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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating t... See more...
Aliases for IL4 Gene
Aliases for IL4 Gene
External Ids for IL4 Gene
- HGNC: 6014
- Entrez Gene: 3565
- Ensembl: ENSG00000113520
- OMIM: 147780
- UniProtKB: P05112
Previous GeneCards Identifiers for IL4 Gene
- GC05P131531
- GC05P132456
- GC05P132041
- GC05P132085
- GC05P132037
- GC05P132009
- GC05P127201
Summaries for IL4 Gene
-
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL4 Gene
IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Schistosomiasis and Allergic Hypersensitivity Disease. Among its related pathways are Hematopoietic cell lineage and ERK Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
UniProtKB/Swiss-Prot Summary for IL4 Gene
-
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
Additional gene information for IL4 Gene
- Monarch Initiative
- Search for IL4 at DataMed
- Search for IL4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL4 Gene
Genomics for IL4 Gene
GeneHancer (GH) Regulatory Elements for IL4 Gene
Promoters and enhancers for IL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL4 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL4
- Top Transcription factor binding sites by QIAGEN in the IL4 gene promoter:
-
- AML1a
Genomic Locations for IL4 Gene
Genomic Locations for IL4 Gene
- chr5:132,673,986-132,682,678
- (GRCh38/hg38)
- Size:
- 8,693 bases
- Orientation:
- Plus strand
- chr5:132,009,373-132,018,368
- (GRCh37/hg19)
- Size:
- 8,996 bases
- Orientation:
- Plus strand
Genomic View for IL4 Gene
Genes around IL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by HGNC
- 5q31.1 by Entrez Gene
- 5q31.1 by Ensembl
IL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL4 Gene
Proteins for IL4 Gene
-
Protein details for IL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05112-IL4_HUMAN
- Recommended name:
- Interleukin-4
- Protein Accession:
- P05112
- Q14630
- Q6NZ77
Protein attributes for IL4 Gene
- Size:
- 153 amino acids
- Molecular mass:
- 17492 Da
- Quaternary structure:
- No Data Available
Three dimensional structures from OCA and Proteopedia for IL4 Gene
Protein Expression for IL4 Gene
Post-translational modifications for IL4 Gene
Other Protein References for IL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Miltenyi Biotec B.V. & Co. KG
- Anti IL-4 Antibody (130-091-647)
- Anti IL-4 Antibody (130-095-753)
- Anti IL-4 Antibody (130-098-815)
- Anti IL-4 Antibody (130-107-199)
- Anti IL-4 Antibody (130-107-144)
- Anti IL-4 Antibody (130-108-049)
- Recombinant Anti IL-4 Antibody (130-114-844)
- Recombinant Anti IL-4 Antibody (130-114-884)
- Recombinant Anti IL-4 Antibody (130-114-886)
- Recombinant Anti IL-4 Antibody (130-114-842)
- Recombinant Anti IL-4 Antibody (130-114-885)
- Recombinant Anti IL-4 Antibody (130-114-843)
- G Biosciences Immunotag™ IL4 Antibody and Immunotag™ Interleukin 4 Antibody
- SouthernBiotech Rat Anti-Human IL-4-LE/AF, Rat Anti-Human IL-4-BIOT, and Rat Anti-Human IL-4-UNLB
- NSJ Bioreagents Human IL4 Antibody
- Creative Diagnostics Anti-IL4 monoclonal antibody, clone TS-6
-
Creative Biolabs
- Anti-Human IL4 Therapeutic Antibody (Pascolizumab)
- Recombinant Mouse Anti-IL4 Antibody (m19C11)
- Recombinant Mouse Anti-IL4 Antibody (5B5)
