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This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | NAS | 10443688 |
GO:0005138 | interleukin-6 receptor binding | NAS | 1883960 |
GO:0005515 | protein binding | IPI | 11238858 |
GO:0008083 | growth factor activity | IDA | 2261637 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IDA | 3023045 |
GO:0005623 | cell | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005896 | interleukin-6 receptor complex | IDA | 2261637 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
5 | Toll-like Receptor Signaling Pathway |
.37
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001781 | neutrophil apoptotic process | IDA | 7595060 |
GO:0002384 | hepatic immune response | TAS | 12832423 |
GO:0002446 | neutrophil mediated immunity | TAS | 16034137 |
GO:0002548 | monocyte chemotaxis | IC | 10510402 |
GO:0002675 | positive regulation of acute inflammatory response | IDA | 2444978 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Siltuximab | Approved, Investigational | Pharma | Target, antagonist, antibody | 24 | ||
Vitamin C | Approved | Nutra | 748,748 | |||
Vitamin E | Approved, Vet_approved | Nutra | 526,534 | |||
Adalimumab | Approved | Pharma | 602 | |||
Etanercept | Approved, Investigational | Pharma | 454 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL6 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL6 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il6 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il6 30 |
|
||
Cow (Bos Taurus) |
Mammalia | IL6 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL6 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL6 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708101 | Likely Benign: not provided | 22,727,619(+) | A/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
709119 | Benign: not provided | 22,727,515(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
717506 | Likely Benign: not provided | 22,727,607(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
768143 | Benign: not provided | 22,727,518(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
777811 | Benign: not provided | 22,731,419(+) | A/T | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759518 | CNV | loss | 17122850 |
nsv7393 | OTHER | inversion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
kaposi sarcoma |
|
|
rheumatoid arthritis, systemic juvenile |
|
|
inflammatory bowel disease 1 |
|
|
arteriovenous malformations of the brain |
|
|
diabetes mellitus, type i |
|