IL6 Gene (Protein Coding)

Interleukin 6

GC07P022725
GIFtS:
50
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcrip... See more...

Aliases for IL6 Gene

Aliases for IL6 Gene

  • Interleukin 6 2 3 5
  • IL-6 2 3 4
  • B-Cell Stimulatory Factor 2 3 4
  • CTL Differentiation Factor 3 4
  • Hybridoma Growth Factor 3 4
  • Interferon Beta-2 3 4
  • Interleukin-6 3 4
  • IFN-Beta-2 3 4
  • BSF-2 3 4
  • IFNB2 3 4
  • BSF2 2 3
  • CDF 3 4
  • HGF 2 3
  • HSF 2 3
  • Interleukin 6 (Interferon, Beta 2) 2
  • B-Cell Differentiation Factor 3
  • Interferon, Beta 2 2
  • Interleukin BSF-2 3
  • IL6 5

External Ids for IL6 Gene

Previous HGNC Symbols for IL6 Gene

  • IFNB2

Previous GeneCards Identifiers for IL6 Gene

  • GC07P022409
  • GC07P022509
  • GC07P022540
  • GC07P022732
  • GC07P022765

Summaries for IL6 Gene

Entrez Gene Summary for IL6 Gene

  • This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020]

CIViC Summary for IL6 Gene

GeneCards Summary for IL6 Gene

IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are IL-6 signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.

UniProtKB/Swiss-Prot Summary for IL6 Gene

  • Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
  • IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
  • Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).

Gene Wiki entry for IL6 Gene

Additional gene information for IL6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL6 Gene

Genomics for IL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL6

Top Transcription factor binding sites by QIAGEN in the IL6 gene promoter:
  • C/EBPbeta
  • FOXJ2
  • FOXJ2 (long isoform)
  • GR
  • GR-alpha
  • GR-beta
  • IRF-2
  • Nkx2-2
  • STAT3
  • YY1

Genomic Locations for IL6 Gene

Latest Assembly
chr7:22,725,884-22,732,002
(GRCh38/hg38)
Size:
6,119 bases
Orientation:
Plus strand

Previous Assembly
chr7:22,766,819-22,771,617
(GRCh37/hg19 by Entrez Gene)
Size:
4,799 bases
Orientation:
Plus strand

chr7:22,765,503-22,771,621
(GRCh37/hg19 by Ensembl)
Size:
6,119 bases
Orientation:
Plus strand

Genomic View for IL6 Gene

Genes around IL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL6 Gene

Proteins for IL6 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for IL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05231-IL6_HUMAN
    Recommended name:
    Interleukin-6
    Protein Accession:
    P05231
    Secondary Accessions:
    • Q9UCU2
    • Q9UCU3
    • Q9UCU4

    Protein attributes for IL6 Gene

    Size:
    212 amino acids
    Molecular mass:
    23718 Da
    Quaternary structure:
    • Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST (PubMed:12829785). Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003). Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).

    Three dimensional structures from OCA and Proteopedia for IL6 Gene

neXtProt entry for IL6 Gene

Protein Expression for IL6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL6 Gene

Other Protein References for IL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for IL6

Protein products for research

  • Abcam proteins for IL6

Assay products for research

  • Abcam assays for IL6

No data available for DME Specific Peptides for IL6 Gene

Domains & Families for IL6 Gene

Gene Families for IL6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL6 Gene

InterPro:
Blocks:
  • Interleukin-6 signature

Suggested Antigen Peptide Sequences for IL6 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55231, highly similar to Interleukin-6 (B4DNQ5_HUMAN)
  • cDNA FLJ52006, moderately similar to Interleukin-6 (B4DNV3_HUMAN)
  • Interferon beta-2 (IL6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05231

UniProtKB/Swiss-Prot:

IL6_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL6: view

Function for IL6 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for IL6 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).
UniProtKB/Swiss-Prot Function:
IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
UniProtKB/Swiss-Prot Function:
Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
UniProtKB/Swiss-Prot Induction:
Plasma levels are highly increased upon exercise, due to enhanced production by contracting skeletal muscles.
GENATLAS Biochemistry:
interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non hodgkin lymphoma by stimulating MMP2 and MMP9

