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The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a prot... See more...
Aliases for IL6ST Gene
Aliases for IL6ST Gene
- GP130 2 3
- Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form 3
- Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) 2
- Interleukin Receptor Beta Chain 3
- Interleukin-6 Signal Transducer 4
- Membrane Glycoprotein Gp130 3
- IL-6R-Beta 4
- CDW130 3
- CDw130 4
- HIES4 3
- IL6ST 5
- Gp130 4
External Ids for IL6ST Gene
- HGNC: 6021
- Entrez Gene: 3572
- Ensembl: ENSG00000134352
- OMIM: 600694
- UniProtKB: P40189
Previous GeneCards Identifiers for IL6ST Gene
- GC05M055398
- GC05M056665
- GC05M055207
- GC05M055252
- GC05M055272
- GC05M052204
- GC05M055230
Summaries for IL6ST Gene
-
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
GeneCards Summary for IL6ST Gene
IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Stuve-Wiedemann Syndrome. Among its related pathways are Interleukin-11 Signaling Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot Summary for IL6ST Gene
-
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Additional gene information for IL6ST Gene
- HGNC(6021)
- Entrez Gene(3572)
- Ensembl(ENSG00000134352)
- OMIM(600694)
- UniProtKB(P40189)
- Open Targets Platform(ENSG00000134352)
- Monarch Initiative
- Search for IL6ST at DataMed
- Search for IL6ST at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL6ST Gene
Genomics for IL6ST Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL6ST Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL6ST on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL6ST
- Top Transcription factor binding sites by QIAGEN in the IL6ST gene promoter:
-
- aMEF-2
- E4BP4
- FOXF2
- GATA-1
- LCR-F1
- MEF-2
- STAT1
- STAT3
Genomic Locations for IL6ST Gene
Genomic Locations for IL6ST Gene
- chr5:55,935,095-55,995,022
- (GRCh38/hg38)
- Size:
- 59,928 bases
- Orientation:
- Minus strand
- chr5:55,230,923-55,290,821
- (GRCh37/hg19)
- Size:
- 59,899 bases
- Orientation:
- Minus strand
Genomic View for IL6ST Gene
Genes around IL6ST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q11.2 by HGNC
- 5q11.2 by Entrez Gene
- 5q11.2 by Ensembl
IL6ST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL6ST Gene
Proteins for IL6ST Gene
-
Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40189-IL6RB_HUMAN
- Recommended name:
- Interleukin-6 receptor subunit beta
- Protein Accession:
- P40189
- A0N0L4
- Q5FC04
- Q9UQ41
Protein attributes for IL6ST Gene
- Size:
- 918 amino acids
- Molecular mass:
- 103537 Da
- Quaternary structure:
-
- Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).
- (Microbial infection) The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6.
Three dimensional structures from OCA and Proteopedia for IL6ST Gene
Protein Expression for IL6ST Gene
Post-translational modifications for IL6ST Gene
- Phosphorylation of Ser-782 down-regulates cell surface expression.
- Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
-
Glycosylation at Asn43, Asn83, Asn131, Asn157, Asn227, Asn379, Asn383, Asn390, Asn553, Asn564, Asn687, and Asn818
- NX_P40189 (NX_P40189-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- IL6RB_HUMAN (649)
Other Protein References for IL6ST Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences IL6ST / CD130 / gp130 Antibody (LS-B10905) and IL6ST / CD130 / gp130 Antibody (LS-B16775)
- G Biosciences Immunotag™ CD130/gp130 Antibody
- Creative Diagnostics Anti-gp130 monoclonal antibody, clone 39206
-
Creative Biolabs
- Recombinant Mouse Anti-Human IL6ST Antibody
- Mouse Anti-IL6ST Recombinant Antibody (CBFYH-2591)
- Recombinant Mouse Anti-IL6ST Antibody (9X23)
- Mouse Anti-ITGB1/ITGA2 Recombinant Antibody (CBYY-I1587)
- Mouse Anti-IL6ST Recombinant Antibody (CBWJC-3839)
- Mouse Anti-IL6ST Recombinant Antibody (CBXC-1864)
- Mouse Anti-IL6ST Recombinant Antibody (CBYY-C2576)
- GeneTex Anti-CD130 antibody
- Novus Biologicals Antibodies for IL6ST
-
Abcam antibodies for IL6ST
- Invitrogen Antibodies for IL6ST (AFLGC-IL6ST)
- antibodies-online: Show 66 available IL6ST Antibodies ranked by validation data
- Compare Top IL6ST Antibodies
-
Recommended
- 90 WB Antibodies (anti-human)
