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This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcrip... See more...
Aliases for IL6 Gene
Aliases for IL6 Gene
External Ids for IL6 Gene
- HGNC: 6018
- Entrez Gene: 3569
- Ensembl: ENSG00000136244
- OMIM: 147620
- UniProtKB: P05231
Previous HGNC Symbols for IL6 Gene
- IFNB2
Previous GeneCards Identifiers for IL6 Gene
- GC07P022409
- GC07P022509
- GC07P022540
- GC07P022732
Summaries for IL6 Gene
-
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for IL6 Gene
IL6 (Interleukin 6) is a Protein Coding gene. Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are Transcriptional misregulation in cancer and Folate Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and growth factor activity.
UniProtKB/Swiss-Prot Summary for IL6 Gene
-
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Additional gene information for IL6 Gene
- HGNC(6018)
- Entrez Gene(3569)
- Ensembl(ENSG00000136244)
- OMIM(147620)
- UniProtKB(P05231)
- Open Targets Platform(ENSG00000136244)
- Monarch Initiative
- Search for IL6 at DataMed
- Search for IL6 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL6 Gene
Genomics for IL6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL6 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL6
- Top Transcription factor binding sites by QIAGEN in the IL6 gene promoter:
-
- C/EBPbeta
- FOXJ2
- FOXJ2 (long isoform)
- GR
- GR-alpha
- GR-beta
- IRF-2
- Nkx2-2
- STAT3
- YY1
Genomic Locations for IL6 Gene
Genomic Locations for IL6 Gene
- chr7:22,725,884-22,732,002
- (GRCh38/hg38)
- Size:
- 6,119 bases
- Orientation:
- Plus strand
- chr7:22,765,503-22,771,621
- (GRCh37/hg19)
- Size:
- 6,119 bases
- Orientation:
- Plus strand
Genomic View for IL6 Gene
Genes around IL6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.3 by HGNC
- 7p15.3 by Entrez Gene
- 7p15.3 by Ensembl
IL6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL6 Gene
Proteins for IL6 Gene
-
Protein details for IL6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05231-IL6_HUMAN
- Recommended name:
- Interleukin-6
- Protein Accession:
- P05231
- Q9UCU2
- Q9UCU3
- Q9UCU4
Protein attributes for IL6 Gene
- Size:
- 212 amino acids
- Molecular mass:
- 23718 Da
- Quaternary structure:
-
- Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling (PubMed:28265003). Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation (PubMed:28265003). May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling (PubMed:28265003).
Protein Expression for IL6 Gene
Post-translational modifications for IL6 Gene
- N- and O-glycosylated.
-
Glycosylation at Asn73
- NX_P05231 (NX_P05231-1)
- Modification sites at PhosphoSitePlus
Other Protein References for IL6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IL-6 Antibody
- NSJ Bioreagents IL-6 Antibody
-
BioLegend
- IL-6 Antibody (501107)
- IL-6 Antibody (501201)
- IL-6 Antibody (501202)
- IL-6 Antibody (501103)
- IL-6 Antibody (501105)
- IL-6 Antibody (501204)
- IL-6 Antibody (501104)
- IL-6 Antibody (501101)
- IL-6 Antibody (501106)
- IL-6 Antibody (501112)
- IL-6 Antibody (501102)
- IL-6 Antibody (501113)
- IL-6 Antibody (501114)
- IL-6 (MaxPar(R) Ready) Antibody
- IL-6 Antibody (501120)
- IL-6 Antibody (501119)
- PerCP/Cyanine5.5 IL-6 Antibody (501118)
- PerCP/Cyanine5.5 IL-6 Antibody (501117)
-
Custom Antibody ServicesOriGene Antibodies for IL6
- AM05403PU-N
- AM05404BT-N
- AM05404PU-N
- AM05676AF-N
- AM05873PU-N
- AM06012PU-N
- AM06090SU-N
- AM26304PU-N
- AM26383PU-L
- AM26384PU-L
- AM26385PU-L
- AM26386PU-L
- AM26387PU-L
- AM26388PU-L
- AM26715PU-N
- AM31262AF-N
- AM31351AF-N
- AM31351RP-N
- AM31374AF-N
- AM33372PU-S
- AM33372PU-T
- AM50337PU-N
- AM50337PU-S
- AP01157BT-N
- AP01157BT-S
- AP01157PU-N
- AP01157PU-S
- AP26368PU-N
- AP52199PU-N
- CF500066
- CF500067
- CF500071
- PP012B1
- PP012B2
- PP012P1
- PP012P2
- PP036B1
- PP036B2
- PP036P1
- PP036P2
- PP1028B1
- PP1028B2
- PP1028P1
- PP1028P2
- SM012AX
- SM1695A
- SM481
- SP1250
- SP2128A
- TA319282
- TA319506
- TA328214
- TA328215
- TA328216