LifeMap Function Summary for IL6 Gene

During embryonic development, IL6 as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for IL6 Gene

Gene Ontology (GO) - Molecular Function for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,TAS 28720735
GO:0005138 interleukin-6 receptor binding IEA,NAS 1883960
GO:0005515 protein binding IPI 11238858
GO:0008083 growth factor activity IEA,IDA 2261637
genes like me logo Genes that share ontologies with IL6: view
genes like me logo Genes that share phenotypes with IL6: view

Human Phenotype Ontology for IL6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL6 Gene

MGI Knock Outs for IL6:
  • Il6 Il6<tm1Kopf>
  • Il6 Il6<tm1Mur>
  • Il6 Il6<tm1Poli>
  • Il6 Il6<tm1.1(KOMP)Vlcg>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL6 Gene

Localization for IL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
nucleus 4
cytosol 4
cytoskeleton 3
mitochondrion 3
peroxisome 3
endosome 3
lysosome 3
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 3023045
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005896 interleukin-6 receptor complex IDA 2261637
genes like me logo Genes that share ontologies with IL6: view

Pathways & Interactions for IL6 Gene

PathCards logo

SuperPathways for IL6 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
2 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
3 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
4 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
Hepatitis B
.37
Lipid and atherosclerosis
.32
Chagas disease
.31
5 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
genes like me logo Genes that share pathways with IL6: view

Pathways by source for IL6 Gene

14 GeneGo (Thomson Reuters) pathways for IL6 Gene
  • Bacterial infections in CF airways
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Development A2B receptor- action via G-protein alpha s
  • Immune response Bacterial infections in normal airways
74 Qiagen pathways for IL6 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
1 GeneTex pathway for IL6 Gene

SIGNOR curated interactions for IL6 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001781 neutrophil apoptotic process IDA 7595060
GO:0002314 germinal center B cell differentiation ISS --
GO:0002377 immunoglobulin production ISS --
GO:0002384 hepatic immune response TAS 12832423
GO:0002446 neutrophil mediated immunity TAS 16034137
genes like me logo Genes that share ontologies with IL6: view

Drugs & Compounds for IL6 Gene

Products:

  1. Drug products for research

(139) Drugs for IL6 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Siltuximab Approved, Investigational Pharma Target, antagonist, antibody 29
Vitamin C Approved Nutra 836,836
Vitamin E Approved, Vet_approved Nutra 553,561
Adalimumab Approved, Experimental Pharma 623
Etanercept Approved, Investigational Pharma 468

(51) Additional Compounds for IL6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL6: view

Transcripts for IL6 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for IL6 Gene

3 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6

Alternative Splicing Database (ASD) splice patterns (SP) for IL6 Gene

No ASD Table

Relevant External Links for IL6 Gene

GeneLoc Exon Structure for
IL6

Expression for IL6 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL6 Gene

mRNA expression in normal human tissues for IL6 Gene
mRNA expression by BioGPS for IL6 GenemRNA expression by GTEx for IL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL6 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.0), Heart - Atrial Appendage (x6.6), and Lung (x4.5).

Protein differential expression in normal tissues from HIPED for IL6 Gene

This gene is overexpressed in Vitreous humor (36.3) and Bone marrow mesenchymal stem cell (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL6 Gene



Protein tissue co-expression partners for IL6 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL6

SOURCE GeneReport for Unigene cluster for IL6 Gene:

Hs.654458

mRNA Expression by UniProt/SwissProt for IL6 Gene:

P05231-IL6_HUMAN
Tissue specificity: Produced by skeletal muscle.