- 38 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 18 DB Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 17 FACS Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 15 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
-
Boster Bio Antibodies for IL6ST
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
- Sino Biological Antibodies for IL6ST
Protein Products
-
OriGene Purified Proteins for IL6ST
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6ST
- Origene Custom Protein Services for IL6ST
- Sino Biological Recombinant Proteins for IL6ST
- Sino Biological Cell Lysates for IL6ST
-
ProSci Proteins for IL6ST
-
Abcam proteins for IL6ST
Assay Products
- RayBiotech Human sgp130 ELISA
- antibodies-online: Show 36 available IL6ST Elisa Kits ranked by validation data
- Compare Top IL6ST Elisa Kits
-
Quality Products:
- ABIN625085
- ABIN414382
- ABIN1672730
- ABIN5524591
- ABIN2708120
- ABIN6719982
- ABIN2684725
- ABIN5594616
- ABIN6385973
- ABIN4885339
- ABIN5499330
- ABIN1672759
- ABIN415373
- ABIN4993088
- ABIN1979529
- ABIN2708443
- ABIN6719983
- ABIN367709
- ABIN6385974
- ABIN4885740
- ABIN368150
- ABIN416316
- ABIN5594617
- ABIN2748146
- ABIN6385972
- ABIN579315
-
Abcam assays for IL6ST
- Sino Biological Assays for IL6ST
No data available for DME Specific Peptides for IL6ST Gene
Domains & Families for IL6ST Gene
Gene Families for IL6ST Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL6ST Gene
- InterPro:
- Blocks:
-
- Long hematopoietin receptor, gp130 family 2
- Fibronectin type III repeat signature
- Ig-like C2-type
- ProtoNet:
Suggested Antigen Peptide Sequences for IL6ST Gene
- GenScript: Design optimal peptide antigens:
-
- Oncostatin-M receptor subunit alpha (IL6RB_HUMAN)
- Gp130 (Q13514_HUMAN)
- Interleukin 6 signal transducer (Gp130, oncostatin M receptor) (Q17RA0_HUMAN)
- IL6ST nirs variant 5 (Q5FC03_HUMAN)
- IL6ST nirs variant 2 (Q5FC06_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40189UniProtKB/Swiss-Prot:
IL6RB_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL6ST Gene
Molecular function for IL6ST Gene
- UniProtKB/Swiss-Prot Function:
- Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
- UniProtKB/Swiss-Prot Induction:
- LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.
- GENATLAS Biochemistry:
- interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
Phenotypes From GWAS Catalog for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0004897 | ciliary neurotrophic factor receptor activity | IDA | 12643274 |
| GO:0004915 | contributes_to interleukin-6 receptor activity | IDA | 2261637 |
| GO:0004921 | interleukin-11 receptor activity | IEA | -- |
| GO:0004923 | contributes_to leukemia inhibitory factor receptor activity | IDA | 8999038 |
Phenotypes for IL6ST Gene
- MGI mutant phenotypes for IL6ST:
-
inferred from 11 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- GenomeRNAi human phenotypes for IL6ST:
Animal Models for IL6ST Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL6ST - Select products 50% OFF >
- * IL6ST CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL6ST
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6ST
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
miRNA for IL6ST Gene
- miRTarBase miRNAs that target IL6ST
-
- mmu-miR-301b-3p (MIRT007884)
- mmu-miR-425-5p (MIRT008557)
- mmu-miR-24-3p (MIRT013864)
- mmu-miR-149-5p (MIRT014562)
- hsa-miR-590-3p (MIRT016213)
- hsa-miR-335-5p (MIRT017169)
- hsa-miR-215-5p (MIRT024434)
- hsa-miR-192-5p (MIRT026283)
- hsa-miR-615-3p (MIRT040397)
- mmu-miR-142a-3p (MIRT053468)
- hsa-miR-190a-3p (MIRT215958)
- hsa-miR-5011-5p (MIRT215961)
- hsa-miR-302c-3p (MIRT216008)
- hsa-miR-512-3p (MIRT216012)
- hsa-miR-4501 (MIRT216019)
- hsa-miR-25-3p (MIRT216029)
- hsa-miR-32-5p (MIRT216030)
- hsa-miR-92a-3p (MIRT216031)
- hsa-miR-363-3p (MIRT216033)
- hsa-miR-367-3p (MIRT216034)
- hsa-miR-92b-3p (MIRT216035)
- hsa-miR-4789-5p (MIRT216039)
- hsa-miR-6074 (MIRT216040)
- hsa-miR-4729 (MIRT216059)
- hsa-miR-4661-5p (MIRT216085)
- hsa-miR-559 (MIRT216093)
- hsa-miR-548b-5p (MIRT216094)
- hsa-miR-548a-5p (MIRT216095)
- hsa-miR-548c-5p (MIRT216096)
- hsa-miR-548d-5p (MIRT216098)
- hsa-miR-548j-5p (MIRT216100)
- hsa-miR-548h-5p (MIRT216101)
- hsa-miR-548i (MIRT216102)
- hsa-miR-548w (MIRT216103)
- hsa-miR-548y (MIRT216106)
- hsa-miR-548o-5p (MIRT216107)
- hsa-miR-548ab (MIRT216108)
