Aliases for IL37 Gene
External Ids for IL37 Gene
Previous HGNC Symbols for IL37 Gene
Previous GeneCards Identifiers for IL37 Gene
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL37 Gene
IL37 (Interleukin 37) is a Protein Coding gene. Diseases associated with IL37 include Adult-Onset Still's Disease and Idiopathic Anterior Uveitis. Among its related pathways are PEDF Induced Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL1F10.
UniProtKB/Swiss-Prot Summary for IL37 Gene
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.