- Mouse Anti-IL1B Recombinant Antibody (CBYY-I0706)
- Recombinant Mouse Anti-IL4 Antibody
- Mouse Anti-IFNB1 Recombinant Antibody (CBYY-I1304)
- Recombinant Human Anti-IL4 Antibody (H7WM208)
- Anti-human IL4 Fab Fragment (6A1)
-
BioLegend
- IL-4 Antibody (500808)
- IL-4 Antibody (500705)
- IL-4 Antibody (500702)
- IL-4 Antibody (500704)
- IL-4 Antibody (500811)
- IL-4 Antibody (500802)
- IL-4 Antibody (500803)
- IL-4 Antibody (500812)
- IL-4 Antibody (500804)
- IL-4 Antibody (500807)
- IL-4 Antibody (500806)
- IL-4 Antibody (500810)
- IL-4 Antibody (500701)
- IL-4 Antibody (500703)
- IL-4 Antibody (500818)
- IL-4 Antibody (500817)
- PerCP/Cyanine5.5 IL-4 Antibody (500822)
- PerCP/Cyanine5.5 IL-4 Antibody (500821)
- IL-4 Antibody (500713)
- IL-4 Antibody (500712)
- IL-4 Antibody (500714)
- IL-4 Antibody (500710)
- IL-4 Antibody (500823)
- IL-4 Antibody (500824)
- IL-4 Antibody (500825)
- IL-4 Antibody (500826)
- IL-4 Antibody (500827)
- IL-4 (MaxPar(R) Ready) Antibody
- IL-4 Antibody (500828)
- IL-4 Antibody (500831)
- IL-4 Antibody (500832)
- APC/Cyanine7 IL-4 Antibody (500833)
- APC/Cyanine7 IL-4 Antibody (500834)
- IL-4 Antibody (500835)
- IL-4 Antibody (500836)
-
Custom Antibody ServicesOriGene Antibodies for IL4
- AM05868PU-N
- AM05868RP-N
- AM31261AF-N
- AM31266RP-N
- AM39038PU-N
- AM39038RP-N
- AP20623PU-N
- PM1001A
- PP011B1
- PP011B2
- PP011P1
- PP011P2
- PP035B1
- PP035B2
- PP035P1
- PP035P2
- PP1026B1
- PP1026B2
- PP1026P1
- PP1026P2
- SM101P
- SM1696PX
- SM1702P
- SM2241P
- TA313321
- TA319039
- TA319286
- TA319287
- TA319288
- TA320371
- TA320372
- TA324803
- TA328210
- TA328211
- TA328484
- TA328485
- TA328570
- TA328571
- TA336229
- TA336230
- TA347886
- TA352736
- TA352767
- TA352768
- TA352771
- TA352772
- TA352778
- TA352779
- TA354415
- TA600022
- TA700022
- Novus Biologicals Antibodies for IL4
-
Abcam antibodies for IL4
- Invitrogen Antibodies for IL4 (AFLGC-IL4)
- antibodies-online: Show 260 available IL-4 Antibodies ranked by validation data
- Compare Top IL-4 Antibodies
-
Recommended
- 185 WB Antibodies (anti-human)
- 54 FACS Antibodies (anti-human)
- 9 IHC Antibodies (anti-human)
- 6 Neut Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 ELISPOT (Capture) Antibody (anti-human)
- 1 ELISPOT (Detection) Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (fro) Antibody (anti-human)
- 1 ICS Antibody (anti-human)
- 99 WB Antibodies (anti-mouse)
- 81 FACS Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 3 IHC (fro) Antibodies (anti-mouse)
- 2 in vivo Antibodies (anti-mouse)
- 1 BCA Antibody (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 45 WB Antibodies (anti-rat)
- 2 FACS Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for IL4
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL4
- Sino Biological Antibodies for IL4
Protein Products
- RayBiotech Recombinant Human IL-4
-
BioLegend
- Human IL-4 ELISA MAX(TM) Standard
- Recombinant Human IL-4 (ELISA Std.)
- Recombinant Human IL-4 (carrier-free) (574006)
- Recombinant Human IL-4 (carrier-free) (574004)
- Recombinant Human IL-4 (carrier-free) (574002)
- Recombinant Human IL-4 (carrier-free) (574008)
- Recombinant Human IL-4 (Animal-Free)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766206)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766202)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766204)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766208)