- hsa-miR-548ad-5p (MIRT216109)
- hsa-miR-548ae-5p (MIRT216110)
- hsa-miR-548ak (MIRT216111)
- hsa-miR-548am-5p (MIRT216112)
- hsa-miR-548ap-5p (MIRT216113)
- hsa-miR-548aq-5p (MIRT216114)
- hsa-miR-548ar-5p (MIRT216115)
- hsa-miR-548as-5p (MIRT216116)
- hsa-miR-548au-5p (MIRT216117)
- hsa-miR-548ay-5p (MIRT216119)
- hsa-miR-548bb-5p (MIRT216120)
- hsa-miR-4650-3p (MIRT381714)
- hsa-miR-1303 (MIRT485468)
- hsa-miR-5589-3p (MIRT485469)
- hsa-miR-4272 (MIRT485470)
- hsa-miR-548p (MIRT485471)
- hsa-miR-3924 (MIRT493503)
- hsa-miR-4473 (MIRT493504)
- hsa-miR-6073 (MIRT493505)
- hsa-miR-4720-3p (MIRT493506)
- hsa-miR-4804-3p (MIRT493507)
- hsa-miR-4328 (MIRT493508)
- hsa-miR-7852-3p (MIRT493509)
- hsa-miR-6507-3p (MIRT493510)
- hsa-miR-8054 (MIRT493511)
- hsa-miR-548l (MIRT493512)
- hsa-miR-548k (MIRT493513)
- hsa-miR-548av-5p (MIRT493514)
- hsa-miR-223-3p (MIRT493515)
- hsa-miR-142-3p (MIRT493516)
- hsa-miR-520f-3p (MIRT493517)
- hsa-miR-1277-5p (MIRT511363)
- hsa-miR-6867-5p (MIRT511364)
- hsa-miR-223-5p (MIRT511365)
- hsa-miR-190b (MIRT511366)
- hsa-miR-190a-5p (MIRT511367)
- hsa-miR-511-3p (MIRT511368)
- hsa-miR-4766-3p (MIRT522996)
- hsa-miR-3941 (MIRT522997)
- hsa-miR-3908 (MIRT522998)
- hsa-miR-4703-5p (MIRT522999)
- hsa-miR-3942-5p (MIRT523000)
- hsa-miR-603 (MIRT523001)
- hsa-miR-362-3p (MIRT523002)
- hsa-miR-329-3p (MIRT523003)
- hsa-miR-8485 (MIRT523004)
- hsa-miR-5706 (MIRT536667)
- hsa-miR-4782-5p (MIRT536668)
- hsa-miR-516b-5p (MIRT536669)
- hsa-miR-488-5p (MIRT536670)
- hsa-miR-4778-5p (MIRT536671)
- hsa-miR-2355-3p (MIRT556947)
- hsa-miR-676-3p (MIRT556948)
- mmu-miR-1896 (MIRT586827)
- mmu-miR-1199-5p (MIRT586828)
- mmu-miR-1934-5p (MIRT586829)
- hsa-miR-6820-3p (MIRT702738)
- hsa-miR-3164 (MIRT702739)
- hsa-miR-3118 (MIRT702740)
- hsa-miR-134-5p (MIRT702741)
- hsa-miR-3607-5p (MIRT702742)
- hsa-miR-3177-5p (MIRT721898)
- hsa-miR-4252 (MIRT721899)
- hsa-miR-20b-3p (MIRT721900)
- hsa-miR-3137 (MIRT721901)
- hsa-miR-449b-3p (MIRT721902)
- hsa-miR-892a (MIRT721903)
- rno-miR-17-5p (MIRT733302)
- mmu-miR-130a-3p (MIRT734129)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL6ST
- Browse OriGene Inhibitory RNA Products For IL6ST
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6ST
Clone Products
- Applied Biological Materials (abm): Clones for IL6ST - Select products 50% OFF >
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- MG226651
- MR226651
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- RC215123L4
- RC223001
- RC223001L3
- RC223001L4
- RC231426
- RC231426L3
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- RR210402
- RR210402L3
- RR210402L4
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- MR226651L4V
- RC215123L1V
- RC215123L2V
- RC215123L3V
- RC215123L4V
- RC223001L3V
- RC223001L4V
- RC231426L3V
- RC231426L4V
- RR210402L3V
- RR210402L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL6ST
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6ST
Cell Line Products
-
Horizon Cell Lines for IL6ST
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL6ST Gene
Localization for IL6ST Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Golgi apparatus (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005896 | interleukin-6 receptor complex | IDA | 2261637 |
| GO:0005900 | oncostatin-M receptor complex | IDA | 8999038 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
Pathways & Interactions for IL6ST Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL27-mediated signaling events | ||
| 2 | Interleukin-6 family signaling | ||
| 3 | RAF-independent MAPK1/3 activation | ||
| 4 | PEDF Induced Signaling |
IL-6 Pathway
.61
|
|
| 5 | JAK-STAT signaling pathway | ||
Pathways by source for IL6ST Gene
4 Sino Biological pathways for IL6ST Gene
9 BioSystems pathways for IL6ST Gene
12 Reactome pathways for IL6ST Gene
9 GeneGo (Thomson Reuters) pathways for IL6ST Gene
- Cell adhesion PLAU signaling
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Development CNTF receptor signaling
- Immune response Oncostatin M signaling via MAPK in human cells
4 R&D Systems pathways for IL6ST Gene
6 Qiagen pathways for IL6ST Gene
- CNTF Signaling
- ERK5 Signaling
- IL-6 Pathway
- NFAT and Cardiac Hypertrophy
- OSM Pathway
1 Cell Signaling Technology pathway for IL6ST Gene
Interacting Proteins for IL6ST Gene