- TA328217
- TA328488
- TA328489
- TA328572
- TA328573
- TA328574
- TA341222
- TA341223
- TA352780
- TA354416
- TA500065
- TA500065S
- TA500066
- TA500066S
- TA500067
- TA500067S
- TA500071
- TA500071S
- TA600023
- TA700023
- Novus Biologicals Antibodies for IL6
-
Abcam antibodies for IL6
- Invitrogen Antibodies for IL6 (AFLGC-Il6)
- antibodies-online: Show 471 available Interleukin 6 Antibodies ranked by validation data
- Compare Top Interleukin 6 Antibodies
-
Recommended
- 322 WB Antibodies (anti-human)
- 57 FACS Antibodies (anti-human)
- 36 IHC (p) Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 11 Neut Antibodies (anti-human)
- 10 IHC Antibodies (anti-human)
- 8 EIA Antibodies (anti-human)
- 5 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 Inhibition Antibody (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 Func Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 129 WB Antibodies (anti-mouse)
- 27 Neut Antibodies (anti-mouse)
- 24 IHC (p) Antibodies (anti-mouse)
- 13 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 IHC Antibodies (anti-mouse)
- 6 IP Antibodies (anti-mouse)
- 4 MA Antibodies (anti-mouse)
- 2 InhA Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 EIA Antibody (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 1 ICFC Antibody (anti-mouse)
- 108 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for IL6
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL6
- Sino Biological Antibodies for IL6
Protein Products
- G Biosciences Human IL-6, Lyophilized
-
BioLegend
- Search Origene for MassSpec and Protein Over-expression Lysates for IL6
- Origene Custom Protein Services for IL6
- Sino Biological Recombinant Proteins for IL6
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IL6
-
ProSci Proteins for IL6
- interleukin 6 [90-482]
- interleukin 6 [90-483]
- interleukin-6 isoform 1 precursor [90-486]
- interleukin 6 [40-466]
- interleukin 6 (interferon, beta 2) [40-523]
- interleukin 6 [91-007]
- interleukin 6 (interferon, beta 2) [96-446]
- interleukin 6 [92-168]
- interleukin 6 [40-112]
- interleukin 6 [90-290]
- interleukin 6 (interferon, beta 2) [40-249]
-
Abcam proteins for IL6
Assay Products
- RayBiotech Human IL-6 ELISA and Human IL-6 ELISA (For Lysates)
-
BioLegend
- Human IL-6 ELISA MAX(TM) Deluxe
- Human IL-6 ELISA MAX(TM) Standard
- LEGEND MAX(TM) Human IL-6 ELISA Kit with Pre-coated Plates
- LEGENDplex(TM) Human IL-6 Capture Bead A7, 13X
- LEGENDplex(TM) Human IL-6 Capture Bead A10, 13X
- LEGENDplex(TM) Human IL-6 Capture Bead B5, 13X
- LEGENDplex(TM) Human IL-6 Capture Beads A6, 13X
- LEGENDplex(TM) Human IL-6 Capture Beads A8, 13X
- LEGENDplex(TM) Human IL-6 Capture Bead A4, 13X
- LEGENDplex(TM) Human IL-6 Capture Bead B7, 13X
- LEGENDplex(TM) Human IL-6 Capture Bead B2, 13X
-
Custom Assay ServicesOriGene ELISA Kits for IL6
- EA100029
- EA100030
- EA100127
- EA100128
- EA100167
- EA100168
- EA100279
- EA100280
- EA100281
- EA101287
- EA101288
- EA101289
- EA101290
- EA101291
- EA101446
- EA101447
- EA101448
- EA101449
- EA101450
- EA101451
- EA101452
- EA101453
- EA101454
- EA101455
- EA101456
- EA101457
- EA101458
- EA101459
- EA101460
- EA101461
- EA101462
- EA101687
- EA101688
- EA101689
- EA101713
- EA101714
- EA101715
- EA101716
- EA101717
- EA101812
- EA102145
- EA102146
- EA102147
- EA102148
- EA102149
- EA102150
- Novus Biologicals ELISA Kits for IL6
- antibodies-online: Show 392 available Interleukin 6 Elisa Kits ranked by validation data
- Compare Top Interleukin 6 Elisa Kits
-
Quality Products:
- ABIN365163
- ABIN1115673
- ABIN411303
- ABIN414886
- ABIN625026
- ABIN2506958
- ABIN1446059
- ABIN612713
- ABIN5523459
- ABIN2690567
- ABIN6574135
- ABIN1115672
- ABIN411304
- ABIN625150
- ABIN415514
- ABIN365175
- ABIN924819
- ABIN625151
- ABIN5523461
- ABIN2690566
- ABIN1115674
- ABIN921064
- ABIN416249
- ABIN625205
- ABIN365191
- ABIN578858
- ABIN5523464
- ABIN2472111
- ABIN491785
- ABIN1873515
- ABIN365439
- ABIN5523460
- ABIN1115679
- ABIN1055304
- ABIN1559541
- ABIN2535628
- ABIN6218801
- ABIN2948820
