Aliases for IL4 Gene
Aliases for IL4 Gene
External Ids for IL4 Gene
- HGNC: 6014
- Entrez Gene: 3565
- Ensembl: ENSG00000113520
- OMIM: 147780
- UniProtKB: P05112
Previous GeneCards Identifiers for IL4 Gene
- GC05P131531
- GC05P132456
- GC05P132041
- GC05P132085
- GC05P132037
- GC05P132009
- GC05P127201
Summaries for IL4 Gene
-
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL4 Gene
IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Allergic Bronchopulmonary Aspergillosis and Schistosomiasis. Among its related pathways are Akt Signaling and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
UniProtKB/Swiss-Prot for IL4 Gene
-
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).
Additional gene information for IL4 Gene
- Monarch Initiative
- Search for IL4 at DataMed
- Search for IL4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL4 Gene
Genomics for IL4 Gene
GeneHancer (GH) Regulatory Elements for IL4 Gene
Promoters and enhancers for IL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL4 gene promoter:
-
- AML1a
Regulatory Element Products
Genomic Locations for IL4 Gene
Genomic Locations for IL4 Gene
- chr5:132,673,986-132,682,678
- (GRCh38/hg38)
- Size:
- 8,693 bases
- Orientation:
- Plus strand
- chr5:132,009,373-132,018,368
- (GRCh37/hg19)
- Size:
- 8,996 bases
- Orientation:
- Plus strand
Genomic View for IL4 Gene
Genes around IL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
- 5q31.1 by Ensembl
IL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL4 Gene
Proteins for IL4 Gene
-
Protein details for IL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05112-IL4_HUMAN
- Recommended name:
- Interleukin-4
- Protein Accession:
- P05112
- Q14630
- Q6NZ77
Protein attributes for IL4 Gene
- Size:
- 153 amino acids
- Molecular mass:
- 17492 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for IL4 Gene
Protein Expression for IL4 Gene
Post-translational modifications for IL4 Gene
Other Protein References for IL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL4 (IL-4)
-
Custom Antibody ServicesOriGene Antibodies for IL4
- AM05019PU-N
- AM05402BT-N
- AM05868PU-N
- AM05868RP-N
- AM31261AF-N
- AM31266RP-N
- AM31308AF-N
- AM31331BT-N
- AM39038PU-N
- AM39038RP-N
- AP20623PU-N
- BM542
- PM1001A
- PP011B1
- PP011B2
- PP011P1
- PP011P2
- PP035B1
- PP035B2
- PP035P1
- PP035P2
- PP1026B1
- PP1026B2
- PP1026P1
- PP1026P2
- SM101P
- SM1696PX
- SM1702P
- SM2241P
- TA313321
- TA319039
- TA319286
- TA319287
- TA319288
- TA320371
- TA320372
- TA324803
- TA328210
- TA328211
- TA328484
- TA328485
- TA328570
- TA328571
- TA336229
- TA336230
- TA347886
- TA352736
- TA352767
- TA352768
- TA352771
- TA352772
- TA352778
- TA352779
- TA600022
- TA700022
- Novus Biologicals Antibodies for IL4
-
Abcam antibodies for IL4
- Invitrogen Antibodies for IL4
- antibodies-online: Search results for 712 available IL-4 Antibodies ranked by validation data
- Compare Top IL-4 Antibodies
-
Recommended
- 218 WB Antibodies (anti-human)
- 69 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 100 WB Antibodies (anti-mouse)
- 53 FACS Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- GeneTex IL4 Antibody for IL4
-
Custom Antibody ServicesProSci Antibodies for IL4
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL4
- Sino Biological Antibodies for IL4
Protein Products
- R&D Systems Proteins and Enzymes for IL4 (IL-4)
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4
- Origene Custom Protein Services for IL4
- Sino Biological Cell Lysates for IL4
- Sino Biological Recombinant Proteins for IL4
- ProSpec Recombinant Proteins for IL4
- GeneTex Proteins for IL4
-
ProSci Proteins for IL4
- interleukin 4 [96-443]
- interleukin 4 [90-472]
- interleukin 4 [90-473]
- interleukin 4 [90-474]
- interleukin 4 [90-475]
- interleukin 4 [90-476]
- interleukin 4 [90-477]
- interleukin 4� [90-478]
- interleukin 4� [90-479]
- interleukin 4 [90-480]
- interleukin 4 [90-481]
- interleukin 4 [91-040]
- interleukin 4 [91-879]
- interleukin 4 [91-958]
- interleukin 4 [92-512]
- interleukin 4 [92-568]
- interleukin 4 [40-246]
- interleukin 4 [40-433]
- interleukin 4 [40-464]
- interleukin 4 [40-604]
- interleukin 4 [40-619]
-
