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This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble for... See more...
Aliases for IL4R Gene
Aliases for IL4R Gene
External Ids for IL4R Gene
- HGNC: 6015
- Entrez Gene: 3566
- Ensembl: ENSG00000077238
- OMIM: 147781
- UniProtKB: P24394
Previous GeneCards Identifiers for IL4R Gene
- GC16P026753
- GC16P027424
- GC16P027252
- GC16P027317
- GC16P027291
- GC16P027248
- GC16P025413
Summaries for IL4R Gene
-
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for IL4R Gene
IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1. Among its related pathways are AKT Siganaling Pathway and Development IGF-1 receptor signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor and interleukin-4 receptor activity. An important paralog of this gene is CSF2RB.
UniProtKB/Swiss-Prot Summary for IL4R Gene
-
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
-
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Additional gene information for IL4R Gene
- HGNC(6015)
- Entrez Gene(3566)
- Ensembl(ENSG00000077238)
- OMIM(147781)
- UniProtKB(P24394)
- Open Targets Platform(ENSG00000077238)
- Monarch Initiative
- Search for IL4R at DataMed
- Search for IL4R at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL4R Gene
Genomics for IL4R Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL4R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL4R on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL4R
- Top Transcription factor binding sites by QIAGEN in the IL4R gene promoter:
-
- GATA-3
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for IL4R Gene
Genomic Locations for IL4R Gene
- chr16:27,313,668-27,364,778
- (GRCh38/hg38)
- Size:
- 51,111 bases
- Orientation:
- Plus strand
- chr16:27,324,989-27,376,099
- (GRCh37/hg19)
- Size:
- 51,111 bases
- Orientation:
- Plus strand
Genomic View for IL4R Gene
Genes around IL4R on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p12.1 by HGNC
- 16p12.1 by Entrez Gene
- 16p12.1 by Ensembl
IL4R Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL4R Gene
Proteins for IL4R Gene
-
Protein details for IL4R Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P24394-IL4RA_HUMAN
- Recommended name:
- Interleukin-4 receptor subunit alpha
- Protein Accession:
- P24394
- B4E076
- B9EKU8
- H3BSY5
- Q96P01
- Q9H181
- Q9H182
- Q9H183
- Q9H184
- Q9H185
- Q9H186
- Q9H187
- Q9H188
Protein attributes for IL4R Gene
- Size:
- 825 amino acids
- Molecular mass:
- 89658 Da
- Quaternary structure:
-
- The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1 (By similarity).
Three dimensional structures from OCA and Proteopedia for IL4R Gene
Protein Expression for IL4R Gene
Post-translational modifications for IL4R Gene
- On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
- The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
-
Glycosylation at Asn53, Asn98, Asn128, Asn134, Asn176, and Asn209
- NX_P24394 (NX_P24394-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- IL4RA_HUMAN (2053)
Other Protein References for IL4R Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IL-4R alpha Antibody
-
BioLegend
-
Custom Antibody ServicesOriGene Antibodies for IL4R
- Novus Biologicals Antibodies for IL4R
-
Abcam antibodies for IL4R
- Invitrogen Antibodies for IL4R (AFLGC-IL4R)
- antibodies-online: Show 33 available IL4 Receptor Antibodies ranked by validation data
- Compare Top IL4 Receptor Antibodies
-
Recommended
- 65 WB Antibodies (anti-human)
- 15 FACS Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 9 WB Antibodies (anti-rat)
- 32 WB Antibodies (anti-mouse)
- 5 FACS Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 Neut Antibody (anti-mouse)
-
Boster Bio Antibodies for IL4R
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL4R
- Sino Biological Antibodies for IL4R
Protein Products
- G Biosciences Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN0980), Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN1944), and Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN1949)
-
OriGene Purified Proteins for IL4R
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4R
- Origene Custom Protein Services for IL4R
- Sino Biological Recombinant Proteins for IL4R
- Sino Biological Cell Lysates for IL4R
- ProSpec Recombinant Proteins for IL4R
-
ProSci Proteins for IL4R
-
Abcam proteins for IL4R
Assay Products
- RayBiotech Custom Human IL-4 R alpha ELISA
- Novus Biologicals ELISA Kits for IL4R
-
Abcam assays for IL4R
- Sino Biological Assays for IL4R
No data available for DME Specific Peptides for IL4R Gene
Domains & Families for IL4R Gene
Gene Families for IL4R Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL4R Gene
- InterPro:
- Blocks:
-
- Short hematopoietin receptor, family 1
- ProtoNet:
Suggested Antigen Peptide Sequences for IL4R Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ58656, highly similar to Interleukin-4 receptor alpha chain (B4E076_HUMAN)
- Interleukin 4 receptor (B9EGC0_HUMAN)
- Interleukin-4 receptor subunit alpha (IL4RA_HUMAN)
- IL4R nirs variant 1 (Q5FC08_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P24394UniProtKB/Swiss-Prot:
IL4RA_HUMAN :- The extracellular domain represents the IL4 binding protein (IL4BP).
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
- Domain:
-
- The extracellular domain represents the IL4 binding protein (IL4BP).
