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The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a prot... See more...
Aliases for IL6ST Gene
Aliases for IL6ST Gene
- Interleukin 6 Signal Transducer 2 3 5
- Interleukin-6 Receptor Subunit Beta 2 3 4
- Oncostatin-M Receptor Subunit Alpha 3 4
- Gp130, Oncostatin M Receptor 2 3
- IL-6 Receptor Subunit Beta 3 4
- Membrane Glycoprotein 130 3 4
- IL-6R Subunit Beta 3 4
- CD130 Antigen 3 4
- IL-6RB 3 4
- Gp130 Of The Rheumatoid Arthritis Antigenic Peptide-Bearing Soluble Form 3
External Ids for IL6ST Gene
- HGNC: 6021
- Entrez Gene: 3572
- Ensembl: ENSG00000134352
- OMIM: 600694
- UniProtKB: P40189
Previous GeneCards Identifiers for IL6ST Gene
- GC05M055398
- GC05M056665
- GC05M055207
- GC05M055252
- GC05M055272
- GC05M052204
- GC05M055230
Summaries for IL6ST Gene
-
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
GeneCards Summary for IL6ST Gene
IL6ST (Interleukin 6 Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Recurrent Infection Syndrome 4, Autosomal Recessive and Kaposi Sarcoma. Among its related pathways are Transcription Androgen Receptor nuclear signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is IL31RA.
UniProtKB/Swiss-Prot Summary for IL6ST Gene
-
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Additional gene information for IL6ST Gene
- Monarch Initiative
- Search for IL6ST at DataMed
- Search for IL6ST at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL6ST Gene
Genomics for IL6ST Gene
GeneHancer (GH) Regulatory Elements for IL6ST Gene
Promoters and enhancers for IL6ST Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL6ST on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL6ST gene promoter:
-
- aMEF-2
- E4BP4
- FOXF2
- GATA-1
- LCR-F1
- MEF-2
- STAT1
- STAT3
Genomic Locations for IL6ST Gene
Genomic Locations for IL6ST Gene
- chr5:55,935,095-55,995,022
- (GRCh38/hg38)
- Size:
- 59,928 bases
- Orientation:
- Minus strand
- chr5:55,230,923-55,290,821
- (GRCh37/hg19)
- Size:
- 59,899 bases
- Orientation:
- Minus strand
Genomic View for IL6ST Gene
Genes around IL6ST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q11.2 by HGNC
- 5q11.2 by Entrez Gene
- 5q11.2 by Ensembl
IL6ST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL6ST Gene
Proteins for IL6ST Gene
-
Protein details for IL6ST Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40189-IL6RB_HUMAN
- Recommended name:
- Interleukin-6 receptor subunit beta
- Protein Accession:
- P40189
- A0N0L4
- Q5FC04
- Q9UQ41
Protein attributes for IL6ST Gene
- Size:
- 918 amino acids
- Molecular mass:
- 103537 Da
- Quaternary structure:
-
- Component of a hexamer of two molecules each of IL6, IL6R and IL6ST (PubMed:12829785). Forms heterodimers composed of LIFR and IL6ST (type I OSM receptor) which are activated by LIF and OSM (PubMed:8999038). Also forms heterodimers composed of OSMR and IL6ST (type II receptor) which are activated by OSM but not by LIF (PubMed:8999038). Homodimer. Interacts with HCK (PubMed:9406996). Interacts with INPP5D/SHIP1 (By similarity).
- (Microbial infection) The homodimer binds two molecules of herpes virus 8/HHV-8 protein vIL-6.
Three dimensional structures from OCA and Proteopedia for IL6ST Gene
Protein Expression for IL6ST Gene
Post-translational modifications for IL6ST Gene
- Phosphorylation of Ser-782 down-regulates cell surface expression.
- Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
-
Glycosylation at Asn43, Asn83, Asn131, Asn157, Asn227, Asn379, Asn383, Asn390, Asn553, Asn564, and Asn687
- NX_P40189 (NX_P40189-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- IL6RB_HUMAN (649)
Other Protein References for IL6ST Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CD130/gp130 Antibody
- Atlas Antibodies Anti-IL6ST Antibody
-
Creative Biolabs
- Mouse Anti-IL4 Recombinant Antibody (CBYY-I0507)
- Recombinant Mouse Anti-Human IL6ST Antibody
- Mouse Anti-IL6ST Recombinant Antibody (B-R3)
- Mouse Anti-IL6ST Recombinant Antibody (CBFYH-2594)
- Mouse Anti-ICAM3 Recombinant Antibody (CBYY-I1601)
- Mouse Anti-IL6ST Recombinant Antibody (CBFYH-2591)
- Rat Anti-IFNGR2 Recombinant Antibody (CBYY-I1506)
- Mouse Anti-IL6ST Recombinant Antibody (CBFYH-3280)
- Recombinant Mouse Anti-IL6ST Antibody (9X23)
- Mouse Anti-IL6ST Recombinant Antibody (CBYY-I1602)
- Mouse Anti-IL6ST Recombinant Antibody (28126)
- Recombinant Mouse Anti-IL6ST Antibody Fab Fragment (10.51)
- Mouse Anti-IL6ST Recombinant Antibody (11D101)
- Recombinant Mouse Anti-IL6ST Antibody (10.51)
- Mouse Anti-IL6ST Recombinant Antibody (28105)
- Mouse Anti-IL6ST Recombinant Antibody (2E1B02)
- Rat Anti-IL6ST Recombinant Antibody (KGP130)
- Mouse Anti-IL6ST Recombinant Antibody (CBYY-C2575)
- Mouse Anti-FABP6 Recombinant Antibody (CBYY-I0870)
- Mouse Anti-IL6ST Recombinant Antibody (MM0318-9X23)
- Mouse Anti-IL6ST Recombinant Antibody (CBFYC-2779)
- Mouse Anti-ITGB1/ITGA2 Recombinant Antibody (CBYY-I1587)
- Mouse Anti-IL6ST Recombinant Antibody (29104)
- Recombinant Mouse Anti-IL6ST Antibody (CBL445)
- Recombinant Mouse Anti-IL6ST Antibody (B-P4)
- Recombinant Mouse Anti-IL6ST Antibody (CBL446)
- GeneTex Anti-CD130 antibody
- Novus Biologicals Antibodies for IL6ST
-
Abcam antibodies for IL6ST
- Invitrogen Antibodies for IL6ST (AFLGC-IL6ST)
- antibodies-online: Show 66 available IL6ST Antibodies ranked by validation data
- Compare Top IL6ST Antibodies
-
Recommended
- 90 WB Antibodies (anti-human)
- 38 FACS Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 18 DB Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 17 FACS Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 15 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
-
Biorbyt antibodies for IL6ST
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
- Sino Biological Antibodies for IL6ST
Protein Products
- Atlas Antibodies PrEST Antigen IL6ST
-
OriGene Purified Proteins for IL6ST
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6ST
- Origene Custom Protein Services for IL6ST
- Sino Biological Recombinant Proteins for IL6ST
- Sino Biological Cell Lysates for IL6ST
-
ProSci Proteins for IL6ST
-
Abcam proteins for IL6ST
Assay Products
- RayBiotech Human sgp130 ELISA
- Aviva Systems Biology IL6ST ELISA Kit (Human) : 96 Wells (OKEH02802) and IL6ST ELISA Kit (Human) (OKCD00784)
- Novus Biologicals ELISA Kits for IL6ST
- antibodies-online: Show 36 available IL6ST Elisa Kits ranked by validation data
- Compare Top IL6ST Elisa Kits
-
Quality Products:
- ABIN625085
- ABIN414382
- ABIN1672730
- ABIN5524591
- ABIN2708120
- ABIN6719982
- ABIN2684725
- ABIN5594616
- ABIN6385973
- ABIN4885339
- ABIN5499330
- ABIN1672759
- ABIN415373
- ABIN4993088
- ABIN1979529
- ABIN2708443
- ABIN6719983
- ABIN367709
- ABIN6385974
- ABIN4885740
- ABIN368150
- ABIN416316
- ABIN5594617
- ABIN2748146
- ABIN6385972
- ABIN579315
-
Abcam assays for IL6ST
- Sino Biological Assays for IL6ST
No data available for DME Specific Peptides for IL6ST Gene
Domains & Families for IL6ST Gene
Gene Families for IL6ST Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- CD markers
- Plasma proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL6ST Gene
Suggested Antigen Peptide Sequences for IL6ST Gene
- GenScript: Design optimal peptide antigens:
-
- Oncostatin-M receptor subunit alpha (IL6RB_HUMAN)
- Gp130 (Q13514_HUMAN)
- Interleukin 6 signal transducer (Gp130, oncostatin M receptor) (Q17RA0_HUMAN)
- IL6ST nirs variant 5 (Q5FC03_HUMAN)
- IL6ST nirs variant 2 (Q5FC06_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40189UniProtKB/Swiss-Prot:
IL6RB_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL6ST Gene
Molecular function for IL6ST Gene
- UniProtKB/Swiss-Prot Function:
- Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
- UniProtKB/Swiss-Prot Induction:
- LIF and OSM activate the type I OSM receptor while only OSM can activate the type II OSM receptor.