- ABIN4970492
- ABIN1051239
-
Abcam assays for IL6
- Sino Biological Assays for IL6
No data available for DME Specific Peptides for IL6 Gene
Domains & Families for IL6 Gene
Gene Families for IL6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IL6 Gene
- InterPro:
- Blocks:
-
- Interleukin-6 signature
- ProtoNet:
Suggested Antigen Peptide Sequences for IL6 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ55231, highly similar to Interleukin-6 (B4DNQ5_HUMAN)
- cDNA FLJ52006, moderately similar to Interleukin-6 (B4DNV3_HUMAN)
- Interferon beta-2 (IL6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05231- Family:
-
- Belongs to the IL-6 superfamily.
Function for IL6 Gene
Molecular function for IL6 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
- GENATLAS Biochemistry:
- interleukin 6,23.7kDa,involved in the regulation of immune response,hematopoiesis,platelet production,acute phase reaction and bone resorption (susceptibility factor for osteopenia),playing a role in the aggressiveness of non hodgkin lymphoma by stimulating MMP2 and MMP9
LifeMap Function Summary for IL6 Gene
During embryonic development, IL6 as signaling molecule is secreted from the following cells
- Liver
- Adipose
It affects the following cells:
- Liver
IL6 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Blood
- Adipose
- Heart
Phenotypes From GWAS Catalog for IL6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | NAS | 10443688 |
| GO:0005138 | interleukin-6 receptor binding | NAS | 1883960 |
| GO:0005515 | protein binding | IPI | 11238858 |
| GO:0008083 | growth factor activity | IDA | 2261637 |
Phenotypes for IL6 Gene
- MGI mutant phenotypes for IL6:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for IL6:
Animal Models for IL6 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for IL6
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL6 - Select products 50% OFF >
- * IL6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6
miRNA for IL6 Gene
- miRTarBase miRNAs that target IL6
-
- hsa-let-7a-5p (MIRT005420)
- hsa-miR-203a-3p (MIRT006061)
- hsa-miR-142-3p (MIRT006790)
- hsa-miR-26a-5p (MIRT007374)
- hsa-miR-335-5p (MIRT016949)
- hsa-miR-365a-3p (MIRT020073)
- hsa-miR-155-5p (MIRT021049)
- hsa-miR-124-3p (MIRT022183)
- hsa-miR-1-3p (MIRT023501)
- hsa-miR-98-5p (MIRT027449)
- bta-miR-15b (MIRT053807)
- bta-miR-16a (MIRT053833)
- bta-miR-155 (MIRT053955)
- bta-miR-223 (MIRT054007)
- hsa-miR-107 (MIRT054777)
- mmu-miR-98-5p (MIRT437909)
- hsa-let-7c-5p (MIRT438050)
- hsa-miR-223-3p (MIRT438284)
- hsa-miR-149-5p (MIRT438344)
- mmu-let-7a-5p (MIRT438710)
- hsa-let-7f-5p (MIRT731223)
- hsa-miR-146b-5p (MIRT731232)
- hsa-miR-9-5p (MIRT731346)
- mmu-let-7i-5p (MIRT731503)
- hsa-miR-146a-5p (MIRT732454)
- mmu-miR-142a-3p (MIRT732821)
- hsa-miR-125a-3p (MIRT733375)
- mmu-miR-410-5p (MIRT733484)
- mmu-miR-146a-5p (MIRT733715)
- hsa-miR-106a-5p (MIRT734163)
- hsa-miR-136-5p (MIRT734880)
- mmu-miR-181b-5p (MIRT734963)
- mmu-miR-223-3p (MIRT735275)
- hsa-miR-451a (MIRT735462)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL6
- Browse OriGene Inhibitory RNA Products For IL6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6
Clone Products
- Applied Biological Materials (abm): Clones for IL6 - Select products 50% OFF >
- * IL6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL6
- Addgene plasmids for IL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6
Cell Line Products
-
Horizon Cell Lines for IL6
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL6 Gene
Localization for IL6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL6 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| endoplasmic reticulum | 5 |
| nucleus | 4 |
| cytosol | 4 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| peroxisome | 3 |
| endosome | 3 |
| lysosome | 3 |
| golgi apparatus | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IDA | 3023045 |
| GO:0005623 | cell | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005896 | interleukin-6 receptor complex | IDA | 2261637 |