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
Function for IL4R Gene
Molecular function for IL4R Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
- UniProtKB/Swiss-Prot Function:
- Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
- GENATLAS Biochemistry:
- interleukin 4,receptor (see IL2RG),expressed on T-cell,with a polymorphism associated with increased signaling and susceptibility to atopy asthma and hyper IgE syndrome
Phenotypes From GWAS Catalog for IL4R Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IEA | -- |
| GO:0004913 | interleukin-4 receptor activity | TAS | 2307934 |
| GO:0005515 | protein binding | IPI | 8266078 |
Phenotypes for IL4R Gene
- MGI mutant phenotypes for IL4R:
-
inferred from 8 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for IL4R:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability ratio
- Decreased viability
- Increased epidermal growth factor (EGF) endocytosis
- Increased IL-8 secretion
- Reduced mammosphere formation
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Two nuclei (binuclear)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL4R - Select products 50% OFF >
- * IL4R CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL4R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4R
miRNA for IL4R Gene
- miRTarBase miRNAs that target IL4R
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4R
- Browse OriGene Inhibitory RNA Products For IL4R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4R
Clone Products
- Applied Biological Materials (abm): Clones for IL4R - Select products 50% OFF >
- * IL4R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227371
- MR227371
- MR227371L1
- MR227371L2
- MR227371L3
- MR227371L4
- RC214464
- RC214464L1
- RC214464L2
- RC214464L3
- RC214464L4
- RC234914
- RC234935
- RC239259
- RG214464
- RG234914
- RG234935
- RR207090
- RR207090L3
- RR207090L4
- MR227371L1V
- MR227371L2V
- MR227371L3V
- MR227371L4V
- RC214464L1V
- RC214464L2V
- RC214464L3V
- RC214464L4V
- RR207090L3V
- RR207090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL4R
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4R
Cell Line Products
-
Horizon Cell Lines for IL4R
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL4R Gene
Localization for IL4R Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL4R Gene
- Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 4 |
| nucleus | 4 |
| cytosol | 3 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Plasma membrane (3)
- Centriolar satellite (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2307934 |
Pathways & Interactions for IL4R Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
| 3 | Th17 cell differentiation | ||
| 4 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 5 | Jak Stat Signaling Pathway | ||
Pathways by source for IL4R Gene
4 Sino Biological pathways for IL4R Gene
3 BioSystems pathways for IL4R Gene
4 Reactome pathways for IL4R Gene
1 GeneGo (Thomson Reuters) pathway for IL4R Gene
- Immune response IL-4 signaling pathway
5 R&D Systems pathways for IL4R Gene
16 Qiagen pathways for IL4R Gene
- Akt Signaling
- Antioxidant Action of Vitamin-C
- Glucocorticoid Receptor Signaling
- IL-4 Pathway
- JAK-STAT Pathway
Interacting Proteins for IL4R Gene
Selected Interacting proteins:
P24394-IL4RA_HUMAN
ENSP00000379111
for IL4R Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IL4R
SIGNOR curated interactions for IL4R Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002532 | production of molecular mediator involved in inflammatory response | IEA | -- |
| GO:0002639 | positive regulation of immunoglobulin production | IEA | -- |
| GO:0006955 | immune response | TAS | 2307934 |
| GO:0007165 | signal transduction | TAS | 2307934 |
Drugs & Compounds for IL4R Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- G Biosciences Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN0980), Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN1944), and Human IL-4 R alpha/CD124/IL-4RA/IL-4R/Interleukin-4 Receptor Subunit Alpha/prot, Lyophilized (BAN1949)
Transcripts for IL4R Gene
mRNA/cDNA for IL4R Gene
- 5 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000170630 3380 nts (view in UCSC)
- ENST00000395762 3624 nts (view in UCSC)
- ENST00000543915 3539 nts (view in UCSC)
- ENST00000561742 379 nts (view in UCSC)
- ENST00000561946 611 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL4R - Select products 50% OFF >
- * IL4R CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL4R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4R
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4R
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4R
- Browse OriGene Inhibitory RNA Products For IL4R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4R
Clone Products
- Applied Biological Materials (abm): Clones for IL4R - Select products 50% OFF >
- * IL4R as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227371
- MR227371
- MR227371L1
- MR227371L2
- MR227371L3
- MR227371L4
- RC214464
- RC214464L1
- RC214464L2
- RC214464L3
- RC214464L4
- RC234914
- RC234935
- RC239259
- RG214464
- RG234914
- RG234935
- RR207090
- RR207090L3
- RR207090L4
- MR227371L1V
- MR227371L2V
- MR227371L3V
- MR227371L4V
- RC214464L1V
- RC214464L2V
- RC214464L3V
- RC214464L4V
- RR207090L3V
- RR207090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL4R
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4R
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - |
Relevant External Links for IL4R Gene
- GeneLoc Exon Structure for
- IL4R
Expression for IL4R Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
- Fibroblasts (Uncategorized)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for IL4R Gene
This gene is overexpressed in Whole Blood (x10.5).