- GENATLAS Biochemistry:
- interleukin 6,signal transducer (GP130),needed for IL6R activity and signal transduction of the IL-6 related cytokines,mediated by JAK kinases,ubiquitously expressed,with a membrane bound and an alternatively spliced secreted form
Phenotypes From GWAS Catalog for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0004897 | ciliary neurotrophic factor receptor activity | IDA | 12643274 |
| GO:0004915 | contributes_to interleukin-6 receptor activity | IBA,IDA | 2261637 |
| GO:0004921 | interleukin-11 receptor activity | IEA | -- |
| GO:0004923 | contributes_to leukemia inhibitory factor receptor activity | IBA,IDA | 8999038 |
Phenotypes for IL6ST Gene
- MGI mutant phenotypes for IL6ST:
-
inferred from 11 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- neoplasm
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for IL6ST:
Animal Models for IL6ST Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6ST
- genomics-online: gRNA clones - Search for available IL6ST gRNA products
- Overview of 158 available IL6ST gene related products
- Applied Biological Materials (abm): CRISPR Clones for IL6ST - Select products 50% OFF >
- * IL6ST CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * IL6ST CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
miRNA for IL6ST Gene
- miRTarBase miRNAs that target IL6ST
-
- hsa-mir-590-3p (MIRT016213)
- hsa-mir-335-5p (MIRT017169)
- hsa-mir-215-5p (MIRT024434)
- hsa-mir-192-5p (MIRT026283)
- hsa-mir-615-3p (MIRT040397)
- hsa-mir-190a-3p (MIRT215958)
- hsa-mir-5011-5p (MIRT215961)
- hsa-mir-302c-3p (MIRT216008)
- hsa-mir-512-3p (MIRT216012)
- hsa-mir-4501 (MIRT216019)
- hsa-mir-25-3p (MIRT216029)
- hsa-mir-32-5p (MIRT216030)
- hsa-mir-92a-3p (MIRT216031)
- hsa-mir-363-3p (MIRT216033)
- hsa-mir-367-3p (MIRT216034)
- hsa-mir-92b-3p (MIRT216035)
- hsa-mir-4789-5p (MIRT216039)
- hsa-mir-6074 (MIRT216040)
- hsa-mir-4729 (MIRT216059)
- hsa-mir-4661-5p (MIRT216085)
- hsa-mir-559 (MIRT216093)
- hsa-mir-548b-5p (MIRT216094)
- hsa-mir-548a-5p (MIRT216095)
- hsa-mir-548c-5p (MIRT216096)
- hsa-mir-548d-5p (MIRT216098)
- hsa-mir-548j-5p (MIRT216100)
- hsa-mir-548h-5p (MIRT216101)
- hsa-mir-548i (MIRT216102)
- hsa-mir-548w (MIRT216103)
- hsa-mir-548y (MIRT216106)
- hsa-mir-548o-5p (MIRT216107)
- hsa-mir-548ab (MIRT216108)
- hsa-mir-548ad-5p (MIRT216109)
- hsa-mir-548ae-5p (MIRT216110)
- hsa-mir-548ak (MIRT216111)
- hsa-mir-548am-5p (MIRT216112)
- hsa-mir-548ap-5p (MIRT216113)
- hsa-mir-548aq-5p (MIRT216114)
- hsa-mir-548ar-5p (MIRT216115)
- hsa-mir-548as-5p (MIRT216116)
- hsa-mir-548au-5p (MIRT216117)
- hsa-mir-548ay-5p (MIRT216119)
- hsa-mir-548bb-5p (MIRT216120)
- hsa-mir-4650-3p (MIRT381714)
- hsa-mir-1303 (MIRT485468)
- hsa-mir-5589-3p (MIRT485469)
- hsa-mir-4272 (MIRT485470)
- hsa-mir-548p (MIRT485471)
- hsa-mir-3924 (MIRT493503)
- hsa-mir-4473 (MIRT493504)
- hsa-mir-6073 (MIRT493505)
- hsa-mir-4720-3p (MIRT493506)
- hsa-mir-4804-3p (MIRT493507)
- hsa-mir-4328 (MIRT493508)
- hsa-mir-7852-3p (MIRT493509)
- hsa-mir-6507-3p (MIRT493510)
- hsa-mir-8054 (MIRT493511)
- hsa-mir-548l (MIRT493512)
- hsa-mir-548k (MIRT493513)
- hsa-mir-548av-5p (MIRT493514)
- hsa-mir-223-3p (MIRT493515)
- hsa-mir-142-3p (MIRT493516)
- hsa-mir-520f-3p (MIRT493517)
- hsa-mir-1277-5p (MIRT511363)
- hsa-mir-6867-5p (MIRT511364)
- hsa-mir-223-5p (MIRT511365)
- hsa-mir-190b (MIRT511366)
- hsa-mir-190a-5p (MIRT511367)
- hsa-mir-511-3p (MIRT511368)
- hsa-mir-4766-3p (MIRT522996)
- hsa-mir-3941 (MIRT522997)
- hsa-mir-3908 (MIRT522998)
- hsa-mir-4703-5p (MIRT522999)
- hsa-mir-3942-5p (MIRT523000)
- hsa-mir-603 (MIRT523001)
- hsa-mir-362-3p (MIRT523002)
- hsa-mir-329-3p (MIRT523003)
- hsa-mir-8485 (MIRT523004)
- hsa-mir-5706 (MIRT536667)
- hsa-mir-4782-5p (MIRT536668)
- hsa-mir-516b-5p (MIRT536669)
- hsa-mir-488-5p (MIRT536670)
- hsa-mir-4778-5p (MIRT536671)
- hsa-mir-2355-3p (MIRT556947)
- hsa-mir-676-3p (MIRT556948)
- hsa-mir-6820-3p (MIRT702738)
- hsa-mir-3164 (MIRT702739)
- hsa-mir-3118 (MIRT702740)
- hsa-mir-134-5p (MIRT702741)
- hsa-mir-3607-5p (MIRT702742)
- hsa-mir-3177-5p (MIRT721898)
- hsa-mir-4252 (MIRT721899)
- hsa-mir-20b-3p (MIRT721900)