- Search Origene for MassSpec and Protein Over-expression Lysates for IL4
- Origene Custom Protein Services for IL4
- Sino Biological Recombinant Proteins for IL4
- Sino Biological Cell Lysates for IL4
- ProSpec Recombinant Proteins for IL4
-
ProSci Proteins for IL4
- interleukin 4 [40-246]
- interleukin 4 [92-512]
- interleukin 4 [92-568]
- interleukin 4 [91-040]
- interleukin 4 [91-879]
- interleukin 4 [40-433]
- interleukin 4 [40-464]
- interleukin 4 [40-604]
- interleukin 4 [40-619]
- interleukin 4 [96-443]
- interleukin 4 [90-472]
- interleukin 4 [90-473]
- interleukin 4 [90-474]
- interleukin 4 [90-475]
- interleukin 4 [90-476]
- interleukin 4 [90-477]
- interleukin 4� [90-478]
- interleukin 4� [90-479]
- interleukin 4 [90-480]
- interleukin 4 [90-481]
- interleukin 4 [91-958]
-
Abcam proteins for IL4
Assay Products
- RayBiotech Human IL-4 ELISA
-
Creative Diagnostics
- Mouse Interleukin 4, Il4 ELISA Kit (DEIA114)
- Mouse Interleukin 4, Il4 ELISA Kit (DEIA200)
- Swine IL-4 ELISA Kit
- Rat Interleukin 4, Il4 ELISA Kit
- Swine Interleukin 4, IL4 ELISA Kit
- IL4 Human ELISA Kit
- IL4 Mouse ELISA Kit
- Human Interleukin 4, IL4 ELISA Kit (DEIA113)
- Human Interleukin 4, IL4 ELISA Kit (DEIA185)
-
Custom Assay ServicesOriGene ELISA Kits for IL4
- EA100021
- EA100022
- EA100125
- EA100126
- EA100165
- EA100166
- EA100274
- EA100275
- EA100276
- EA101247
- EA101248
- EA101249
- EA101282
- EA101283
- EA101284
- EA101285
- EA101286
- EA101429
- EA101430
- EA101431
- EA101432
- EA101433
- EA101434
- EA101435
- EA101436
- EA101437
- EA101438
- EA101439
- EA101440
- EA101441
- EA101442
- EA101443
- EA101444
- EA101445
- EA101773
- EA101774
- EA101775
- EA101811
- EA101840
- EA101841
- EA101842
- EA101843
- EA101844
- EA102142
- EA102143
- EA102144
- Novus Biologicals ELISA Kits for IL4
- antibodies-online: Show 309 available IL-4 Elisa Kits ranked by validation data
- Compare Top IL-4 Elisa Kits
-
Quality Products:
- ABIN411299
- ABIN625024
- ABIN1115665
- ABIN414884
- ABIN365162
- ABIN2690565
- ABIN2472120
- ABIN491778
- ABIN3032949
- ABIN1029012
- ABIN1115664
- ABIN411300
- ABIN625147
- ABIN415512
- ABIN365174
- ABIN625148
- ABIN2472099
- ABIN491779
- ABIN3032817
- ABIN924818
- ABIN625203
- ABIN411301
- ABIN1115666
- ABIN416248
- ABIN365190
- ABIN2472110
- ABIN4993139
- ABIN625204
- ABIN491780
- ABIN1029016
- ABIN413940
- ABIN364639
- ABIN4881466
- ABIN1081702
- ABIN2851277
- ABIN579001
- ABIN5592260
- ABIN6384691
- ABIN993321
- ABIN5655973
-
Abcam assays for IL4
- Sino Biological Assays for IL4
No data available for DME Specific Peptides for IL4 Gene
Domains & Families for IL4 Gene
Gene Families for IL4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted secreted proteins
Protein Domains for IL4 Gene
- Blocks:
-
- Interleukin-4/interleukin-13
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL4 Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin 4 (B0JFA2_HUMAN)
- Interleukin 4, isoform CRA_a (D4HNR6_HUMAN)
- Pitrakinra (IL4_HUMAN)
- Interleukin4 nirs variant1 (Q5FC01_HUMAN)
- Interleukin 4, isoform 1 (Q6NWP0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P05112- Family:
-
- Belongs to the IL-4/IL-13 family.
