Aliases for IL5 Gene
External Ids for IL5 Gene
Previous GeneCards Identifiers for IL5 Gene
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
GeneCards Summary for IL5 Gene
IL5 (Interleukin 5) is a Protein Coding gene. Diseases associated with IL5 include Pulmonary Eosinophilia and Chronic Eosinophilic Pneumonia. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-5 receptor binding.
UniProtKB/Swiss-Prot Summary for IL5 Gene
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.