Aliases for IL33 Gene
External Ids for IL33 Gene
Previous HGNC Symbols for IL33 Gene
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for IL33 Gene
IL33 (Interleukin 33) is a Protein Coding gene. Diseases associated with IL33 include Igg4-Related Disease and Granulomatous Mastitis. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include cytokine activity.
UniProtKB/Swiss-Prot Summary for IL33 Gene
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).