Pathways & Interactions for IL6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 3 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
|
| 4 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 5 | Toll-like Receptor Signaling Pathway |
.37
|
|
Pathways by source for IL6 Gene
35 BioSystems pathways for IL6 Gene
16 Reactome pathways for IL6 Gene
47 KEGG pathways for IL6 Gene
14 GeneGo (Thomson Reuters) pathways for IL6 Gene
- Bacterial infections in CF airways
- Cytokine production by Th17 cells in CF
- Cytokine production by Th17 cells in CF (Mouse model)
- Development A2B receptor- action via G-protein alpha s
- Immune response Bacterial infections in normal airways
11 R&D Systems pathways for IL6 Gene
74 Qiagen pathways for IL6 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
1 GeneTex pathway for IL6 Gene
Interacting Proteins for IL6 Gene
Selected Interacting proteins:
P05231-IL6_HUMAN
ENSP00000385675
for IL6 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL6
SIGNOR curated interactions for IL6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001781 | neutrophil apoptotic process | IDA | 7595060 |
| GO:0002384 | hepatic immune response | TAS | 12832423 |
| GO:0002446 | neutrophil mediated immunity | TAS | 16034137 |
| GO:0002548 | monocyte chemotaxis | IC | 10510402 |
| GO:0002675 | positive regulation of acute inflammatory response | IDA | 2444978 |
Drugs & Compounds for IL6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Siltuximab | Approved, Investigational | Pharma | Target, antagonist, antibody | 24 | ||
| Vitamin C | Approved | Nutra | 748,748 | |||
| Vitamin E | Approved, Vet_approved | Nutra | 526,534 | |||
| Adalimumab | Approved | Pharma | 602 | |||
| Etanercept | Approved, Investigational | Pharma | 454 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IL6 Gene
mRNA/cDNA for IL6 Gene
- 3 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258743 1127 nts (view in UCSC)
- ENST00000401630 765 nts (view in UCSC)
- ENST00000401651 539 nts (view in UCSC)
- ENST00000404625 1527 nts (view in UCSC)
- ENST00000406575 649 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL6 - Select products 50% OFF >
- * IL6 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL6
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL6
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL6
- Browse OriGene Inhibitory RNA Products For IL6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL6
Clone Products
- Applied Biological Materials (abm): Clones for IL6 - Select products 50% OFF >
- * IL6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IL6
- Addgene plasmids for IL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL6
Relevant External Links for IL6 Gene
- GeneLoc Exon Structure for
- IL6
Expression for IL6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Endochondral Osteoblasts Autopod Periosteum
- Endochondral Osteoblasts Zeugopod Periosteum
- Endochondral Osteoblasts Vertebrae
- Endochondral Osteoblasts Rib
- Endochondral Osteoblasts Stylopod Periosteum
- Mesenchymal Stem Cells
-
Fibroblasts
- Dermal Fibroblasts Ventral Dermis
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
-
Dermis (Integumentary System)
- Dermal Fibroblasts Ventral Dermis
- Dermal Fibroblasts Cranial Dermis
- Dermal Fibroblasts Dorsal Dermis
- Inner Cell Mass (Early Embryo)
- Umbilical Cord (Extraembryonic Tissues)
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- PureStem E15, Meso-prx/latp Progenitor
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Hematopoietic Bone Marrow
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
- Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
- Brain (Nervous System)
- Placenta (Extraembryonic Tissues)
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
- Amnion (Extraembryonic Tissues)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Smooth Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IL6 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x10.0), Heart - Atrial Appendage (x6.6), and Lung (x4.5).