Selected Interacting proteins:
P40189-IL6RB_HUMAN
ENSP00000370698
for IL6ST Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IL6ST
SIGNOR curated interactions for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
| GO:0002821 | positive regulation of adaptive immune response | IC | 14764690 |
| GO:0005977 | glycogen metabolic process | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IGI | 8999038 |
Drugs & Compounds for IL6ST Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| SC 144 | Pharma | Gp130 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for IL6ST Gene
| Compound | Action | Cas Number |
|---|---|---|
| SC 144 | Gp130 inhibitor | 895158-95-9 |
Transcripts for IL6ST Gene
mRNA/cDNA for IL6ST Gene
- 8 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336909 8776 nts (view in UCSC)
- ENST00000381286 201 nts (view in UCSC)
- ENST00000381287 8667 nts (view in UCSC)
- ENST00000381293 612 nts (view in UCSC)
- ENST00000381294 2574 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL6ST - Select products 50% OFF >
- * IL6ST CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL6ST
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for IL6ST - Select products 50% OFF >
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- MG226651
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| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - |
Relevant External Links for IL6ST Gene
- GeneLoc Exon Structure for
- IL6ST
Expression for IL6ST Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Bone (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Adipose (Muscoskeletal System)
- Trophoblast (Extraembryonic Tissues)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (34.5), Serum (14.9), and Amniocyte (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL6ST Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL6ST
SOURCE GeneReport for Unigene cluster for IL6ST Gene:
Hs.532082mRNA Expression by UniProt/SwissProt for IL6ST Gene:
P40189-IL6RB_HUMAN
Tissue specificity:
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Evidence on tissue expression from TISSUES for IL6ST Gene
- Liver(4.7)
- Blood(4.5)
- Bone marrow(4.5)
- Nervous system(4.2)
- Heart(3.3)
- Spleen(3.2)
- Intestine(3.2)
- Stomach(3.1)
- Muscle(3)
- Kidney(3)
- Lung(3)
- Lymph node(2.9)
- Pancreas(2.9)
- Skin(2.6)
- Thyroid gland(2.2)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for IL6ST
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL6ST Gene
Orthologs for IL6ST Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL6ST 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL6ST 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL6ST 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il6st 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Il6st 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL6ST 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL6ST 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL6ST 30 |
|
||
| GP130 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | IL6ST 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il6st 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | il6st 30 31 |
|
OneToOne |
- Species where no ortholog for IL6ST was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IL6ST Gene
- ENSEMBL:
- Gene Tree for IL6ST (if available)
- TreeFam:
- Gene Tree for IL6ST (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL6ST: view image
Paralogs for IL6ST Gene
Paralogs for IL6ST Gene
(2) SIMAP similar genes for IL6ST Gene using alignment to 8 proteins:
- IL6RB_HUMAN
- D6RH03_HUMAN
- Q17RA0_HUMAN
- Q5FC02_HUMAN
- Q5FC03_HUMAN
- Q5FC05_HUMAN
- Q5FC06_HUMAN
- Q5FC07_HUMAN
Pseudogenes.org Pseudogenes for IL6ST Gene
Variants for IL6ST Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL6ST Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 635407 | Pathogenic: Stüve-Wiedemann syndrome | 55,960,534(-) | G/A | NONSENSE,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 636252 | Uncertain Significance: GP130-deficient hyper-IgE syndrome | 55,952,253(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 636253 | Uncertain Significance: GP130-deficient hyper-IgE syndrome | 55,952,247(-) | T/G | INTRON_VARIANT | |
| 638017 | Pathogenic: Stüve-Wiedemann syndrome | 55,247,753(-) | A/G | ||
