Aliases for IL6 Gene
External Ids for IL6 Gene
Previous HGNC Symbols for IL6 Gene
Previous GeneCards Identifiers for IL6 Gene
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for IL6 Gene
IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Rheumatoid Arthritis, Systemic Juvenile and Kaposi Sarcoma. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.
UniProtKB/Swiss-Prot Summary for IL6 Gene
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.