The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein... See more...

Aliases for IL36RN Gene

Aliases for IL36RN Gene

  • Interleukin 36 Receptor Antagonist 2 3 5
  • Interleukin-1 Receptor Antagonist Homolog 1 2 3 4
  • Interleukin-1 HY1 2 3 4
  • Interleukin-36 Receptor Antagonist Protein 3 4
  • Interleukin 1 Family, Member 5 (Delta) 2 3
  • Interleukin-1-Like Protein 1 3 4
  • IL-1 Related Protein 3 2 3
  • IL-1ra Homolog 1 3 4
  • IL-36Ra 3 4
  • IL1HY1 3 4
  • IL1RP3 3 4
  • IL1F5 3 4
  • FIL1D 3 4
  • IL1L1 3 4
  • IL-1F5 (IL-1HY1, FIL1-Delta, IL-1RP3, IL-1L1, IL-1-Delta) 3
  • IL1F5 (Canonical Product IL-1F5a) 3
  • Interleukin-1 Family Member 5 4
  • Family Of Interleukin 1-Delta 2
  • IL-1-Related Protein 3 4
  • Interleukin-1 Delta 4
  • FIL1(DELTA) 3
  • FIL1 Delta 4
  • IL-1 Delta 4
  • PSORS14 3
  • IL-1HY1 4
  • IL-1RP3 4
  • IL36RA 3
  • IL-1F5 4
  • IL-1L1 4
  • PSORP 3
  • FIL1 3

External Ids for IL36RN Gene

Previous HGNC Symbols for IL36RN Gene

  • IL1F5

Previous GeneCards Identifiers for IL36RN Gene

  • GC02P113817
  • GC02P113059
  • GC02P113976
  • GC02P114222
  • GC02P114263
  • GC02P113060
  • GC02P113197
  • GC02P113369
  • GC02P113609
  • GC02P113836

Summaries for IL36RN Gene

Entrez Gene Summary for IL36RN Gene

  • The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL36RN Gene

IL36RN (Interleukin 36 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL36RN include Psoriasis 14, Pustular and Pustulosis Palmaris Et Plantaris. Among its related pathways are PEDF Induced Signaling and IL-1 Family Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor antagonist activity. An important paralog of this gene is IL1RN.

UniProtKB/Swiss-Prot Summary for IL36RN Gene

  • Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

Gene Wiki entry for IL36RN Gene

Additional gene information for IL36RN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL36RN Gene

Genomics for IL36RN Gene

GeneHancer (GH) Regulatory Elements for IL36RN Gene

Promoters and enhancers for IL36RN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J113056 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 512.8 -0.1 -137 5.8 ZNF217 CTCF PHB2 TSC22D4 GATAD2B CTBP1 ZNF585B HES1 GABPA ZNF207 IL36RN IL36B IL1RN IL1B WASH2P RNU6-1180P IL36A ENSG00000270019 POLR1B IL36G
GH02J113076 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.5 +22.9 22863 9.8 EP300 ZNF217 CTCF CLOCK REST CUX1 RAD21 ZBTB7A TEAD1 ZBTB26 IL1RN lnc-IL1F10-2 IL36B IL1B IL36A IL36RN PSD4 IL36G IL37 PAX8-AS1
GH02J113071 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.8 +14.1 14083 2.4 RBM25 ZNF316 MAFF MAFG ZMYM3 MAFK CTCF BACH1 EMSY IL1F10 IL36B IL1RN PSD4 IL36RN IL36A IL37 NDUFB4P6 CDK8P2 lnc-IL1F10-1
GH02J113155 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5 +99.1 99142 3.7 POLR2G NCOR1 ZFX ZIC2 POLR2A TCF7 ZNF623 ZBTB26 CUX1 TGIF2 PSD4 IL1RN PAX8-AS1 WASH2P RNU6-1180P IL36RN IL36B IL1B IL36G RF01061-090
GH02J113069 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.6 +11.1 11062 3 ZNF217 RFX1 CTBP1 GATA3 PKNOX1 DPF2 SCRT1 ZNF24 CREB1 IL1F10 IL36B IL36RN PSD4 lnc-IL1F10-1 lnc-PAX8-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL36RN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL36RN

