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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Schistosomiasis and Vernal Conjunctivitis. Among its related pathways are Immune response Fc epsilon RI pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA,IBA | 21873635 |
GO:0005126 | cytokine receptor binding | IEA | -- |
GO:0005136 | interleukin-4 receptor binding | IEA,TAS | 11418631 |
GO:0005515 | protein binding | IPI | 8266078 |
GO:0008083 | growth factor activity | IEA,NAS | 11418631 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | TAS | 11418631 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | Allograft rejection |
.44
THC Differentiation Pathway
.39
|
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | Th17 cell differentiation | ||
5 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001774 | microglial cell activation | IBA | 21873635 |
GO:0002227 | innate immune response in mucosa | IBA | 21873635 |
GO:0002230 | positive regulation of defense response to virus by host | IBA | 21873635 |
GO:0002674 | negative regulation of acute inflammatory response | IBA | 21873635 |
GO:0002677 | negative regulation of chronic inflammatory response | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Histamine | Approved, Investigational | Pharma | Agonist, Full agonist | 1151 | ||
Montelukast | Approved | Pharma | Antagonist | 302 | ||
Calcitriol | Approved | Nutra | TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist | 175 | ||
Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1512 | ||
Coal tar | Approved | Pharma | 321 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Calcitriol | TNF-α and IL-1β production inhibitor | 32222-06-3 |
Suplatast Tosylate | 94055-76-2 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | - |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Il4 30 17 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv28e197 | CNV | deletion | 19546169 |
esv2348204 | CNV | deletion | 18987734 |
esv2730791 | CNV | deletion | 23290073 |
esv2730792 | CNV | deletion | 23290073 |
esv2730793 | CNV | deletion | 23290073 |
nsv528281 | CNV | gain | 19592680 |
nsv529021 | CNV | loss | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
schistosomiasis |
|
|
vernal conjunctivitis |
|
|
allergic rhinitis |
|
|
allergic bronchopulmonary aspergillosis |
|
|
allergic asthma |
|