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL4R Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL4R
SOURCE GeneReport for Unigene cluster for IL4R Gene:
Hs.513457mRNA Expression by UniProt/SwissProt for IL4R Gene:
P24394-IL4RA_HUMAN
Tissue specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Evidence on tissue expression from TISSUES for IL4R Gene
- Blood(4.6)
- Lymph node(3.3)
- Spleen(3.3)
- Bone marrow(3.1)
- Lung(3)
- Intestine(3)
- Liver(2.7)
- Skin(2.7)
- Nervous system(2.6)
- Heart(2.6)
- Muscle(2.3)
- Pancreas(2.2)
- Kidney(2.2)
- Stomach(2.1)
Primer Products
-
OriGene qPCR primer pairs for IL4R
-
OriGene qPCR primer pairs and template standards for IL4R
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4R Gene
Orthologs for IL4R Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL4R 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL4R 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL4R 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il4r 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Il4ra 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL4R 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IL4R 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL4RA 31 |
|
OneToOne |
- Species where no ortholog for IL4R was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL4R Gene
- ENSEMBL:
- Gene Tree for IL4R (if available)
- TreeFam:
- Gene Tree for IL4R (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL4R: view image
Paralogs for IL4R Gene
Variants for IL4R Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL4R Gene
- IL4RA_HUMAN-P24394
- Allelic variants in IL4RA are associated with a susceptibility to atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
- IL4RA_HUMAN-P24394
- Allelic variants in IL4RA are associated with cedar pollen sensitization. Individuals develop Japanese cedar pollinosis with increased exposure to cedar pollen. Japanese cedar pollinosis is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL4R Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 708028 | Benign: not provided | 27,358,957(+) | G/A | MISSENSE_VARIANT | |
| 710743 | Benign: not provided | 27,358,967(+) | C/G | SYNONYMOUS_VARIANT | |
| 718605 | Benign: not provided | 27,344,896(+) | C/T | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 750336 | Likely Benign: not provided | 27,359,004(+) | G/C | INTRON_VARIANT | |
| 768763 | Benign: not provided | 27,355,905(+) | C/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1333n106 | CNV | deletion | 24896259 |
| dgv4962n54 | CNV | loss | 21841781 |
| dgv4963n54 | CNV | loss | 21841781 |
| dgv811e212 | CNV | loss | 25503493 |
| dgv812e212 | CNV | loss | 25503493 |
| esv24900 | CNV | loss | 19812545 |
| esv2664327 | CNV | deletion | 23128226 |
| esv2762344 | CNV | loss | 21179565 |
| esv3553287 | CNV | deletion | 23714750 |
| esv3638324 | CNV | loss | 21293372 |
| nsv1059454 | CNV | gain | 25217958 |
| nsv516053 | CNV | gain+loss | 19592680 |
| nsv571721 | CNV | loss | 21841781 |
| nsv833179 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
77% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.76;
96.66% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL4R Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IL4R Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ige responsiveness, atopic |
|
|
| human immunodeficiency virus type 1 |
|
|
| allergic rhinitis |
|
|
| rhinitis |
|
|
| beta-lactam allergy |
|
|
Search IL4R in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL4R
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL4R Gene
Publications for IL4R Gene
- The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. (PMID: 10233717) Kruse S … Deichmann KA (Immunology 1999) 3 4 23 41
- The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. (PMID: 9392697) Hershey GK … Chatila TA (The New England journal of medicine 1997) 3 4 23 41
- TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population. (PMID: 19470040) Javor J … Svecova D (Journal of the European Academy of Dermatology and Venereology : JEADV 2010) 3 23 41
- Interleukin-4/interleukin-4 receptor gene polymorphisms in hand osteoarthritis. (PMID: 20219689) Vargiolu M … Meliconi R (Osteoarthritis and cartilage 2010) 3 23 41
- Cytokine polymorphisms and Alzheimer disease: possible associations. (PMID: 20213229) Ribizzi G … Megna M (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2010) 3 23 41
ExternalLinks
Products for IL4R Gene
- View all 24 R&D Systems IL4R (IL-4R alpha) Products
- View all 4 R&D Systems IL4R (IL-4R alpha) Proteins and Enzymes
- View all 18 R&D Systems IL4R (IL-4R alpha) Primary Antibodies
- View all R&D Systems IL4R (IL-4R alpha) Luminex Assays
- View all R&D Systems IL4R (IL-4R alpha) cDNA Clones
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- MG227371
- MR227371
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- MR227371L3
- MR227371L4
- RC214464
- RC214464L1
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- RC214464L3
- RC214464L4
- RC234914
- RC234935
- RC239259
- RG214464
- RG234914
- RG234935
- RR207090
- RR207090L3
- RR207090L4
- MR227371L1V
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- MR227371L3V
- MR227371L4V
- RC214464L1V
- RC214464L2V
- RC214464L3V
- RC214464L4V
- RR207090L3V
- RR207090L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- antibodies-online: Show 33 available IL4 Receptor Antibodies ranked by validation data
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- antibodies-online: Show 30 available IL4 Receptor Elisa Kits ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL4R
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Sources for IL4R Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
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- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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- (104) diseasecard
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
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- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
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- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (175) Open Targets Platform
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- (177) snoDB
- (178) MirGeneDB