Abcam proteins for IL4
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IL4
- EA100021
- EA100022
- EA100274
- EA101282
- EA101283
- EA101284
- EA101285
- EA101286
- EA101247
- EA101248
- EA101249
- EA102142
- EA102143
- EA102144
- EA101429
- EA101430
- EA101431
- EA101432
- EA101433
- EA101434
- EA101435
- EA101436
- EA101437
- EA101438
- EA101439
- EA101440
- EA101441
- EA101442
- EA101443
- EA101444
- EA101445
- EA101811
- EA100275
- EA100125
- EA100126
- EA100276
- EA100165
- EA100166
- EA101840
- EA101841
- EA101842
- EA101843
- EA101844
- EA101773
- EA101774
- EA101775
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IL4 (IL-4)
- Novus Biologicals ELISA Kits for IL4
- antibodies-online: Search results for 278 available IL-4 Elisa Kits ranked by validation data
- Compare Top IL-4 Elisa Kits
-
Recommended
- 2 Cat (Feline) ELISA Kits
- 10 Chicken ELISA Kits
- 11 Cow (Bovine) ELISA Kits
- 12 Dog (Canine) ELISA Kits
- 1 Duck ELISA Kit
- 5 Goat ELISA Kits
- 10 Guinea Pig ELISA Kits
- 4 Hamster ELISA Kits
- 6 Horse (Equine) ELISA Kits
- 75 Human ELISA Kits
- 9 Monkey ELISA Kits
- 43 Mouse (Murine) ELISA Kits
- 20 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 42 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 10 Sheep (Ovine) ELISA Kits
- 1 Sigmodon hispidus (Hispid cotton rat) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
-
Abcam assays for IL4
- Sino Biological Assays for IL4
No data available for DME Specific Peptides for IL4 Gene
Domains & Families for IL4 Gene
Gene Families for IL4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for IL4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05112- Family:
-
- Belongs to the IL-4/IL-13 family.
Function for IL4 Gene
Molecular function for IL4 Gene
- UniProtKB/Swiss-Prot Function:
- Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).
- GENATLAS Biochemistry:
- interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis
LifeMap Function Summary for IL4 Gene
During embryonic development, IL4 as signaling molecule is secreted from the following cells
- Limb
-
Skeletal Muscle
- Multinuclear Myocytes (Sacral Back Muscles)
- Multinuclear Myocytes (Thoracic Vertebral Colomn Muscles)
- Multinuclear Myocytes (Pelvic Muscles)
- Multinuclear Myocytes (Lumbar Back Muscles)
- Multinuclear Myocytes (Anterior Neck Muscles)
- Multinuclear Myocytes (Trunk Muscles)
- Multinuclear Myocytes (Lumbar Vertebrae Column Muscles)
- Multinuclear Myocytes (Cervical Back Muscles)
- Multinuclear Myocytes (Thoracic Back Muscles)
- Multinuclear Myocytes (Posterior Neck Muscles)
It affects the following cells:
-
Somite
- Mononuclear Myocytes (Lumbar Primary Hypaxial Myotome)
- Mononuclear Myocytes (Sacral Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Primary Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Hypaxial Myotome)
- Mononuclear Myocytes (Thoracic Primary Epaxial Myotome)
- Mononuclear Myocytes (Cervical Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Epaxial Myotome)
- Mononuclear Myocytes (Sacral Epaxial Myotome)
- Mononuclear Myocytes (Lumbar Primary Epaxial Myotome)
- Mononuclear Myocytes (Lumbar Epaxial Myotome)
- Mononuclear Myocytes (Sacral Primary Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Primary Hypaxial Myotome)
- Mononuclear Myocytes (Lumbar Hypaxial Myotome)
- Mononuclear Myocytes (Sacral Primary Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Primary Hypaxial Myotome)
- Limb
IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
-
and also in
Phenotypes From GWAS Catalog for IL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005136 | interleukin-4 receptor binding | TAS,IEA | 11418631 |
| GO:0005515 | protein binding | IPI | 8266078 |
| GO:0008083 | growth factor activity | NAS,IEA | 11418631 |
Phenotypes for IL4 Gene
- MGI mutant phenotypes for IL4:
-
inferred from 16 alleles
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for IL4:
-
- Decreased viability ratio
- Synthetic lethal with imatinib mesylate
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
Animal Models for IL4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL4
-
CRISPR Products
-
OriGene CRISPR knockouts for IL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4