This gene is overexpressed in Vitreous humor (36.3) and Bone marrow mesenchymal stem cell (32.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL6 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL6
SOURCE GeneReport for Unigene cluster for IL6 Gene:
Hs.654458Evidence on tissue expression from TISSUES for IL6 Gene
- Lung(4.9)
- Nervous system(4.3)
- Intestine(4)
- Bone marrow(4)
- Liver(4)
- Blood(4)
- Heart(4)
- Spleen(3.9)
- Lymph node(3.9)
- Muscle(3.9)
- Skin(3.6)
- Kidney(3.5)
- Bone(3.5)
- Pancreas(3.4)
- Adrenal gland(3.4)
- Urine(3.1)
- Eye(3.1)
- Stomach(2.9)
- Gall bladder(2.9)
- Saliva(2.8)
- Thyroid gland(2.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL6 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- lymphatic
- nervous
- skeleton
Regions:
Head and neck:
- brain
- head
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- lymph node
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IL6
-
OriGene qPCR primer pairs and template standards for IL6
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for IL6 Gene
Orthologs for IL6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL6 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL6 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il6 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il6 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | IL6 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL6 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL6 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL6 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IL6 31 |
|
OneToOne |
- Species where no ortholog for IL6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL6 Gene
- ENSEMBL:
- Gene Tree for IL6 (if available)
- TreeFam:
- Gene Tree for IL6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL6: view image
Paralogs for IL6 Gene
No data available for Paralogs for IL6 Gene
Variants for IL6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL6 Gene
- IL6_HUMAN-P05231
- Genetic variations in IL6 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL6 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708101 | Likely Benign: not provided | 22,727,619(+) | A/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 709119 | Benign: not provided | 22,727,515(+) | C/A | MISSENSE_VARIANT,INTRON_VARIANT | |
| 717506 | Likely Benign: not provided | 22,727,607(+) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 768143 | Benign: not provided | 22,727,518(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
| 777811 | Benign: not provided | 22,731,419(+) | A/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759518 | CNV | loss | 17122850 |
| nsv7393 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.52;
43.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL6 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IL6 Gene
(729) MalaCards diseases for IL6 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| kaposi sarcoma |
|
|
| rheumatoid arthritis, systemic juvenile |
|
|
| inflammatory bowel disease 1 |
|
|
| arteriovenous malformations of the brain |
|
|
| diabetes mellitus, type i |
|
Search IL6 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL6_HUMAN- Rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]: An inflammatory articular disorder with systemic onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. {ECO:0000269 PubMed:9769329}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. {ECO:0000269 PubMed:11001912}.
Additional Disease Information for IL6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for IL6 Gene
Publications for IL6 Gene
- Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PMID: 20486195) Chou IC … Tsai FJ (Journal of clinical laboratory analysis 2010) 3 23 41
- The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: a pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort. (PMID: 19506792) Giampietro PF … Ghebranious N (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010) 3 23 41
- Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F … Ferrari R (Current pharmaceutical design 2010) 3 23 41
- Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter. (PMID: 19934771) Sagiv-Friedgut K … Leshinsky-Silver E (Journal of pediatric gastroenterology and nutrition 2010) 3 23 41
- Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population. (PMID: 19936625) Sobti RC … Wanchu A (Molecular and cellular biochemistry 2010) 3 23 41
ExternalLinks
Products for IL6 Gene
- View all 100 R&D Systems IL6 (IL-6) Products
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- AM05403PU-N
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- AM26383PU-L
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- AM26715PU-N
- AM31262AF-N
- AM31351AF-N
- AM31351RP-N
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- AM33372PU-S
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- AP01157BT-N
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- PP1028P1
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- SM012AX
- SM1695A
- SM481
- SP1250
- SP2128A
- TA319282
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- TA341222
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- TA700023
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- EA100029
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- Origene Custom Protein Services for IL6
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- High-throughput Antibody Production Service
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- Novus Biologicals Antibodies for IL6
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- Taconic Biosciences Mouse Models for IL6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IL6 (AFLGC-Il6)
- VectorBuilder Custom and pre-made DNA vectors for IL6 (ie. gene expression, shRNA knockdown, CRISPR)
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