IL4 Gene (Protein Coding)

Interleukin 4

GC05P132673
GIFtS:
46
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating t... See more...

Aliases for IL4 Gene

Aliases for IL4 Gene

  • Interleukin 4 2 3 5
  • Lymphocyte Stimulatory Factor 1 2 3 4
  • IL-4 2 3 4
  • B_cell Stimulatory Factor 1 2 3
  • B Cell Growth Factor 1 2 3
  • Interleukin-4 3 4
  • Binetrakin 3 4
  • Pitrakinra 3 4
  • BCGF-1 2 3
  • BCGF1 2 3
  • BSF-1 3 4
  • BSF1 2 3
  • B-Cell Stimulatory Factor 1 4
  • Interleukin 4 Variant 2 3
  • MGC79402 2
  • IL4 5

External Ids for IL4 Gene

Previous GeneCards Identifiers for IL4 Gene

  • GC05P131531
  • GC05P132456
  • GC05P132041
  • GC05P132085
  • GC05P132037
  • GC05P132009
  • GC05P127201

Summaries for IL4 Gene

Entrez Gene Summary for IL4 Gene

  • The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL4 Gene

IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Schistosomiasis and Vernal Conjunctivitis. Among its related pathways are Immune response Fc epsilon RI pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.

UniProtKB/Swiss-Prot Summary for IL4 Gene

  • Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).

Gene Wiki entry for IL4 Gene

Additional gene information for IL4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL4 Gene

Genomics for IL4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL4

Top Transcription factor binding sites by QIAGEN in the IL4 gene promoter:
  • AML1a

Genomic Locations for IL4 Gene

Genomic Locations for IL4 Gene
chr5:132,673,986-132,682,678
(GRCh38/hg38)
Size:
8,693 bases
Orientation:
Plus strand
chr5:132,009,373-132,018,368
(GRCh37/hg19)
Size:
8,996 bases
Orientation:
Plus strand

Genomic View for IL4 Gene

Genes around IL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL4 Gene

Proteins for IL4 Gene

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  • Protein details for IL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05112-IL4_HUMAN
    Recommended name:
    Interleukin-4
    Protein Accession:
    P05112
    Secondary Accessions:
    • Q14630
    • Q6NZ77

    Protein attributes for IL4 Gene

    Size:
    153 amino acids
    Molecular mass:
    17492 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL4 Gene

    Alternative splice isoforms for IL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL4 Gene

Protein Expression for IL4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL4 Gene

  • Glycosylation at Asn62
  • Modification sites at PhosphoSitePlus

Other Protein References for IL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL4

Protein Products

  • Abcam proteins for IL4

Assay Products

No data available for DME Specific Peptides for IL4 Gene

Domains & Families for IL4 Gene

Gene Families for IL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL4 Gene

InterPro:
Blocks:
  • Interleukin-4/interleukin-13
ProtoNet:

Suggested Antigen Peptide Sequences for IL4 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 4 (B0JFA2_HUMAN)
  • Interleukin 4, isoform CRA_a (D4HNR6_HUMAN)
  • Pitrakinra (IL4_HUMAN)
  • Interleukin4 nirs variant1 (Q5FC01_HUMAN)
  • Interleukin 4, isoform 1 (Q6NWP0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05112

UniProtKB/Swiss-Prot:

IL4_HUMAN :
  • Belongs to the IL-4/IL-13 family.
Family:
  • Belongs to the IL-4/IL-13 family.
genes like me logo Genes that share domains with IL4: view

Function for IL4 Gene

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Molecular function for IL4 Gene

UniProtKB/Swiss-Prot Function:
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
GENATLAS Biochemistry:
interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis

LifeMap Function Summary for IL4 Gene

It affects the following cells:
IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for IL4 Gene

Gene Ontology (GO) - Molecular Function for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005136 interleukin-4 receptor binding IEA,TAS 11418631
GO:0005515 protein binding IPI 8266078
GO:0008083 growth factor activity IEA,NAS 11418631
genes like me logo Genes that share ontologies with IL4: view
genes like me logo Genes that share phenotypes with IL4: view

Animal Models for IL4 Gene

MGI Knock Outs for IL4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL4 Gene

Localization for IL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL4 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space TAS 11418631
genes like me logo Genes that share ontologies with IL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL4 Gene

Pathways & Interactions for IL4 Gene

PathCards logo

SuperPathways for IL4 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 Allograft rejection
Allograft rejection
.65
Autoimmune thyroid disease
.60
Allograft Rejection
.46
Asthma
.44
THC Differentiation Pathway
.39
Intestinal immune network for IgA production
.38
3 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
4 Th17 cell differentiation
Th1 and Th2 cell differentiation
.55
Th17 cell differentiation
.55
Inflammatory bowel disease (IBD)
.37
5 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
genes like me logo Genes that share pathways with IL4: view