- genomics-online: gRNA clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
- Applied Biological Materials CRISPR for IL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4
- GenScript: Design CRISPR guide RNA sequences for IL4
miRNA for IL4 Gene
- miRTarBase miRNAs that target IL4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4
- Browse OriGene Inhibitory RNA Products For IL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4
- genomics-online: shRNA clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IL4
- VectorBuilder custom plasmid, inducible vectors for IL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4
- Applied Biological Materials Clones for IL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IL4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL4 Gene
Localization for IL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| lysosome | 2 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | TAS | 11418631 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL4 Gene
Pathways & Interactions for IL4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.61
|
.47
|
| 2 | Allograft rejection |
.44
|
|
| 3 | TGF-Beta Pathway |
.60
.57
|
.40
|
| 4 | Th17 cell differentiation | ||
| 5 | Akt Signaling |
.60
.60
|
|
Pathways by source for IL4 Gene
17 BioSystems pathways for IL4 Gene
5 Reactome pathways for IL4 Gene
17 KEGG pathways for IL4 Gene
3 GeneGo (Thomson Reuters) pathways for IL4 Gene
6 R&D Systems pathways for IL4 Gene
30 Qiagen pathways for IL4 Gene
1 Cell Signaling Technology pathway for IL4 Gene
Interacting Proteins for IL4 Gene
Selected Interacting proteins:
P05112-IL4_HUMAN
ENSP00000231449
for IL4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | TAS,IEA | 3016727 |
| GO:0008203 | cholesterol metabolic process | ISS | 11971948 |
| GO:0010469 | regulation of signaling receptor activity | IEA | -- |
| GO:0010633 | negative regulation of epithelial cell migration | IDA | 11698262 |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
Drugs & Compounds for IL4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Histamine | Approved, Investigational | Pharma | Full agonist, Agonist | 1105 | ||
| Montelukast | Approved | Pharma | Antagonist | 280 | ||
| Calcitriol | Approved | Nutra | TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist | 223 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1232 | ||
| Coal tar | Approved | Pharma | 218 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for IL4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcitriol | TNF-α and IL-1β production inhibitor | 32222-06-3 |
| Suplatast Tosylate | 94055-76-2 |
Transcripts for IL4 Gene
mRNA/cDNA for IL4 Gene
- (3) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000231449 616 bps (uc003kxk.3)
- ENST00000350025 414 bps (uc003kxl.3)
- ENST00000495905 305 bps (uc063gwb.1)
- ENST00000622422 717 bps (uc063gwa.1)
CRISPR Products
-
OriGene CRISPR knockouts for IL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4
- genomics-online: gRNA clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
- Applied Biological Materials CRISPR for IL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4
- GenScript: Design CRISPR guide RNA sequences for IL4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4
- Browse OriGene Inhibitory RNA Products For IL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4
- genomics-online: shRNA clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IL4
- VectorBuilder custom plasmid, inducible vectors for IL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4
- Applied Biological Materials Clones for IL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Expression for IL4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Anterior Neck Muscles
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Trunk Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Lumbar Vertebrae Column Muscles
-
Limb (Muscoskeletal System)
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Ovalbumin speci?c type 1 regulatory T- cells (Ovasave)
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IL4 Gene
This gene is overexpressed in Pituitary (x4.7).
