Aliases for IL6R Gene
External Ids for IL6R Gene
Previous GeneCards Identifiers for IL6R Gene
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]
GeneCards Summary for IL6R Gene
IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus and Interleukin 6, Serum Level Of, Quantitative Trait Locus. Among its related pathways are Signaling by GPCR and RAF-independent MAPK1/3 activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and interleukin-6 receptor binding. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot Summary for IL6R Gene
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.