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Aliases for IL5RA Gene

Aliases for IL5RA Gene

  • Interleukin 5 Receptor Subunit Alpha 2 3 5
  • Interleukin 5 Receptor, Alpha 2 3
  • IL-5 Receptor Subunit Alpha 3 4
  • IL-5R Subunit Alpha 3 4
  • CD125 Antigen 3 4
  • CDw125 3 4
  • IL5R 3 4
  • Interleukin-5 Receptor Subunit Alpha 3
  • Interleukin-5 Receptor Alpha Chain 3
  • Interleukin 5 Receptor Type 3 3
  • IL-5R-Alpha 4
  • HSIL5R3 3
  • IL-5RA 4
  • CD125 3

External Ids for IL5RA Gene

Previous HGNC Symbols for IL5RA Gene

  • IL5R

Previous GeneCards Identifiers for IL5RA Gene

  • GC03M003040
  • GC03M003086
  • GC03M003045

Summaries for IL5RA Gene

Entrez Gene Summary for IL5RA Gene

  • The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

GeneCards Summary for IL5RA Gene

IL5RA (Interleukin 5 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL5RA include Asthma. Among its related pathways are Akt Signaling and MAPK Pathway. Gene Ontology (GO) annotations related to this gene include cytokine receptor activity and interleukin-5 receptor activity. An important paralog of this gene is IL13RA2.

UniProtKB/Swiss-Prot for IL5RA Gene

  • This is the receptor for interleukin-5. The alpha chain binds to IL5.

Tocris Summary for IL5RA Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL5RA Gene

Additional gene information for IL5RA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL5RA Gene

Genomics for IL5RA Gene

GeneHancer (GH) Regulatory Elements for IL5RA Gene

Promoters and enhancers for IL5RA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J003125 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.7 -710 3 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B CBX5 TRNT1 IL5RA CRBN ENSG00000271870 GC03P003130
GH03J003109 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.4 +16.5 16461 2.1 PKNOX1 ATF1 BMI1 BATF ATF7 IKZF2 RUNX3 EGR2 CEBPB JUNB IL5RA CNTN4-AS1 ENSG00000253049
GH03J003191 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11 -65.5 -65481 1.7 HDAC1 ATF1 NFRKB TCF12 GATA2 CREM ZBTB2 ZBTB11 ZEB2 ZNF592 TRNT1 IL5RA CRBN GC03M003375
GH03J003170 Enhancer 1 Ensembl ENCODE dbSUPER 12.2 -46.9 -46928 6.2 CTCF IRF2 ZNF654 GATAD2B RAD21 SP1 ZNF316 GATA3 HNF4G ZBTB33 TRNT1 CRBN IL5RA ENSG00000271870
GH03J003145 Enhancer 0.4 dbSUPER 12.9 -20.6 -20595 3.4 REST ATF2 TRNT1 CRBN IL5RA ENSG00000253049 ENSG00000271870 GC03P003130
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL5RA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL5RA gene promoter:
  • RelA
  • FOXL1
  • FOXO4
  • AML1a
  • CUTL1
  • Meis-1b
  • Meis-1a
  • Meis-1
  • AREB6

Genomic Locations for IL5RA Gene

Genomic Locations for IL5RA Gene
60,290 bases
Minus strand
57,065 bases
Minus strand

Genomic View for IL5RA Gene

Genes around IL5RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL5RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL5RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5RA Gene

Proteins for IL5RA Gene

  • Protein details for IL5RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interleukin-5 receptor subunit alpha
    Protein Accession:
    Secondary Accessions:
    • B3IU77
    • B4E2G0
    • Q14633
    • Q15469
    • Q6ISX9

    Protein attributes for IL5RA Gene

    420 amino acids
    Molecular mass:
    47685 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Interacts with SDCBP.

    Three dimensional structures from OCA and Proteopedia for IL5RA Gene

    Alternative splice isoforms for IL5RA Gene


neXtProt entry for IL5RA Gene

Post-translational modifications for IL5RA Gene

  • Glycosylation at isoforms=2, 3, 4244, Asn216, Asn131, and Asn35
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IL5RA Gene

Domains & Families for IL5RA Gene

Gene Families for IL5RA Gene

Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry



  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL5RA: view

Function for IL5RA Gene

Molecular function for IL5RA Gene

UniProtKB/Swiss-Prot Function:
This is the receptor for interleukin-5. The alpha chain binds to IL5.
GENATLAS Biochemistry:
interleukin 5,receptor,alpha subunit,with a membrane anchored and an alternatively spliced secreted form heterodimerizing with CSF2RB

Phenotypes From GWAS Catalog for IL5RA Gene

Gene Ontology (GO) - Molecular Function for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004896 cytokine receptor activity IEA --
GO:0004914 interleukin-5 receptor activity TAS 1495999
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IEA,IPI 1495999
genes like me logo Genes that share ontologies with IL5RA: view
genes like me logo Genes that share phenotypes with IL5RA: view

Animal Models for IL5RA Gene

MGI Knock Outs for IL5RA:

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for IL5RA (IL-5 R alpha/CD125)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL5RA Gene

Localization for IL5RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5RA Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL5RA gene
Compartment Confidence
plasma membrane 5
extracellular 4

Gene Ontology (GO) - Cellular Components for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 1495999
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL5RA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL5RA Gene

Pathways & Interactions for IL5RA Gene

SuperPathways for IL5RA Gene

SuperPathway Contained pathways
1 RET signaling
2 Akt Signaling
3 G beta-gamma signalling through PI3Kgamma
4 Signaling by GPCR
5 PEDF Induced Signaling
genes like me logo Genes that share pathways with IL5RA: view