| 638565 | Pathogenic: HYPER-IgE RECURRENT INFECTION SYNDROME 4, AUTOSOMAL RECESSIVE | 55,956,082(-) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3306206 | CNV | mobile element insertion | 20981092 |
| esv3309217 | CNV | mobile element insertion | 20981092 |
| esv3337710 | CNV | insertion | 20981092 |
| esv3395799 | CNV | insertion | 20981092 |
| nsv598182 | CNV | loss | 21841781 |
| nsv830307 | CNV | gain | 17160897 |
| nsv968176 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.43;
90.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL6ST Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL6ST Gene
Disorders for IL6ST Gene
(21) MalaCards diseases for IL6ST Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyper-ige recurrent infection syndrome 4, autosomal recessive |
|
|
| stuve-wiedemann syndrome |
|
|
| hyper ige recurrent infection syndrome 4 |
|
|
| hyper ige syndrome |
|
|
| kaposi sarcoma |
|
|
Search IL6ST in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL6RB_HUMAN- Hyper-IgE recurrent infection syndrome 4, autosomal recessive (HIES4) [MIM:618523]: An immunologic disorder characterized by recurrent infections, mainly affecting the respiratory tract, skin and eye, and skeletal abnormalities including craniosynostosis and scoliosis. Immunologic workup shows increased serum IgE, intermittent eosinophilia, impaired development of certain B- and T-cell populations, as well as impaired acute-phase response. Disease onset is in early childhood. {ECO:0000269 PubMed:28747427, ECO:0000269 PubMed:30309848}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IL6ST
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for IL6ST Gene
Publications for IL6ST Gene
- Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M … Kishimoto T (Cell 1990) 2 3 4 23
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. (PMID: 19915009) Waetzig GH … Seegert D (The Journal of biological chemistry 2010) 3 4 23
- Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. (PMID: 14527405) Boulanger MJ … Garcia KC (Molecular cell 2003) 3 4 23
- Structure of an extracellular gp130 cytokine receptor signaling complex. (PMID: 11251120) Chow D … Garcia KC (Science (New York, N.Y.) 2001) 3 4 23
- Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling. (PMID: 11238858) Li H … Nicholas J (Journal of virology 2001) 3 4 23
ExternalLinks
Products for IL6ST Gene
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- VectorBuilder Custom and pre-made DNA vectors for IL6ST (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IL6ST (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 66 available IL6ST Antibodies ranked by validation data
- Compare Top IL6ST Antibodies
- Recommended
- 90 WB Antibodies (anti-human)
- 38 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 18 DB Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 17 FACS Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 15 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- antibodies-online: Show 36 available IL6ST Elisa Kits ranked by validation data
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- ABIN625085
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- ABIN6385973
- ABIN4885339
- ABIN5499330
- ABIN1672759
- ABIN415373
- ABIN4993088
- ABIN1979529
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- antibodies-online: Show 27 available IL6ST Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
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- Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- Horizon Cell Lines for IL6ST
- Browse GeneCopoeia Cell Lines
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- Boster Bio Antibodies for IL6ST
Sources for IL6ST Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
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- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (115) NCBI Bookshelf
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
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- (145) Aminode
- (146) GeneCopoeia
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- (148) RNACentral
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- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
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- (178) MirGeneDB