Genomic Locations for IL36RN Gene

Genomic Locations for IL36RN Gene
chr2:113,058,638-113,065,382
(GRCh38/hg38)
Size:
6,745 bases
Orientation:
Plus strand
chr2:113,816,215-113,822,959
(GRCh37/hg19)
Size:
6,745 bases
Orientation:
Plus strand

Genomic View for IL36RN Gene

Genes around IL36RN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL36RN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL36RN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL36RN Gene

Proteins for IL36RN Gene

  • Protein details for IL36RN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBH0-I36RA_HUMAN
    Recommended name:
    Interleukin-36 receptor antagonist protein
    Protein Accession:
    Q9UBH0
    Secondary Accessions:
    • A8K2I4
    • Q56AT9
    • Q7RTZ6

    Protein attributes for IL36RN Gene

    Size:
    155 amino acids
    Molecular mass:
    16962 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL36RN Gene

neXtProt entry for IL36RN Gene

Post-translational modifications for IL36RN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL36RN Gene

No data available for DME Specific Peptides for IL36RN Gene

Domains & Families for IL36RN Gene

Gene Families for IL36RN Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL36RN Gene

Blocks:
  • Interleukin-1 precursor family signature
  • Interleukin-1 receptor antagonist precursor IL-1RA signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL36RN Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-1-like protein 1 (I36RA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBH0

UniProtKB/Swiss-Prot:

I36RA_HUMAN :
  • Belongs to the IL-1 family.
Family:
  • Belongs to the IL-1 family.
genes like me logo Genes that share domains with IL36RN: view

Function for IL36RN Gene

Molecular function for IL36RN Gene

UniProtKB/Swiss-Prot Function:
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
UniProtKB/Swiss-Prot Induction:
By phorbol ester (PMA) and bacterial lipopolysaccharides (LPS) treatment in macrophage cell line. By Aspergillus fumigatus conidia in peripheral blood mnonocytes.

Phenotypes From GWAS Catalog for IL36RN Gene

Gene Ontology (GO) - Molecular Function for IL36RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA 21873635
GO:0005149 interleukin-1 receptor binding IBA,IEA 21873635
GO:0005152 interleukin-1 receptor antagonist activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with IL36RN: view
genes like me logo Genes that share phenotypes with IL36RN: view

Human Phenotype Ontology for IL36RN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL36RN Gene

MGI Knock Outs for IL36RN:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL36RN

CRISPR Products

miRNA for IL36RN Gene

miRTarBase miRNAs that target IL36RN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL36RN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL36RN Gene

Localization for IL36RN Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL36RN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL36RN gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL36RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with IL36RN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL36RN Gene

Pathways & Interactions for IL36RN Gene

genes like me logo Genes that share pathways with IL36RN: view

Pathways by source for IL36RN Gene

1 KEGG pathway for IL36RN Gene
1 R&D Systems pathway for IL36RN Gene

Gene Ontology (GO) - Biological Process for IL36RN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IMP 23147407
GO:0002376 immune system process IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with IL36RN: view

No data available for SIGNOR curated interactions for IL36RN Gene

Transcripts for IL36RN Gene

mRNA/cDNA for IL36RN Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL36RN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL36RN Gene

No ASD Table

Relevant External Links for IL36RN Gene

GeneLoc Exon Structure for
IL36RN

Expression for IL36RN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL36RN Gene

mRNA differential expression in normal tissues according to GTEx for IL36RN Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.1), Skin - Not Sun Exposed (Suprapubic) (x13.9), and Esophagus - Mucosa (x10.3).