Evidence on tissue expression from TISSUES for IL6 Gene

  • Lung(4.9)
  • Nervous system(4.1)
  • Blood(4)
  • Intestine(3.8)
  • Bone marrow(3.7)
  • Liver(3.7)
  • Heart(3.6)
  • Spleen(3.6)
  • Lymph node(3.5)
  • Muscle(3.5)
  • Skin(3.3)
  • Kidney(3.2)
  • Pancreas(3.2)
  • Adrenal gland(3.2)
  • Bone(3.1)
  • Urine(2.8)
  • Eye(2.8)
  • Gall bladder(2.7)
  • Stomach(2.6)
  • Saliva(2.5)
  • Thyroid gland(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL6 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • lymphatic
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • head
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • lymph node
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL6: view

Primer products for research

Orthologs for IL6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL6 29 30
  • 99.69 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL6 29 30
  • 76.81 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Il6 29 16 30
  • 61.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il6 29
  • 59.01 (n)
Cow
(Bos Taurus)
 Mammalia IL6 30
  • 52 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia IL6 30
  • 40 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia IL6 30
  • 36 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves IL6 29 30
  • 53.43 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia IL6 30
  • 29 (a)
 OneToOne
Species where no ortholog for IL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL6 Gene

ENSEMBL:
Gene Tree for IL6 (if available)
TreeFam:
Gene Tree for IL6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL6: view image
Alliance of Genome Resources:
Additional Orthologs for IL6

Paralogs for IL6 Gene

No data available for Paralogs for IL6 Gene

Variants for IL6 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Polymorphic Variants from UniProtKB/Swiss-Prot for IL6 Gene

IL6_HUMAN-P05231
Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL6 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
14718 Risk Factor: Diabetes mellitus type 2, susceptibility to; Diabetes mellitus, type 1, susceptibility to; Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to; Rheumatoid arthritis, systemic juvenile, susceptibility to; Kaposi sarcoma, susceptibility to; Crohn disease-associated growth failure, susceptibility to 22,727,026(+) C/G
NG_011640.1:g.4880C>G 		GENIC_UPSTREAM_TRANSCRIPT
14719 Benign: INTERLEUKIN 6 POLYMORPHISM 22,726,602(+) A/G
NR_131935.1(IL6-AS1):n.157T>C 		NON_CODING_TRANSCRIPT
rs140764737 Likely Benign: not provided 22,727,607(+) C/T
NM_000600.5(IL6):c.183C>T (p.Leu61=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON
rs142759801 Benign: not provided 22,727,515(+) C/A
NM_000600.5(IL6):c.91C>A (p.Pro31Thr) 		MISSENSE_VARIANT,INTRON
rs201410817 Likely Benign: not provided 22,727,619(+) A/C
NM_000600.5(IL6):c.195A>C (p.Ser65=) 		NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL6 Gene

Variant ID Type Subtype PubMed ID
esv2759518 CNV loss 17122850
nsv7393 OTHER inversion 18451855

Variation tolerance for IL6 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 43.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL6 Gene

Human Gene Mutation Database (HGMD)
IL6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL6
Leiden Open Variation Database (LOVD)
IL6

SNP Genotyping and Copy Number Assays for research

Disorders for IL6 Gene

MalaCards: The human disease database

(775) MalaCards diseases for IL6 Gene - From: OMI, CVR, GTR, ORP, COP, and GCD

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
rheumatoid arthritis, systemic juvenile
  • systemic juvenile rheumatoid arthritis
inflammatory bowel disease 1
  • ibd1
arteriovenous malformations of the brain
  • bavm
type 2 diabetes mellitus
  • t2d
- elite association - COSMIC cancer census association via MalaCards
Search IL6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL6_HUMAN
  • Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:9769329}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
  • Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. {ECO:0000269 PubMed:11001912}.

Additional Disease Information for IL6

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL6: view

No data available for Genatlas for IL6 Gene

Publications for IL6 Gene

  1. Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PMID: 20486195) Chou IC … Tsai FJ (Journal of clinical laboratory analysis 2010) 3 22 40
  2. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F … Ferrari R (Current pharmaceutical design 2010) 3 22 40
  3. The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort. (PMID: 19506792) Giampietro PF … Ghebranious N (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010) 3 22 40
  4. Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter. (PMID: 19934771) Sagiv-Friedgut K … Leshinsky-Silver E (Journal of pediatric gastroenterology and nutrition 2010) 3 22 40
  5. Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population. (PMID: 19936625) Sobti RC … Wanchu A (Molecular and cellular biochemistry 2010) 3 22 40

ExternalLinks

View latest publications for IL6 gene in Mastermind

Products for IL6 Gene

  • Abcam antibodies for IL6
  • Abcam proteins for IL6