This gene is overexpressed in Cervix (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL4 Gene
NURSA nuclear receptor signaling pathways regulating expression of IL4 Gene:
IL4SOURCE GeneReport for Unigene cluster for IL4 Gene:
Hs.73917Evidence on tissue expression from TISSUES for IL4 Gene
- Blood(4.8)
- Spleen(3.7)
- Lymph node(3.5)
- Lung(3)
- Skin(2.9)
- Bone marrow(2.8)
- Nervous system(2.6)
- Intestine(2.5)
- Liver(2.3)
- Heart(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for IL4
-
OriGene qPCR primer pairs for IL4
- genomics-online: primer clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4 Gene
Orthologs for IL4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IL4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL4 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Il4 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Il4 16 34 33 |
|
- Species where no ortholog for IL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IL4 Gene
- ENSEMBL:
- Gene Tree for IL4 (if available)
- TreeFam:
- Gene Tree for IL4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL4: view image
Paralogs for IL4 Gene
No data available for Paralogs for IL4 Gene
Variants for IL4 Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000510871 | -- | 132,676,663(+) | G/A | intron_variant | |
| rs1000533509 | -- | 132,677,138(+) | T/G | intron_variant | |
| rs1000670746 | -- | 132,682,872(+) | G/A | downstream_transcript_variant | |
| rs1000743818 | -- | 132,681,196(+) | T/C | intron_variant | |
| rs1001000682 | -- | 132,672,668(+) | G/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv28e197 | CNV | deletion | 19546169 |
| esv2348204 | CNV | deletion | 18987734 |
| esv2730791 | CNV | deletion | 23290073 |
| esv2730792 | CNV | deletion | 23290073 |
| esv2730793 | CNV | deletion | 23290073 |
| nsv528281 | CNV | gain | 19592680 |
| nsv529021 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL4 Gene
Disorders for IL4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| allergic bronchopulmonary aspergillosis |
|
|
| schistosomiasis |
|
|
| intrinsic asthma |
|
|
| vernal conjunctivitis |
|
|
| food allergy |
|
Search IL4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IL4_HUMAN- Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for IL4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IL4 Gene
Publications for IL4 Gene
- Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion. (PMID: 19347053) Steinbrugger I … Weger M (Molecular vision 2009) 3 22 44 58
- Genetic variants in immunoregulatory genes and risk for childhood lymphomas. (PMID: 19508433) Andrie E … Petridou ET (European journal of haematology 2009) 3 22 44 58
- Common polymorphisms in interleukin genes (IL4, IL6, IL8 and IL12) are not associated with alcoholic liver disease or alcoholism in Spanish men. (PMID: 19185507) Marcos M … Laso FJ (Cytokine 2009) 3 22 44 58
- Polymorphisms of RANTES and IL-4 genes in cerebral infarction. (PMID: 18696265) Um JY … Kim HM (Journal of molecular neuroscience : MN 2009) 3 22 44 58
- [Association of immune system gene polymorphisms with quantitative features which are pathogenetically important in chronic viral hepatitis]. (PMID: 18610832) Goncharova IA … pyzurev VP (Molekuliarnaia biologiia 2008) 3 22 44 58
Products for IL4 Gene
- R&D Systems Antibodies for IL4 (IL-4)
- R&D Systems Proteins and Enzymes for IL4 (IL-4)
- R&D Systems ELISAs, ELISpot and FluoroSpot Kits, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IL4 (IL-4)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IL4
- AM05019PU-N
- AM05402BT-N
- AM05868PU-N
- AM05868RP-N
- AM31261AF-N
- AM31266RP-N
- AM31308AF-N
- AM31331BT-N
- AM39038PU-N
- AM39038RP-N
- AP20623PU-N
- BM542
- PM1001A
- PP011B1
- PP011B2
- PP011P1
- PP011P2
- PP035B1
- PP035B2
- PP035P1
- PP035P2
- PP1026B1
- PP1026B2
- PP1026P1
- PP1026P2
- SM101P
- SM1696PX
- SM1702P
- SM2241P
- TA313321
- TA319039
- TA319286
- TA319287
- TA319288
- TA320371
- TA320372
- TA324803
- TA328210
- TA328211
- TA328484
- TA328485
- TA328570
- TA328571
- TA336229
- TA336230
- TA347886
- TA352736
- TA352767
- TA352768
- TA352771
- TA352772
- TA352778
- TA352779
- TA600022
- TA700022
- Custom Assay ServicesOriGene ELISA Kits for IL4
- EA100021
- EA100022
- EA100274
