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Aliases for IL37 Gene

Aliases for IL37 Gene

  • Interleukin 37 2 3 5
  • Interleukin-1-Related Protein 2 3 4
  • Interleukin-1 Homolog 4 2 3 4
  • Interleukin 1, Zeta 2 3
  • Interleukin-23 3 4
  • FIL1 Zeta 3 4
  • IL-1 Zeta 3 4
  • IL-1RP1 3 4
  • IL-1F7 3 4
  • IL-1H4 3 4
  • IL1RP1 3 4
  • IL1F7 3 4
  • FIL1Z 3 4
  • IL-1H 3 4
  • IL-37 3 4
  • IL1H4 3 4
  • Interleukin 1 Family, Member 7 (Zeta) 2
  • IL1F7 (Canonical Product IL-1F7b) 3
  • IL-1F7b (IL-1H4, IL-1H, IL-1RP1) 3
  • Interleukin 1 Family Member 7 3
  • Interleukin-1 Family Member 7 4
  • Interleukin-1 Superfamily Z 3
  • Interleukin-1 Zeta 4
  • Interleukin-37 3
  • IL-1X Protein 3
  • FIL1(ZETA) 3
  • IL-1X 4
  • FIL1 3

External Ids for IL37 Gene

Previous HGNC Symbols for IL37 Gene

  • IL1F7

Previous GeneCards Identifiers for IL37 Gene

  • GC02P113672
  • GC02P112912
  • GC02P112914
  • GC02P113041
  • GC02P113142

Summaries for IL37 Gene

Entrez Gene Summary for IL37 Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL37 Gene

IL37 (Interleukin 37) is a Protein Coding gene. Diseases associated with IL37 include Rheumatoid Arthritis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding. An important paralog of this gene is IL36G.

UniProtKB/Swiss-Prot for IL37 Gene

  • Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

Gene Wiki entry for IL37 Gene

Additional gene information for IL37 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL37 Gene

Genomics for IL37 Gene

GeneHancer (GH) Regulatory Elements for IL37 Gene

Promoters and enhancers for IL37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I112912 Promoter 0.5 EPDnew 550.8 +1.9 1933 0.1 IL37 CDK8P2 GC02P113651
GH02I112781 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 14.5 -127.4 -127430 3.9 PKNOX1 ARNT BMI1 BATF POLR2B E2F8 ETV6 IKZF2 RUNX3 CREM IL1A IL37 IL1B ENSG00000243389 CHCHD5 ENSG00000207383 CKAP2L GC02P113658
GH02I112811 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -97.8 -97759 4.3 ELF3 ATF1 BMI1 BATF IRF4 RAD21 RARA EGR1 ETV6 FOS IL1B IL1RN IL1A IL37 IL36B IL36G CKAP2L IL36RN GC02M112788
GH02I112884 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 16.3 -25.7 -25717 1.3 RB1 ARID4B THRB ZNF48 RAD21 RARA ARID2 ZSCAN5C ZNF207 ZNF143 PIR39579 IL1B IL1RN IL1A IL37 IL36G CKAP2L IL36B IL36RN PIR40727
GH02I112867 Enhancer 1.4 Ensembl ENCODE dbSUPER 15.9 -41.8 -41824 3.6 PKNOX1 CLOCK SMAD1 ATF1 FEZF1 ZNF2 ZNF121 ZNF213 KLF7 FOS IL1B WASH2P IL1A RABL2A IL37 RGPD8 CKAP2L ZC3H8 PIR40727 XIAPP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IL37 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IL37 Gene

Genomic Locations for IL37 Gene
7,819 bases
Plus strand

Genomic View for IL37 Gene

Genes around IL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL37 Gene

Proteins for IL37 Gene

  • Protein details for IL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B5BU97
    • Q56AP9
    • Q8TD04
    • Q8TD05
    • Q9HBF2
    • Q9HBF3
    • Q9UHA6

    Protein attributes for IL37 Gene

    218 amino acids
    Molecular mass:
    24126 Da
    Quaternary structure:
    • Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18.