Protein differential expression in normal tissues from HIPED for IL36RN Gene

This gene is overexpressed in Cervix (62.2) and Oral epithelium (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL36RN Gene



Protein tissue co-expression partners for IL36RN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL36RN

SOURCE GeneReport for Unigene cluster for IL36RN Gene:

Hs.516301

mRNA Expression by UniProt/SwissProt for IL36RN Gene:

Q9UBH0-I36RA_HUMAN
Tissue specificity: Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.

Evidence on tissue expression from TISSUES for IL36RN Gene

  • Skin(4.6)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL36RN Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • nervous
Regions:
Head and neck:
  • brain
  • head
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • hair
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with IL36RN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IL36RN Gene

Orthologs for IL36RN Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL36RN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1F5 30
  • 99.35 (n)
IL36RN 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IL36RN 31 30
  • 89.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il1f5 17 31 30
  • 84.3 (n)
cow
(Bos Taurus)
Mammalia IL36RN 31 30
  • 83.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il36rn 30
  • 82.58 (n)
oppossum
(Monodelphis domestica)
Mammalia IL36RN 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL36RN 31
  • 37 (a)
OneToOne
Species where no ortholog for IL36RN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL36RN Gene

ENSEMBL:
Gene Tree for IL36RN (if available)
TreeFam:
Gene Tree for IL36RN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL36RN: view image

Paralogs for IL36RN Gene

Paralogs for IL36RN Gene

(4) SIMAP similar genes for IL36RN Gene using alignment to 3 proteins:

  • I36RA_HUMAN
  • C9JTH1_HUMAN
  • U3KPW9_HUMAN
genes like me logo Genes that share paralogs with IL36RN: view

Variants for IL36RN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL36RN Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
575254 Conflicting Interpretations: Pustular psoriasis, generalized 113,062,235(+) C/T MISSENSE_VARIANT
636595 Uncertain Significance: not provided 113,060,923(+) G/C MISSENSE_VARIANT
639584 Uncertain Significance: Pustular psoriasis, generalized 113,062,144(+) C/T MISSENSE_VARIANT
643910 Uncertain Significance: Pustular psoriasis, generalized 113,062,172(+) C/T MISSENSE_VARIANT
662407 Uncertain Significance: Pustular psoriasis, generalized 113,062,577(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IL36RN Gene

Structural Variations from Database of Genomic Variants (DGV) for IL36RN Gene

Variant ID Type Subtype PubMed ID
nsv1136395 CNV deletion 24896259
nsv2881 CNV deletion 18451855

Variation tolerance for IL36RN Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL36RN Gene

Human Gene Mutation Database (HGMD)
IL36RN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL36RN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL36RN Gene

Disorders for IL36RN Gene

MalaCards: The human disease database

(19) MalaCards diseases for IL36RN Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I36RA_HUMAN
  • Psoriasis 14, pustular (PSORS14) [MIM:614204]: A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. {ECO:0000269 PubMed:21839423, ECO:0000269 PubMed:21848462, ECO:0000269 PubMed:22903787}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL36RN

genes like me logo Genes that share disorders with IL36RN: view

No data available for Genatlas for IL36RN Gene

Publications for IL36RN Gene

  1. Four new members expand the interleukin-1 superfamily. (PMID: 10625660) Smith DE … Sims JE (The Journal of biological chemistry 2000) 2 3 4 23 54
  2. IL1HY1: A novel interleukin-1 receptor antagonist gene. (PMID: 10512743) Mulero JJ … Ford JE (Biochemical and biophysical research communications 1999) 2 3 4 23 54
  3. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R … Kastelein RA (Journal of immunology (Baltimore, Md. : 1950) 2001) 3 4 23 54
  4. A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. (PMID: 11093146) Barton JL … Nicklin MJ (European journal of immunology 2000) 3 4 23 54
  5. The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. (PMID: 23147407) Gresnigt MS … van de Veerdonk FL (European journal of immunology 2013) 3 4 54

Products for IL36RN Gene

Sources for IL36RN Gene