This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by ... See more...

Aliases for IL5 Gene

Aliases for IL5 Gene

  • Interleukin 5 2 3 5
  • Eosinophil Differentiation Factor 2 3 4
  • T-Cell Replacing Factor 2 3 4
  • Interleukin-5 2 3 4
  • IL-5 2 3 4
  • TRF 2 3 4
  • Colony-Stimulating Factor, Eosinophil 2 3
  • B-Cell Differentiation Factor I 3 4
  • EDF 2 3
  • Interleukin 5 (Colony-Stimulating Factor, Eosinophil) 2
  • B Cell Differentiation Factor I 2
  • IL5 5

External Ids for IL5 Gene

Previous GeneCards Identifiers for IL5 Gene

  • GC05M131399
  • GC05M132324
  • GC05M131907
  • GC05M131953
  • GC05M131905
  • GC05M127069
  • GC05M131881

Summaries for IL5 Gene

Entrez Gene Summary for IL5 Gene

  • This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

GeneCards Summary for IL5 Gene

IL5 (Interleukin 5) is a Protein Coding gene. Diseases associated with IL5 include Allergic Disease and Pulmonary Eosinophilia. Among its related pathways are RET signaling and IL4-mediated signaling events. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-5 receptor binding.

UniProtKB/Swiss-Prot Summary for IL5 Gene

  • Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Tocris Summary for IL5 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL5 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL5 Gene

Genomics for IL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J132555 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.8 -807 3.5 SP1 ZNF207 NCOR1 MYC IKZF1 ZNF600 ZNF580 ZNF592 KLF9 POLR2A RAD50 IL5 lnc-IL5-3 AFF4 IL4 ENSG00000202533 ENSG00000224431 ZCCHC10 IRF1-AS1 ENSG00000248648
GH05J132543 Promoter 0.3 EPDnew 250.4 +13.3 13322 0.1 IL5 KIF3A CCNI2 RNU7-15P RNA5SP192 RF00017-4408 RAD50 lnc-IL5-3 IRF1 ENSG00000283782
GH05J132406 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 +136.6 136582 26.6 BCLAF1 SP1 ZNF207 ZNF654 IKZF1 MYC NCOR1 JUND ZNF592 ATF2 RAD50 AFF4 MIR3936HG ENSG00000224431 MIR3936 IRF1 SLC22A5 ZCCHC10 P4HA2 RAPGEF6
GH05J132529 Enhancer 1 FANTOM5 Ensembl ENCODE 22.5 +27.5 27463 0.8 TAL1 ZNF316 ATF1 TCF12 MAFK TEAD4 MAFF MEIS2 HDAC1 DPF2 HSALNG0044860 IL5 RAD50 SOWAHA IL4 ENSG00000230612 IL13 CSF2 IL3 SLC22A5
GH05J132736 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 -180.7 -180673 3.1 ZNF207 ZNF600 KLF9 POLR2A BRCA1 NFIC ZIC2 YY1 MXD4 CTCF KIF3A SEPTIN8 ENSG00000230612 IL4 TH2LCRR IL13 SHROOM1 IL5 RAD50 RNU7-15P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL5

Top Transcription factor binding sites by QIAGEN in the IL5 gene promoter:
  • C/EBPalpha
  • GATA-1
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta
  • POU3F2 (N-Oct-5b)

Genomic Locations for IL5 Gene

Latest Assembly
chr5:132,539,194-132,556,864
(GRCh38/hg38)
Size:
17,671 bases
Orientation:
Minus strand

Previous Assembly
chr5:131,877,137-131,879,214
(GRCh37/hg19 by Entrez Gene)
Size:
2,078 bases
Orientation:
Minus strand

chr5:131,877,136-131,892,530
(GRCh37/hg19 by Ensembl)
Size:
15,395 bases
Orientation:
Minus strand

Genomic View for IL5 Gene

Genes around IL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL5 Gene

Proteins for IL5 Gene

  • Protein details for IL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05113-IL5_HUMAN
    Recommended name:
    Interleukin-5
    Protein Accession:
    P05113
    Secondary Accessions:
    • Q13840

    Protein attributes for IL5 Gene

    Size:
    134 amino acids
    Molecular mass:
    15238 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IL5 Gene

neXtProt entry for IL5 Gene

Post-translational modifications for IL5 Gene

  • Glycosylation at Thr22 and Asn47
  • Modification sites at PhosphoSitePlus

Other Protein References for IL5 Gene

Antibodies for research

  • Abcam antibodies for IL5

Assay products for research

No data available for DME Specific Peptides for IL5 Gene

Domains & Families for IL5 Gene

Gene Families for IL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL5 Gene

InterPro:
Blocks:
  • Interleukin-5 signature

Suggested Antigen Peptide Sequences for IL5 Gene

GenScript: Design optimal peptide antigens:
  • T-cell replacing factor (IL5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05113

UniProtKB/Swiss-Prot:

IL5_HUMAN :
  • Belongs to the IL-5 family.
Family:
  • Belongs to the IL-5 family.
genes like me logo Genes that share domains with IL5: view

Function for IL5 Gene

Molecular function for IL5 Gene

UniProtKB/Swiss-Prot Function:
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
GENATLAS Biochemistry:
interleukin 5,colony-stimulating factor (eosinophil),homodimerizing,inducing terminal differentiation of B cells to immunoglobulin secreting cells