- hsa-mir-3137 (MIRT721901)
- hsa-mir-449b-3p (MIRT721902)
- hsa-mir-892a (MIRT721903)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL6ST
- Browse OriGene Inhibitory RNA Products For IL6ST
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6ST
- genomics-online: shRNA clones - Search for available IL6ST shRNA products
- Overview of 158 available IL6ST gene related products
Clone Products
-
- MG226651
- MR226651
- MR226651L3
- MR226651L3V
- MR226651L4
- MR226651L4V
- RC215123
- RC215123L1
- RC215123L1V
- RC215123L2
- RC215123L2V
- RC215123L3
- RC215123L3V
- RC215123L4
- RC215123L4V
- RC223001
- RC223001L3
- RC223001L3V
- RC223001L4
- RC223001L4V
- RC231426
- RC231426L3
- RC231426L3V
- RC231426L4
- RC231426L4V
- RG215123
- RG223001
- RG231426
- RR210402
- RR210402L1
- RR210402L1V
- RR210402L2
- RR210402L2V
- RR210402L3
- RR210402L3V
- RR210402L4
- RR210402L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL6ST
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6ST
- genomics-online: cdna clones - Search for available IL6ST CDNA products
- Overview of 158 available IL6ST gene related products
- orf clones - Search for available IL6ST ORF products
- Overview of 158 available IL6ST gene related products
- Applied Biological Materials (abm): Clones for IL6ST - Select products 50% OFF >
- * IL6ST as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * IL6ST tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for IL6ST
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL6ST Gene
Localization for IL6ST Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL6ST Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005896 | interleukin-6 receptor complex | IDA,IBA | 2261637 |
| GO:0005900 | oncostatin-M receptor complex | IDA | 8999038 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
Pathways & Interactions for IL6ST Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th1 Differentiation Pathway | ||
| 2 | Interleukin-6 family signaling | ||
| 3 | RAF-independent MAPK1/3 activation | ||
| 4 | PEDF Induced Signaling |
IL-6 Pathway
.61
|
|
| 5 | JAK-STAT signaling pathway (KEGG) | ||
Pathways by source for IL6ST Gene
2 Sino Biological pathways for IL6ST Gene
9 BioSystems pathways for IL6ST Gene
12 Reactome pathways for IL6ST Gene
9 GeneGo (Thomson Reuters) pathways for IL6ST Gene
3 R&D Systems pathways for IL6ST Gene
6 Qiagen pathways for IL6ST Gene
- CNTF Signaling
- ERK5 Signaling
- IL-6 Pathway
- NFAT and Cardiac Hypertrophy
- OSM Pathway
1 Cell Signaling Technology pathway for IL6ST Gene
Interacting Proteins for IL6ST Gene
Selected Interacting proteins:
P40189-IL6RB_HUMAN
ENSP00000370698
for IL6ST Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IL6ST
SIGNOR curated interactions for IL6ST Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002675 | positive regulation of acute inflammatory response | IC | 8999038 |
| GO:0002821 | positive regulation of adaptive immune response | IC | 14764690 |
| GO:0005977 | glycogen metabolic process | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0008284 | positive regulation of cell proliferation | IBA,IGI | 8999038 |
Drugs & Compounds for IL6ST Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| SC 144 | Pharma | Gp130 inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for IL6ST Gene
| Compound | Action | Cas Number |
|---|---|---|
| SC 144 | Gp130 inhibitor | 895158-95-9 |
Transcripts for IL6ST Gene
mRNA/cDNA for IL6ST Gene
- (8) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (410) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000381298 9027 bps (ENST00000381298.6)
- ENST00000651614 8412 bps
- ENST00000503773 3031 bps (ENST00000503773.6)
- ENST00000502326 3007 bps (ENST00000502326.7)
- ENST00000381294 2574 bps (ENST00000381294.7)
CRISPR Products
-
OriGene CRISPR knockouts for IL6ST
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6ST
- genomics-online: gRNA clones - Search for available IL6ST gRNA products
- Overview of 158 available IL6ST gene related products
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-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
miRNA Products