    Three dimensional structures from OCA and Proteopedia for IL37 Gene

    Alternative splice isoforms for IL37 Gene


neXtProt entry for IL37 Gene

Post-translational modifications for IL37 Gene

No data available for DME Specific Peptides for IL37 Gene

Domains & Families for IL37 Gene

Gene Families for IL37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IL37 Gene

Suggested Antigen Peptide Sequences for IL37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-1 family.
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL37: view

Function for IL37 Gene

Molecular function for IL37 Gene

UniProtKB/Swiss-Prot Function:
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
UniProtKB/Swiss-Prot Induction:
Highly induced by bacterial lipopolysaccharides (LPS) and TGFB1, more moderately by IFNG, IL18, IL1B, TNF and the dinucleotide CpG (at protein level). Constitutive expression in bone marrow macrophages is down-regulated in the presence of IL4 and CSF2. Induced by phorbol myristate acetate (PMA) in different cell lines.

Phenotypes From GWAS Catalog for IL37 Gene

Gene Ontology (GO) - Molecular Function for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005149 interleukin-1 receptor binding TAS 10625660
genes like me logo Genes that share ontologies with IL37: view

Phenotypes for IL37 Gene

GenomeRNAi human phenotypes for IL37:
genes like me logo Genes that share phenotypes with IL37: view

Animal Model Products

miRNA for IL37 Gene

miRTarBase miRNAs that target IL37

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL37 Gene

Localization for IL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL37 Gene

Cytoplasm, cytosol. Nucleus. Secreted. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL37 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 10744718
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IL37: view

Pathways & Interactions for IL37 Gene

genes like me logo Genes that share pathways with IL37: view

Pathways by source for IL37 Gene

1 R&D Systems pathway for IL37 Gene

Gene Ontology (GO) - Biological Process for IL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 10625660
GO:0010469 regulation of receptor activity IEA --
GO:0019221 cytokine-mediated signaling pathway IBA --
genes like me logo Genes that share ontologies with IL37: view

No data available for SIGNOR curated interactions for IL37 Gene

Drugs & Compounds for IL37 Gene

No Compound Related Data Available

Transcripts for IL37 Gene

Unigene Clusters for IL37 Gene

Interleukin 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP4: - - -
SP5: - -

Relevant External Links for IL37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL37 Gene

mRNA differential expression in normal tissues according to GTEx for IL37 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x28.2) and Skin - Not Sun Exposed (Suprapubic) (x22.9).

Protein differential expression in normal tissues from HIPED for IL37 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL37 Gene

Protein tissue co-expression partners for IL37 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL37 Gene:


SOURCE GeneReport for Unigene cluster for IL37 Gene:


mRNA Expression by UniProt/SwissProt for IL37 Gene:

Tissue specificity: In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

Evidence on tissue expression from TISSUES for IL37 Gene

  • Blood(4.4)
  • Lung(4.2)
  • Intestine(4.1)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with IL37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL37 Gene

Orthologs for IL37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL37 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IL37 33 34
  • 81.38 (n)
(Bos Taurus)
Mammalia IL37 33 34
  • 73.81 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
-- 34
  • 27 (a)
-- 34
  • 26 (a)
-- 34
  • 23 (a)
Species where no ortholog for IL37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL37 Gene

Gene Tree for IL37 (if available)
Gene Tree for IL37 (if available)

Paralogs for IL37 Gene

Paralogs for IL37 Gene

(2) SIMAP similar genes for IL37 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IL37: view

Variants for IL37 Gene

Sequence variations from dbSNP and Humsavar for IL37 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000272376 -- 112,914,573(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000372026 -- 112,907,921(+) A/G upstream_transcript_variant
rs1000387037 -- 112,917,383(+) G/C intron_variant
rs1000569633 -- 112,915,408(+) G/A intron_variant
rs1000705713 -- 112,909,430(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL37 Gene

Variant ID Type Subtype PubMed ID
nsv2879 CNV insertion 18451855
nsv1003372 CNV loss 25217958
esv3584019 CNV loss 25503493

Variation tolerance for IL37 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.54; 82.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL37 Gene

Disorders for IL37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IL37 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards
Search IL37 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL37

genes like me logo Genes that share disorders with IL37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL37 Gene

Publications for IL37 Gene

  1. Four new members expand the interleukin-1 superfamily. (PMID: 10625660) Smith DE … Sims JE (The Journal of biological chemistry 2000) 2 3 4 22 58
  2. The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. (PMID: 18390730) Sharma S … Bufler P (Journal of immunology (Baltimore, Md. : 1950) 2008) 3 4 22 58
  3. IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. (PMID: 11145836) Pan G … Vandlen R (Cytokine 2001) 3 4 22 58
  4. IL-37 is a fundamental inhibitor of innate immunity. (PMID: 20935647) Nold MF … Dinarello CA (Nature immunology 2010) 3 4 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58

Products for IL37 Gene

Sources for IL37 Gene

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