Phenotypes From GWAS Catalog for IL5 Gene

Gene Ontology (GO) - Molecular Function for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005137 interleukin-5 receptor binding IEA --
GO:0005515 protein binding IPI 1495999
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with IL5: view
genes like me logo Genes that share phenotypes with IL5: view

Animal Models for IL5 Gene

MGI Knock Outs for IL5:
  • Il5 Il5<tm1.1(icre)Lky>
  • Il5 Il5<tm1Anjm>
  • Il5 Il5<tm2Anjm>
  • Il5 Il5<tm1Kopf>
  • Il5 Il5<tm1Ktk>
  • Il5 Il5<tm3Anjm>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL5 Gene

Localization for IL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL5 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,TAS 3024129
genes like me logo Genes that share ontologies with IL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL5 Gene

Pathways & Interactions for IL5 Gene

PathCards logo

SuperPathways for IL5 Gene

SuperPathway Contained pathways
1 RET signaling
2 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
3 Allograft rejection
.44
4 TGF-Beta Pathway
.60
.60
.57
.43
.40
5 Akt Signaling
.60
.60
.55
genes like me logo Genes that share pathways with IL5: view

SIGNOR curated interactions for IL5 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with IL5: view

Drugs & Compounds for IL5 Gene

(101) Drugs for IL5 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mepolizumab Approved, Investigational Pharma Target, antagonist, antibody 0
Reslizumab Approved, Investigational Pharma Target, antagonist 25
Prednisolone Approved, Vet_approved Pharma 1686
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 440
Methylprednisolone Approved, Vet_approved Pharma Apoptosis inducer,GR agonist, Glucocorticoid receptor agonist 1686

(47) Additional Compounds for IL5 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AS 101
106566-58-9
GIT 27
6501-72-0

(4) Tocris Compounds for IL5 Gene

Compound Action Cas Number
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release 106566-58-9
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines 6501-72-0
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1

(1) ApexBio Compounds for IL5 Gene

Compound Action Cas Number
Suplatast Tosylate 94055-76-2
genes like me logo Genes that share compounds with IL5: view

Transcripts for IL5 Gene

mRNA/cDNA for IL5 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL5

Alternative Splicing Database (ASD) splice patterns (SP) for IL5 Gene

No ASD Table

Relevant External Links for IL5 Gene

GeneLoc Exon Structure for
IL5

Expression for IL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL5 Gene

This gene is overexpressed in Testis (x25.2).

Protein differential expression in normal tissues from HIPED for IL5 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL5 Gene



Protein tissue co-expression partners for IL5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL5

SOURCE GeneReport for Unigene cluster for IL5 Gene:

Hs.2247

Evidence on tissue expression from TISSUES for IL5 Gene

  • Blood(3.4)
  • Spleen(3.1)
  • Lung(3)
  • Lymph node(3)
  • Intestine(2.8)
  • Bone marrow(2.8)
  • Skin(2.7)
  • Nervous system(2.5)
  • Muscle(2.4)
  • Heart(2.4)
  • Liver(2.4)
  • Kidney(2.3)
  • Bone(2)
genes like me logo Genes that share expression patterns with IL5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL5 Gene

Orthologs for IL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL5 29 30
  • 99.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL5 29 30
  • 81.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL5 29 30
  • 80.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il5 29 16 30
  • 79.2 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il5 29
  • 78.63 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL5 30
  • 53 (a)
OneToOne
Species where no ortholog for IL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL5 Gene

ENSEMBL:
Gene Tree for IL5 (if available)
TreeFam:
Gene Tree for IL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL5: view image
Alliance of Genome Resources:
Additional Orthologs for IL5

Paralogs for IL5 Gene

No data available for Paralogs for IL5 Gene

Variants for IL5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL5 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs112946922 Benign: not provided 132,543,371(-) C/A
NM_000879.3(IL5):c.108G>T (p.Leu36=)
SYNONYMOUS
rs142865560 Benign: not provided 132,541,904(-) C/T
NM_000879.3(IL5):c.312G>A (p.Lys104=)
SYNONYMOUS
rs2069818 Benign: not provided 132,541,832(-) G/T
NM_000879.3(IL5):c.384C>A (p.Thr128=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for IL5 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL5 Gene

Human Gene Mutation Database (HGMD)
IL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL5
Leiden Open Variation Database (LOVD)
IL5

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL5 Gene

Disorders for IL5 Gene

MalaCards: The human disease database

(189) MalaCards diseases for IL5 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
allergic disease
  • allergic hypersensitivity disease
pulmonary eosinophilia
  • asthmatic pulmonary eosinophilia
chronic eosinophilic pneumonia
  • cryptogenic pulmonary eosinophilia
eosinophilic pneumonia
  • pneumonia, eosinophilic
allergic rhinitis
  • alrh
- elite association - COSMIC cancer census association via MalaCards
Search IL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL5

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL5 Gene

Publications for IL5 Gene

  1. Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes. (PMID: 18849614) Llanes E … Cárdaba B (International archives of allergy and immunology 2009) 3 22 40
  2. IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans. (PMID: 17620072) Namkung JH … Yang JM (Allergy 2007) 3 22 40
  3. Polymorphisms in eosinophil pathway genes, asthma and atopy. (PMID: 17362254) Kabesch M … Nickel R (Allergy 2007) 3 22 40
  4. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. (PMID: 16449530) Lan Q … Chanock S (Blood 2006) 3 22 40
  5. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. (PMID: 15805995) Hong SJ … Hong TJ (The Journal of allergy and clinical immunology 2005) 3 22 40

Products for IL5 Gene

Sources for IL5 Gene