Inhibitory RNA Products
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- Overview of 158 available IL6ST gene related products
Clone Products
-
- MG226651
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- MR226651L3
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- RC231426
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- RR210402
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL6ST
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6ST
- genomics-online: cdna clones - Search for available IL6ST CDNA products
- Overview of 158 available IL6ST gene related products
- orf clones - Search for available IL6ST ORF products
- Overview of 158 available IL6ST gene related products
- Applied Biological Materials (abm): Clones for IL6ST - Select products 50% OFF >
- * IL6ST as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
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| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - |
Expression for IL6ST Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
- Bone (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
- T-Cytotoxic Cells Thymus
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Cartilage (Muscoskeletal System)
- Bone Marrow Stromal Cells Bone Marrow
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Adipose (Muscoskeletal System)
- Trophoblast (Extraembryonic Tissues)
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Ovary (Reproductive System)
This gene is overexpressed in Bone marrow mesenchymal stem cell (34.5), Serum (14.9), and Amniocyte (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL6ST Gene
NURSA nuclear receptor signaling pathways regulating expression of IL6ST Gene:
IL6STSOURCE GeneReport for Unigene cluster for IL6ST Gene:
Hs.532082mRNA Expression by UniProt/SwissProt for IL6ST Gene:
P40189-IL6RB_HUMAN
Tissue specificity:
Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Evidence on tissue expression from TISSUES for IL6ST Gene
- Liver(4.6)
- Blood(4.4)
- Bone marrow(4.4)
- Nervous system(3.9)
- Stomach(2.6)
- Kidney(2.5)
- Spleen(2.5)
- Lung(2.4)
- Heart(2.3)
- Intestine(2.3)
- Pancreas(2.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for IL6ST
- genomics-online: primer clones - Search for available IL6ST Primer products
- Overview of 158 available IL6ST gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL6ST Gene
Orthologs for IL6ST Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL6ST 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL6ST 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IL6ST 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Il6st 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Il6st 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IL6ST 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL6ST 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL6ST 32 |
|
||
| GP130 33 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | IL6ST 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il6st 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | il6st 33 32 |
|
OneToOne |
- Species where no ortholog for IL6ST was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IL6ST Gene
- ENSEMBL:
- Gene Tree for IL6ST (if available)
- TreeFam:
- Gene Tree for IL6ST (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL6ST: view image
Paralogs for IL6ST Gene
Paralogs for IL6ST Gene
(2) SIMAP similar genes for IL6ST Gene using alignment to 8 proteins:
- IL6RB_HUMAN
- D6RH03_HUMAN
- Q17RA0_HUMAN
- Q5FC02_HUMAN
- Q5FC03_HUMAN
- Q5FC05_HUMAN
- Q5FC06_HUMAN
- Q5FC07_HUMAN
Pseudogenes.org Pseudogenes for IL6ST Gene
Variants for IL6ST Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036165 | A colorectal cancer sample | p.Thr415Ile | |||
| rs1000024946 | -- | 55,941,947(-) | A/G | intron_variant | |
| rs1000219531 | -- | 55,940,338(-) | T/C | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000306985 | -- | 55,974,174(-) | G/T | intron_variant | |
| rs1000310224 | -- | 55,960,161(-) | G/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3306206 | CNV | mobile element insertion | 20981092 |