Function for IL4 Gene
Molecular function for IL4 Gene
- UniProtKB/Swiss-Prot Function:
- Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
- GENATLAS Biochemistry:
- interleukin 4,15kDa,B-cell stimulating factor 1,important switch factor directing Ig-E synthesis
LifeMap Function Summary for IL4 Gene
During embryonic development, IL4 as signaling molecule is secreted from the following cells
- Limb
-
Skeletal Muscle
- Multinuclear Myocytes (Sacral Back Muscles)
- Multinuclear Myocytes (Thoracic Vertebral Colomn Muscles)
- Multinuclear Myocytes (Pelvic Muscles)
- Multinuclear Myocytes (Lumbar Back Muscles)
- Multinuclear Myocytes (Anterior Neck Muscles)
- Multinuclear Myocytes (Trunk Muscles)
- Multinuclear Myocytes (Lumbar Vertebrae Column Muscles)
- Multinuclear Myocytes (Cervical Back Muscles)
- Multinuclear Myocytes (Thoracic Back Muscles)
- Multinuclear Myocytes (Posterior Neck Muscles)
It affects the following cells:
-
Somite
- Mononuclear Myocytes (Lumbar Primary Hypaxial Myotome)
- Mononuclear Myocytes (Sacral Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Primary Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Hypaxial Myotome)
- Mononuclear Myocytes (Thoracic Primary Epaxial Myotome)
- Mononuclear Myocytes (Cervical Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Epaxial Myotome)
- Mononuclear Myocytes (Sacral Epaxial Myotome)
- Mononuclear Myocytes (Lumbar Primary Epaxial Myotome)
- Mononuclear Myocytes (Lumbar Epaxial Myotome)
- Mononuclear Myocytes (Sacral Primary Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Hypaxial Myotome)
- Mononuclear Myocytes (Cervical Primary Hypaxial Myotome)
- Mononuclear Myocytes (Lumbar Hypaxial Myotome)
- Mononuclear Myocytes (Sacral Primary Epaxial Myotome)
- Mononuclear Myocytes (Thoracic Primary Hypaxial Myotome)
- Limb
IL4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
-
and also in
Phenotypes From GWAS Catalog for IL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005136 | interleukin-4 receptor binding | TAS,IEA | 11418631 |
| GO:0005515 | protein binding | IPI | 8266078 |
| GO:0008083 | growth factor activity | NAS,IEA | 11418631 |
Phenotypes for IL4 Gene
- MGI mutant phenotypes for IL4:
-
inferred from 16 alleles
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- no phenotypic analysis
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for IL4:
-
- Decreased viability ratio
- Synthetic lethal with imatinib mesylate
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
Animal Models for IL4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL4 - Select products 50% OFF >
- * IL4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4
- genomics-online: gRNA clones - Search for available IL-4 gRNA products
- Overview of 164 available IL-4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4
miRNA for IL4 Gene
- miRTarBase miRNAs that target IL4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4
- Browse OriGene Inhibitory RNA Products For IL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4
- genomics-online: shRNA clones - Search for available IL-4 shRNA products
- Overview of 164 available IL-4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for IL4 - Select products 50% OFF >
- * IL4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226748
- MR226748
- MR226748L3
- MR226748L4
- RC209972
- RC209972L1
- RC209972L2
- RC209972L3
- RC209972L4
- RC213286
- RC213286L3
- RC213286L4
- RG209972
- RG213286
- RR206501
- RR206501L1
- RR206501L2
- RR206501L3
- RR206501L4
- MR226748L3V
- MR226748L4V
- RC209972L1V
- RC209972L2V
- RC209972L3V
- RC209972L4V
- RC213286L3V
- RC213286L4V
- RR206501L1V
- RR206501L2V
- RR206501L3V
- RR206501L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL4
- Addgene plasmids for IL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4
- genomics-online: cdna clones - Search for available IL-4 CDNA products
- Overview of 164 available IL-4 gene related products
- orf clones - Search for available IL-4 ORF products
- Overview of 164 available IL-4 gene related products
Cell Line Products
-
Horizon Cell Lines for IL4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL4 Gene
Localization for IL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| cytosol | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | TAS | 11418631 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL4 Gene
Pathways & Interactions for IL4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | Allograft rejection |
.44
THC Differentiation Pathway
.39
|
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
| 4 | Th17 cell differentiation | ||
| 5 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
Pathways by source for IL4 Gene
17 BioSystems pathways for IL4 Gene
5 Reactome pathways for IL4 Gene
16 KEGG pathways for IL4 Gene
3 GeneGo (Thomson Reuters) pathways for IL4 Gene
- Immune response CD16 signaling in NK cells
- Immune response IL-4 signaling pathway
- Immune response TLR signaling pathways
6 R&D Systems pathways for IL4 Gene
30 Qiagen pathways for IL4 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Cytokine Network
- Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for IL4 Gene
Interacting Proteins for IL4 Gene
Selected Interacting proteins:
P05112-IL4_HUMAN
ENSP00000231449
for IL4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL4
SIGNOR curated interactions for IL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006955 | immune response | IEA,TAS | 3016727 |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0008203 | cholesterol metabolic process | ISS | 11971948 |
| GO:0010628 | positive regulation of gene expression | ISS | -- |
| GO:0010633 | negative regulation of epithelial cell migration | IDA | 11698262 |
Drugs & Compounds for IL4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Histamine | Approved, Investigational | Pharma | Full agonist, Agonist | 1227 | ||
| Montelukast | Approved | Pharma | Antagonist | 291 | ||
| Calcitriol | Approved | Nutra | TNF-α and IL-1β production inhibitor, Vitamin D receptor (VDR) agonist | 235 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1440 | ||
| Coal tar | Approved | Pharma | 293 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for IL4 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcitriol | TNF-α and IL-1β production inhibitor | 32222-06-3 |
| Suplatast Tosylate | 94055-76-2 |
Drug Products
- RayBiotech Recombinant Human IL-4
-
BioLegend
- Human IL-4 ELISA MAX(TM) Standard
- Recombinant Human IL-4 (ELISA Std.)