Pathways by source for IL4 Gene

3 GeneGo (Thomson Reuters) pathways for IL4 Gene
  • Immune response CD16 signaling in NK cells
  • Immune response IL-4 signaling pathway
  • Immune response TLR signaling pathways
30 Qiagen pathways for IL4 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Cytokine Network
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for IL4 Gene

SIGNOR curated interactions for IL4 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IBA 21873635
GO:0002227 innate immune response in mucosa IBA 21873635
GO:0002230 positive regulation of defense response to virus by host IBA 21873635
GO:0002674 negative regulation of acute inflammatory response IBA 21873635
GO:0002677 negative regulation of chronic inflammatory response IBA 21873635
genes like me logo Genes that share ontologies with IL4: view

Drugs & Compounds for IL4 Gene

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  1. Drug

(89) Drugs for IL4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma Agonist, Full agonist 1151
Montelukast Approved Pharma Antagonist 302
Calcitriol Approved Nutra TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist 175
Aspirin Approved, Vet_approved Pharma Channel blocker 1512
Coal tar Approved Pharma 321

(36) Additional Compounds for IL4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for IL4 Gene

Compound Action Cas Number
Calcitriol TNF-α and IL-1β production inhibitor 32222-06-3
Suplatast Tosylate 94055-76-2
genes like me logo Genes that share compounds with IL4: view

Transcripts for IL4 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL4 Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4

Alternative Splicing Database (ASD) splice patterns (SP) for IL4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for IL4 Gene

GeneLoc Exon Structure for
IL4

Expression for IL4 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL4 Gene

mRNA expression in normal human tissues for IL4 Gene
mRNA expression by GTEx for IL4 GenemRNA expression by BioGPS for IL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL4 Gene

This gene is overexpressed in Pituitary (x4.7).

Protein differential expression in normal tissues from HIPED for IL4 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL4 Gene



Protein tissue co-expression partners for IL4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL4

SOURCE GeneReport for Unigene cluster for IL4 Gene:

Hs.73917

Evidence on tissue expression from TISSUES for IL4 Gene

  • Blood(4.8)
  • Spleen(3.9)
  • Lymph node(3.8)
  • Bone marrow(3.5)
  • Nervous system(3.3)
  • Lung(3.3)
  • Intestine(3.2)
  • Skin(3.2)
  • Liver(3.1)
  • Heart(3.1)
  • Muscle(3)
  • Kidney(2.9)
  • Bone(2.9)
  • Pancreas(2.6)
  • Stomach(2.4)
  • Eye(2.4)
  • Saliva(2.4)
  • Urine(2.3)
  • Thyroid gland(2.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with IL4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4 Gene

Orthologs for IL4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL4 30 31
  • 99.78 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia IL4 30 31
  • 75.19 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL4 30 31
  • 72.26 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il4 30
  • 60.91 (n)
Mouse
(Mus musculus)
 Mammalia Il4 30 17 31
  • 57.79 (n)
 OneToOne
Species where no ortholog for IL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL4 Gene

ENSEMBL:
Gene Tree for IL4 (if available)
TreeFam:
Gene Tree for IL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL4: view image

Paralogs for IL4 Gene

No data available for Paralogs for IL4 Gene

Variants for IL4 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL4 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
782744 Benign: not provided 132,679,863(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
rs4986964 - p.Cys27Arg

Additional dbSNP identifiers (rs#s) for IL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL4 Gene

Variant ID Type Subtype PubMed ID
dgv28e197 CNV deletion 19546169
esv2348204 CNV deletion 18987734
esv2730791 CNV deletion 23290073
esv2730792 CNV deletion 23290073
esv2730793 CNV deletion 23290073
nsv528281 CNV gain 19592680
nsv529021 CNV loss 19592680

Variation tolerance for IL4 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL4 Gene

Human Gene Mutation Database (HGMD)
IL4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL4 Gene

Disorders for IL4 Gene

MalaCards: The human disease database

(319) MalaCards diseases for IL4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schistosomiasis
  • katayama fever
vernal conjunctivitis
  • conjunctivitis vernal
allergic rhinitis
  • alrh
allergic bronchopulmonary aspergillosis
  • pulmonary aspergillus disease
allergic asthma
  • atopic asthma
- elite association - COSMIC cancer census association via MalaCards
Search IL4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL4_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for IL4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL4: view

No data available for Genatlas for IL4 Gene

Publications for IL4 Gene

  1. The interleukin-4 -34TT and -590TT genotype is correlated with increased expression and protein production in aggressive periodontitis. (PMID: 19959237) Gonzales JR … Meyle J (Molecular immunology 2010) 3 23 41
  2. Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial. (PMID: 19515749) Schoof N … Kube D (Annals of oncology : official journal of the European Society for Medical Oncology 2009) 3 23 41
  3. Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. (PMID: 19347053) Steinbrugger I … Weger M (Molecular vision 2009) 3 23 41
  4. Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men. (PMID: 19185507) Marcos M … Laso FJ (Cytokine 2009) 3 23 41
  5. Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E … Petridou ET (European journal of haematology 2009) 3 23 41

ExternalLinks

View latest publications for IL4 gene in Mastermind

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