| esv3309217 | CNV | mobile element insertion | 20981092 |
| esv3337710 | CNV | insertion | 20981092 |
| esv3395799 | CNV | insertion | 20981092 |
| nsv598182 | CNV | loss | 21841781 |
| nsv830307 | CNV | gain | 17160897 |
| nsv968176 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.43;
90.95% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL6ST Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL6ST Gene
Disorders for IL6ST Gene
(12) MalaCards diseases for IL6ST Gene - From: HGMD, OMIM, ClinVar, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyper-ige recurrent infection syndrome 4, autosomal recessive |
|
|
| kaposi sarcoma |
|
|
| liver benign neoplasm |
|
|
| hepatocellular adenoma |
|
|
| conjunctival disease |
|
|
Search IL6ST in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL6ST
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IL6ST Gene
Publications for IL6ST Gene
- Molecular cloning and expression of an IL-6 signal transducer, gp130. (PMID: 2261637) Hibi M … Kishimoto T (Cell 1990) 2 3 4 23 56
- N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130. (PMID: 19915009) Waetzig GH … Seegert D (The Journal of biological chemistry 2010) 3 4 23 56
- Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling. (PMID: 11238858) Li H … Nicholas J (Journal of virology 2001) 3 4 23 56
- Structure of an extracellular gp130 cytokine receptor signaling complex. (PMID: 11251120) Chow D … Garcia KC (Science (New York, N.Y.) 2001) 3 4 23 56
- Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. (PMID: 10880057) Tanaka M … Nakao K (The Journal of clinical investigation 2000) 3 4 23 56
ExternalLinks
Products for IL6ST Gene
- View all 47 R&D Systems IL6ST (gp130) Products
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- Learn more about R&D Systems custom IL6ST antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IL6ST
- Custom Assay Services
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- OriGene qPCR primer pairs for IL6ST
- OriGene CRISPR knockouts for IL6ST
- MG226651
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- Find your target
- Browse Primary Antibodies
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- antibodies-online: Show 66 available IL6ST Antibodies ranked by validation data
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- Recommended
- 90 WB Antibodies (anti-human)
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- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 17 FACS Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 15 WB Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- antibodies-online: Show 36 available IL6ST Elisa Kits ranked by validation data
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- ABIN625085
- ABIN414382
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- ABIN2684725
- ABIN5594616
- ABIN6385973
- ABIN4885339
- ABIN5499330
- ABIN1672759
- ABIN415373
- ABIN4993088
- ABIN1979529
- ABIN2708443
- ABIN6719983
- ABIN367709
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- ABIN579315
- antibodies-online: Show 27 available IL6ST Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL6ST
- Search Santa Cruz Biotechnology (SCBT) for IL6ST siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL6ST
- Horizon Cell Lines for IL6ST
- genomics-online: cdna clones - Search for available IL6ST CDNA products
- Overview of 158 available IL6ST gene related products
- orf clones - Search for available IL6ST ORF products
- Overview of 158 available IL6ST gene related products
- genomics-online: gRNA clones - Search for available IL6ST gRNA products
- Overview of 158 available IL6ST gene related products
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- Overview of 158 available IL6ST gene related products
- genomics-online: shRNA clones - Search for available IL6ST shRNA products
- Overview of 158 available IL6ST gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6ST
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6ST
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- Biorbyt antibodies for IL6ST
Sources for IL6ST Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Ab