- Recombinant Human IL-4 (carrier-free) (574006)
- Recombinant Human IL-4 (carrier-free) (574004)
- Recombinant Human IL-4 (carrier-free) (574002)
- Recombinant Human IL-4 (carrier-free) (574008)
- Recombinant Human IL-4 (Animal-Free)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766206)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766202)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766204)
- Recombinant Human IL-4 (293E-expressed) (carrier-free) (766208)
- ApexBio compounds for IL4
Transcripts for IL4 Gene
mRNA/cDNA for IL4 Gene
- 3 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000231449 615 bps (ENST00000231449.7)
- ENST00000350025 414 bps (ENST00000350025.2)
- ENST00000495905 305 bps (ENST00000495905.1)
- ENST00000622422 717 bps (ENST00000622422.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IL4 - Select products 50% OFF >
- * IL4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IL4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL4
- genomics-online: gRNA clones - Search for available IL-4 gRNA products
- Overview of 164 available IL-4 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL4
- Browse OriGene Inhibitory RNA Products For IL4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL4
- genomics-online: shRNA clones - Search for available IL-4 shRNA products
- Overview of 164 available IL-4 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for IL4 - Select products 50% OFF >
- * IL4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226748
- MR226748
- MR226748L3
- MR226748L4
- RC209972
- RC209972L1
- RC209972L2
- RC209972L3
- RC209972L4
- RC213286
- RC213286L3
- RC213286L4
- RG209972
- RG213286
- RR206501
- RR206501L1
- RR206501L2
- RR206501L3
- RR206501L4
- MR226748L3V
- MR226748L4V
- RC209972L1V
- RC209972L2V
- RC209972L3V
- RC209972L4V
- RC213286L3V
- RC213286L4V
- RR206501L1V
- RR206501L2V
- RR206501L3V
- RR206501L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL4
- Addgene plasmids for IL4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL4
- genomics-online: cdna clones - Search for available IL-4 CDNA products
- Overview of 164 available IL-4 gene related products
- orf clones - Search for available IL-4 ORF products
- Overview of 164 available IL-4 gene related products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | - |
Relevant External Links for IL4 Gene
- GeneLoc Exon Structure for
- IL4
Expression for IL4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Multinuclear Myocytes Anterior Neck Muscles
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Trunk Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Lumbar Vertebrae Column Muscles
-
Limb (Muscoskeletal System)
- Multinuclear Myocytes Forelimb Dorsal Muscles
- Multinuclear Myocytes Hindlimb Ventral Muscle
- Multinuclear Myocytes Forelimb Ventral Muscles
- Multinuclear Myocytes Hindlimb Dorsal Muscle
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Ovalbumin speci?c type 1 regulatory T- cells (Ovasave)
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IL4 Gene
This gene is overexpressed in Pituitary (x4.7).
This gene is overexpressed in Cervix (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL4
SOURCE GeneReport for Unigene cluster for IL4 Gene:
Hs.73917Evidence on tissue expression from TISSUES for IL4 Gene
- Blood(4.8)
- Spleen(3.7)
- Lymph node(3.5)
- Lung(3)
- Skin(2.9)
- Bone marrow(2.8)
- Nervous system(2.6)
- Intestine(2.5)
- Liver(2.3)
- Heart(2.1)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for IL4
-
OriGene qPCR primer pairs and template standards for IL4
- genomics-online: primer clones - Search for available IL-4 Primer products
- Overview of 164 available IL-4 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL4 Gene
Orthologs for IL4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL4 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IL4 31 30 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL4 31 30 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Il4 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Il4 17 31 30 |
|
- Species where no ortholog for IL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IL4 Gene
- ENSEMBL:
- Gene Tree for IL4 (if available)
- TreeFam:
- Gene Tree for IL4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL4: view image
Paralogs for IL4 Gene
No data available for Paralogs for IL4 Gene
Variants for IL4 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv28e197 | CNV | deletion | 19546169 |
| esv2348204 | CNV | deletion | 18987734 |
| esv2730791 | CNV | deletion | 23290073 |
| esv2730792 | CNV | deletion | 23290073 |
| esv2730793 | CNV | deletion | 23290073 |
| nsv528281 | CNV | gain | 19592680 |
| nsv529021 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.26;
5.83% of all genes are more intolerant (likely to be disease-causing)
