78,740,025(-) T/A
NM_000880.4(IL7):c.205A>T (p.Arg69Ter)
NONSENSE
rs200025901 Benign: not provided 78,804,906(-) C/T
NM_000880.4(IL7):c.10+7G>A
INTRON
rs200683891 Benign: not provided 78,798,108(-) A/G
NM_000880.4(IL7):c.111T>C (p.Tyr37=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL7 Gene

Variant ID Type Subtype PubMed ID
dgv3851n106 CNV deletion 24896259
esv2759622 CNV loss 17122850
nsv1026069 CNV gain 25217958
nsv611577 CNV gain 21841781
nsv971670 CNV duplication 23825009

Variation tolerance for IL7 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL7 Gene

Human Gene Mutation Database (HGMD)
IL7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL7
Leiden Open Variation Database (LOVD)
IL7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL7 Gene

Disorders for IL7 Gene

MalaCards: The human disease database

(70) MalaCards diseases for IL7 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
epidermodysplasia verruciformis 5
  • epidermodysplasia verruciformis, susceptibility to, 5
epidermodysplasia verruciformis 1
  • epidermodysplasia verruciformis, susceptibility to, 1
lymphopenia
  • lymphocytopenia
childhood t-cell acute lymphoblastic leukemia
  • childhood precursor t-lymphoblastic lymphoma/leukemia
severe combined immunodeficiency, x-linked
  • scidx1
- elite association - COSMIC cancer census association via MalaCards
Search IL7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL7_HUMAN
  • Epidermodysplasia verruciformis 5 (EV5) [MIM:618309]: A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive. {ECO:0000269 PubMed:25981006}. Note=The disease may be caused by variants affecting the gene represented in this entry.

Additional Disease Information for IL7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL7: view

No data available for Genatlas for IL7 Gene

Publications for IL7 Gene

  1. Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. (PMID: 19141282) McElroy CA … Walsh ST (Structure (London, England : 1993) 2009) 3 4 22
  2. Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation. (PMID: 10850801) Cosenza L … Smith T (Protein science : a publication of the Protein Society 2000) 3 4 22
  3. Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis. (PMID: 9407080) Cosenza L … Murphy JR (The Journal of biological chemistry 1997) 3 4 22
  4. Generalized verrucosis and HPV-3 susceptibility associated with CD4 T-cell lymphopenia caused by inherited human interleukin-7 deficiency. (PMID: 25981006) Horev L … Zlotogorski A (Journal of the American Academy of Dermatology 2015) 4 72
  5. Bone invading NSCLC cells produce IL-7: mice model and human histologic data. (PMID: 20067635) Roato I … Ferracini R (BMC cancer 2010) 3 22

Products for IL7 Gene

  • Addgene plasmids for IL7

Sources for IL7 Gene