SIGNOR curated interactions for IL5RA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IL5RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002437 inflammatory response to antigenic stimulus IEA --
GO:0007165 signal transduction TAS 1732409
GO:0008283 cell proliferation TAS 1732409
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with IL5RA: view

Drugs & Compounds for IL5RA Gene

(11) Drugs for IL5RA Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benralizumab Approved, Investigational Pharma Target, antibody 0
AF 12198 Pharma Type I IL-1 receptor antagonist, Potent, selective human type I IL-1 receptor antagonist 0
Ro 26-4550 trifluoroacetate Pharma reversible inhibitor of interleukin-2 (IL-2) binding to its receptor, Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 0
YM 90709 Pharma Interleukin-5 receptor antagonist 0
IL-5 Pharma Agonist 0

(6) Additional Compounds for IL5RA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lyn peptide inhibitor
R 7050

(5) Tocris Compounds for IL5RA Gene

Compound Action Cas Number
AF 12198 Potent, selective human type I IL-1 receptor antagonist 185413-30-3
Lyn peptide inhibitor Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable 222018-18-0
R 7050 Inhibitor of TNF-alpha receptor 1 signaling 303997-35-5
Ro 26-4550 trifluoroacetate Competitive inhibitor of IL-2/ IL-2Ralpha receptor interaction 1217448-66-2
YM 90709 Interleukin-5 receptor antagonist 163769-88-8
genes like me logo Genes that share compounds with IL5RA: view

Transcripts for IL5RA Gene

mRNA/cDNA for IL5RA Gene

(9) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL5RA Gene

Interleukin 5 receptor, alpha:
Representative Sequences:

Clone Products

  • R&D Systems cDNA Clones for IL5RA (IL-5 R alpha/CD125)

Alternative Splicing Database (ASD) splice patterns (SP) for IL5RA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - - - -

Relevant External Links for IL5RA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL5RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL5RA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5RA Gene

This gene is overexpressed in Whole Blood (x5.0) and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for IL5RA Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL5RA Gene

Protein tissue co-expression partners for IL5RA Gene

NURSA nuclear receptor signaling pathways regulating expression of IL5RA Gene:


SOURCE GeneReport for Unigene cluster for IL5RA Gene:


mRNA Expression by UniProt/SwissProt for IL5RA Gene:

Tissue specificity: Expressed on eosinophils and basophils.

Evidence on tissue expression from TISSUES for IL5RA Gene

  • Blood(4.4)
genes like me logo Genes that share expression patterns with IL5RA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL5RA Gene

Orthologs for IL5RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL5RA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IL5RA 34 33
  • 98.89 (n)
(Bos Taurus)
Mammalia IL5RA 34 33
  • 81.98 (n)
(Canis familiaris)
Mammalia IL5RA 34 33
  • 80.9 (n)
(Mus musculus)
Mammalia Il5ra 16 34 33
  • 76.94 (n)
(Rattus norvegicus)
Mammalia Il5ra 33
  • 76.72 (n)
(Monodelphis domestica)
Mammalia IL5RA 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia IL5RA 34
  • 57 (a)
(Gallus gallus)
Aves IL5RA 34 33
  • 55.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia il5ra 33
  • 46.36 (n)
Species where no ortholog for IL5RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL5RA Gene

Gene Tree for IL5RA (if available)
Gene Tree for IL5RA (if available)
Evolutionary constrained regions (ECRs) for IL5RA: view image

Paralogs for IL5RA Gene

Paralogs for IL5RA Gene

(2) SIMAP similar genes for IL5RA Gene using alignment to 6 proteins:

  • B3IU76_HUMAN
  • C9J3K8_HUMAN
  • C9J6C4_HUMAN
genes like me logo Genes that share paralogs with IL5RA: view

Variants for IL5RA Gene

Sequence variations from dbSNP and Humsavar for IL5RA Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000206168 -- 3,111,271(-) C/G upstream_transcript_variant
rs1000207507 -- 3,086,733(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000275057 -- 3,074,283(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000304252 -- 3,111,460(-) G/A upstream_transcript_variant
rs1000338642 -- 3,084,489(-) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL5RA Gene

Variant ID Type Subtype PubMed ID
dgv4636n100 CNV gain 25217958
esv2422274 CNV duplication 17116639
esv2751994 CNV gain 17911159
esv3568570 CNV loss 25503493
esv3893627 CNV loss 25118596
nsv1013843 CNV loss 25217958
nsv518298 CNV gain 19592680
nsv521796 CNV loss 19592680
nsv589371 CNV loss 21841781
nsv589394 CNV loss 21841781
nsv589395 CNV loss 21841781
nsv819643 CNV loss 19587683

Variation tolerance for IL5RA Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.58; 44.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL5RA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL5RA Gene

Disorders for IL5RA Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL5RA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search IL5RA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL5RA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL5RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL5RA Gene

Publications for IL5RA Gene

  1. Molecular cloning and expression of the human interleukin 5 receptor. (PMID: 1732409) Murata Y … Takatsu K (The Journal of experimental medicine 1992) 2 3 4 22 58
  2. The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus. (PMID: 17914408) Burgstaller S … Cross NC (Leukemia 2007) 3 22 44 58
  3. Association analysis of interleukin 5 receptor alpha subunit (IL5RA) polymorphisms and asthma. (PMID: 16217591) Cheong HS … Shin HD (Journal of human genetics 2005) 3 22 44 58
  4. Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. (PMID: 1495999) Tavernier J … Devos R (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 58
  5. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. (PMID: 1833065) Tavernier J … Plaetinck G (Cell 1991) 3 4 22 58

Products for IL5RA Gene

Sources for IL5RA Gene

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