- EA101282
- EA101283
- EA101284
- EA101285
- EA101286
- EA101247
- EA101248
- EA101249
- EA102142
- EA102143
- EA102144
- EA101429
- EA101430
- EA101431
- EA101432
- EA101433
- EA101434
- EA101435
- EA101436
- EA101437
- EA101438
- EA101439
- EA101440
- EA101441
- EA101442
- EA101443
- EA101444
- EA101445
- EA101811
- EA100275
- EA100125
- EA100126
- EA100276
- EA100165
- EA100166
- EA101840
- EA101841
- EA101842
- EA101843
- EA101844
- EA101773
- EA101774
- EA101775
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4
- Origene Custom Protein Services for IL4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4
- Browse OriGene Inhibitory RNA Products For IL4
- OriGene qPCR primer pairs and template standards for IL4
- OriGene qPCR primer pairs for IL4
- OriGene CRISPR knockouts for IL4
- OriGene ORF clones in human for IL4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IL4
- GenScript: Next-day shipping of latest version cDNA ORF clones for IL4 in any vector
- GenScript Purified and Recombinant Proteins for IL4
- GenScript Custom Purified and Recombinant Proteins Services for IL4
- GenScript Custom Assay Services for IL4
- GenScript Custom overexpressing Cell Line Services for IL4
- GenScript: Design CRISPR guide RNA sequences for IL4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL4
- Sino Biological Human cDNA Clone for IL4
- Sino Biological Cell Lysates for IL4
- Sino Biological Recombinant Proteins for IL4
- Sino Biological Antibodies for IL4
- Sino Biological Assays for IL4
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL4
- Novus Biologicals proteins and lysates for IL4
- Novus Biologicals ELISA Kits for IL4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IL4
- Abcam proteins for IL4
- Abcam assays for IL4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IL4
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL4
- VectorBuilder custom plasmid, inducible vectors for IL4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IL4
- antibodies-online: Search results for 712 available IL-4 Antibodies ranked by validation data
- Compare Top IL-4 Antibodies
- Recommended
- 218 WB Antibodies (anti-human)
- 69 FACS Antibodies (anti-human)
- 6 IHC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 100 WB Antibodies (anti-mouse)
- 53 FACS Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IHC (fro) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- antibodies-online: Search results for 278 available IL-4 Elisa Kits ranked by validation data
- Compare Top IL-4 Elisa Kits
- Recommended
- 2 Cat (Feline) ELISA Kits
- 10 Chicken ELISA Kits
- 11 Cow (Bovine) ELISA Kits
- 12 Dog (Canine) ELISA Kits
- 1 Duck ELISA Kit
- 5 Goat ELISA Kits
- 10 Guinea Pig ELISA Kits
- 4 Hamster ELISA Kits
- 6 Horse (Equine) ELISA Kits
- 75 Human ELISA Kits
- 9 Monkey ELISA Kits
- 43 Mouse (Murine) ELISA Kits
- 20 Pig (Porcine) ELISA Kits
- 14 Rabbit ELISA Kits
- 42 Rat (Rattus) ELISA Kits
- 3 Rhesus Monkey ELISA Kits
- 10 Sheep (Ovine) ELISA Kits
- 1 Sigmodon hispidus (Hispid cotton rat) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 203 available IL-4 Proteins ranked by validation data
- Compare Top IL-4 Proteins
- GeneTex IL4 Antibody for IL4
- GeneTex Proteins for IL4
- Santa Cruz Biotechnology (SCBT) Antibodies for IL4
- Search Santa Cruz Biotechnology (SCBT) for IL4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL4
- Custom Antibody ServicesProSci Antibodies for IL4
- ProSci Proteins for IL4
- interleukin 4 [96-443]
- interleukin 4 [90-472]
- interleukin 4 [90-473]
- interleukin 4 [90-474]
- interleukin 4 [90-475]
- interleukin 4 [90-476]
- interleukin 4 [90-477]
- interleukin 4� [90-478]
- interleukin 4� [90-479]
- interleukin 4 [90-480]
- interleukin 4 [90-481]
- interleukin 4 [91-040]
- interleukin 4 [91-879]
- interleukin 4 [91-958]
- interleukin 4 [92-512]
- interleukin 4 [92-568]
- interleukin 4 [40-246]
- interleukin 4 [40-433]
- interleukin 4 [40-464]
- interleukin 4 [40-604]
- interleukin 4 [40-619]
- Horizon Cell Lines for IL4
- genomics-online: cdna clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
- orf clones - Search results for 150 available IL-4 gene related products
- Overview of 150 available IL-4 gene related products
- genomics-online: gRNA clones -